Molecular Imaging最新文献_第3页

Radionuclide Imaging for Neuroscience: Current Opinion and Future Directions. 神经科学的放射性核素成像:当前的观点和未来的方向。

IF 2.8 4区医学

Molecular Imaging Pub Date : 2020-01-01 DOI: 10.1177/1536012120936397

Antony D Gee, Matthias M Herth, Michelle L James, Aruna Korde, Peter J H Scott, Neil Vasdev

引用次数: 3

Peptide Based Imaging Agents for HER2 Imaging in Oncology. 肿瘤HER2成像的肽基显像剂。

IF 2.8 4区医学

Molecular Imaging Pub Date : 2020-01-01 DOI: 10.1177/1536012120960258

Maxwell Ducharme, Suzanne E Lapi

{"title":"Peptide Based Imaging Agents for HER2 Imaging in Oncology.","authors":"Maxwell Ducharme, Suzanne E Lapi","doi":"10.1177/1536012120960258","DOIUrl":"https://doi.org/10.1177/1536012120960258","url":null,"abstract":"Breast cancer continues to be the most lethal cancer type in women and one of the most diagnosed. Understanding Breast cancer receptor status is one of the most vital processes for determining treatment options. One type of breast cancer, human epidermal growth factor receptor 2 (HER2) positive, has approved receptor-based therapies including trastuzumab and pertuzumab that can significantly increase the likelihood of survival. Current methods to determine HER2 status include biopsies with immunohistochemical staining and/or fluorescence in situ hybridization. However, positron emission tomography (PET) imaging techniques using 89Zr-trastuzumab or 89Zr-pertuzumab are currently in clinical trials for a non-invasive, full body diagnostic approach. Although the antibodies have strong specificity to the HER2 positive lesions, challenges involving long post-injection time for imaging due to the blood circulation of the antibodies and matching of long-live isotopes leading to increased dose to the patient leave opportunities for alternative PET imaging probes. Peptides have been shown to allow for shorter injection-to-imaging time and can be used with shorter lived isotopes. HER2 specific peptides under development will help improve the diagnosis and potentially therapy options for HER2 positive breast cancer. Peptides showing specificity for HER2 could start widespread development of molecular imaging techniques for HER2 positive cancers.","PeriodicalId":18855,"journal":{"name":"Molecular Imaging","volume":"19 ","pages":"1536012120960258"},"PeriodicalIF":2.8,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1536012120960258","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38403380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Targeted Imaging Agent to HSP70 Induced In Vivo. 靶向显像剂对体内诱导HSP70的影响。

IF 2.8 4区医学

Molecular Imaging Pub Date : 2020-01-01 DOI: 10.1177/1536012120942685

Pradip Ghosh, Brian E O'Neill, King C Li

引用次数: 0

Magnetofluorescent Nanoprobe for Multimodal and Multicolor Bioimaging. 用于多模态和多色生物成像的磁荧光纳米探针。

IF 2.8 4区医学

Molecular Imaging Pub Date : 2020-01-01 DOI: 10.1177/1536012120969477

Aditya Yadav, Chethana Rao, Navneet Chandra Verma, Pushpendra Mani Mishra, Chayan Kanti Nandi

引用次数: 1

Research Progress of Radiolabeled Asn-Gly-Arg (NGR) Peptides for Imaging and Therapy. 放射标记Asn-Gly-Arg (NGR)肽在成像和治疗中的研究进展。

IF 2.8 4区医学

Molecular Imaging Pub Date : 2020-01-01 DOI: 10.1177/1536012120934957

Liqin Zhu, Zhikai Ding, Xingliang Li, Hongyuan Wei, Yue Chen

引用次数: 13

Two Patient Studies of a Companion Diagnostic Immuno-Positron Emission Tomography (PET) Tracer for Measuring Human CA6 Expression in Cancer for Antibody Drug Conjugate (ADC) Therapy. 两例伴随诊断免疫-正电子发射断层扫描(PET)示踪剂用于检测抗体药物偶联(ADC)治疗中癌症中人类CA6表达的患者研究。

IF 2.8 4区医学

Molecular Imaging Pub Date : 2020-01-01 DOI: 10.1177/1536012120939398

Arutselvan Natarajan, Shyam M Srinivas, Carmen Azevedo, Lacey Greene, Anne-Laure Bauchet, Erwan Jouannot, Anne-Sophie Lacoste-Bourgeacq, Isabelle Guizon, Patrick Cohen, Anne-Laure Naneix, Ohad Ilovich, Jordan Cisneros, Krithika Rupanarayan, Frederick T Chin, Andrei Iagaru, Frederick M Dirbas, Amer Karam, Sanjiv S Gambhir

{"title":"Two Patient Studies of a Companion Diagnostic Immuno-Positron Emission Tomography (PET) Tracer for Measuring Human CA6 Expression in Cancer for Antibody Drug Conjugate (ADC) Therapy.","authors":"Arutselvan Natarajan, Shyam M Srinivas, Carmen Azevedo, Lacey Greene, Anne-Laure Bauchet, Erwan Jouannot, Anne-Sophie Lacoste-Bourgeacq, Isabelle Guizon, Patrick Cohen, Anne-Laure Naneix, Ohad Ilovich, Jordan Cisneros, Krithika Rupanarayan, Frederick T Chin, Andrei Iagaru, Frederick M Dirbas, Amer Karam, Sanjiv S Gambhir","doi":"10.1177/1536012120939398","DOIUrl":"https://doi.org/10.1177/1536012120939398","url":null,"abstract":"An antigen binding fragment (BFab) derived from a tumor-associated mucin 1-sialoglycotope antigen (CA6) targeting antibody (huDS6) was engineered. We synthesized a companion diagnostic positron emission tomography (PET) tracer by radiolabeling BFab with [64Cu] to measure CA6 expression on cancer tissues prior to anti-human CA6 (huDS6-DM4 antibody-drug conjugate) therapy for ovarian and breast cancer patients. After chemotherapy, the ovarian patient received PET scan with 18F-2-fluoro-2-deoxyglucose ([18F]FDG: 10 mCi), followed by [64Cu]-DOTA-BFab ([64Cu]BFab; 5.5 mCi) 1 week later for PET scanning of CA6 expression and subsequent surgery. The breast cancer patient was treated with chemotherapy before primary tumor resection and subsequent [18F]FDG-PET scan. 4 weeks later the patient received of [64Cu]BFab (11.7 mCi) for CA6 PET scan. Whole body [18F]FDG-PET of the breast cancer patient indicated FDG-avid tumor metastases to the liver, bilateral hila and thoracic spine, but no uptake was observed for the ovarian patient. Each patient was also imaged by PET/CT with [64Cu]BFab at 1 and 24 hours after tracer administration. The [64Cu]BFab tracer was well tolerated by both patients without adverse effects, and no significant tracer uptake was observed in both patients. Immunohistochemistry (IHC) data indicated CA6 expressions were weak to intermediate and matched with the [64Cu]BFab-PET signals.","PeriodicalId":18855,"journal":{"name":"Molecular Imaging","volume":"19 ","pages":"1536012120939398"},"PeriodicalIF":2.8,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1536012120939398","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38625616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

High-Efficiency Production of Radiopharmaceuticals via Droplet Radiochemistry: A Review of Recent Progress. 利用微滴放射化学高效生产放射性药物的研究进展

IF 2.8 4区医学

Molecular Imaging Pub Date : 2020-01-01 DOI: 10.1177/1536012120973099

Jia Wang, R Michael van Dam

引用次数: 11

Multi-Wavelength Fluorescence in Image-Guided Surgery, Clinical Feasibility and Future Perspectives. 多波长荧光在图像引导手术中的应用、临床可行性和未来展望。

IF 2.2 4区医学

Molecular Imaging Pub Date : 2020-01-01 DOI: 10.1177/1536012120962333

Florian van Beurden, Danny M van Willigen, Borivoj Vojnovic, Matthias N van Oosterom, Oscar R Brouwer, Henk G van der Poel, Hisataka Kobayashi, Fijs W B van Leeuwen, Tessa Buckle

引用次数: 0

Sound Out the Deep Colors: Photoacoustic Molecular Imaging at New Depths. 发出深颜色:新深度的光声分子成像。

IF 2.8 4区医学

Molecular Imaging Pub Date : 2020-01-01 DOI: 10.1177/1536012120981518

Mucong Li, Nikhila Nyayapathi, Hailey I Kilian, Jun Xia, Jonathan F Lovell, Junjie Yao

{"title":"Sound Out the Deep Colors: Photoacoustic Molecular Imaging at New Depths.","authors":"Mucong Li, Nikhila Nyayapathi, Hailey I Kilian, Jun Xia, Jonathan F Lovell, Junjie Yao","doi":"10.1177/1536012120981518","DOIUrl":"https://doi.org/10.1177/1536012120981518","url":null,"abstract":"Photoacoustic tomography (PAT) has become increasingly popular for molecular imaging due to its unique optical absorption contrast, high spatial resolution, deep imaging depth, and high imaging speed. Yet, the strong optical attenuation of biological tissues has traditionally prevented PAT from penetrating more than a few centimeters and limited its application for studying deeply seated targets. A variety of PAT technologies have been developed to extend the imaging depth, including employing deep-penetrating microwaves and X-ray photons as excitation sources, delivering the light to the inside of the organ, reshaping the light wavefront to better focus into scattering medium, as well as improving the sensitivity of ultrasonic transducers. At the same time, novel optical fluence mapping algorithms and image reconstruction methods have been developed to improve the quantitative accuracy of PAT, which is crucial to recover weak molecular signals at larger depths. The development of highly-absorbing near-infrared PA molecular probes has also flourished to provide high sensitivity and specificity in studying cellular processes. This review aims to introduce the recent developments in deep PA molecular imaging, including novel imaging systems, image processing methods and molecular probes, as well as their representative biomedical applications. Existing challenges and future directions are also discussed.","PeriodicalId":18855,"journal":{"name":"Molecular Imaging","volume":"19 ","pages":"1536012120981518"},"PeriodicalIF":2.8,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1536012120981518","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38725464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Altered Forebrain Functional Connectivity and Neurotransmission in a Kinase-Inactive Met Mouse Model of Autism. 自闭症激酶不活跃 Met 小鼠模型的前脑功能连接性和神经传递发生改变

IF 2.2 4区医学

Molecular Imaging Pub Date : 2019-01-01 DOI: 10.1177/1536012118821034

Shiyu Tang, Elizabeth M Powell, Wenjun Zhu, Fu-Sun Lo, Reha S Erzurumlu, Su Xu

{"title":"Altered Forebrain Functional Connectivity and Neurotransmission in a Kinase-Inactive Met Mouse Model of Autism.","authors":"Shiyu Tang, Elizabeth M Powell, Wenjun Zhu, Fu-Sun Lo, Reha S Erzurumlu, Su Xu","doi":"10.1177/1536012118821034","DOIUrl":"10.1177/1536012118821034","url":null,"abstract":"MET, the gene encoding the tyrosine kinase receptor for hepatocyte growth factor, is a susceptibility gene for autism spectrum disorder (ASD). Genetically altered mice with a kinase-inactive Met offer a potential model for understanding neural circuit organization changes in autism. Here, we focus on the somatosensory thalamocortical circuitry because distinct somatosensory sensitivity phenotypes accompany ASD, and this system plays a major role in sensorimotor and social behaviors in mice. We employed resting-state functional magnetic resonance imaging and in vivo high-resolution proton MR spectroscopy to examine neuronal connectivity and neurotransmission of wild-type, heterozygous Met-Emx1, and fully inactive homozygous Met-Emx1 mice. Met-Emx1 brains showed impaired maturation of large-scale somatosensory network connectivity when compared with wild-type controls. Significant sex × genotype interaction in both network features and glutamate/gamma-aminobutyric acid (GABA) balance was observed. Female Met-Emx1 brains showed significant connectivity and glutamate/GABA balance changes in the somatosensory thalamocortical system when compared with wild-type brains. The glutamate/GABA ratio in the thalamus was correlated with the connectivity between the somatosensory cortex and the thalamus in heterozygous Met-Emx1 female brains. The findings support the hypothesis that aberrant functioning of the somatosensory thalamocortical system is at the core of the conspicuous somatosensory behavioral phenotypes observed in Met-Emx1 mice.","PeriodicalId":18855,"journal":{"name":"Molecular Imaging","volume":"18 ","pages":"1536012118821034"},"PeriodicalIF":2.2,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e9/8a/10.1177_1536012118821034.PMC6322103.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36994952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0