Nature Reviews Endocrinology最新文献_第5页

Lipid sensing and brain hormone receptors in food intake and glucose regulation 脂质感知和脑激素受体在食物摄入和葡萄糖调节中的作用

IF 39.1 1区医学

Nature Reviews Endocrinology Pub Date : 2026-07-14 DOI: 10.1038/s41574-026-01278-1

Ameth N. Garrido, Sulayman Aslan Lyons, Dorsa Moslemian, Jacqueline L. Beaudry, Tony K. T. Lam

{"title":"Lipid sensing and brain hormone receptors in food intake and glucose regulation","authors":"Ameth N. Garrido, Sulayman Aslan Lyons, Dorsa Moslemian, Jacqueline L. Beaudry, Tony K. T. Lam","doi":"10.1038/s41574-026-01278-1","DOIUrl":"10.1038/s41574-026-01278-1","url":null,"abstract":"The body possesses critical nutrient sensors that rapidly coordinate feeding behaviour and systemic metabolism through hormones and neural pathways. In this Review, we highlight the mechanisms by which lipid sensing triggers the release of small intestinal-derived cholecystokinin, peptide YY, glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide, as well as kidney-derived growth differentiation factor 15, to regulate satiety and glucose homeostasis through the brain. We discuss how dysregulation of lipid sensing pathways contributes to obesity and type 2 diabetes mellitus, and how interventions including bariatric surgery, modulation of the gut microbiota and pharmacological agonists restore polyhormonal secretion and action on metabolism. We propose that lipid sensing in the small intestine and the kidney orchestrates an endocrine and neural axis that governs energy balance, providing a lipid-sensing-dependent framework for the development of next-generation therapies in obesity and metabolic disease to remotely and concurrently target multiple brain hormone receptors to lower food intake and body weight. Lipid sensing in the gut is a key mechanism by which the body regulates food intake and metabolism. This Review discusses how lipid sensing triggers hormonal and neural mechanisms that regulate satiety and glucose homeostasis and how these pathways are affected by obesity and metabolic disease.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"22 10","pages":"587-601"},"PeriodicalIF":39.1,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148432049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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From ENDO 2026 来自ENDO 2026。

IF 39.1 1区医学

Nature Reviews Endocrinology Pub Date : 2026-07-06 DOI: 10.1038/s41574-026-01280-7

Claire Greenhill

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Strengthening the metabolic alliance: exercise as an essential partner of obesity pharmacotherapy 加强代谢联盟：运动是肥胖药物治疗的重要伙伴。

IF 39.1 1区医学

Nature Reviews Endocrinology Pub Date : 2026-06-30 DOI: 10.1038/s41574-026-01276-3

Jonatan R. Ruiz, Andreea Ciudin, Javier Butragueño

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Reply to ‘Post-thyrotoxicosis weight gain: time to stratify and treat?’ 回复“甲状腺毒症后体重增加：该分层治疗了吗？”

IF 39.1 1区医学

Nature Reviews Endocrinology Pub Date : 2026-06-23 DOI: 10.1038/s41574-026-01273-6

Jacqueline Jonklaas

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Post-thyrotoxicosis weight gain: time to stratify and treat? 甲状腺毒症后体重增加：分层和治疗的时间？

IF 39.1 1区医学

Nature Reviews Endocrinology Pub Date : 2026-06-23 DOI: 10.1038/s41574-026-01274-5

Angelos Kyriacou, Akheel A. Syed, Petros Perros

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Macronutrient mixtures and interactions in health and disease 健康和疾病中的常量营养素混合物和相互作用。

IF 39.1 1区医学

Nature Reviews Endocrinology Pub Date : 2026-06-22 DOI: 10.1038/s41574-026-01266-5

Stephen J. Simpson, David G. Le Couteur, Lewin Small, Amanda E. Brandon, David Raubenheimer

{"title":"Macronutrient mixtures and interactions in health and disease","authors":"Stephen J. Simpson, David G. Le Couteur, Lewin Small, Amanda E. Brandon, David Raubenheimer","doi":"10.1038/s41574-026-01266-5","DOIUrl":"10.1038/s41574-026-01266-5","url":null,"abstract":"Nutrition shapes development, health and risk of disease over the life course and across generations. The predominant approaches to understanding these relationships have either been to consider the effects of single nutrients, one at a time, or to consider associations with food types and dietary patterns. Although, to date, the single-nutrient approach has defined much of the scientific enquiry and public debate on the macronutrients — carbohydrate, fat and protein — there is an emerging appreciation that their proportions and quality matter more than their individual effects. Growing evidence demonstrates that macronutrient interactions operate at multiple biological levels, and research on dietary protein has proven a particularly productive entry point for characterizing these mixture effects. In this narrative Review, we begin by analysing key issues and introducing a framework for navigating the complexity of macronutrient mixtures (nutritional geometry), then consider the role of macronutrient proportions on food intake, systemic physiology, health and the risk of disease across the life course. Finally, we discuss how human nutritional biology has been subverted within the modern, industrialized food environment, contributing to the global burden of obesity and related diseases of unhealthy ageing. Increasing evidence demonstrates that the proportions, quality and balance of macronutrients in the diet influence health and disease to a greater extent than the individual effects of these macronutrients. This Review introduces a framework for navigating the complexity of macronutrient mixtures, and discusses their role in energy intake, systemic physiology, body composition and health across the life course.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"22 11","pages":"660-673"},"PeriodicalIF":39.1,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148298951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Myostatin-targeting antibody protects lean mass during incretin-induced weight loss 肌生成抑制素靶向抗体在肠促胰岛素诱导的体重减轻过程中保护瘦质量。

IF 39.1 1区医学

Nature Reviews Endocrinology Pub Date : 2026-06-22 DOI: 10.1038/s41574-026-01275-4

Senegal Carty

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Hepatic neurons and metabolically induced liver dysfunction 肝神经元与代谢性肝功能障碍。

IF 39.1 1区医学

Nature Reviews Endocrinology Pub Date : 2026-06-19 DOI: 10.1038/s41574-026-01270-9

Sally N. Pauss, Kavaljit H. Chhabra, David E. Stec, Cassandra D. Gipson, Terry D. Hinds Jr.

{"title":"Hepatic neurons and metabolically induced liver dysfunction","authors":"Sally N. Pauss, Kavaljit H. Chhabra, David E. Stec, Cassandra D. Gipson, Terry D. Hinds Jr.","doi":"10.1038/s41574-026-01270-9","DOIUrl":"10.1038/s41574-026-01270-9","url":null,"abstract":"Hepatic nerves have an underexplored role in liver function. The global prevalence of liver disease has reached unprecedented levels, with over 1.6 billion individuals affected by metabolic dysfunction-associated steatotic liver disease (MASLD). A comprehensive understanding of these liver disease mechanisms is essential for identifying the aetiologies of such conditions. Studies from the past 5 years suggest that hepatic nerves might influence the progression of MASLD to metabolic dysfunction-associated steatohepatitis and hepatocellular carcinoma. As MASLD advances, hepatic sympathetic activity increases while hepatic sympathetic innervation diminishes. Conversely, both parasympathetic and sympathetic innervation might contribute to hepatic fibrosis and liver dysfunction. This Review examines the function of hepatic neurons, their modulation by metabolic disease and the potential to target these mechanisms to develop novel treatments for liver diseases. Growing evidence suggests that hepatic nerves have an important role in liver function, in both health and disease. This Review explores the contribution of the hepatic sympathetic and parasympathetic nervous systems in the development of metabolic-associated steatotic liver disease and its progression to metabolic dysfunction-associated steatohepatitis and hepatocellular carcinoma.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"22 11","pages":"634-645"},"PeriodicalIF":39.1,"publicationDate":"2026-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148283892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epstein–Barr virus might protect against type 1 diabetes mellitus eb病毒可能预防1型糖尿病。

IF 39.1 1区医学

Nature Reviews Endocrinology Pub Date : 2026-06-19 DOI: 10.1038/s41574-026-01272-7

Cyril Debuysschere, Mahdi Ouafi, Magloire Pandoua Nekoua, Enagnon Kazali Alidjinou, Didier Hober

引用次数: 0

From bench to bedside: the evolving role of iodine in thyroid cancer management 从实验室到床边：碘在甲状腺癌治疗中的作用演变。

IF 39.1 1区医学

Nature Reviews Endocrinology Pub Date : 2026-06-18 DOI: 10.1038/s41574-026-01271-8

Vincenzo Condello, Joachim N. Nilsson, Jan Zedenius, C. Christofer Juhlin

{"title":"From bench to bedside: the evolving role of iodine in thyroid cancer management","authors":"Vincenzo Condello, Joachim N. Nilsson, Jan Zedenius, C. Christofer Juhlin","doi":"10.1038/s41574-026-01271-8","DOIUrl":"10.1038/s41574-026-01271-8","url":null,"abstract":"Iodine metabolism has a central role in thyroid physiology and thyroid cancer biology, shaping both tumour behaviour and therapeutic strategies. Within the past 20 years, advancements in molecular research and targeted therapies have transformed the understanding of iodine metabolism in thyroid cancer and subsequently changed clinical management. In differentiated thyroid carcinomas, the ability of tumour cells to concentrate iodide provides the biological foundation of radioactive iodine treatment. However, loss of iodide-handling machinery function drives refractoriness in advanced disease, posing a major clinical challenge. Molecular genetics has now been integrated into routine clinical practice and genetically guided strategies to restore iodine uptake in previously non-avid lesions have emerged. This Review synthesizes these breakthroughs across molecular science, pathology, physics and clinical practice. We describe emerging predictive markers of radioiodine-refractory disease and summarize the current state of knowledge on iodide-handling mechanisms, their dysregulation in thyroid tumourigenesis and therapeutic advances made in the past 15 years aimed at redifferentiation. By bridging molecular insights with translational and clinical perspectives, we aim to highlight evolving paradigms that promise to refine patient stratification and improve outcomes in differentiated thyroid carcinoma. Diagnosing and treating thyroid cancer often involves administering radioactive iodine, but in certain tumour types, reduced ability to take in iodine limits the efficacy of this technique. In this Review, the authors discuss how molecular aberrations in thyroid cancer affect iodine uptake and describe redifferentiation strategies that aim to improve the effectiveness of radioiodine administration.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"22 10","pages":"602-614"},"PeriodicalIF":39.1,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148278175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0