Beata Lecka-Czernik, Clifford J. Rosen, Nicola Napoli
{"title":"The role of bone in whole-body energy metabolism","authors":"Beata Lecka-Czernik, Clifford J. Rosen, Nicola Napoli","doi":"10.1038/s41574-025-01162-4","DOIUrl":"https://doi.org/10.1038/s41574-025-01162-4","url":null,"abstract":"<p>The skeleton is one of the largest organs in the body and is integrated with systemic energy metabolism. This integration is mediated in part through the process of skeletal remodelling, which is fundamental for maintenance of bone mass and quality. Remodelling is an energetically expensive process that contributes to energy balance owing to constant substrate flow to the skeleton in the form of glucose, lipids and amino acids, as well as output of hormonal factors regulating peripheral metabolism. Bone remodelling is orchestrated by osteocytes, the most abundant cells in bone. Hence, it stands to reason that osteocytes must also regulate substrate availability and utilization not only for their own function but also for those of other skeletal cells (namely, osteoblasts and osteoclasts). Osteocytes also secrete factors (such as osteokines) that are engaged in complex molecular signalling networks that influence glucose metabolism, insulin sensitivity and energy homeostasis. Importantly, whole-body metabolism and bone homeostasis share similar regulatory mechanisms, including the RANKL and parathyroid hormone signalling pathways. This Review summarizes our current understanding of how the skeleton regulates whole-body energy metabolism and leads to the conclusion that bone might not be the core regulator of systemic energy metabolism but rather acts as an organ that instead regulates these complex processes.</p>","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"14 1","pages":""},"PeriodicalIF":40.5,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144898104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A call for a multidisciplinary intervention to address severe insulin resistance during pregnancy","authors":"Clipper F. Young, Diana Isaacs","doi":"10.1038/s41574-025-01164-2","DOIUrl":"10.1038/s41574-025-01164-2","url":null,"abstract":"Immediate attention is paramount for addressing the escalating prevalence of severe insulin resistance during pregnancy. A collaborative and multidisciplinary approach involving clinical care, public health initiatives and advanced technologies is essential for enhancing care, improving maternal and fetal outcomes, and mitigating long-term metabolic risks.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"21 10","pages":"586-587"},"PeriodicalIF":40.0,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144898113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luigi Barrea, Ludovica Verde, Annamaria Colao, Lawrence J. Mandarino, Giovanna Muscogiuri
{"title":"Medical nutrition therapy for the management of type 2 diabetes mellitus","authors":"Luigi Barrea, Ludovica Verde, Annamaria Colao, Lawrence J. Mandarino, Giovanna Muscogiuri","doi":"10.1038/s41574-025-01161-5","DOIUrl":"https://doi.org/10.1038/s41574-025-01161-5","url":null,"abstract":"<p>Type 2 diabetes mellitus (T2DM) is a major global health concern. Medical nutrition therapy has a key role in T2DM management, with dietary interventions being central to improving glycaemic control and overall metabolic health. Growing evidence suggests that certain dietary strategies can exert direct metabolic benefits independent of weight reduction. The Mediterranean diet has consistently demonstrated metabolic and cardiovascular benefits, along with improved glycaemic control, even in the absence of substantial weight reduction. Low-energy and very-low-energy diets, characterized by moderate to severe caloric restriction, respectively, have also been associated with improvements in cardiometabolic markers and glycaemic regulation. Ketogenic diets promote nutritional ketosis and have shown benefits on glycaemic control, insulin sensitivity and other metabolic outcomes, often preceding substantial weight loss. Intermittent fasting strategies, such as alternate-day fasting or the 5:2 model, and time-restricted eating, have likewise been linked to enhanced glycaemic control and favourable metabolic and cardiovascular effects, although their long-term efficacy and safety require further investigation. This Review aims to provide an evidence-based synthesis of the main nutritional strategies used in the treatment of T2DM, with a focus on their underlying mechanisms, clinical efficacy and potential for sustainable long-term implementation.</p>","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"134 1","pages":""},"PeriodicalIF":40.5,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144851324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shlomo Melmed, Luigi di Filippo, Maria Fleseriu, Moisés Mercado, Niki Karavitaki, Mark Gurnell, Roberto Salvatori, Stylianos Tsagarakis, Marco Losa, Pietro Maffei, Alberto M. Pereira, Eliza B. Geer, Laurence Katznelson, Aart Jan van der Lely, Jens Bollerslev, Daniela Esposito, Susan M. Webb, Maria Chiara Zatelli, Elena Valassi, Sebastian Neggers, Philippe Chanson, Ken K. Y. Ho, Adriana G. Ioachimescu, Beverly M. K. Biller, Susan L. Samson, Ursula B. Kaiser, Katharina Schilbach, Raúl M. Luque, Felipe F. Casanueva, Ilan Shimon, Cesar L. Boguszewski, Nienke Biermasz, Annamaria Colao, Rosa Pirchio, Steven W. J. Lamberts, Pinar Kadioglu, Michael Buchfelder, Stefano Frara, Sabrina Chiloiro, Stephan Petersenn, Monica R. Gadelha, Manel Puig-Domingo, Anton Luger, Thierry Brue, Albert Beckers, Diego Ferone, David R. Clemmons, Yona Greenman, Mónica Marazuela, Pietro Mortini, Christian J. Strasburger, Andrea Giustina
{"title":"Consensus on acromegaly therapeutic outcomes: an update","authors":"Shlomo Melmed, Luigi di Filippo, Maria Fleseriu, Moisés Mercado, Niki Karavitaki, Mark Gurnell, Roberto Salvatori, Stylianos Tsagarakis, Marco Losa, Pietro Maffei, Alberto M. Pereira, Eliza B. Geer, Laurence Katznelson, Aart Jan van der Lely, Jens Bollerslev, Daniela Esposito, Susan M. Webb, Maria Chiara Zatelli, Elena Valassi, Sebastian Neggers, Philippe Chanson, Ken K. Y. Ho, Adriana G. Ioachimescu, Beverly M. K. Biller, Susan L. Samson, Ursula B. Kaiser, Katharina Schilbach, Raúl M. Luque, Felipe F. Casanueva, Ilan Shimon, Cesar L. Boguszewski, Nienke Biermasz, Annamaria Colao, Rosa Pirchio, Steven W. J. Lamberts, Pinar Kadioglu, Michael Buchfelder, Stefano Frara, Sabrina Chiloiro, Stephan Petersenn, Monica R. Gadelha, Manel Puig-Domingo, Anton Luger, Thierry Brue, Albert Beckers, Diego Ferone, David R. Clemmons, Yona Greenman, Mónica Marazuela, Pietro Mortini, Christian J. Strasburger, Andrea Giustina","doi":"10.1038/s41574-025-01148-2","DOIUrl":"https://doi.org/10.1038/s41574-025-01148-2","url":null,"abstract":"<p>The 15th Acromegaly Consensus Conference in September 2023 updated recommendations on therapeutic outcomes for acromegaly. Since the publication of medical management guidelines in 2018, new pharmacological agents and new treatment approaches have been developed. Fifty-two experts in the management of acromegaly reviewed the current literature and assessed changes in drug approvals, clinical practice standards and management. Current outcome goals were considered, with a focus on the effect of current and emerging somatostatin receptor ligands, the growth hormone receptor antagonist pegvisomant and the dopamine agonist cabergoline on biochemical control, clinical control, adenoma mass and surgical outcomes. Participants assessed factors that determine pharmacological choices, as well as the proposed use of each agent. Here, we present consensus recommendations highlighting how an evidence-based acromegaly management algorithm could be optimized in clinical practice.</p>","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"87 1","pages":""},"PeriodicalIF":40.5,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144825460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ruth T. Casey, Emile Hendriks, Cheri Deal, Steven G. Waguespack, Verena Wiegering, Antje Redlich, Scott Akker, Rathi Prasad, Martin Fassnacht, Roderick Clifton-Bligh, Laurence Amar, Stefan Bornstein, Letizia Canu, Evangelia Charmandari, Alexandra Chrisoulidou, Maria Currás Freixes, Ronald de Krijger, Luisa de Sanctis, Antonio Fojo, Amol J. Ghia, Angela Huebner, Vasilis Kosmoliaptsis, Michaela Kuhlen, Marco Raffaelli, Charlotte Lussey-Lepoutre, Stephen D. Marks, Naris Nilubol, Mirko Parasiliti-Caprino, Henri H.J.L.M. Timmers, Anna Lena Zietlow, Mercedes Robledo, Anne-Paule Gimenez-Roqueplo, Ashley B. Grossman, David Taïeb, Eamonn R. Maher, Jacques W. M. Lenders, Graeme Eisenhofer, Camilo Jimenez, Karel Pacak, Christina Pamporaki
{"title":"Author Correction: International consensus statement on the diagnosis and management of phaeochromocytoma and paraganglioma in children and adolescents","authors":"Ruth T. Casey, Emile Hendriks, Cheri Deal, Steven G. Waguespack, Verena Wiegering, Antje Redlich, Scott Akker, Rathi Prasad, Martin Fassnacht, Roderick Clifton-Bligh, Laurence Amar, Stefan Bornstein, Letizia Canu, Evangelia Charmandari, Alexandra Chrisoulidou, Maria Currás Freixes, Ronald de Krijger, Luisa de Sanctis, Antonio Fojo, Amol J. Ghia, Angela Huebner, Vasilis Kosmoliaptsis, Michaela Kuhlen, Marco Raffaelli, Charlotte Lussey-Lepoutre, Stephen D. Marks, Naris Nilubol, Mirko Parasiliti-Caprino, Henri H.J.L.M. Timmers, Anna Lena Zietlow, Mercedes Robledo, Anne-Paule Gimenez-Roqueplo, Ashley B. Grossman, David Taïeb, Eamonn R. Maher, Jacques W. M. Lenders, Graeme Eisenhofer, Camilo Jimenez, Karel Pacak, Christina Pamporaki","doi":"10.1038/s41574-025-01167-z","DOIUrl":"10.1038/s41574-025-01167-z","url":null,"abstract":"","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"21 10","pages":"656-656"},"PeriodicalIF":40.0,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41574-025-01167-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144825459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mengxi Du, David A. Drew, Marcus D. Goncalves, Yin Cao, Andrew T. Chan
{"title":"Early-onset colorectal cancer as an emerging disease of metabolic dysregulation","authors":"Mengxi Du, David A. Drew, Marcus D. Goncalves, Yin Cao, Andrew T. Chan","doi":"10.1038/s41574-025-01159-z","DOIUrl":"https://doi.org/10.1038/s41574-025-01159-z","url":null,"abstract":"<p>Colorectal cancer (CRC) is one of the most common malignancies and the second leading cause of cancer-related death worldwide. Early-onset CRC (EOCRC), diagnosed in adults under the age of 50 years, has emerged as a pressing public health concern owing to its alarming rise in incidence since the 1990s. This trend, observed in the USA and at least eight other high-income countries, starkly contrasts with the declining incidence rates of late-onset CRC (age 50 years and above), largely attributed to early disease detection and lifestyle changes. Concurrent with the rising number of cases of EOCRC, the burden of metabolic diseases, particularly obesity and type 2 diabetes mellitus (T2DM), has surged among young populations. Despite well-documented links between metabolic dysfunction and late-onset CRC, understanding the precise role of obesity and T2DM in the pathogenesis of EOCRC remains in its infancy. This narrative Review synthesizes evidence on the relationship of obesity and T2DM with EOCRC, focusing on pathophysiological mechanisms and the mediating roles of diet and lifestyle factors. It also discusses potential clinical and public health strategies to address obesity and T2DM for EOCRC prevention, highlighting knowledge gaps and future research directions.</p>","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"35 1","pages":""},"PeriodicalIF":40.5,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144797101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mickael Tordjman, Zahi A. Fayad, Tammie L. S. Benzinger, Maria G. Trivieri, Meena Bansal, Reshmi Srinath, Bachir Taouli
{"title":"Imaging in patients with obesity: challenges, applications and future directions","authors":"Mickael Tordjman, Zahi A. Fayad, Tammie L. S. Benzinger, Maria G. Trivieri, Meena Bansal, Reshmi Srinath, Bachir Taouli","doi":"10.1038/s41574-025-01166-0","DOIUrl":"10.1038/s41574-025-01166-0","url":null,"abstract":"Imaging has a growing role in the evaluation of obesity-related disorders and the effects of weight loss, especially given the increasing use of glucagon-like peptide 1 agonists. New imaging biomarkers are emerging. Artificial intelligence applications for automated quantification of body composition underline future capabilities of whole-body MRI to comprehensively assess patients with obesity.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"21 10","pages":"588-590"},"PeriodicalIF":40.0,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144797098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Adipose tissue thermogenesis is not proportional to temperature","authors":"Olivia Tysoe","doi":"10.1038/s41574-025-01163-3","DOIUrl":"10.1038/s41574-025-01163-3","url":null,"abstract":"","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"21 10","pages":"591-591"},"PeriodicalIF":40.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144796709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Author Correction: Drug Insight: selective agonists and antagonists of the glucocorticoid receptor","authors":"Andrew McMaster, David W. Ray","doi":"10.1038/s41574-025-01165-1","DOIUrl":"10.1038/s41574-025-01165-1","url":null,"abstract":"","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"21 10","pages":"656-656"},"PeriodicalIF":40.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41574-025-01165-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144797097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
