Nature Reviews Endocrinology最新文献

Food insecurity in the development of metabolic diseases.

IF 39.1 1区医学

Nature Reviews Endocrinology Pub Date : 2026-10-20 DOI: 10.1038/s41574-026-01314-0

Rafael Pérez-Escamilla, Sonia Hernández-Cordero, Bianca Franco-Lares, Vania Lara-Mejía

{"title":"Food insecurity in the development of metabolic diseases.","authors":"Rafael Pérez-Escamilla, Sonia Hernández-Cordero, Bianca Franco-Lares, Vania Lara-Mejía","doi":"10.1038/s41574-026-01314-0","DOIUrl":"https://doi.org/10.1038/s41574-026-01314-0","url":null,"abstract":"This Review discusses the current evidence on the relationship between food insecurity, obesity, metabolic syndrome and type 2 diabetes mellitus (T2DM), and identifies potential interventions to mitigate the effect of food insecurity on these conditions. Studies in adults (mainly cross-sectional) have consistently found associations between food insecurity and several cardiometabolic diseases, including obesity (mainly among women), hyperlipidaemia, metabolic syndrome, hypertension, cardiovascular disease and T2DM. These associations represent plausible causal relationships given that food insecurity can be a powerful psycho-emotional stressor that can cause distress, anxiety and depressive symptoms across the life course; poor dietary quality can increase the risk of metabolic syndrome and T2DM through increased visceral adiposity and insulin resistance, inflammation and an unhealthy microbiome; and food insecurity can cause healthcare behavioural trade-offs such as prioritizing purchasing food over medications for T2DM prevention or management. Community-based, healthy lifestyle promotion, early-life nutrition and Food as Medicine programmes could mitigate the negative effect of food insecurity on T2DM risk and metabolic health. There is a need to rigorously evaluate the results of promising large-scale interventions on food insecurity and cardiometabolic health outcomes.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":" ","pages":""},"PeriodicalIF":39.1,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149228341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new role in lipid metabolism for an orphan transporter. 孤儿转运蛋白在脂质代谢中的新作用。

IF 39.1 1区医学

Nature Reviews Endocrinology Pub Date : 2026-10-19 DOI: 10.1038/s41574-026-01319-9

Senegal Carty

引用次数: 0

The genome-wide puzzle: utilizing GWAS to unveil the genetic architecture of polyendocrine metabolic ovarian syndrome. 全基因组谜题：利用GWAS揭示卵巢多内分泌代谢综合征的遗传结构。

IF 39.1 1区医学

Nature Reviews Endocrinology Pub Date : 2026-10-19 DOI: 10.1038/s41574-026-01316-y

Selina Williams

引用次数: 0

The β-cells in type 1 diabetes mellitus: findings from human pancreas studies. 1型糖尿病中的β-细胞：来自人类胰腺研究的发现。

IF 39.1 1区医学

Nature Reviews Endocrinology Pub Date : 2026-10-16 DOI: 10.1038/s41574-026-01312-2

Decio L Eizirik, Eugenia Martin-Vazquez, Arturo Roca-Rivada, Xiaoyan Yi

{"title":"The β-cells in type 1 diabetes mellitus: findings from human pancreas studies.","authors":"Decio L Eizirik, Eugenia Martin-Vazquez, Arturo Roca-Rivada, Xiaoyan Yi","doi":"10.1038/s41574-026-01312-2","DOIUrl":"https://doi.org/10.1038/s41574-026-01312-2","url":null,"abstract":"Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease characterized by long-term and dynamic interactions between the immune system and pancreatic β-cells, ultimately leading to severe insulin deficiency. A paradigm shift in T1DM research has occurred in the past few years, with research now focusing on the human disease because of access to human pancreatic tissue and pancreas-draining lymph nodes. Advances in high-resolution imaging, single-cell and spatial multi-omics, and histopathology based on artificial intelligence have profoundly reshaped our understanding of disease initiation and progression. These studies revealed that β-cell loss and/or dysfunction might begin earlier than previously appreciated, preferentially affecting small β-cell-rich islets and insulin-positive cell clusters, with larger islets showing transient resistance. Substantial β-cell mass often persists at diagnosis, accompanied by functional impairment rather than immediate cell death. Across disease stages, β-cells exhibit conserved molecular signatures dominated by interferon signalling, enhanced antigen presentation and adaptive immune-evasion programmes, with evidence of heterogeneity linked to age, disease duration and immune context. Parallel analyses of pancreatic lymph nodes show early immune dysregulation, including altered regulatory T cell signatures and expansion of stem-like cytotoxic T cell populations, even before overt hyperglycaemia. Together, these findings support an integrated model of T1DM progression that enables alignment of clinical staging with evolving β-cell and immune phenotypes.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":" ","pages":""},"PeriodicalIF":39.1,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149207260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The immune hub of metabolism: how adipose tissue macrophage infiltration redefined obesity. 代谢的免疫中枢：脂肪组织巨噬细胞浸润如何重新定义肥胖。

IF 39.1 1区医学

Nature Reviews Endocrinology Pub Date : 2026-10-14 DOI: 10.1038/s41574-026-01317-x

Olivia Horrigan

引用次数: 0

Optimizing metabolic health through deep-phenotyping-based personalized nutrition 通过基于深度表型的个性化营养优化代谢健康

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2026-10-07 DOI: 10.1038/s41574-026-01308-y

Lee Reicher,Guy Lutsker,Ayya Keshet,Eran Segal

引用次数: 0

Glycation and receptors: coming of AGE in the midst of danger 糖基化和受体：AGE在危险中的到来

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2026-10-07 DOI: 10.1038/s41574-026-01309-x

Ann Marie Schmidt,Alexander Shekhtman,Ravichandran Ramasamy

引用次数: 0

Effects of weight cycling in the presence and absence of obesity 存在和不存在肥胖时体重循环的影响

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2026-10-02 DOI: 10.1038/s41574-026-01311-3

Faidon Magkos,Norbert Stefan

引用次数: 0

Author Correction: Diagnosis and management of Silver–Russell syndrome: second international consensus statement 作者更正：银罗素综合征的诊断和治疗：第二次国际共识声明

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2026-09-30 DOI: 10.1038/s41574-026-01313-1

Emma Wakeling,Justin H. Davies,Eloïse Giabicani,Susan M. O’Connell,Madeleine D. Harbison,Amélie Perriere,Jennifer B. Salem,Matthias Begemann,Gerhard Binder,Frédéric Brioude,Dayna Morris-Carney,Jovanna Dahlgren,Bea Dickinson,Bruno Donadille,Beatrice Dubern,Katja Eggermann,Gabriella Gazdagh,Karen Grønskov,Anita C. Hokken Koelega,Youn Hee Jee,Alicia Jurians,Masayo Kagami,Satomi Koyama,Emilie Kulak,Asmahane Ladjouze,Paola Lombardi,Mohamad Maghnie,Louise McClelland,Veronica Mericq,Giuseppa Patti,Klaudia Raabe,Andrea Riccio,Silvia Russo,Helen L. Storr,I. Karen Temple,Zeynep Tümer,Thomas Eggermann,Deborah J. G. Mackay,Irene Netchine

引用次数: 0

Adipocyte-derived oxylipin suppresses breast cancer growth 脂肪细胞衍生的氧脂素抑制乳腺癌的生长

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2026-09-25 DOI: 10.1038/s41574-026-01310-4

Claire Greenhill

引用次数: 0