对立神经肽控制cAMP信号以调节饱腹感

IF 31 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Nature Reviews Endocrinology Pub Date : 2024-11-29 DOI:10.1038/s41574-024-01068-7

Senegal Carty

引用次数: 0

摘要

众所周知，神经肽在调节摄食行为中起着关键作用。然而，神经肽控制饱腹感和饥饿感背后的机制的许多方面尚不清楚。最近的一项小鼠研究表明，两种神经肽，神经肽Y和α - msh，对下丘脑室旁核表达mc4r神经元（PVHMC4R神经元）的cAMP信号传导产生相反的作用，在刺激时促进饱腹感。结果表明，神经肽Y水平的下降和α - msh水平的上升是如何在用餐过程中逐渐促进饱腹感的。研究人员随后进行了体内成像，显示PVHMC4R神经元中的cAMP信号是如何响应神经肽Y和α - msh而发生的。为了做到这一点，他们在转基因小鼠的PVHMC4R神经元中病毒表达了一个荧光cAMP传感器，然后通过梯度折射率透镜通过双光子显微镜对神经元进行成像。与饲喂转基因小鼠相比，禁食转基因小鼠PVHMC4R神经元cAMP水平明显降低。为了模拟进食过程中α - msh的升高，科学家们对转基因小鼠的POMC神经元进行了光遗传刺激，POMC神经元在被激活时释放α - msh。随着α - msh的增加，PVHMC4R神经元中cAMP水平显著升高。相反，当研究人员通过光遗传学刺激AgRP神经元来模拟与饥饿相关的神经肽信号时，cAMP的水平下降了。AgRP神经元在被激活时释放神经肽Y。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Opposing neuropeptides control cAMP signalling to regulate satiety

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Opposing neuropeptides control cAMP signalling to regulate satiety

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来源期刊

Nature Reviews Endocrinology 医学-内分泌学与代谢

CiteScore

42.00

自引率

0.70%

发文量

158

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Endocrinology aspires to be the foremost platform for reviews and commentaries catering to the scientific communities it serves. The journal aims to publish articles characterized by authority, accessibility, and clarity, enhanced with easily understandable figures, tables, and other visual aids. The goal is to offer an unparalleled service to authors, referees, and readers, striving to maximize the usefulness and impact of each article. Nature Reviews Endocrinology publishes Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives relevant to researchers and clinicians in the fields of endocrinology and metabolism. Its broad scope ensures that the work it publishes reaches the widest possible audience.