对 GIPR 信号调控的新认识

IF 3.7 3区医学 Q2 CHEMISTRY, MEDICINAL

Chemical Research in Toxicology Pub Date : 2024-08-22 DOI:10.1038/s41574-024-01027-2

Yusman Manchanda, Alejandra Tomas

引用次数: 0

摘要

最近的两项研究揭示了葡萄糖依赖性促胰岛素多肽受体（GIPR）信号调节的新模式。Kizilkaya 等人研究了 β-arrestin 2 与天然 GIPR 编码变体耦合变化的影响，而 Regmi 等人则研究了脂肪细胞中 GIPR 的表达谱和功能调节。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

New insights into the regulation of GIPR signalling

Two recent studies have unravelled novel modes of glucose-dependent insulinotropic polypeptide receptor (GIPR) signalling regulation. Kizilkaya et al. characterized the effect of changes in β-arrestin 2 coupling with naturally occurring GIPR coding variants, whereas Regmi et al. investigated GIPR expression profiles and functional regulation in adipocytes.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Chemical Research in Toxicology 医学-毒理学

CiteScore

7.90

自引率

7.30%

发文量

215

审稿时长

3.5 months

期刊介绍： Chemical Research in Toxicology publishes Articles, Rapid Reports, Chemical Profiles, Reviews, Perspectives, Letters to the Editor, and ToxWatch on a wide range of topics in Toxicology that inform a chemical and molecular understanding and capacity to predict biological outcomes on the basis of structures and processes. The overarching goal of activities reported in the Journal are to provide knowledge and innovative approaches needed to promote intelligent solutions for human safety and ecosystem preservation. The journal emphasizes insight concerning mechanisms of toxicity over phenomenological observations. It upholds rigorous chemical, physical and mathematical standards for characterization and application of modern techniques.