Nature Reviews Rheumatology最新文献_第3页

Off-the-shelf CAR T cells for refractory autoimmunity 治疗难治性自身免疫的现成 CAR T 细胞

IF 29.4 1区医学

Nature Reviews Rheumatology Pub Date : 2024-07-29 DOI: 10.1038/s41584-024-01148-y

Maria Papatriantafyllou

引用次数: 0

UNC93B1 variants promote SLE via TLR activation UNC93B1 变体通过 TLR 激活促进系统性红斑狼疮的发生。

IF 29.4 1区医学

Nature Reviews Rheumatology Pub Date : 2024-07-26 DOI: 10.1038/s41584-024-01147-z

Holly Webster

引用次数: 0

Integrin signalling in joint development, homeostasis and osteoarthritis 关节发育、稳态和骨关节炎中的整合素信号传递

IF 29.4 1区医学

Nature Reviews Rheumatology Pub Date : 2024-07-16 DOI: 10.1038/s41584-024-01130-8

Michael Z. Miao, Janice S. Lee, Kenneth M. Yamada, Richard F. Loeser

{"title":"Integrin signalling in joint development, homeostasis and osteoarthritis","authors":"Michael Z. Miao, Janice S. Lee, Kenneth M. Yamada, Richard F. Loeser","doi":"10.1038/s41584-024-01130-8","DOIUrl":"10.1038/s41584-024-01130-8","url":null,"abstract":"Integrins are key regulators of cell–matrix interactions during joint development and joint tissue homeostasis, as well as in the development of osteoarthritis (OA). The signalling cascades initiated by the interactions of integrins with a complex network of extracellular matrix (ECM) components and intracellular adaptor proteins orchestrate cellular responses necessary for maintaining joint tissue integrity. Dysregulated integrin signalling, triggered by matrix degradation products such as matrikines, disrupts this delicate balance, tipping the scales towards an environment conducive to OA pathogenesis. The interplay between integrin signalling and growth factor pathways further underscores the multifaceted nature of OA. Moreover, emerging insights into the role of endocytic trafficking in regulating integrin signalling add a new layer of complexity to the understanding of OA development. To harness the therapeutic potential of targeting integrins for mitigation of OA, comprehensive understanding of their molecular mechanisms across joint tissues is imperative. Ultimately, deciphering the complexities of integrin signalling will advance the ability to treat OA and alleviate its global burden. Integrins are involved in joint tissue development and homeostasis, and perturbations in the availability of integrin ligands or in downstream integrin signalling are linked to the pathogenesis of osteoarthritis (OA). This Review discusses current evidence and future perspectives for therapeutically targeting integrins in OA.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":null,"pages":null},"PeriodicalIF":29.4,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141625031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The pathogenesis of gout: molecular insights from genetic, epigenomic and transcriptomic studies 痛风的发病机制：从基因、表观基因组和转录组研究中获得的分子见解。

IF 29.4 1区医学

Nature Reviews Rheumatology Pub Date : 2024-07-11 DOI: 10.1038/s41584-024-01137-1

Megan P. Leask, Tania O. Crișan, Aichang Ji, Hirotaka Matsuo, Anna Köttgen, Tony R. Merriman

{"title":"The pathogenesis of gout: molecular insights from genetic, epigenomic and transcriptomic studies","authors":"Megan P. Leask, Tania O. Crișan, Aichang Ji, Hirotaka Matsuo, Anna Köttgen, Tony R. Merriman","doi":"10.1038/s41584-024-01137-1","DOIUrl":"10.1038/s41584-024-01137-1","url":null,"abstract":"The pathogenesis of gout involves a series of steps beginning with hyperuricaemia, followed by the deposition of monosodium urate crystal in articular structures and culminating in an innate immune response, mediated by the NLRP3 inflammasome, to the deposited crystals. Large genome-wide association studies (GWAS) of serum urate levels initially identified the genetic variants with the strongest effects, mapping mainly to genes that encode urate transporters in the kidney and gut. Other GWAS highlighted the importance of uncommon genetic variants. More recently, genetic and epigenetic genome-wide studies have revealed new pathways in the inflammatory process of gout, including genetic associations with epigenomic modifiers. Epigenome-wide association studies are also implicating epigenomic remodelling in gout, which perhaps regulates the responsiveness of the innate immune system to monosodium urate crystals. Notably, genes implicated in gout GWAS do not include those encoding components of the NLRP3 inflammasome itself, but instead include genes encoding molecules involved in its regulation. Knowledge of the molecular mechanisms underlying gout has advanced through the translation of genetic associations into specific molecular mechanisms. Notable examples include ABCG2, HNF4A, PDZK1, MAF and IL37. Current genetic studies are dominated by participants of European ancestry; however, studies focusing on other population groups are discovering informative population-specific variants associated with gout. Genetic, epigenetic and transcriptomic studies in hyperuricaemia and gout have, in the past 6 years, provided important insights into the underlying molecular mechanisms, revealing new inflammatory pathways and epigenetic factors and expanding research beyond European populations.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":null,"pages":null},"PeriodicalIF":29.4,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141590798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Itaconate targets fibroblast-like synoviocytes in RA 伊塔康酸可靶向治疗风湿性关节炎的成纤维细胞样滑膜细胞

IF 29.4 1区医学

Nature Reviews Rheumatology Pub Date : 2024-07-10 DOI: 10.1038/s41584-024-01142-4

Sarah Onuora

引用次数: 0

Update on the pathophysiology and treatment of primary Sjögren syndrome 原发性斯约格伦综合征的最新病理生理学和治疗方法。

IF 29.4 1区医学

Nature Reviews Rheumatology Pub Date : 2024-07-09 DOI: 10.1038/s41584-024-01135-3

Chiara Baldini, Giovanni Fulvio, Gaetano La Rocca, Francesco Ferro

{"title":"Update on the pathophysiology and treatment of primary Sjögren syndrome","authors":"Chiara Baldini, Giovanni Fulvio, Gaetano La Rocca, Francesco Ferro","doi":"10.1038/s41584-024-01135-3","DOIUrl":"10.1038/s41584-024-01135-3","url":null,"abstract":"Sjögren syndrome or Sjögren disease is a chronic form of autoimmune epithelitis characterized by lymphocytic infiltration of the exocrine glands, particularly the salivary and lacrimal glands, leading to progressive glandular dysfunction and subsequent xerostomia and xerophthalmia. Other common manifestations include pain and fatigue, various systemic manifestations and non-Hodgkin’s lymphoma. Sjögren syndrome is therefore a complex and disabling disease associated with a reduced quality of life and with considerable long-term damage. Most of the available treatments are merely symptomatic with limited efficacy in both preventing glandular damage and suppressing systemic disease activity. In the past 10 years, great progress has been made in understanding the pathophysiology of Sjögren syndrome, opening new avenues towards a more targeted and individualized therapeutic approach to the disease. Indeed, several randomized controlled trials have just been completed or are poised to commence evaluating the effectiveness of novel drugs targeting both innate and adaptive immune pathways, including pro-inflammatory cytokines, the type I interferon system, B cell activation, B cell and T cell co-stimulation pathway, and ectopic germinal centre formation. Novel clinical trials are also ongoing exploring various targeted approaches (that is, IgG recycling inhibition, nuclease therapy and CAR-T cell therapy) for Sjögren syndrome. Sjögren syndrome is a chronic autoimmune disease affecting exocrine glands, causing dryness and systemic symptoms. Treatment has been primarily symptomatic, but advances in our understanding of its pathophysiology offer promise for targeted therapies, aiming for personalized care and improved outcomes.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":null,"pages":null},"PeriodicalIF":29.4,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141563769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathogenic antibodies target stromal antigens in RA 致病抗体靶向 RA 的基质抗原

IF 29.4 1区医学

Nature Reviews Rheumatology Pub Date : 2024-07-08 DOI: 10.1038/s41584-024-01141-5

Jessica McHugh

引用次数: 0

Integrin-mediated ILC2 adhesion protects against lupus nephritis 整合素介导的 ILC2 粘附可预防狼疮性肾炎

IF 29.4 1区医学

Nature Reviews Rheumatology Pub Date : 2024-07-08 DOI: 10.1038/s41584-024-01140-6

Jessica McHugh

引用次数: 0

How muscle influences bone health 肌肉如何影响骨骼健康

IF 29.4 1区医学

Nature Reviews Rheumatology Pub Date : 2024-07-05 DOI: 10.1038/s41584-024-01138-0

Maria Papatriantafyllou

引用次数: 0

Mitophagy as a link between ECM stiffness and chondrocyte senescence 有丝分裂是 ECM 硬度与软骨细胞衰老之间的纽带

IF 29.4 1区医学

Nature Reviews Rheumatology Pub Date : 2024-06-21 DOI: 10.1038/s41584-024-01136-2

Maria Papatriantafyllou

引用次数: 0