微生物硫化氢阻碍 L 细胞产生 GLP-1

IF 31 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Senegal Carty
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引用次数: 0

摘要

肠道微生物群对消化和新陈代谢健康有很大影响。最近发表在《自然-代谢》(Nature Metabolism)上的一项研究报告称,肠道微生物群释放的硫化氢与肠道中 GLP-1 的产生之间存在联系。为了阐明这种反应背后的机制,研究人员研究了小鼠肠内分泌 L 细胞与脱硫弧菌之间的相互作用。他们发现,将培养的L细胞暴露于脱硫弧菌的培养上清中会抑制GLP-1在葡萄糖作用下的产生。由于脱硫弧菌是硫化氢(H2S)的主要制造者,研究人员用H2S供体硫氢化钠(NaHS)处理细胞,从而检验了H2S抑制L细胞产生GLP-1的假设。与假设相符的是,细胞在接触 NaHS 后产生的 GLP-1 比不接触 NaHS 时少。研究人员还用水杨酸铋(一种能封闭H2S的非处方药物)和脱硫梭菌上清液处理细胞,结果表明这种处理方法能以剂量依赖的方式挽救GLP-1的产生。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Microbial hydrogen sulfide hampers L-cell GLP-1 production

Microbial hydrogen sulfide hampers L-cell GLP-1 production
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来源期刊
Nature Reviews Endocrinology
Nature Reviews Endocrinology 医学-内分泌学与代谢
CiteScore
42.00
自引率
0.70%
发文量
158
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Endocrinology aspires to be the foremost platform for reviews and commentaries catering to the scientific communities it serves. The journal aims to publish articles characterized by authority, accessibility, and clarity, enhanced with easily understandable figures, tables, and other visual aids. The goal is to offer an unparalleled service to authors, referees, and readers, striving to maximize the usefulness and impact of each article. Nature Reviews Endocrinology publishes Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives relevant to researchers and clinicians in the fields of endocrinology and metabolism. Its broad scope ensures that the work it publishes reaches the widest possible audience.
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