Nature Reviews Endocrinology最新文献_第3页

Early life factors that affect obesity and the need for complex solutions 影响肥胖的早期生活因素和复杂解决方案的必要性

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2024-09-23 DOI: 10.1038/s41574-024-01035-2

Kylie D. Hesketh, Miaobing Zheng, Karen J. Campbell

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引用次数: 0

The multifactorial effect of obesity on the effectiveness and outcomes of cancer therapies 肥胖对癌症治疗效果和结果的多因素影响

IF 31 1区医学

Nature Reviews Endocrinology Pub Date : 2024-09-23 DOI: 10.1038/s41574-024-01032-5

Joanne Lysaght, Melissa J. Conroy

{"title":"The multifactorial effect of obesity on the effectiveness and outcomes of cancer therapies","authors":"Joanne Lysaght, Melissa J. Conroy","doi":"10.1038/s41574-024-01032-5","DOIUrl":"10.1038/s41574-024-01032-5","url":null,"abstract":"Epidemiology studies have demonstrated a clear association between obesity and the development of several distinct malignancies, with excessive visceral adiposity being an increasingly prevalent feature in patients with cancer presenting for therapeutic intervention. Clinical trials and meta-analyses have helped to inform effective and safe dosing of traditional systemically administered anticancer agents in adult patients with cancer and obesity, but there remains much debate not only regarding the effect of obesity on the more novel targeted molecular and immune-based therapies, but also about how obesity is best defined and measured clinically. Low muscle mass is associated with poor outcomes in cancer, and body composition studies using biochemical and imaging modalities are helping to fully delineate the importance of both obesity and sarcopenia in clinical outcomes; such studies might also go some way to explaining how obesity can paradoxically be associated with favourable clinical outcomes in certain cancers. As the cancer survivorship period increases and the duration of anticancer treatment lengthens, this Review highlights the challenges facing appropriate treatment selection and emphasizes how a multidisciplinary approach is warranted to manage weight and skeletal muscle loss during and after cancer treatment. This Review outlines the multifaceted influence of obesity on cancer treatment effectiveness and associated toxicities, and explores complex issues, such as body composition and the obesity paradox, that link obesity with outcomes for patients with cancer.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":null,"pages":null},"PeriodicalIF":31.0,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142276872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Brown adipose tissue fights the battle against leukaemia 棕色脂肪组织对抗白血病

IF 31 1区医学

Nature Reviews Endocrinology Pub Date : 2024-09-20 DOI: 10.1038/s41574-024-01043-2

Pamela Fischer-Posovszky, Julia Zinngrebe

引用次数: 0

The glymphatic system as a nexus between obesity and neurological diseases. 作为肥胖症与神经系统疾病之间的纽带的消化系统。

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2024-09-20 DOI: 10.1038/s41574-024-01042-3

Bandy Chen,Stephanie Lenck,Jean-Leon Thomas,Marc Schneeberger

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Female-specific inflammatory signalling exacerbates central nervous system autoimmunity in obesity 女性特有的炎症信号加剧了肥胖症中枢神经系统的自身免疫性

IF 31 1区医学

Nature Reviews Endocrinology Pub Date : 2024-09-19 DOI: 10.1038/s41574-024-01040-5

Olivia Tysoe

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Effects of diet on atherosclerotic plaque development 饮食对动脉粥样硬化斑块形成的影响。

IF 31 1区医学

Nature Reviews Endocrinology Pub Date : 2024-09-19 DOI: 10.1038/s41574-024-01044-1

Claire Greenhill

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Skeletal muscle loss and sarcopenia in obesity pharmacotherapy 肥胖症药物治疗中的骨骼肌损失和肌肉疏松症

IF 31 1区医学

Nature Reviews Endocrinology Pub Date : 2024-09-18 DOI: 10.1038/s41574-024-01041-4

David C. D. Hope, Tricia M-M Tan

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The role of DNA damage in diabetic complications DNA 损伤在糖尿病并发症中的作用

IF 31 1区医学

Nature Reviews Endocrinology Pub Date : 2024-09-12 DOI: 10.1038/s41574-024-01038-z

Varun Kumar, Ali Önder Yildirim, Peter P. Nawroth

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Harnessing cellular therapeutics for type 1 diabetes mellitus: progress, challenges, and the road ahead 利用细胞疗法治疗 1 型糖尿病：进展、挑战和未来之路

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2024-09-03 DOI: 10.1038/s41574-024-01029-0

Alessandro Grattoni, Gregory Korbutt, Alice A. Tomei, Andrés J. García, Andrew R. Pepper, Cherie Stabler, Michael Brehm, Klearchos Papas, Antonio Citro, Haval Shirwan, Jeffrey R. Millman, Juan Melero-Martin, Melanie Graham, Michael Sefton, Minglin Ma, Norma Kenyon, Omid Veiseh, Tejal A. Desai, M. Cristina Nostro, Marjana Marinac, Megan Sykes, Holger A. Russ, Jon Odorico, Qizhi Tang, Camillo Ricordi, Esther Latres, Nicholas E. Mamrak, Jaime Giraldo, Mark C. Poznansky, Paul de Vos

{"title":"Harnessing cellular therapeutics for type 1 diabetes mellitus: progress, challenges, and the road ahead","authors":"Alessandro Grattoni, Gregory Korbutt, Alice A. Tomei, Andrés J. García, Andrew R. Pepper, Cherie Stabler, Michael Brehm, Klearchos Papas, Antonio Citro, Haval Shirwan, Jeffrey R. Millman, Juan Melero-Martin, Melanie Graham, Michael Sefton, Minglin Ma, Norma Kenyon, Omid Veiseh, Tejal A. Desai, M. Cristina Nostro, Marjana Marinac, Megan Sykes, Holger A. Russ, Jon Odorico, Qizhi Tang, Camillo Ricordi, Esther Latres, Nicholas E. Mamrak, Jaime Giraldo, Mark C. Poznansky, Paul de Vos","doi":"10.1038/s41574-024-01029-0","DOIUrl":"https://doi.org/10.1038/s41574-024-01029-0","url":null,"abstract":"<p>Type 1 diabetes mellitus (T1DM) is a growing global health concern that affects approximately 8.5 million individuals worldwide. T1DM is characterized by an autoimmune destruction of pancreatic β cells, leading to a disruption in glucose homeostasis. Therapeutic intervention for T1DM requires a complex regimen of glycaemic monitoring and the administration of exogenous insulin to regulate blood glucose levels. Advances in continuous glucose monitoring and algorithm-driven insulin delivery devices have improved the quality of life of patients. Despite this, mimicking islet function and complex physiological feedback remains challenging. Pancreatic islet transplantation represents a potential functional cure for T1DM but is hindered by donor scarcity, variability in harvested cells, aggressive immunosuppressive regimens and suboptimal clinical outcomes. Current research is directed towards generating alternative cell sources, improving transplantation methods, and enhancing cell survival without chronic immunosuppression. This Review maps the progress in cell replacement therapies for T1DM and outlines the remaining challenges and future directions. We explore the state-of-the-art strategies for generating replenishable β cells, cell delivery technologies and local targeted immune modulation. Finally, we highlight relevant animal models and the regulatory aspects for advancing these technologies towards clinical deployment.</p>","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":null,"pages":null},"PeriodicalIF":40.5,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142123522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The promising potential of gene therapy for diabetes mellitus 基因疗法治疗糖尿病的巨大潜力

IF 31 1区医学

Nature Reviews Endocrinology Pub Date : 2024-08-29 DOI: 10.1038/s41574-024-01030-7

Stefan R. Bornstein, J. Fraser Wright, Charlotte Steenblock

引用次数: 0