Nature Reviews Endocrinology最新文献_第3页

The genetics behind thyroid disease 甲状腺疾病背后的基因

IF 4 1区医学

Nature Reviews Endocrinology Pub Date : 2026-02-25 DOI: 10.1038/s41574-026-01238-9

Senegal Carty

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The long-overlooked effect of hypothyroidism on the global burden of non-communicable diseases 长期被忽视的甲状腺功能减退对全球非传染性疾病负担的影响

IF 4 1区医学

Nature Reviews Endocrinology Pub Date : 2026-02-16 DOI: 10.1038/s41574-026-01235-y

Leonidas H. Duntas, Peter A. Kopp

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Making a droplet: the adipogenin–seipin complex at work 形成一个液滴：脂肪原-吸素复合物在起作用。

IF 4 1区医学

Nature Reviews Endocrinology Pub Date : 2026-02-10 DOI: 10.1038/s41574-026-01234-z

Daniel Tews, Pamela Fischer-Posovszky

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Blood–brain barrier permeability of adipokines and myokines 脂肪因子和肌肉因子的血脑屏障通透性。

IF 4 1区医学

Nature Reviews Endocrinology Pub Date : 2026-02-03 DOI: 10.1038/s41574-026-01232-1

Andreas Schäffler, Andreas Schmid, Thomas Karrasch

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Brain neurons promote skeletal dysfunction in ageing 在衰老过程中，大脑神经元促进骨骼功能障碍。

IF 4 1区医学

Nature Reviews Endocrinology Pub Date : 2026-02-03 DOI: 10.1038/s41574-026-01233-0

Olivia Tysoe

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GPR110 as a regulator of MASH GPR110作为MASH的调节因子。

IF 4 1区医学

Nature Reviews Endocrinology Pub Date : 2026-01-16 DOI: 10.1038/s41574-026-01231-2

Claire Greenhill

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Blood-based obesity biomarkers and their relevance for disease risk. 基于血液的肥胖生物标志物及其与疾病风险的相关性

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2026-01-15 DOI: 10.1038/s41574-025-01229-2

Tobias Pischon,Katharina Nimptsch

{"title":"Blood-based obesity biomarkers and their relevance for disease risk.","authors":"Tobias Pischon,Katharina Nimptsch","doi":"10.1038/s41574-025-01229-2","DOIUrl":"https://doi.org/10.1038/s41574-025-01229-2","url":null,"abstract":"Obesity is a risk factor for chronic diseases and early death; however, the underlying mechanisms are not fully understood. Whereas insulin resistance and inflammation are established pathways in several of these relationships, it is less clear how increases in body adipose tissue relate to these pathways and disease risk. Several adipose tissue-derived blood-based biomarkers have been identified as purported mediators, including adipokines, inflammatory cytokines and sex steroid hormones. Traditionally, these markers were discovered in animal models and their relevance in humans has then been investigated in epidemiological studies. Today, proteomics and metabolomics approaches in human observational studies are used to discover obesity biomarkers in blood, supported by Mendelian randomization studies to draw causal inferences. Here we review adipose tissue-derived blood-based obesity biomarkers and their relevance for disease risk, along with their potential role as mediators. Proteomics and metabolomics studies have partly re-identified traditional biomarkers, but more large-scale prospective analyses are needed to obtain evidence of the relevance of omics-based and traditional obesity biomarkers to disease.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"85 1","pages":""},"PeriodicalIF":40.5,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145971827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Endocrine regulation of the hepatic fasting response: cues, cooperation and consequences 肝脏禁食反应的内分泌调节：提示、合作和后果。

IF 4 1区医学

Nature Reviews Endocrinology Pub Date : 2026-01-09 DOI: 10.1038/s41574-025-01228-3

Dana Goldberg, Ido Goldstein

{"title":"Endocrine regulation of the hepatic fasting response: cues, cooperation and consequences","authors":"Dana Goldberg, Ido Goldstein","doi":"10.1038/s41574-025-01228-3","DOIUrl":"10.1038/s41574-025-01228-3","url":null,"abstract":"Upon fasting, mammals undergo a fasting response in which the liver’s main role is producing fuel (glucose and ketone bodies) to supply extra-hepatic tissues. Glucose is produced by glycogenolysis and gluconeogenesis, and ketone bodies are produced by ketogenesis, which is preceded by lipolysis and fatty acid oxidation. Hepatic fuel production during fasting is controlled by hormonal and metabolic cues, collectively termed here ‘fasting cues’. In this Review, we discuss fasting cues that directly signal hepatocytes and whose plasma levels increase upon fasting, namely, glucagon, glucocorticoids, growth hormone, adrenaline, free fatty acids, asprosin and GP73. We outline the fasting-dependent increases in blood levels of these cues, how they regulate transcription and the metabolic consequences of these cues in hepatocytes. We put particular emphasis on their role in directing fuel production. The perception of endocrine control of fuel production is shifting from the classic ‘counter-regulatory’ notion that fasting cues are simply opposing insulin action, to the realization that fasting cues cooperate with each other to elicit a synergistic response and also complement each other’s actions indirectly. We discuss these modes of crosstalk and cooperation between fasting cues and describe the effects of signal integration on the transcriptional and metabolic response to fasting. During fasting, the liver produces fuel under the control of several hormonal and metabolic cues. In this Review, the authors outline the effects of the cues (glucagon, glucocorticoids, growth hormone, adrenaline, free fatty acids, asprosin and GP73) that are known to directly signal to hepatocytes under fasting conditions.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"22 5","pages":"302-316"},"PeriodicalIF":40.0,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145937875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The public health burden of diabetes mellitus and thyroid disease: twin epidemics 糖尿病和甲状腺疾病的公共卫生负担：双重流行病。

IF 4 1区医学

Nature Reviews Endocrinology Pub Date : 2026-01-08 DOI: 10.1038/s41574-025-01226-5

Salman Razvi

{"title":"The public health burden of diabetes mellitus and thyroid disease: twin epidemics","authors":"Salman Razvi","doi":"10.1038/s41574-025-01226-5","DOIUrl":"10.1038/s41574-025-01226-5","url":null,"abstract":"Thyroid dysfunction and diabetes mellitus frequently occur together, with evidence showing higher rates of each condition in individuals affected by the other. Beyond their statistical association, emerging research indicates shared mechanisms involving autoimmunity, obesity, ageing and insulin resistance, which might explain their bidirectional relationship. This Review synthesizes current evidence on these links, with a particular focus on how thyroid dysfunction influences glycaemic control and how antidiabetic therapies affect thyroid function. Unlike earlier reviews, we frame thyroid disorders within the broader category of non-communicable diseases (NCDs), emphasizing their public health relevance and the need for greater attention in global funding and policy agendas. By combining clinical insights with a population health perspective, this Review aims to promote earlier detection, integrated management strategies and recognition of thyroid disease as a neglected NCD priority. This Review explores the link between diabetes mellitus and thyroid disease from an epidemiological and mechanistic perspective, and discusses the public health implications of this link and provides recommendations for clinical management and public health policy.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"22 4","pages":"242-254"},"PeriodicalIF":40.0,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145934351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tailoring interventions to close gaps in diabetes mellitus care. 调整干预措施以缩小糖尿病护理的差距。

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2026-01-07 DOI: 10.1038/s41574-025-01217-6

Alicia Diaz-Thomas,Susanne Cabrera,Rocio I Pereira,Pallavi Iyer

{"title":"Tailoring interventions to close gaps in diabetes mellitus care.","authors":"Alicia Diaz-Thomas,Susanne Cabrera,Rocio I Pereira,Pallavi Iyer","doi":"10.1038/s41574-025-01217-6","DOIUrl":"https://doi.org/10.1038/s41574-025-01217-6","url":null,"abstract":"Diabetes mellitus is one of the fastest-growing chronic medical conditions worldwide. It disproportionately affects some minoritized populations, including certain racial and ethnic groups, migrant populations, and rural communities. Disparities in diabetes mellitus prevalence, morbidity and mortality in minoritized populations are related to longstanding structural and social inequities and are closely tied to social factors. However, current interventions to improve diabetes mellitus outcomes among people from minoritized populations have primarily focused on trying to change individual behaviour, without sufficiently addressing the root structural barriers that drive disparities. Here, we aim to describe the structural inequities in the diagnosis, management and outcomes of minoritized people with diabetes mellitus and to discuss practical measures that can ensure equitable care for people in minoritized groups who have diabetes mellitus. Using a framework to examine diabetes mellitus disparities, we will consider interventions at system levels, including public health approaches, the endocrine healthcare workforce, care quality standards, access to high-quality care (including advanced technologies) and involvement in research. We will also discuss strategies to address intermediate factors, including food insecurity and literacy, and to improve diabetes mellitus care services among migrant and refugee populations and racial and/or ethnic minority communities.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"44 1","pages":""},"PeriodicalIF":40.5,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145907661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0