Nature Reviews Endocrinology最新文献

Liver-specific actions of GH and IGF1 that protect against MASLD GH 和 IGF1 对肝脏的特异性作用可防止 MASLD

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2024-09-25 DOI: 10.1038/s41574-024-01037-0

Rhonda D. Kineman, Mercedes del Rio-Moreno, David J. Waxman

{"title":"Liver-specific actions of GH and IGF1 that protect against MASLD","authors":"Rhonda D. Kineman, Mercedes del Rio-Moreno, David J. Waxman","doi":"10.1038/s41574-024-01037-0","DOIUrl":"https://doi.org/10.1038/s41574-024-01037-0","url":null,"abstract":"Metabolic dysfunction-associated steatotic liver disease (MASLD; also known as nonalcoholic fatty liver disease) is a chronic condition associated with metabolic syndrome, a group of conditions that includes obesity, insulin resistance, hyperlipidaemia and cardiovascular disease. Primary growth hormone (GH) deficiency is associated with MASLD, and the decline in circulating levels of GH with weight gain might contribute to the development of MASLD. Raising endogenous GH secretion or administering GH replacement therapy in the context of MASLD enhances insulin-like growth factor 1 (IGF1) production and reduces steatosis and the severity of liver injury. GH and IGF1 indirectly control MASLD progression by regulating systemic metabolic function. Evidence supports the proposal that GH and IGF1 also have a direct role in regulating liver metabolism and health. This Review focuses on how GH acts on the hepatocyte in a sex-dependent manner to limit lipid accumulation, reduce stress, and promote survival and regeneration. In addition, we discuss how GH and IGF1 might regulate non-parenchymal cells of the liver to control inflammation and fibrosis, which have a major effect on hepatocyte survival and regeneration. Development of a better understanding of how GH and IGF1 coordinate the functions of specific, individual liver cell types might provide insight into the aetiology of MASLD initiation and progression and suggest novel approaches for the treatment of MASLD.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":null,"pages":null},"PeriodicalIF":40.5,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142317017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Control of tuberal hypothalamic development and its implications in metabolic disorders 小结节下丘脑发育的控制及其对代谢紊乱的影响

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2024-09-23 DOI: 10.1038/s41574-024-01036-1

Marysia Placzek, Kavitha Chinnaiya, Dong Won Kim, Seth Blackshaw

引用次数: 0

Early life factors that affect obesity and the need for complex solutions 影响肥胖的早期生活因素和复杂解决方案的必要性

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2024-09-23 DOI: 10.1038/s41574-024-01035-2

Kylie D. Hesketh, Miaobing Zheng, Karen J. Campbell

{"title":"Early life factors that affect obesity and the need for complex solutions","authors":"Kylie D. Hesketh, Miaobing Zheng, Karen J. Campbell","doi":"10.1038/s41574-024-01035-2","DOIUrl":"https://doi.org/10.1038/s41574-024-01035-2","url":null,"abstract":"The prevalence of obesity increases with age but is apparent even in early life. Early childhood is a critical period for development that is known to influence future health. Even so, the focus on obesity in this phase, and the factors that affect the development of obesity, has only emerged over the past two decades. Furthermore, there is a paucity of iterative work in this area that would move the field forward. Obesity is a complex condition involving the interplay of multiple influences at different levels: the individual and biological level, the sociocultural level, and the environmental and system levels. This Review provides a brief overview of the evidence for these factors with a focus on aspects specific to early life. By spotlighting the complex web of interactions between the broad range of influences, both causal and risk markers, we highlight the complex nature of the condition. Much work in the early life field remains observational and many of the intervention studies are limited by a focus on single influences and a disjointed approach to solutions. Yet the complexity of obesity necessitates coordinated multi-focused solutions and joined-up action across the first 2,000 days from conception, and beyond.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":null,"pages":null},"PeriodicalIF":40.5,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142276905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The multifactorial effect of obesity on the effectiveness and outcomes of cancer therapies 肥胖对癌症治疗效果和结果的多因素影响

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2024-09-23 DOI: 10.1038/s41574-024-01032-5

Joanne Lysaght, Melissa J. Conroy

{"title":"The multifactorial effect of obesity on the effectiveness and outcomes of cancer therapies","authors":"Joanne Lysaght, Melissa J. Conroy","doi":"10.1038/s41574-024-01032-5","DOIUrl":"https://doi.org/10.1038/s41574-024-01032-5","url":null,"abstract":"Epidemiology studies have demonstrated a clear association between obesity and the development of several distinct malignancies, with excessive visceral adiposity being an increasingly prevalent feature in patients with cancer presenting for therapeutic intervention. Clinical trials and meta-analyses have helped to inform effective and safe dosing of traditional systemically administered anticancer agents in adult patients with cancer and obesity, but there remains much debate not only regarding the effect of obesity on the more novel targeted molecular and immune-based therapies, but also about how obesity is best defined and measured clinically. Low muscle mass is associated with poor outcomes in cancer, and body composition studies using biochemical and imaging modalities are helping to fully delineate the importance of both obesity and sarcopenia in clinical outcomes; such studies might also go some way to explaining how obesity can paradoxically be associated with favourable clinical outcomes in certain cancers. As the cancer survivorship period increases and the duration of anticancer treatment lengthens, this Review highlights the challenges facing appropriate treatment selection and emphasizes how a multidisciplinary approach is warranted to manage weight and skeletal muscle loss during and after cancer treatment.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":null,"pages":null},"PeriodicalIF":40.5,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142276872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brown adipose tissue fights the battle against leukaemia. 棕色脂肪组织对抗白血病

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2024-09-20 DOI: 10.1038/s41574-024-01043-2

Pamela Fischer-Posovszky,Julia Zinngrebe

引用次数: 0

The glymphatic system as a nexus between obesity and neurological diseases. 作为肥胖症与神经系统疾病之间的纽带的消化系统。

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2024-09-20 DOI: 10.1038/s41574-024-01042-3

Bandy Chen,Stephanie Lenck,Jean-Leon Thomas,Marc Schneeberger

引用次数: 0

Female-specific inflammatory signalling exacerbates central nervous system autoimmunity in obesity 女性特有的炎症信号加剧了肥胖症中枢神经系统的自身免疫性

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2024-09-19 DOI: 10.1038/s41574-024-01040-5

Olivia Tysoe

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Effects of diet on atherosclerotic plaque development. 饮食对动脉粥样硬化斑块形成的影响。

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2024-09-19 DOI: 10.1038/s41574-024-01044-1

Claire Greenhill

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Skeletal muscle loss and sarcopenia in obesity pharmacotherapy 肥胖症药物治疗中的骨骼肌损失和肌肉疏松症

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2024-09-18 DOI: 10.1038/s41574-024-01041-4

David C. D. Hope, Tricia M-M Tan

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The role of DNA damage in diabetic complications DNA 损伤在糖尿病并发症中的作用

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2024-09-12 DOI: 10.1038/s41574-024-01038-z

Varun Kumar, Ali Önder Yildirim, Peter P. Nawroth

引用次数: 0