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Nature Reviews Endocrinology最新文献

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Fusion with blood vessel organoids supports pancreatic islet function. 与血管类器官的融合支持胰岛功能。
IF 40.5 1区 医学
Nature Reviews Endocrinology Pub Date : 2025-10-22 DOI: 10.1038/s41574-025-01201-0
Senegal Carty
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引用次数: 0
Diabetes mellitus and work participation. 糖尿病与工作参与。
IF 4 1区 医学
Nature Reviews Endocrinology Pub Date : 2025-10-20 DOI: 10.1038/s41574-025-01194-w
Dunya Tomic, Karen Walker-Bone, Tessa Keegel, Ella Zomer, Sophia Zoungas, Dianna J Magliano
{"title":"Diabetes mellitus and work participation.","authors":"Dunya Tomic, Karen Walker-Bone, Tessa Keegel, Ella Zomer, Sophia Zoungas, Dianna J Magliano","doi":"10.1038/s41574-025-01194-w","DOIUrl":"https://doi.org/10.1038/s41574-025-01194-w","url":null,"abstract":"<p><p>Work participation is beneficial for health. Diabetes mellitus is highly prevalent among adults, and although it poses a substantial healthcare cost burden, the true burden might be greater than is currently appreciated through effects on work participation. This Review summarizes the evidence regarding the effect of diabetes mellitus on paid employment. Several studies report increased risks of unemployment, early retirement and productivity loss among those with diabetes mellitus. The presence of diabetes mellitus complications and comorbidities probably further decreases work participation. Studies of workplace interventions demonstrate that work ability can be improved in people with diabetes mellitus. However, most existing research does not consider work characteristics (for example, type of work and working hours) in diabetes mellitus management. Whether diabetes mellitus itself increases occupational injury risk is unclear, with conflicting results reported. Most studies were cross-sectional and limited by use of self-reported diabetes mellitus and outcome measures, without consideration of the type of diabetes mellitus. Guidance on diabetes mellitus and employment has, to date, not been strongly grounded in evidence. Detailed research exploring factors implicated in work outcomes for people with diabetes mellitus, including age, sex, occupation and diabetes mellitus type, is needed to inform policy and support sustainable employment for those with diabetes mellitus.</p>","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":" ","pages":""},"PeriodicalIF":40.0,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145337342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interleukin-18 in obesity and obesity-related metabolic diseases. 白介素-18在肥胖及肥胖相关代谢疾病中的作用。
IF 40.5 1区 医学
Nature Reviews Endocrinology Pub Date : 2025-10-17 DOI: 10.1038/s41574-025-01199-5
Christian Stoess,Janset Onyuru,Phillipp Hartmann,Hal M Hoffman,Lori Broderick,Ariel E Feldstein
{"title":"Interleukin-18 in obesity and obesity-related metabolic diseases.","authors":"Christian Stoess,Janset Onyuru,Phillipp Hartmann,Hal M Hoffman,Lori Broderick,Ariel E Feldstein","doi":"10.1038/s41574-025-01199-5","DOIUrl":"https://doi.org/10.1038/s41574-025-01199-5","url":null,"abstract":"","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"1 1","pages":""},"PeriodicalIF":40.5,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145311382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The complexity of the relationship between thyroid disease and body weight. 甲状腺疾病与体重关系的复杂性。
IF 40.5 1区 医学
Nature Reviews Endocrinology Pub Date : 2025-10-14 DOI: 10.1038/s41574-025-01190-0
Jacqueline Jonklaas
{"title":"The complexity of the relationship between thyroid disease and body weight.","authors":"Jacqueline Jonklaas","doi":"10.1038/s41574-025-01190-0","DOIUrl":"https://doi.org/10.1038/s41574-025-01190-0","url":null,"abstract":"The factors influencing the control of body weight are numerous and include many hormones. Even though levels of thyroid hormone might not always be the major factor affecting weight, in the sense that large changes in weight can occur despite a euthyroid state, there are notable changes in weight, appetite and body composition associated with excesses and deficiencies of thyroid hormone. Exploring the effect of thyroid hormone on weight is facilitated by studying the disease states of hypothyroidism and hyperthyroidism, the development and treatment of which can be associated with substantial changes in body weight. As is illustrated in the ensuing discussion, hypothyroidism is associated with modest increases in body weight and accompanying changes in body composition, with reversal of these alterations with its treatment. By contrast, hyperthyroidism can be accompanied by profound weight loss with reversal of the weight loss with restoration of euthyroidism. Using iatrogenic hyperthyroidism, whether during treatment for hypothyroidism or during off-label use in euthyroid individuals, has not proven to be an effective weight loss strategy.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"91 1","pages":""},"PeriodicalIF":40.5,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145288497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: Mechanisms of diabetic kidney disease and established and emerging treatments. 作者更正：糖尿病肾病的机制和已建立的和新兴的治疗方法。
IF 4 1区 医学
Nature Reviews Endocrinology Pub Date : 2025-10-10 DOI: 10.1038/s41574-025-01198-6
Victor Martinez Leon, Rachel Hilburg, Katalin Susztak
{"title":"Author Correction: Mechanisms of diabetic kidney disease and established and emerging treatments.","authors":"Victor Martinez Leon, Rachel Hilburg, Katalin Susztak","doi":"10.1038/s41574-025-01198-6","DOIUrl":"https://doi.org/10.1038/s41574-025-01198-6","url":null,"abstract":"","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":" ","pages":""},"PeriodicalIF":40.0,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Marking 20 years of Nature Reviews Endocrinology 纪念《自然评论》内分泌学20周年
IF 4 1区 医学
Nature Reviews Endocrinology Pub Date : 2025-10-10 DOI: 10.1038/s41574-025-01188-8
{"title":"Marking 20 years of Nature Reviews Endocrinology","authors":"","doi":"10.1038/s41574-025-01188-8","DOIUrl":"10.1038/s41574-025-01188-8","url":null,"abstract":"The November 2025 issue marks 20 years since the launch of Nature Reviews Endocrinology (originally Nature Clinical Practice Endocrinology &amp; Metabolism). Here, we reflect on the past 20 years and consider what the future holds.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"21 11","pages":"657-657"},"PeriodicalIF":40.0,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41574-025-01188-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145248861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic potential of myokines and myometabolites for brain ageing and neurodegeneration. 肌因子和肌代谢物对脑老化和神经变性的治疗潜力。
IF 40.5 1区 医学
Nature Reviews Endocrinology Pub Date : 2025-10-08 DOI: 10.1038/s41574-025-01195-9
Mamta Rai,Fabio Demontis
{"title":"Therapeutic potential of myokines and myometabolites for brain ageing and neurodegeneration.","authors":"Mamta Rai,Fabio Demontis","doi":"10.1038/s41574-025-01195-9","DOIUrl":"https://doi.org/10.1038/s41574-025-01195-9","url":null,"abstract":"","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"11 1","pages":""},"PeriodicalIF":40.5,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145246801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel UCP1-independent thermogenic mechanism identified. 新发现的不依赖于ucp1的产热机制
IF 4 1区 医学
Nature Reviews Endocrinology Pub Date : 2025-10-07 DOI: 10.1038/s41574-025-01193-x
Olivia Tysoe
{"title":"Novel UCP1-independent thermogenic mechanism identified.","authors":"Olivia Tysoe","doi":"10.1038/s41574-025-01193-x","DOIUrl":"https://doi.org/10.1038/s41574-025-01193-x","url":null,"abstract":"","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":" ","pages":""},"PeriodicalIF":40.0,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Translating cellular senescence research into clinical practice for metabolic disease. 将细胞衰老研究转化为代谢性疾病的临床实践。
IF 40.5 1区 医学
Nature Reviews Endocrinology Pub Date : 2025-10-06 DOI: 10.1038/s41574-025-01187-9
Selim Chaib,Allyson K Palmer,Saranya P Wyles,Nicolas Musi,James L Kirkland,Tamara Tchkonia
{"title":"Translating cellular senescence research into clinical practice for metabolic disease.","authors":"Selim Chaib,Allyson K Palmer,Saranya P Wyles,Nicolas Musi,James L Kirkland,Tamara Tchkonia","doi":"10.1038/s41574-025-01187-9","DOIUrl":"https://doi.org/10.1038/s41574-025-01187-9","url":null,"abstract":"Translational research on cellular senescence has led to numerous early-phase clinical trials targeting senescent cells to treat, prevent or alleviate multiple disorders and diseases, including metabolic diseases and their comorbidities. Cellular senescence is a cell fate that occurs in response to stressors, including metabolic disruptions, and is one of the hallmarks (or pillars) of ageing. In their senescent state, cells cease proliferation and can develop a senescence-associated secretory and metabolic phenotype that contributes to the pathogenesis of metabolic dysfunction associated with obesity and ageing. Metabolic stress, which is central to the development of metabolic diseases, can trigger cellular senescence, thereby enabling a vicious cycle that exacerbates metabolic dysfunction. Therapies targeting senescent cells (senotherapeutics), either alone or in combination with other gerotherapies or lifestyle interventions, hold great promise for addressing the ongoing obesity epidemic and the need for improved therapies to prevent and treat metabolic diseases and their complications and comorbidities. In this Review, we discuss novel senotherapeutics, including challenges related to the translation of these therapies and the need to establish gerodiagnostic biomarkers to track the elimination of senescent cells, define eligibility and measure efficacy, as well as considerations for clinical trial design and execution.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"30 1","pages":""},"PeriodicalIF":40.5,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145235893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The progesterone receptor's journey through mouse models. 小鼠模型中的孕激素受体之旅。
IF 40.5 1区 医学
Nature Reviews Endocrinology Pub Date : 2025-10-06 DOI: 10.1038/s41574-025-01192-y
Nikhil Srivastava
{"title":"The progesterone receptor's journey through mouse models.","authors":"Nikhil Srivastava","doi":"10.1038/s41574-025-01192-y","DOIUrl":"https://doi.org/10.1038/s41574-025-01192-y","url":null,"abstract":"","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"123 1","pages":""},"PeriodicalIF":40.5,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145235894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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