一种针对下丘脑的新型抗肥胖肽

IF 40 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Senegal Carty
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引用次数: 0

摘要

预测哪些氨基酸序列是由切割酶产生的计算工具可以加速发现具有治疗潜力的生物活性肽。最近发表在《自然》杂志上的一项研究提出了一种肽预测程序,该程序用于寻找由激素原转化酶(也称为原蛋白转化酶枯草素/克辛(PCSK)酶)产生的新型抗肥胖肽。在使用他们的程序预测PCSK酶活性的推定肽产物的氨基酸序列后,该团队创建了一个包含100个未知功能的预测肽的文库。接下来,他们测试了这些肽中的哪些可能能够影响神经元信号和胰腺β细胞活性来调节代谢。他们用肽处理大鼠嗜铬细胞瘤细胞系和大鼠β细胞系的细胞,然后测量Fos mRNA转录的变化。BRP是PCSK切割BRINP2蛋白的预测产物,在两种细胞系中引起Fos表达的显著增加。为了确认BRP是否在人类和小鼠中产生,研究人员对来自人类供体和小鼠脑组织的脑脊液样本进行了液相色谱-质谱分析。结果表明,两种样品类型均存在BRP。他们还通过测量野生型小鼠和PCSK1功能受损的转基因小鼠脑内BRP水平来测试PCSK1是否在体内产生BRP。他们发现转基因小鼠的大脑中BRP的水平显著降低,这表明PCSK1的活性有助于BRP的产生。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A novel anti-obesity peptide that targets the hypothalamus

A novel anti-obesity peptide that targets the hypothalamus
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来源期刊
Nature Reviews Endocrinology
Nature Reviews Endocrinology 医学-内分泌学与代谢
CiteScore
42.00
自引率
0.70%
发文量
158
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Endocrinology aspires to be the foremost platform for reviews and commentaries catering to the scientific communities it serves. The journal aims to publish articles characterized by authority, accessibility, and clarity, enhanced with easily understandable figures, tables, and other visual aids. The goal is to offer an unparalleled service to authors, referees, and readers, striving to maximize the usefulness and impact of each article. Nature Reviews Endocrinology publishes Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives relevant to researchers and clinicians in the fields of endocrinology and metabolism. Its broad scope ensures that the work it publishes reaches the widest possible audience.
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