Nature Reviews Endocrinology最新文献_第2页

Publisher Correction: Current understanding of the molecular and cellular pathology of diabetic retinopathy 出版商更正：目前对糖尿病视网膜病变分子和细胞病理学的认识

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2024-10-24 DOI: 10.1038/s41574-024-01053-0

David A. Antonetti, Paolo S. Silva, Alan W. Stitt

引用次数: 0

Inflammation and resolution in obesity 肥胖症的炎症与消解

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2024-10-24 DOI: 10.1038/s41574-024-01047-y

Matúš Soták, Madison Clark, Bianca E. Suur, Emma Börgeson

{"title":"Inflammation and resolution in obesity","authors":"Matúš Soták, Madison Clark, Bianca E. Suur, Emma Börgeson","doi":"10.1038/s41574-024-01047-y","DOIUrl":"https://doi.org/10.1038/s41574-024-01047-y","url":null,"abstract":"Inflammation is an essential physiological defence mechanism, but prolonged or excessive inflammation can cause disease. Indeed, unresolved systemic and adipose tissue inflammation drives obesity-related cardiovascular disease and type 2 diabetes mellitus. Drugs targeting pro-inflammatory cytokine pathways or inflammasome activation have been approved for clinical use for the past two decades. However, potentially serious adverse effects, such as drug-induced weight gain and increased susceptibility to infections, prevented their wider clinical implementation. Furthermore, these drugs do not modulate the resolution phase of inflammation. This phase is an active process orchestrated by specialized pro-resolving mediators, such as lipoxins, and other endogenous resolution mechanisms. Pro-resolving mediators mitigate inflammation and development of obesity-related disease, for instance, alleviating insulin resistance and atherosclerosis in experimental disease models, so mechanisms to modulate their activity are, therefore, of great therapeutic interest. Here, we review current clinical attempts to either target pro-inflammatory mediators (IL-1β, NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome, tumour necrosis factor (TNF) and IL-6) or utilize endogenous resolution pathways to reduce obesity-related inflammation and improve cardiometabolic outcomes. A remaining challenge in the field is to establish more precise biomarkers that can differentiate between acute and chronic inflammation and to assess the functionality of individual leukocyte populations. Such advancements would improve the monitoring of drug effects and support personalized treatment strategies that battle obesity-related inflammation and cardiometabolic disease.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":null,"pages":null},"PeriodicalIF":40.5,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142488981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Modelling human liver disease: from steatotic liver disease to MASH-HCC 人类肝病建模：从脂肪肝到 MASH-HCC

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2024-10-24 DOI: 10.1038/s41574-024-01054-z

Christian Stoess, Ariel E. Feldstein

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Limiting the use and misuse of liothyronine in hypothyroidism 限制甲状腺功能减退症患者使用和滥用甲状腺素

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2024-10-24 DOI: 10.1038/s41574-024-01055-y

Laszlo Hegedüs, Endre Vezekenyi Nagy, Enrico Papini, Petros Perros

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The complex effects of dietary restriction on longevity and health 限制饮食对长寿和健康的复杂影响

IF 31 1区医学

Nature Reviews Endocrinology Pub Date : 2024-10-22 DOI: 10.1038/s41574-024-01051-2

Claire Greenhill

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IGF2-produced microRNA restricts growth via suppression of IGF1 IGF2 产生的微小核糖核酸通过抑制 IGF1 限制生长

IF 31 1区医学

Nature Reviews Endocrinology Pub Date : 2024-10-15 DOI: 10.1038/s41574-024-01050-3

Olivia Tysoe

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Signals from the dorsal motor nucleus of the vagus promote jejunal fat absorption 迷走神经背运动核发出的信号促进空肠脂肪吸收

IF 31 1区医学

Nature Reviews Endocrinology Pub Date : 2024-10-08 DOI: 10.1038/s41574-024-01048-x

Senegal Carty

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Skeletal stem and progenitor cells in bone physiology, ageing and disease 骨骼干细胞和祖细胞在骨骼生理、老化和疾病中的作用

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2024-10-08 DOI: 10.1038/s41574-024-01039-y

Seppe Melis, Dana Trompet, Andrei S. Chagin, Christa Maes

{"title":"Skeletal stem and progenitor cells in bone physiology, ageing and disease","authors":"Seppe Melis, Dana Trompet, Andrei S. Chagin, Christa Maes","doi":"10.1038/s41574-024-01039-y","DOIUrl":"https://doi.org/10.1038/s41574-024-01039-y","url":null,"abstract":"Skeletal stem cells (SSCs) and related progenitors with osteogenic potential, collectively termed skeletal stem and/or progenitor cells (SSPCs), are crucial for providing osteoblasts for bone formation during homeostatic tissue turnover and fracture repair. Besides mediating normal bone physiology, they also have important roles in various metabolic bone diseases, including osteoporosis. SSPCs are of tremendous interest because they represent prime future targets for osteoanabolic therapies and bone regenerative medicine. Remarkable progress has been made in characterizing various SSC and SSPC populations in postnatal bone. SSPCs exist in the periosteum and within the bone marrow stroma, including subsets localizing around arteriolar and sinusoidal blood vessels; they can display osteogenic, chondrogenic, adipogenic and/or fibroblastic potential, and exert critical haematopoiesis-supportive functions. However, much remains to be clarified. By the current markers, bona fide SSCs are commonly contained within broader SSPC populations characterized by considerable heterogeneity and overlap, whose common versus specific functions in health and disease have not been fully unravelled. Here, we review the present knowledge of the identity, fates and relationships of SSPC populations in the postnatal bone environment, their contributions to bone maintenance, the changes observed upon ageing, and the effect of metabolic diseases such as osteoporosis and diabetes mellitus.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":null,"pages":null},"PeriodicalIF":40.5,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142384877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liver-specific actions of GH and IGF1 that protect against MASLD GH 和 IGF1 对肝脏的特异性作用可防止 MASLD

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2024-09-25 DOI: 10.1038/s41574-024-01037-0

Rhonda D. Kineman, Mercedes del Rio-Moreno, David J. Waxman

{"title":"Liver-specific actions of GH and IGF1 that protect against MASLD","authors":"Rhonda D. Kineman, Mercedes del Rio-Moreno, David J. Waxman","doi":"10.1038/s41574-024-01037-0","DOIUrl":"https://doi.org/10.1038/s41574-024-01037-0","url":null,"abstract":"Metabolic dysfunction-associated steatotic liver disease (MASLD; also known as nonalcoholic fatty liver disease) is a chronic condition associated with metabolic syndrome, a group of conditions that includes obesity, insulin resistance, hyperlipidaemia and cardiovascular disease. Primary growth hormone (GH) deficiency is associated with MASLD, and the decline in circulating levels of GH with weight gain might contribute to the development of MASLD. Raising endogenous GH secretion or administering GH replacement therapy in the context of MASLD enhances insulin-like growth factor 1 (IGF1) production and reduces steatosis and the severity of liver injury. GH and IGF1 indirectly control MASLD progression by regulating systemic metabolic function. Evidence supports the proposal that GH and IGF1 also have a direct role in regulating liver metabolism and health. This Review focuses on how GH acts on the hepatocyte in a sex-dependent manner to limit lipid accumulation, reduce stress, and promote survival and regeneration. In addition, we discuss how GH and IGF1 might regulate non-parenchymal cells of the liver to control inflammation and fibrosis, which have a major effect on hepatocyte survival and regeneration. Development of a better understanding of how GH and IGF1 coordinate the functions of specific, individual liver cell types might provide insight into the aetiology of MASLD initiation and progression and suggest novel approaches for the treatment of MASLD.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":null,"pages":null},"PeriodicalIF":40.5,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142317017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Control of tuberal hypothalamic development and its implications in metabolic disorders 小结节下丘脑发育的控制及其对代谢紊乱的影响

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2024-09-23 DOI: 10.1038/s41574-024-01036-1

Marysia Placzek, Kavitha Chinnaiya, Dong Won Kim, Seth Blackshaw

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