联合疗法可增加体内人类 β 细胞的数量

IF 31 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Olivia Tysoe
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引用次数: 0

摘要

与健康人相比,糖尿病患者的胰腺β细胞数量大幅减少。现在,《科学-转化医学》(Science Translational Medicine)杂志上的一项研究证明,双重酪氨酸调节激酶1A(DYRK1A)抑制剂与胰高血糖素样肽1(GLP1)受体激动剂联合治疗可有效增加体内人类β细胞的数量。研究人员将人类胰岛移植到免疫缺陷(Rag1-/-)小鼠的肾囊下。研究人员将人类胰岛移植到免疫缺陷小鼠(Rag1-/-)的肾脏囊下,并用药物对照组、哈米那、外泌丁4(一种GLP1受体激动剂)或哈米那和外泌丁4的组合(H&E)对这些小鼠进行长达3个月的治疗。"Garcia-Ocaña说:"我们采用了一种组织澄清技术和一种名为iDISCO+的光片显微镜方法,以三维方式观察肾囊下移植的人体小胰岛。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Combination therapy increases human β-cell mass in vivo

Combination therapy increases human β-cell mass in vivo
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来源期刊
Nature Reviews Endocrinology
Nature Reviews Endocrinology 医学-内分泌学与代谢
CiteScore
42.00
自引率
0.70%
发文量
158
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Endocrinology aspires to be the foremost platform for reviews and commentaries catering to the scientific communities it serves. The journal aims to publish articles characterized by authority, accessibility, and clarity, enhanced with easily understandable figures, tables, and other visual aids. The goal is to offer an unparalleled service to authors, referees, and readers, striving to maximize the usefulness and impact of each article. Nature Reviews Endocrinology publishes Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives relevant to researchers and clinicians in the fields of endocrinology and metabolism. Its broad scope ensures that the work it publishes reaches the widest possible audience.
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