脂肪组织老化:对代谢健康和寿命的影响。

IF 40 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Guan Wang, Anying Song, Qiong A. Wang
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引用次数: 0

摘要

脂肪组织在全身能量平衡和胰岛素敏感性中起着关键作用,在整个衰老过程中经历了相当大的重塑,直到过去十年才引起人们的关注。这篇综述全面总结了在不同的脂肪组织库中,在不同的衰老阶段,白色和热源性脂肪组织中发生的动态代谢、细胞和功能变化。我们强调衰老对脂肪组织内不同细胞类型的影响,包括脂肪细胞、脂肪祖细胞、免疫细胞和衰老细胞,以及它们对脂肪组织功能和全身代谢的集体影响。我们还破译了脂肪组织老化与普遍的年龄相关疾病(如代谢功能障碍相关的脂肪肝疾病和心血管疾病)之间的相关性。最后,综述深入探讨了当前抗衰老干预措施对脂肪组织有益的潜力,包括热量限制、二甲双胍、胰高血糖素样肽1受体激动剂和抗衰老药物。讨论延伸到探索通过这些干预措施靶向脂肪组织是否可以成为减轻年龄相关疾病和提高老龄化人口健康寿命和寿命的重要治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Adipose tissue ageing: implications for metabolic health and lifespan

Adipose tissue ageing: implications for metabolic health and lifespan
Adipose tissue, a pivotal player in whole-body energy homeostasis and insulin sensitivity, undergoes considerable remodelling throughout the ageing process, a facet that has garnered little attention until the past decade. This Review comprehensively summarizes the dynamic metabolic, cellular and functional changes that occur in white and thermogenic adipose tissue during distinct ageing stages, across different adipose tissue depots. We emphasize the influence of ageing on different cell types within adipose tissue, including adipocytes, adipocyte progenitors, immune cells and senescent cells, and their collective effect on adipose tissue function and systemic metabolism. We also decipher the correlation between adipose tissue ageing and prevalent age-related conditions such as metabolic dysfunction-associated fatty liver disease and cardiovascular diseases. Finally, the Review delves into the potential of current anti-ageing interventions to beneficially affect adipose tissue, encompassing caloric restriction, metformin, glucagon-like peptide 1 receptor agonists and senolytics. The discussion extends to the exploration of whether targeting adipose tissue through such interventions could emerge as a prominent therapeutic strategy for mitigating age-related diseases and enhancing the healthspan and lifespan of the ageing population. This Review outlines changes in endocrine and metabolic function that occur in various adipose tissue depots during ageing and explains how these alterations contribute to age-related decline in metabolic health. The Review also discusses how various treatments might slow this decline by improving adipose tissue function.
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来源期刊
Nature Reviews Endocrinology
Nature Reviews Endocrinology 医学-内分泌学与代谢
CiteScore
42.00
自引率
0.70%
发文量
158
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Endocrinology aspires to be the foremost platform for reviews and commentaries catering to the scientific communities it serves. The journal aims to publish articles characterized by authority, accessibility, and clarity, enhanced with easily understandable figures, tables, and other visual aids. The goal is to offer an unparalleled service to authors, referees, and readers, striving to maximize the usefulness and impact of each article. Nature Reviews Endocrinology publishes Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives relevant to researchers and clinicians in the fields of endocrinology and metabolism. Its broad scope ensures that the work it publishes reaches the widest possible audience.
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