Nature Reviews Endocrinology最新文献_第9页

The gut microbiome and ageing trajectories: mechanisms and clinical implications 肠道微生物组和衰老轨迹：机制和临床意义。

IF 4 1区医学

Nature Reviews Endocrinology Pub Date : 2026-03-03 DOI: 10.1038/s41574-026-01236-x

Andrea Ticinesi, Stefania Maggi, Antonio Nouvenne, Giovanni Zuliani, Claudio Franceschi

{"title":"The gut microbiome and ageing trajectories: mechanisms and clinical implications","authors":"Andrea Ticinesi, Stefania Maggi, Antonio Nouvenne, Giovanni Zuliani, Claudio Franceschi","doi":"10.1038/s41574-026-01236-x","DOIUrl":"10.1038/s41574-026-01236-x","url":null,"abstract":"This Review discusses the current state of knowledge on the contribution of the gut microbiome as a potential key actor in defining how we age. The gut microbiome is a complex ecosystem that establishes lifelong dynamic interactions with the host at multiple levels (several gut–organ axes), differently influencing ageing patterns and age-related disease onset and progression across populations. Accordingly, the definition of a ‘normative’ gut microbiome remains elusive, depending largely on the interaction with the external environment. In this complex scenario, the causal role of the gut microbiome in defining the ageing trajectory and its precise contribution to various organ-specific age-related diseases is still uncertain in clinical terms and could be context specific. Multiparametric and uniqueness indexes within a given population have shown a certain capacity for predicting disability and mortality. However, the gut microbiome is shaped over time by exposure to different intrinsic and environmental factors, resulting in a high degree of inter-individual variability, a key phenomenon that should be considered to develop novel personalized strategies to counteract age-related disease and frailty. The gut microbiome varies highly between individuals and has a substantial contribution to long-term health. This Review examines the effect of the gut microbiome on ageing and frailty risk, including potential therapies to modify gut microbiome composition to promote healthy ageing.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"22 6","pages":"323-337"},"PeriodicalIF":40.0,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147346368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Dual benefits of HIF activation HIF激活的双重好处。

IF 4 1区医学

Nature Reviews Endocrinology Pub Date : 2026-02-27 DOI: 10.1038/s41574-026-01241-0

Claire Greenhill

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The genetics behind thyroid disease 甲状腺疾病背后的基因

IF 4 1区医学

Nature Reviews Endocrinology Pub Date : 2026-02-25 DOI: 10.1038/s41574-026-01238-9

Senegal Carty

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The long-overlooked effect of hypothyroidism on the global burden of non-communicable diseases 长期被忽视的甲状腺功能减退对全球非传染性疾病负担的影响

IF 4 1区医学

Nature Reviews Endocrinology Pub Date : 2026-02-16 DOI: 10.1038/s41574-026-01235-y

Leonidas H. Duntas, Peter A. Kopp

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Making a droplet: the adipogenin–seipin complex at work 形成一个液滴：脂肪原-吸素复合物在起作用。

IF 4 1区医学

Nature Reviews Endocrinology Pub Date : 2026-02-10 DOI: 10.1038/s41574-026-01234-z

Daniel Tews, Pamela Fischer-Posovszky

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Blood–brain barrier permeability of adipokines and myokines 脂肪因子和肌肉因子的血脑屏障通透性。

IF 4 1区医学

Nature Reviews Endocrinology Pub Date : 2026-02-03 DOI: 10.1038/s41574-026-01232-1

Andreas Schäffler, Andreas Schmid, Thomas Karrasch

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Brain neurons promote skeletal dysfunction in ageing 在衰老过程中，大脑神经元促进骨骼功能障碍。

IF 4 1区医学

Nature Reviews Endocrinology Pub Date : 2026-02-03 DOI: 10.1038/s41574-026-01233-0

Olivia Tysoe

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GPR110 as a regulator of MASH GPR110作为MASH的调节因子。

IF 4 1区医学

Nature Reviews Endocrinology Pub Date : 2026-01-16 DOI: 10.1038/s41574-026-01231-2

Claire Greenhill

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Blood-based obesity biomarkers and their relevance for disease risk 基于血液的肥胖生物标志物及其与疾病风险的相关性

IF 4 1区医学

Nature Reviews Endocrinology Pub Date : 2026-01-15 DOI: 10.1038/s41574-025-01229-2

Tobias Pischon, Katharina Nimptsch

{"title":"Blood-based obesity biomarkers and their relevance for disease risk","authors":"Tobias Pischon, Katharina Nimptsch","doi":"10.1038/s41574-025-01229-2","DOIUrl":"10.1038/s41574-025-01229-2","url":null,"abstract":"Obesity is a risk factor for chronic diseases and early death; however, the underlying mechanisms are not fully understood. Whereas insulin resistance and inflammation are established pathways in several of these relationships, it is less clear how increases in body adipose tissue relate to these pathways and disease risk. Several adipose tissue-derived blood-based biomarkers have been identified as purported mediators, including adipokines, inflammatory cytokines and sex steroid hormones. Traditionally, these markers were discovered in animal models and their relevance in humans has then been investigated in epidemiological studies. Today, proteomics and metabolomics approaches in human observational studies are used to discover obesity biomarkers in blood, supported by Mendelian randomization studies to draw causal inferences. Here we review adipose tissue-derived blood-based obesity biomarkers and their relevance for disease risk, along with their potential role as mediators. Proteomics and metabolomics studies have partly re-identified traditional biomarkers, but more large-scale prospective analyses are needed to obtain evidence of the relevance of omics-based and traditional obesity biomarkers to disease. Obesity is associated with changes in levels of many blood-based factors, such as cytokines and adipokines. This Review explores the utility of such factors as biomarkers for quantifying and predicting obesity-associated disease risk, including the identification of causal relationships.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"22 6","pages":"338-355"},"PeriodicalIF":40.0,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145971827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Endocrine regulation of the hepatic fasting response: cues, cooperation and consequences 肝脏禁食反应的内分泌调节：提示、合作和后果。

IF 4 1区医学

Nature Reviews Endocrinology Pub Date : 2026-01-09 DOI: 10.1038/s41574-025-01228-3

Dana Goldberg, Ido Goldstein

{"title":"Endocrine regulation of the hepatic fasting response: cues, cooperation and consequences","authors":"Dana Goldberg, Ido Goldstein","doi":"10.1038/s41574-025-01228-3","DOIUrl":"10.1038/s41574-025-01228-3","url":null,"abstract":"Upon fasting, mammals undergo a fasting response in which the liver’s main role is producing fuel (glucose and ketone bodies) to supply extra-hepatic tissues. Glucose is produced by glycogenolysis and gluconeogenesis, and ketone bodies are produced by ketogenesis, which is preceded by lipolysis and fatty acid oxidation. Hepatic fuel production during fasting is controlled by hormonal and metabolic cues, collectively termed here ‘fasting cues’. In this Review, we discuss fasting cues that directly signal hepatocytes and whose plasma levels increase upon fasting, namely, glucagon, glucocorticoids, growth hormone, adrenaline, free fatty acids, asprosin and GP73. We outline the fasting-dependent increases in blood levels of these cues, how they regulate transcription and the metabolic consequences of these cues in hepatocytes. We put particular emphasis on their role in directing fuel production. The perception of endocrine control of fuel production is shifting from the classic ‘counter-regulatory’ notion that fasting cues are simply opposing insulin action, to the realization that fasting cues cooperate with each other to elicit a synergistic response and also complement each other’s actions indirectly. We discuss these modes of crosstalk and cooperation between fasting cues and describe the effects of signal integration on the transcriptional and metabolic response to fasting. During fasting, the liver produces fuel under the control of several hormonal and metabolic cues. In this Review, the authors outline the effects of the cues (glucagon, glucocorticoids, growth hormone, adrenaline, free fatty acids, asprosin and GP73) that are known to directly signal to hepatocytes under fasting conditions.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"22 5","pages":"302-316"},"PeriodicalIF":40.0,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145937875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0