Nature Reviews Endocrinology最新文献_第4页

Advances in the management of hyperglycaemia and diabetes mellitus during hospitalization. 住院期间高血糖和糖尿病的处理进展。

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2025-08-04 DOI: 10.1038/s41574-025-01157-1

Thaer Idrees,Iris Castro-Revoredo,Ketan K Dhatariya,Lucas Hernandez,Guillermo E Umpierrez

{"title":"Advances in the management of hyperglycaemia and diabetes mellitus during hospitalization.","authors":"Thaer Idrees,Iris Castro-Revoredo,Ketan K Dhatariya,Lucas Hernandez,Guillermo E Umpierrez","doi":"10.1038/s41574-025-01157-1","DOIUrl":"https://doi.org/10.1038/s41574-025-01157-1","url":null,"abstract":"Diabetes mellitus, which affects over 537 million people worldwide, considerably increases the risk of emergency room visits and admissions to hospital. Inpatient hyperglycaemia in patients with or without diabetes mellitus is associated with higher rates of complications, extended hospital stays and increased mortality when compared with patients with normoglycaemia. The American Diabetes Association recommends a target range of 5.6-10.0 mmol/l (100-180 mg/dl) for levels of glucose in the blood of patients in intensive care units (ICUs), as well as in general medicine and surgery. Insulin therapy remains the cornerstone of managing inpatient hyperglycaemia, with intravenous insulin preferred in ICU and basal-bolus regimens favoured in non-ICU settings. While bedside capillary blood glucose monitoring is standard for adjusting insulin doses, continuous glucose monitoring provides a more comprehensive glycaemic assessment and enhances the prevention of hypoglycaemia in high-risk hospitalized patients. This Review outlines the latest evidence in managing diabetes mellitus and hyperglycaemia within hospitals.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"12 1","pages":""},"PeriodicalIF":40.5,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144777757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Balancing weight and muscle loss in GLP1 receptor agonist therapy GLP1受体激动剂治疗平衡体重和肌肉损失

IF 4 1区医学

Nature Reviews Endocrinology Pub Date : 2025-07-28 DOI: 10.1038/s41574-025-01160-6

Fabian Sanchis-Gomar, Ian J. Neeland, Carl J. Lavie

引用次数: 0

Body weight regulation models in humans: insights for testing their validity 人类体重调节模型：检验其有效性的见解

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2025-07-24 DOI: 10.1038/s41574-025-01149-1

Rodrigo Fernández-Verdejo, Eric Ravussin, Jose E. Galgani

{"title":"Body weight regulation models in humans: insights for testing their validity","authors":"Rodrigo Fernández-Verdejo, Eric Ravussin, Jose E. Galgani","doi":"10.1038/s41574-025-01149-1","DOIUrl":"https://doi.org/10.1038/s41574-025-01149-1","url":null,"abstract":"<p>Maintaining a ‘healthy’ body weight is crucial for survival and involves a partially understood regulatory system that adjusts energy intake and energy output (expenditure and losses) for that purpose. Several models of body weight regulation exist, but experiments testing their validity are lacking. This Review elaborates on how to test the validity of body weight regulation models in humans. We begin by highlighting the interaction between the obesogenic environment and the individual’s biological sensitivity to such environment, which triggers obesity in many, but not all, individuals. We discuss the identity of the regulated parameter(s), often considered to be body weight or body adiposity. We then focus on two models: set point and dual-intervention point. Under the set point model, obesity results from a malfunction of the system (leptin resistance) for preventing weight increases above the defended value. Under the dual-intervention point model, obesity occurs because the system tolerates a wide range of weights in some individuals. This key difference predicts different compensatory responses to energy balance perturbations in individuals according to their weight status, thus becoming instrumental in testing the validity of the models. Finally, we discuss the design of proof-of-concept experiments to advance the understanding of body weight regulation in humans.</p>","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"14 1","pages":""},"PeriodicalIF":40.5,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144694061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highlights from ADA 85th Scientific Sessions ADA第85届科学会议的亮点

IF 4 1区医学

Nature Reviews Endocrinology Pub Date : 2025-07-23 DOI: 10.1038/s41574-025-01158-0

Senegal Carty

引用次数: 0

Combined amylin analogue and GLP1 receptor agonist therapies are highly promising for weight loss 联合胰淀素类似物和GLP1受体激动剂治疗是非常有希望的减肥

IF 4 1区医学

Nature Reviews Endocrinology Pub Date : 2025-07-21 DOI: 10.1038/s41574-025-01156-2

Olivia Tysoe

引用次数: 0

Language evolves — so can you 语言在进化——你也可以

IF 4 1区医学

Nature Reviews Endocrinology Pub Date : 2025-07-17 DOI: 10.1038/s41574-025-01155-3

Sarah C. Westen, Laura M. Jacobsen

引用次数: 0

The role of GLP1 receptor agonists in adult-onset type 1 diabetes mellitus GLP1受体激动剂在成人发病型1型糖尿病中的作用

IF 4 1区医学

Nature Reviews Endocrinology Pub Date : 2025-07-16 DOI: 10.1038/s41574-025-01154-4

Djordje S. Popovic, Theocharis Koufakis, Dimitrios Patoulias, Giuseppe Maltese, Nikolaos Papanas

引用次数: 0

The role of ultra-processed food in obesity 超加工食品在肥胖中的作用

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2025-07-14 DOI: 10.1038/s41574-025-01143-7

Filippa Juul, Euridice Martinez-Steele, Niyati Parekh, Carlos A. Monteiro

{"title":"The role of ultra-processed food in obesity","authors":"Filippa Juul, Euridice Martinez-Steele, Niyati Parekh, Carlos A. Monteiro","doi":"10.1038/s41574-025-01143-7","DOIUrl":"https://doi.org/10.1038/s41574-025-01143-7","url":null,"abstract":"<p>The global increase in obesity has occurred in parallel to a dietary shift from traditional staple foods to ultra-processed foods (UPF), spurring scientific interest in UPF as a driver of the obesity pandemic. Herein, we summarize the current evidence regarding the role of UPF in obesity, with a specific focus on potential biological mechanisms. The literature strongly supports and corroborates ecological, epidemiological and mechanistic lines of research indicating that dietary patterns high in UPF promote overeating and increase the risk of overweight and obesity. Experimental evidence demonstrates that the soft texture, high energy density and hyperpalatable nutrient combinations of UPF facilitate excessive energy intakes by affecting ingestive behaviours, satiety signalling and food reward systems. Although not fully elucidated, it is plausible that several other UPF attributes (such as emulsifiers, non-nutritive sweeteners, acellular nutrients, and contaminants from processing and packaging materials) contribute to their obesogenic effects through a myriad of physiological pathways, including altered absorption kinetics, glycaemic response and the gut microbiota composition and function. To stem the global rise in obesity, multipronged policy efforts are needed to reduce UPF consumption and create health-promoting food systems.</p>","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"12 1","pages":""},"PeriodicalIF":40.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144622488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bile acids in the crosshairs for hypoglycaemia after gastric bypass 胆汁酸对胃旁路术后低血糖的影响

IF 4 1区医学

Nature Reviews Endocrinology Pub Date : 2025-07-14 DOI: 10.1038/s41574-025-01153-5

Marzieh Salehi

引用次数: 0

Can obesity pharmacotherapy be used to manage male infertility? 肥胖药物治疗可以用于治疗男性不育症吗？

IF 4 1区医学

Nature Reviews Endocrinology Pub Date : 2025-07-14 DOI: 10.1038/s41574-025-01151-7

Amy E. Morrison, Dimitris Papamargaritis, Channa N. Jayasena, Neelam Potdar, Thomas Yates, Gregory J. H. Biddle, Malak Hamza, Melanie J. Davies, Narendra L. Reddy

引用次数: 0