Amy E. Morrison, Dimitris Papamargaritis, Channa N. Jayasena, Neelam Potdar, Thomas Yates, Gregory J. H. Biddle, Malak Hamza, Melanie J. Davies, Narendra L. Reddy
{"title":"Can obesity pharmacotherapy be used to manage male infertility?","authors":"Amy E. Morrison, Dimitris Papamargaritis, Channa N. Jayasena, Neelam Potdar, Thomas Yates, Gregory J. H. Biddle, Malak Hamza, Melanie J. Davies, Narendra L. Reddy","doi":"10.1038/s41574-025-01151-7","DOIUrl":null,"url":null,"abstract":"Obesity-related subfertility is an increasingly recognized concern. Pharmacotherapies (particularly glucagon-like peptide 1 receptor agonists and combination therapies), alongside lifestyle intervention, enable meaningful and sustainable weight loss in people with and without type 2 diabetes mellitus. Weight loss can benefit sperm parameters, but the optimal amount and rate of weight loss requires further study.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"38 1","pages":""},"PeriodicalIF":40.0000,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Endocrinology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41574-025-01151-7","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0
Abstract
Obesity-related subfertility is an increasingly recognized concern. Pharmacotherapies (particularly glucagon-like peptide 1 receptor agonists and combination therapies), alongside lifestyle intervention, enable meaningful and sustainable weight loss in people with and without type 2 diabetes mellitus. Weight loss can benefit sperm parameters, but the optimal amount and rate of weight loss requires further study.
期刊介绍:
Nature Reviews Endocrinology aspires to be the foremost platform for reviews and commentaries catering to the scientific communities it serves. The journal aims to publish articles characterized by authority, accessibility, and clarity, enhanced with easily understandable figures, tables, and other visual aids. The goal is to offer an unparalleled service to authors, referees, and readers, striving to maximize the usefulness and impact of each article. Nature Reviews Endocrinology publishes Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives relevant to researchers and clinicians in the fields of endocrinology and metabolism. Its broad scope ensures that the work it publishes reaches the widest possible audience.