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Nature Reviews Rheumatology最新文献

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Fumarate drives interferon release in systemic sclerosis monocytes 富马酸盐驱动系统性硬化症单核细胞释放干扰素
IF 33.7 1区 医学
Nature Reviews Rheumatology Pub Date : 2025-04-16 DOI: 10.1038/s41584-025-01261-6
Sarah Onuora
{"title":"Fumarate drives interferon release in systemic sclerosis monocytes","authors":"Sarah Onuora","doi":"10.1038/s41584-025-01261-6","DOIUrl":"https://doi.org/10.1038/s41584-025-01261-6","url":null,"abstract":"Altered metabolism of the tricarboxylic acid cycle metabolite fumarate drives activation of interferon release in systemic sclerosis monocytes, suggesting a potential therapeutic approach.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"40 1","pages":""},"PeriodicalIF":33.7,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143836708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Upadacitinib effective for GCA in phase III trial 奥达帕替尼在 III 期试验中对 GCA 有效
IF 33.7 1区 医学
Nature Reviews Rheumatology Pub Date : 2025-04-15 DOI: 10.1038/s41584-025-01260-7
Sarah Onuora
{"title":"Upadacitinib effective for GCA in phase III trial","authors":"Sarah Onuora","doi":"10.1038/s41584-025-01260-7","DOIUrl":"https://doi.org/10.1038/s41584-025-01260-7","url":null,"abstract":"In the phase III SELECT-GCA trial, upadacitinib at a dose of 15 mg daily was superior to placebo with respect to achievement of sustained remission of giant cell arteritis at 52 weeks.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"26 1","pages":""},"PeriodicalIF":33.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lipid nanoparticles with PDL1-encoding mRNA spread tolerance 带有 PDL1 编码 mRNA 的脂质纳米颗粒传播耐受性
IF 33.7 1区 医学
Nature Reviews Rheumatology Pub Date : 2025-04-11 DOI: 10.1038/s41584-025-01251-8
Maria Papatriantafyllou
{"title":"Lipid nanoparticles with PDL1-encoding mRNA spread tolerance","authors":"Maria Papatriantafyllou","doi":"10.1038/s41584-025-01251-8","DOIUrl":"https://doi.org/10.1038/s41584-025-01251-8","url":null,"abstract":"Lipid nanoparticle carriers of immunosuppressive mRNA shape tolerogenic antigen-presenting cells that inhibit arthritis progression in mice.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"1 1","pages":""},"PeriodicalIF":33.7,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143819080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decoding the adaptive immune repertoire for disease prediction 解码适应性免疫库以预测疾病
IF 33.7 1区 医学
Nature Reviews Rheumatology Pub Date : 2025-04-10 DOI: 10.1038/s41584-025-01249-2
Laura F. Su
{"title":"Decoding the adaptive immune repertoire for disease prediction","authors":"Laura F. Su","doi":"10.1038/s41584-025-01249-2","DOIUrl":"https://doi.org/10.1038/s41584-025-01249-2","url":null,"abstract":"A simple blood test that can diagnose or predict one’s risk for autoimmune diseases would revolutionize medicine and transform patient care. Published in Science, Zaslavsky et al. advance this vision with a powerful machine learning framework that leverages immune receptor sequences from T cells and B cells for disease classification.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"183 1","pages":""},"PeriodicalIF":33.7,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex- and gender-based personalized medicine in rheumatology 风湿病学中的性别和基于性别的个性化医学
IF 33.7 1区 医学
Nature Reviews Rheumatology Pub Date : 2025-04-07 DOI: 10.1038/s41584-025-01246-5
Elizabeth R. Volkmann, Carol Feghali-Bostwick
{"title":"Sex- and gender-based personalized medicine in rheumatology","authors":"Elizabeth R. Volkmann, Carol Feghali-Bostwick","doi":"10.1038/s41584-025-01246-5","DOIUrl":"https://doi.org/10.1038/s41584-025-01246-5","url":null,"abstract":"Although autoimmune rheumatic diseases are more prevalent in women than men, few clinical trials report findings on the basis of sex and gender. Future clinical trials should report sex and gender differences in treatment and safety outcomes in a standardized manner to improve outcomes for all patients.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"6 1","pages":""},"PeriodicalIF":33.7,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IgG4-related disease and other fibro-inflammatory conditions igg4相关疾病和其他纤维炎性疾病
IF 33.7 1区 医学
Nature Reviews Rheumatology Pub Date : 2025-04-07 DOI: 10.1038/s41584-025-01240-x
Francesco Peyronel, Emanuel Della-Torre, Federica Maritati, Maria L. Urban, Ingeborg Bajema, Nicolas Schleinitz, Augusto Vaglio
{"title":"IgG4-related disease and other fibro-inflammatory conditions","authors":"Francesco Peyronel, Emanuel Della-Torre, Federica Maritati, Maria L. Urban, Ingeborg Bajema, Nicolas Schleinitz, Augusto Vaglio","doi":"10.1038/s41584-025-01240-x","DOIUrl":"https://doi.org/10.1038/s41584-025-01240-x","url":null,"abstract":"<p>IgG4-related disease (IgG4-RD) is a fibro-inflammatory disorder usually characterized by multi-organ involvement. Its pathogenesis is complex and involves genetic and environmental factors, while immune responses usually mediate organ damage and promote fibrosis, which is a key feature of the disease. IgG4 responses, however, are not exclusive to IgG4-RD and can be encountered in other diseases with phenotypes that partially overlap that of IgG4-RD. Although IgG4-RD has clinical and histological hallmarks, the lack of validated diagnostic criteria often makes the diagnosis challenging, requiring a multi-dimensional approach that integrates clinical, radiological and serological data. The present Review covers recent advances in the understanding of disease drivers and its clinical phenotypes, mainly focusing on the differential diagnosis with potential IgG4-RD mimickers, namely histiocytoses, lymphoproliferative disorders, systemic vasculitides and other immune-mediated conditions. The Review also provides a schematic approach to IgG4-RD treatment, including a brief overview of glucocorticoid-sparing agents and emerging therapies, from B cell-depleting monoclonal antibodies to cytokine-targeting drugs, the majority of which are currently under investigation in randomized clinical trials.</p>","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"1715 1","pages":""},"PeriodicalIF":33.7,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex and gender matter for TNF inhibitor therapy in RA 性别和性别影响TNF抑制剂治疗RA
IF 33.7 1区 医学
Nature Reviews Rheumatology Pub Date : 2025-04-02 DOI: 10.1038/s41584-025-01248-3
Holly Webster
{"title":"Sex and gender matter for TNF inhibitor therapy in RA","authors":"Holly Webster","doi":"10.1038/s41584-025-01248-3","DOIUrl":"https://doi.org/10.1038/s41584-025-01248-3","url":null,"abstract":"Findings indicate that women and men with rheumatoid arthritis have different treatment responses to anti-TNF therapy.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"58 1","pages":""},"PeriodicalIF":33.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lupus ABC spearheading a new era of collaboration to advance lupus drug development 狼疮ABC率先合作推进狼疮药物开发的新时代
IF 33.7 1区 医学
Nature Reviews Rheumatology Pub Date : 2025-04-01 DOI: 10.1038/s41584-025-01247-4
Hoang Nguyen, Teodora P. Staeva
{"title":"Lupus ABC spearheading a new era of collaboration to advance lupus drug development","authors":"Hoang Nguyen, Teodora P. Staeva","doi":"10.1038/s41584-025-01247-4","DOIUrl":"https://doi.org/10.1038/s41584-025-01247-4","url":null,"abstract":"Despite having a robust drug development pipeline, lupus remains far behind other rheumatic and autoimmune conditions for which dozens of targeted therapies have been developed. Addressing the pervasive, long-standing challenges impeding the field requires a paradigm shift and a patient-powered, community-wide approach, exemplified by the Lupus Accelerating Breakthroughs Consortium (Lupus ABC).","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"3 1","pages":""},"PeriodicalIF":33.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The causal role of brain circuits in osteoarthritis pain 脑回路在骨关节炎疼痛中的因果作用
IF 33.7 1区 医学
Nature Reviews Rheumatology Pub Date : 2025-03-31 DOI: 10.1038/s41584-025-01234-9
Joana Barroso, Paulo Branco, A. Vania Apkarian
{"title":"The causal role of brain circuits in osteoarthritis pain","authors":"Joana Barroso, Paulo Branco, A. Vania Apkarian","doi":"10.1038/s41584-025-01234-9","DOIUrl":"https://doi.org/10.1038/s41584-025-01234-9","url":null,"abstract":"<p>Osteoarthritis (OA) is a leading cause of chronic pain worldwide, resulting in substantial disability and placing a substantial burden on patients and society. The hallmark symptom of OA is joint pain. Despite extensive research, new treatments for OA pain remain limited, partly owing to a lack of understanding of underlying pain mechanisms. For a long time, OA pain was seen as a reflection of nociceptive activity at the joint level, and the brain has been viewed as a passive recipient of such information. In this Review, we challenge these concepts and discuss how, over time, the activation of peripheral nociceptors leads to adaptations in the brain that dictate the properties and experience of OA pain. These adaptations are further influenced by the inherent properties of the brain. We review general concepts that distinguish pain from nociception, present evidence on the incongruity between joint injury and experience of OA pain, and review brain circuits that are crucial in the perception of OA pain. Finally, we propose a model that integrates nociception, spinal-cord mechanisms, and central nervous system dynamics, each contributing uniquely to pain perception. This framework has the potential to inform the development of personalized treatment strategies.</p>","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"70 1","pages":""},"PeriodicalIF":33.7,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CXCL7 promotes bone erosion in RA CXCL7促进RA的骨侵蚀
IF 33.7 1区 医学
Nature Reviews Rheumatology Pub Date : 2025-03-28 DOI: 10.1038/s41584-025-01245-6
Holly Webster
{"title":"CXCL7 promotes bone erosion in RA","authors":"Holly Webster","doi":"10.1038/s41584-025-01245-6","DOIUrl":"https://doi.org/10.1038/s41584-025-01245-6","url":null,"abstract":"A study provides insights into the role of CXCL7 in bone erosion in rheumatoid arthritis.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"27 1","pages":""},"PeriodicalIF":33.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143734077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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