肾上腺皮质干细胞在健康和疾病中的作用

IF 40 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Yulan Chu, Jordan Setayesh, Typhanie Dumontet, Lauren Krumeich, Johanna Werner, Isabele F. Moretti, Kelly De Sousa, Christopher Kennedy, Christopher La Pensee, Antonio M. Lerario, Gary D. Hammer
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引用次数: 0

摘要

肾上腺皮质是产生生命所必需的类固醇激素的主要部位。肾上腺皮质的正常发育和稳态更新依赖于包膜干细胞和皮质祖细胞。这些细胞群具有高度可塑性,支持对生理需求、损伤和疾病的适应,将类固醇生产和肾上腺(器官)稳态与系统内分泌信号和有机体稳态联系起来。这篇综述整合了过去十年的研究成果,概述了在不同生理和病理条件下肾上腺干细胞生态位的建立和维持机制。通过旁分泌和内分泌信号协调的基因调控网络对干细胞生态位的复杂调控,以环境依赖和性别特异性的方式得到强调。我们讨论了这个复杂的调节网络的失调如何与广泛的肾上腺疾病有关,以及来自肾上腺干细胞研究的新兴知识如何启发未来基于基因和基于细胞的治疗策略的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Adrenocortical stem cells in health and disease

Adrenocortical stem cells in health and disease

Adrenocortical stem cells in health and disease
The adrenal cortex is the major site of production of steroid hormones, which are essential for life. The normal development and homeostatic renewal of the adrenal cortex depend on capsular stem cells and cortical progenitor cells. These cell populations are highly plastic and support adaptation to physiological demands, injury and disease, linking steroid production and adrenal (organ) homeostasis with systemic endocrine cues and organismal homeostasis. This Review integrates findings from the past decade, outlining the mechanisms that govern the establishment and maintenance of the adrenal stem cell niche under different physiological and pathological conditions. The sophisticated regulation of the stem cell niche by gene regulatory networks, coordinated through paracrine and endocrine signalling, is highlighted in a context-dependent and sex-specific manner. We discuss how dysregulation of this intricate regulatory network is implicated in a wide range of adrenal diseases, and how emerging knowledge from adrenal stem cell research is inspiring the future development of gene-based and cell-based therapeutic strategies. This Review outlines the mechanisms that regulate the establishment and maintenance of the adrenal stem cell niche — comprising capsular stem cells and cortical progenitor cells — within the adrenal cortex under different physiological and pathological conditions.
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来源期刊
Nature Reviews Endocrinology
Nature Reviews Endocrinology 医学-内分泌学与代谢
CiteScore
42.00
自引率
0.70%
发文量
158
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Endocrinology aspires to be the foremost platform for reviews and commentaries catering to the scientific communities it serves. The journal aims to publish articles characterized by authority, accessibility, and clarity, enhanced with easily understandable figures, tables, and other visual aids. The goal is to offer an unparalleled service to authors, referees, and readers, striving to maximize the usefulness and impact of each article. Nature Reviews Endocrinology publishes Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives relevant to researchers and clinicians in the fields of endocrinology and metabolism. Its broad scope ensures that the work it publishes reaches the widest possible audience.
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