Nature Reviews Endocrinology最新文献_第9页

Metformin acts through appetite-suppressing metabolite: Lac-Phe 二甲双胍通过抑制食欲的代谢物发挥作用：漆酚

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2024-04-02 DOI: 10.1038/s41574-024-00986-w

Shimona Starling

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Protein tyrosine phosphatase 1B in metabolic diseases and drug development 代谢性疾病和药物开发中的蛋白酪氨酸磷酸酶 1B

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2024-03-22 DOI: 10.1038/s41574-024-00965-1

Mirela Delibegović, Sergio Dall’Angelo, Ruta Dekeryte

{"title":"Protein tyrosine phosphatase 1B in metabolic diseases and drug development","authors":"Mirela Delibegović, Sergio Dall’Angelo, Ruta Dekeryte","doi":"10.1038/s41574-024-00965-1","DOIUrl":"10.1038/s41574-024-00965-1","url":null,"abstract":"Protein tyrosine phosphatase 1B (PTP1B), a non-transmembrane phosphatase, has a major role in a variety of signalling pathways, including direct negative regulation of classic insulin and leptin signalling pathways, and is implicated in the pathogenesis of several cardiometabolic diseases and cancers. As such, PTP1B has been a therapeutic target for over two decades, with PTP1B inhibitors identified either from natural sources or developed throughout the years. Some of these inhibitors have reached phase I and/or II clinical trials in humans for the treatment of type 2 diabetes mellitus, obesity and/or metastatic breast cancer. In this Review, we summarize the cellular processes and regulation of PTP1B, discuss evidence from in vivo preclinical and human studies of the association between PTP1B and different disorders, and discuss outcomes of clinical trials. We outline challenges associated with the targeting of this phosphatase (which was, until the past few years, viewed as difficult to target), the current state of the field of PTP1B inhibitors (and dual phosphatase inhibitors) and future directions for manipulating the activity of this key metabolic enzyme. This Review summarizes cellular processes and regulation of protein tyrosine phosphatase 1B (PTP1B), discussing evidence from in vivo preclinical and human studies. PTP1B inhibitors, which are being developed for type 2 diabetes mellitus, obesity, rare diseases (such as Rett syndrome) and some cancers, are also discussed.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":null,"pages":null},"PeriodicalIF":40.5,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140189004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endocrine and cellular physiology and pathology of the insulin-like growth factor acid-labile subunit 胰岛素样生长因子酸性亚基的内分泌和细胞生理学及病理学

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2024-03-21 DOI: 10.1038/s41574-024-00970-4

Robert C. Baxter

{"title":"Endocrine and cellular physiology and pathology of the insulin-like growth factor acid-labile subunit","authors":"Robert C. Baxter","doi":"10.1038/s41574-024-00970-4","DOIUrl":"10.1038/s41574-024-00970-4","url":null,"abstract":"The acid-labile subunit (ALS) of the insulin-like growth factor (IGF) binding protein (IGFBP) complex, encoded in humans by IGFALS, has a vital role in regulating the endocrine transport and bioavailability of IGF-1 and IGF-2. Accordingly, ALS has a considerable influence on postnatal growth and metabolism. ALS is a leucine-rich glycoprotein that forms high-affinity ternary complexes with IGFBP-3 or IGFBP-5 when they are occupied by either IGF-1 or IGF-2. These complexes constitute a stable reservoir of circulating IGFs, blocking the potentially hypoglycaemic activity of unbound IGFs. ALS is primarily synthesized by hepatocytes and its expression is lower in non-hepatic tissues. ALS synthesis is strongly induced by growth hormone and suppressed by IL-1β, thus potentially serving as a marker of growth hormone secretion and/or activity and of inflammation. IGFALS mutations in humans and Igfals deletion in mice cause modest growth retardation and pubertal delay, accompanied by decreased osteogenesis and enhanced adipogenesis. In hepatocellular carcinoma, IGFALS is described as a tumour suppressor; however, its contribution to other cancers is not well delineated. This Review addresses the endocrine physiology and pathology of ALS, discusses the latest cell and proteomic studies that suggest emerging cellular roles for ALS and outlines its involvement in other disease states. The acid-labile subunit (ALS) of the insulin-like growth factor (IGF) binding protein complex regulates the endocrine transport and bioavailability of IGF-1 and IGF-2 and therefore influences postnatal growth and metabolism. This Review addresses the endocrine physiology and pathology of ALS, discusses the emerging cellular roles for ALS and outlines its involvement in disease states.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":null,"pages":null},"PeriodicalIF":40.5,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140182826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply to ‘Slowly progressive insulin dependent diabetes mellitus in type 1 diabetes endotype 2’ 对 "1 型糖尿病内型 2 中缓慢进展的胰岛素依赖型糖尿病 "的答复

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2024-03-21 DOI: 10.1038/s41574-024-00977-x

Maria J. Redondo, Noel G. Morgan

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The hypothalamic–pituitary–gonadal axis and the enigma of Alzheimer disease sex differences 下丘脑-垂体-性腺轴与阿尔茨海默病性别差异之谜。

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2024-03-21 DOI: 10.1038/s41574-024-00981-1

Florent Sauvé, Loïc Kacimi, Vincent Prévot

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Slowly progressive insulin-dependent diabetes mellitus in type 1 diabetes endotype 2 1 型糖尿病终末型 2 中缓慢进展的胰岛素依赖型糖尿病。

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2024-03-21 DOI: 10.1038/s41574-024-00975-z

Tetsuro Kobayashi, Takashi Kadowaki

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Sex differences in diabetic kidney disease explained 解释糖尿病肾病的性别差异

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2024-03-20 DOI: 10.1038/s41574-024-00982-0

Claire Greenhill

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Reply to ‘Tumour fibrosis in dopamine agonist-exposed prolactinomas is a diminishing concern’ 对 "多巴胺激动剂暴露的催乳素瘤中的肿瘤纤维化问题日益受到关注 "的答复

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2024-03-20 DOI: 10.1038/s41574-024-00978-w

Stephan Petersenn, Maria Fleseriu, Shlomo Melmed

引用次数: 0

Tumour fibrosis in dopamine agonist-exposed prolactinomas is a diminishing concern 暴露于多巴胺激动剂的催乳素瘤的肿瘤纤维化问题日益受到关注。

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2024-03-20 DOI: 10.1038/s41574-024-00976-y

Sunita M. C. De Sousa, Alistair K. Jukes, Nicholas G. Candy, Ian M. Chapman, David J. Torpy, Brindha Shivalingam, Peter-John Wormald, Stephen Santoreneos

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Inceptor loss in mice with obesity 肥胖症小鼠的受体损失。

IF 40.5 1区医学

Nature Reviews Endocrinology Pub Date : 2024-03-18 DOI: 10.1038/s41574-024-00980-2

Shimona Starling

引用次数: 0