Nature Reviews Endocrinology最新文献

{"title":"Paracrine signalling in thermogenesis","authors":"Claire Greenhill","doi":"10.1038/s41574-026-01292-3","DOIUrl":"10.1038/s41574-026-01292-3","url":null,"abstract":"","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"22 10","pages":"572-572"},"PeriodicalIF":39.1,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148630887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-IL-11 treatment improves ovarian function by reducing matrix stiffness","authors":"Olivia Tysoe","doi":"10.1038/s41574-026-01288-z","DOIUrl":"10.1038/s41574-026-01288-z","url":null,"abstract":"","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"22 9","pages":"515-515"},"PeriodicalIF":39.1,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148605564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Local catecholamine catabolism blunts lipolysis in ageing adipose tissue","authors":"Fadi Khalaf","doi":"10.1038/s41574-026-01290-5","DOIUrl":"10.1038/s41574-026-01290-5","url":null,"abstract":"","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"22 10","pages":"573-573"},"PeriodicalIF":39.1,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148605543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dose matters: haploinsufficiency in osteogenesis imperfecta","authors":"Anastasia Sclocco, Wenya Yang, Laura Ventura, Leander Dubois, Elisabeth M. W. Eekhoff, Dimitra Micha, Lidiia Zhytnik","doi":"10.1038/s41574-026-01282-5","DOIUrl":"10.1038/s41574-026-01282-5","url":null,"abstract":"Osteogenesis imperfecta is a common genetic disorder of syndromic bone fragility manifesting in types with variable skeletal and extraskeletal severity. Over the past decades, the deforming types have almost exclusively received all scientific attention, leaving large knowledge gaps about the prevalent osteogenesis imperfecta type 1. However, studies within the past 5 years reveal serious unrecognized aspects of disease burden in this large patient population that contrast with osteogenesis imperfecta type 1’s widely adopted classification as mild osteogenesis imperfecta. These patients present distinct clinical and molecular features, necessitating personalized clinical approaches and dedicated research. To our knowledge, this Review addresses this distinct patient group by recognizing the diverse facets of clinical burden, genetic landscape, bone pathophysiology, disease models and emerging treatment options. Owing to their later diagnosis, disease invisibility, increased mobility and uncharted clinical course compared with patients who have other types of osteogenesis imperfecta, these patients and their treating physicians face distinct healthcare and diagnostic challenges. In contrast to other patients with osteogenesis imperfecta with broader genetic causes, they are primarily characterized by molecular uniformity in the form of collagen type I deficiency. The scarcity of animal and cell models has also contributed to the lack of initiatives to explore osteogenesis imperfecta type 1. This Review aims to break this vicious cycle of osteogenesis imperfecta type 1 obscurity by defining knowledge gaps that future investigations of this disease should aim to address. Osteogenesis imperfecta type 1 can be caused by haploinsufficient variants of COL1A1 and can be difficult to diagnose and manage. In this Review, the authors cover the role of collagen type I haploinsufficiency in osteogenesis imperfecta type 1’s pathogenesis, treatment strategies currently under investigation and aspects of this disease that require further research.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"22 11","pages":"646-659"},"PeriodicalIF":39.1,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148605554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis, staging and management of obesity: a synthesis of contemporary guidelines.","authors":"Clara E Tandar, John C Lin, Fatima C Stanford","doi":"10.1038/s41574-026-01279-0","DOIUrl":"https://doi.org/10.1038/s41574-026-01279-0","url":null,"abstract":"<p><p>Obesity is a chronic, adiposity-based disease with increasing global prevalence and multiple, competing definitions. Traditionally, body mass index (BMI) has been the primary tool for diagnosis, although it does not completely reflect adipose tissue mass, distribution or associated organ dysfunction. In the past 2 years, major professional societies (including the European Association for the Study of Obesity (EASO), the Lancet Diabetes & Endocrinology Commission, the American College of Cardiology (ACC) and the American Association of Clinical Endocrinologists (AACE)) have advanced new diagnostic frameworks that move beyond BMI to incorporate multimodal assessment of adiposity and its clinical consequences. By integrating anthropometric precision with standardized complication assessment, these frameworks support earlier identification of risk, improved prognostication and more equitable, patient-centred obesity care. However, the way in which the new guidelines should be integrated into routine clinical care remains unclear. Here we synthesize current evidence across anthropometric measures of obesity and body composition imaging. We clarify the diagnostic performance, limitations and relevance of these measures across diverse populations. We compare areas of convergence and divergence among the new guidelines, particularly the shift towards defining clinical obesity on the basis of both excess adiposity and evidence of organ dysfunction or functional impairment.</p>","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":" ","pages":""},"PeriodicalIF":39.1,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148549771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutrient and non-nutrient regulators of insulin secretion","authors":"Jelena Kolic,&nbsp;Noor Assaf,&nbsp;James D. Johnson","doi":"10.1038/s41574-026-01281-6","DOIUrl":"10.1038/s41574-026-01281-6","url":null,"abstract":"Regulation of insulin secretion by pancreatic β-cells is central to maintaining glucose homeostasis and overall metabolic health. Glucose is recognized as the major driver of insulin secretion; however, here, we highlight established and emerging evidence of important contributions of other nutrients, including amino acids, fatty acids and alternative fuels, as well as non-nutrient factors, in modulating both basal and postprandial insulin release. We discuss molecular mechanisms underlying insulin release, including roles for reactive oxygen species, and the consequences of β-cell overwork. This Review also addresses the physiological and pathophysiological significance of insulin secretion dynamics, including changes in β-cell mass and function across the lifespan, circadian and pulsatile patterns of secretion, and adaptive responses to metabolic stress. We reflect on how genetic predisposition, environmental exposures, pharmaceuticals, food additives and lifestyle factors can influence insulin secretion and contribute to hyperinsulinaemia, insulin resistance and metabolic disease. We identify knowledge gaps that would benefit from additional study, especially in human models. By integrating evidence from both human in vitro studies and preclinical models, we summarize the multifactorial regulation of insulin secretion and underscore its relevance for developing strategies to prevent and manage diabetes mellitus and related metabolic disorders. This Review explores the regulation of insulin secretion, including the effects of various nutrient and non-nutrient factors. An improved understanding of the complexities of how insulin secretion is regulated could lead to targeted treatments in the future.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"22 11","pages":"674-688"},"PeriodicalIF":39.1,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148459632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxytocin in social conflict","authors":"Dayu Lin","doi":"10.1038/s41574-026-01284-3","DOIUrl":"10.1038/s41574-026-01284-3","url":null,"abstract":"Although oxytocin is widely known as the ‘love hormone’, it is also released during social conflict, promoting acute social defence and facilitating neural circuit plasticity that heightens future social avoidance, vigilance and sensitivity to non-social stressors.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"22 9","pages":"509-510"},"PeriodicalIF":39.1,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148456216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Correction: How can social jetlag affect health?","authors":"Till Roenneberg","doi":"10.1038/s41574-026-01287-0","DOIUrl":"10.1038/s41574-026-01287-0","url":null,"abstract":"","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"22 10","pages":"625-625"},"PeriodicalIF":39.1,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41574-026-01287-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148451592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reframing cancer cachexia: from malnutrition to treatable disease","authors":"Gaofei Wei,&nbsp;Jose M. Garcia,&nbsp;Maria Rohm","doi":"10.1038/s41574-026-01285-2","DOIUrl":"10.1038/s41574-026-01285-2","url":null,"abstract":"Cancer cachexia is a wasting syndrome that is associated with advanced cancer and causes high morbidity and mortality. Now, preclinical and clinical findings define cachexia as a systemic metabolic disorder beyond anorexia. Reframing cachexia as a treatable disease could contribute to increasing the quality of life and survival of patients.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"22 9","pages":"507-508"},"PeriodicalIF":39.1,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148440998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new oral treatment for achondroplasia in children","authors":"Senegal Carty","doi":"10.1038/s41574-026-01283-4","DOIUrl":"10.1038/s41574-026-01283-4","url":null,"abstract":"","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"22 9","pages":"514-514"},"PeriodicalIF":39.1,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148432051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}