Nature Reviews Endocrinology最新文献_第2页

Harnessing cellular therapeutics for type 1 diabetes mellitus: progress, challenges, and the road ahead 利用细胞疗法治疗 1 型糖尿病：进展、挑战和未来之路

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2024-09-03 DOI: 10.1038/s41574-024-01029-0

Alessandro Grattoni, Gregory Korbutt, Alice A. Tomei, Andrés J. García, Andrew R. Pepper, Cherie Stabler, Michael Brehm, Klearchos Papas, Antonio Citro, Haval Shirwan, Jeffrey R. Millman, Juan Melero-Martin, Melanie Graham, Michael Sefton, Minglin Ma, Norma Kenyon, Omid Veiseh, Tejal A. Desai, M. Cristina Nostro, Marjana Marinac, Megan Sykes, Holger A. Russ, Jon Odorico, Qizhi Tang, Camillo Ricordi, Esther Latres, Nicholas E. Mamrak, Jaime Giraldo, Mark C. Poznansky, Paul de Vos

{"title":"Harnessing cellular therapeutics for type 1 diabetes mellitus: progress, challenges, and the road ahead","authors":"Alessandro Grattoni, Gregory Korbutt, Alice A. Tomei, Andrés J. García, Andrew R. Pepper, Cherie Stabler, Michael Brehm, Klearchos Papas, Antonio Citro, Haval Shirwan, Jeffrey R. Millman, Juan Melero-Martin, Melanie Graham, Michael Sefton, Minglin Ma, Norma Kenyon, Omid Veiseh, Tejal A. Desai, M. Cristina Nostro, Marjana Marinac, Megan Sykes, Holger A. Russ, Jon Odorico, Qizhi Tang, Camillo Ricordi, Esther Latres, Nicholas E. Mamrak, Jaime Giraldo, Mark C. Poznansky, Paul de Vos","doi":"10.1038/s41574-024-01029-0","DOIUrl":"https://doi.org/10.1038/s41574-024-01029-0","url":null,"abstract":"Type 1 diabetes mellitus (T1DM) is a growing global health concern that affects approximately 8.5 million individuals worldwide. T1DM is characterized by an autoimmune destruction of pancreatic β cells, leading to a disruption in glucose homeostasis. Therapeutic intervention for T1DM requires a complex regimen of glycaemic monitoring and the administration of exogenous insulin to regulate blood glucose levels. Advances in continuous glucose monitoring and algorithm-driven insulin delivery devices have improved the quality of life of patients. Despite this, mimicking islet function and complex physiological feedback remains challenging. Pancreatic islet transplantation represents a potential functional cure for T1DM but is hindered by donor scarcity, variability in harvested cells, aggressive immunosuppressive regimens and suboptimal clinical outcomes. Current research is directed towards generating alternative cell sources, improving transplantation methods, and enhancing cell survival without chronic immunosuppression. This Review maps the progress in cell replacement therapies for T1DM and outlines the remaining challenges and future directions. We explore the state-of-the-art strategies for generating replenishable β cells, cell delivery technologies and local targeted immune modulation. Finally, we highlight relevant animal models and the regulatory aspects for advancing these technologies towards clinical deployment.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":null,"pages":null},"PeriodicalIF":40.5,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142123522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The promising potential of gene therapy for diabetes mellitus 基因疗法治疗糖尿病的巨大潜力

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2024-08-29 DOI: 10.1038/s41574-024-01030-7

Stefan R. Bornstein, J. Fraser Wright, Charlotte Steenblock

引用次数: 0

Neurons in the diagonal band of Broca moderate food intake 布罗卡对角线带的神经元可调节食物摄入量

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2024-08-29 DOI: 10.1038/s41574-024-01033-4

Senegal Carty

{"title":"Neurons in the diagonal band of Broca moderate food intake","authors":"Senegal Carty","doi":"10.1038/s41574-024-01033-4","DOIUrl":"https://doi.org/10.1038/s41574-024-01033-4","url":null,"abstract":"Identifying neurological mechanisms that regulate feeding behaviour could help to advance the treatment and prevention of obesity and eating disorders. New research in mice has identified and localized a population of neurons that promotes eating to satiate hunger and reduces the desire to eat simply for pleasure.One subset of these DBBPENK neurons projects from the DBB to the paraventricular nucleus of the hypothalamus (PVH) and another subset projects to the lateral nucleus of the hypothalamus (LH). The researchers hypothesized that these two neuronal subpopulations have different roles in feeding control. To test this hypothesis, the researchers compared how strongly PVH-projecting DBBPENK neurons and LH-projecting DBBPENK neurons responded when fasted or fed mice were given either normal chow or fatty, sugary food. They demonstrate that PVH-projecting DBBPENK neurons are more responsive to food presentation in fasted mice than in satiated mice. This was true whether the researchers gave the mice normal chow or fatty, sugary food. LH-projecting DBBPENK neurons, on the other hand, were more active when mice were presented with sugary, fatty food than when they were given normal chow. This response was seen in both fasted and fed mice. The investigators also showed that optogenetic stimulation of PVH-projecting DBBPENK neurons promoted increased feeding in mice, whereas stimulating LH-projecting DBBPENK neurons caused the animals to eat less than wild-type controls.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":null,"pages":null},"PeriodicalIF":40.5,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142090148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author Correction: International consensus statement on the diagnosis and management of phaeochromocytoma and paraganglioma in children and adolescents. 作者更正：关于儿童和青少年嗜铬细胞瘤和副神经节瘤诊断和管理的国际共识声明。

IF 31 1区医学

Nature Reviews Endocrinology Pub Date : 2024-08-27 DOI: 10.1038/s41574-024-01034-3

Ruth T Casey, Emile Hendriks, Cheri Deal, Steven G Waguespack, Verena Wiegering, Antje Redlich, Scott Akker, Rathi Prasad, Martin Fassnacht, Roderick Clifton-Bligh, Laurence Amar, Stefan Bornstein, Letizia Canu, Evangelia Charmandari, Alexandra Chrisoulidou, Maria Currás Freixes, Ronald de Krijger, Luisa de Sanctis, Antonio Fojo, Amol J Ghia, Angela Huebner, Vasilis Kosmoliaptsis, Michaela Kuhlen, Marco Raffaelli, Charlotte Lussey-Lepoutre, Stephen D Marks, Naris Nilubol, Mirko Parasiliti-Caprino, Henri H J L M Timmers, Anna Lena Zietlow, Mercedes Robledo, Anne-Paule Gimenez-Roqueplo, Ashley B Grossman, David Taïeb, Eamonn R Maher, Jacques W M Lenders, Graeme Eisenhofer, Camilo Jimenez, Karel Pacak, Christina Pamporaki

引用次数: 0

The complexity of adipocyte heterogeneity 脂肪细胞异质性的复杂性。

IF 31 1区医学

Nature Reviews Endocrinology Pub Date : 2024-08-27 DOI: 10.1038/s41574-024-01031-6

Claire Greenhill

引用次数: 0

New insights into the regulation of GIPR signalling 对 GIPR 信号调控的新认识

IF 31 1区医学

Nature Reviews Endocrinology Pub Date : 2024-08-22 DOI: 10.1038/s41574-024-01027-2

Yusman Manchanda, Alejandra Tomas

引用次数: 0

Thyroid nodules: diagnosis and management 甲状腺结节：诊断和管理

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2024-08-16 DOI: 10.1038/s41574-024-01025-4

Giorgio Grani, Marialuisa Sponziello, Sebastiano Filetti, Cosimo Durante

{"title":"Thyroid nodules: diagnosis and management","authors":"Giorgio Grani, Marialuisa Sponziello, Sebastiano Filetti, Cosimo Durante","doi":"10.1038/s41574-024-01025-4","DOIUrl":"https://doi.org/10.1038/s41574-024-01025-4","url":null,"abstract":"Thyroid nodules, with a prevalence of almost 25% in the general population, are a common occurrence. Their prevalence varies considerably depending on demographics such as age and sex as well as the presence of risk factors. This article provides a comprehensive overview of the prevalence, risk stratification and current management strategies for thyroid nodules, with a particular focus on changes in diagnostic and therapeutic protocols that have occurred over the past 10 years. Several sonography-based stratification systems (such as Thyroid Imaging Reporting and Data Systems (TIRADS)) might help to predict the malignancy risk of nodules, potentially eliminating the need for biopsy in many instances. However, large or suspicious nodules necessitate cytological evaluation following fine-needle aspiration biopsy for accurate classification. In the case of cytology yielding indeterminate results, additional tools, such as molecular testing, can assist in guiding the management plan. Surgery is no longer the only treatment for symptomatic or malignant nodules: active surveillance or local ablative treatments might be beneficial for appropriately selected patients. To enhance clinician–patient interactions and discussions about diagnostic options, shared decision-making tools have been developed. A personalized, risk-based protocol promotes high-quality care while minimizing costs and unnecessary testing.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":null,"pages":null},"PeriodicalIF":40.5,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141991991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

International consensus statement on the diagnosis and management of phaeochromocytoma and paraganglioma in children and adolescents 关于儿童和青少年嗜铬细胞瘤和副神经节瘤诊断和管理的国际共识声明

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2024-08-15 DOI: 10.1038/s41574-024-01024-5

Ruth T. Casey, Emile Hendriks, Cheri Deal, Steven G. Waguespack, Verena Wiegering, Antje Redlich, Scott Akker, Rathi Prasad, Martin Fassnacht, Roderick Clifton-Bligh, Laurence Amar, Stefan Bornstein, Letizia Canu, Evangelia Charmandari, Alexandra Chrisoulidou, Maria Currás Freixes, Ronald de Krijger, Luisa de Sanctis, Antonio Fojo, Amol J. Ghia, Angela Huebner, Vasilis Kosmoliaptsis, Michaela Kuehlen, Marco Raffaelli, Charlotte Lussey-Lepoutre, Stephen D. Marks, Naris Nilubol, Mirko Parasiliti-Caprino, Henri H.J.L.M. Timmers, Anna Lena Zietlow, Mercedes Robledo, Anne-Paule Gimenez-Roqueplo, Ashley B. Grossman, David Taïeb, Eamonn R. Maher, Jacques W. M. Lenders, Graeme Eisenhofer, Camilo Jimenez, Karel Pacak, Christina Pamporaki

{"title":"International consensus statement on the diagnosis and management of phaeochromocytoma and paraganglioma in children and adolescents","authors":"Ruth T. Casey, Emile Hendriks, Cheri Deal, Steven G. Waguespack, Verena Wiegering, Antje Redlich, Scott Akker, Rathi Prasad, Martin Fassnacht, Roderick Clifton-Bligh, Laurence Amar, Stefan Bornstein, Letizia Canu, Evangelia Charmandari, Alexandra Chrisoulidou, Maria Currás Freixes, Ronald de Krijger, Luisa de Sanctis, Antonio Fojo, Amol J. Ghia, Angela Huebner, Vasilis Kosmoliaptsis, Michaela Kuehlen, Marco Raffaelli, Charlotte Lussey-Lepoutre, Stephen D. Marks, Naris Nilubol, Mirko Parasiliti-Caprino, Henri H.J.L.M. Timmers, Anna Lena Zietlow, Mercedes Robledo, Anne-Paule Gimenez-Roqueplo, Ashley B. Grossman, David Taïeb, Eamonn R. Maher, Jacques W. M. Lenders, Graeme Eisenhofer, Camilo Jimenez, Karel Pacak, Christina Pamporaki","doi":"10.1038/s41574-024-01024-5","DOIUrl":"https://doi.org/10.1038/s41574-024-01024-5","url":null,"abstract":"Phaeochromocytomas and paragangliomas (PPGL) are rare neuroendocrine tumours that arise not only in adulthood but also in childhood and adolescence. Up to 70–80% of childhood PPGL are hereditary, accounting for a higher incidence of metastatic and/or multifocal PPGL in paediatric patients than in adult patients. Key differences in the tumour biology and management, together with rare disease incidence and therapeutic challenges in paediatric compared with adult patients, mandate close expert cross-disciplinary teamwork. Teams should ideally include adult and paediatric endocrinologists, oncologists, cardiologists, surgeons, geneticists, pathologists, radiologists, clinical psychologists and nuclear medicine physicians. Provision of an international Consensus Statement should improve care and outcomes for children and adolescents with these tumours.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":null,"pages":null},"PeriodicalIF":40.5,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141986287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medically not yet explained symptoms in hypothyroidism 医学上无法解释的甲状腺功能减退症症状

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2024-08-13 DOI: 10.1038/s41574-024-01022-7

Laszlo Hegedüs, Christina M. Van Der Feltz-Cornelis, Enrico Papini, Endre V. Nagy, Anthony P. Weetman, Petros Perros

{"title":"Medically not yet explained symptoms in hypothyroidism","authors":"Laszlo Hegedüs, Christina M. Van Der Feltz-Cornelis, Enrico Papini, Endre V. Nagy, Anthony P. Weetman, Petros Perros","doi":"10.1038/s41574-024-01022-7","DOIUrl":"https://doi.org/10.1038/s41574-024-01022-7","url":null,"abstract":"Persistent symptoms are common in the general population and even more so in people with hypothyroidism. When symptoms are unexplained and brought to medical attention, they can be referred to as medically not yet explained symptoms (MNYES), a term preferred to other descriptors by patients, care-givers and experts. MNYES might be neglected by endocrinologists or misattributed to hypothyroidism. Awareness of MNYES could open up more effective and less harmful interventions for patients who present to endocrinologists with unexplained symptoms than costly over-investigations and over-treatment with thyroid hormones (such as levothyroxine and liothyronine). The role of the endocrinologist is to recognize and acknowledge that MNYES could be underlying a patient’s presentation, to communicate effectively with the patient and others involved in the patient’s care, to apply a ‘two-track approach’ in management by paying equal attention to physical and psychosocial contributors, and to collaborate with other relevant health professionals. Categorization of patients into levels of risk for symptom deterioration helps in selecting suitable therapies. Effective management of MNYES demands time, training, expertise and resources.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":null,"pages":null},"PeriodicalIF":40.5,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141973885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbial hydrogen sulfide hampers L-cell GLP-1 production 微生物硫化氢阻碍 L 细胞产生 GLP-1

IF 31 1区医学

Nature Reviews Endocrinology Pub Date : 2024-08-13 DOI: 10.1038/s41574-024-01028-1

Senegal Carty

引用次数: 0