孕激素

IF 40 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Claire Greenhill
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引用次数: 0

摘要

众所周知,母体性类固醇激素(如雌激素和黄体酮)在生殖中起着重要作用,有助于维持妊娠和胚胎发育。然而,孕酮如何影响胚胎和母体代谢尚不清楚;一项新的研究开始调查这个问题。研究人员重点研究了膜孕酮受体ε (mPRε),这是五种孕酮受体之一,在脂肪组织中高度表达。利用mPRε缺失小鼠模型,研究人员发现黄体酮激活白色脂肪组织中的mPRε,从而促进胰岛素抵抗。此外,在怀孕期间,mpr ε缺乏的小鼠比野生型小鼠具有更好的胰岛素敏感性,尽管两组之间的血浆黄体酮和胰岛素水平相似。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Progesterone in pregnancy
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来源期刊
Nature Reviews Endocrinology
Nature Reviews Endocrinology 医学-内分泌学与代谢
CiteScore
42.00
自引率
0.70%
发文量
158
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Endocrinology aspires to be the foremost platform for reviews and commentaries catering to the scientific communities it serves. The journal aims to publish articles characterized by authority, accessibility, and clarity, enhanced with easily understandable figures, tables, and other visual aids. The goal is to offer an unparalleled service to authors, referees, and readers, striving to maximize the usefulness and impact of each article. Nature Reviews Endocrinology publishes Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives relevant to researchers and clinicians in the fields of endocrinology and metabolism. Its broad scope ensures that the work it publishes reaches the widest possible audience.
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