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Nature Reviews Rheumatology最新文献

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A neurogenetic blueprint for fibromyalgia. 纤维肌痛的神经遗传学蓝图。
IF 33.7 1区 医学
Nature Reviews Rheumatology Pub Date : 2026-09-21 DOI: 10.1038/s41584-026-01437-8
Luda Diatchenko, Sahel Jahangiri Esfahani
{"title":"A neurogenetic blueprint for fibromyalgia.","authors":"Luda Diatchenko, Sahel Jahangiri Esfahani","doi":"10.1038/s41584-026-01437-8","DOIUrl":"https://doi.org/10.1038/s41584-026-01437-8","url":null,"abstract":"","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":" ","pages":""},"PeriodicalIF":33.7,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149017359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sulfated chitosan derivative 26SCS restores bone remodelling in rodent models of osteoporosis. 硫酸壳聚糖衍生物26SCS修复骨质疏松症啮齿动物模型的骨重塑。
IF 33.7 1区 医学
Nature Reviews Rheumatology Pub Date : 2026-09-15 DOI: 10.1038/s41584-026-01440-z
Holly Webster
{"title":"Sulfated chitosan derivative 26SCS restores bone remodelling in rodent models of osteoporosis.","authors":"Holly Webster","doi":"10.1038/s41584-026-01440-z","DOIUrl":"https://doi.org/10.1038/s41584-026-01440-z","url":null,"abstract":"","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":" ","pages":""},"PeriodicalIF":33.7,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148977256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Macrophages in fibrin-rich lining niche shape the rheumatoid pannus. 巨噬细胞在富含纤维蛋白的壁龛形成类风湿膜。
IF 33.7 1区 医学
Nature Reviews Rheumatology Pub Date : 2026-09-07 DOI: 10.1038/s41584-026-01428-9
Mariola Kurowska-Stolarska, Stefano Alivernini
{"title":"Macrophages in fibrin-rich lining niche shape the rheumatoid pannus.","authors":"Mariola Kurowska-Stolarska, Stefano Alivernini","doi":"10.1038/s41584-026-01428-9","DOIUrl":"https://doi.org/10.1038/s41584-026-01428-9","url":null,"abstract":"","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":" ","pages":""},"PeriodicalIF":33.7,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148906730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antibiotic-induced loss of gut SCFAs exacerbates alphavirus arthritis 抗生素诱导的肠道SCFAs丢失会加剧甲病毒关节炎。
IF 33.7 1区 医学
Nature Reviews Rheumatology Pub Date : 2026-09-04 DOI: 10.1038/s41584-026-01435-w
Holly Webster
{"title":"Antibiotic-induced loss of gut SCFAs exacerbates alphavirus arthritis","authors":"Holly Webster","doi":"10.1038/s41584-026-01435-w","DOIUrl":"10.1038/s41584-026-01435-w","url":null,"abstract":"Antibiotics cause gut dysbiosis and exacerbate alphavirus-induced arthritis in mice by altering immune cell populations in the joints.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"22 10","pages":"598-598"},"PeriodicalIF":33.7,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vaccination considerations in autoimmune rheumatic diseases. 自身免疫性风湿病的疫苗接种考虑。
IF 33.7 1区 医学
Nature Reviews Rheumatology Pub Date : 2026-09-03 DOI: 10.1038/s41584-026-01427-w
Meliha C Kapetanovic
{"title":"Vaccination considerations in autoimmune rheumatic diseases.","authors":"Meliha C Kapetanovic","doi":"10.1038/s41584-026-01427-w","DOIUrl":"https://doi.org/10.1038/s41584-026-01427-w","url":null,"abstract":"<p><p>Patients with autoimmune rheumatic diseases (ARDs) are at increased risk of numerous vaccine-preventable infections owing to a combination of disease-related immune dysregulation, immunosuppressive therapies - including glucocorticoids - and comorbidities. Age-related immunosenescence further increases this susceptibility in older patients. The SARS-CoV-2 (COVID-19) pandemic and measles outbreaks have underscored the importance of optimizing vaccination strategies and improving adherence to recommendations. Nevertheless, coverage for routinely recommended vaccines, including influenza and pneumococcal vaccines, remains suboptimal in this population. Vaccine hesitancy is an important barrier driven by concerns regarding safety, tolerability, disease flares and the potential induction of new autoimmune phenomena. Advanced therapies - including B cell-depleting agents, chimeric antigen receptor T cell therapy and bispecific T cell engagers - can substantially impair vaccine-induced immune responses, highlighting the importance of optimizing vaccination timing in relation to treatment. Although most studies focus on humoral and cellular immune responses, evidence on the long-term durability of vaccine-induced immunity, the need for booster doses and real-world vaccine effectiveness in patients with ARDs remains limited. Ethical considerations are important. Although vaccination in adults is generally not mandatory, improving vaccine uptake reduces the burden of infections in patients with ARDs, contributes to herd immunity and provides indirect protection for other vulnerable populations.</p>","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":" ","pages":""},"PeriodicalIF":33.7,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148888020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondrial succinate sensing promotes macrophage inflammation in RA 线粒体琥珀酸感知促进类风湿关节炎的巨噬细胞炎症。
IF 33.7 1区 医学
Nature Reviews Rheumatology Pub Date : 2026-09-03 DOI: 10.1038/s41584-026-01434-x
Jessica McHugh
{"title":"Mitochondrial succinate sensing promotes macrophage inflammation in RA","authors":"Jessica McHugh","doi":"10.1038/s41584-026-01434-x","DOIUrl":"10.1038/s41584-026-01434-x","url":null,"abstract":"Intracellular succinate promotes inflammatory macrophage responses through mitochondrial GPR91 signalling, linking metabolic dysregulation to macrophage-driven inflammation in rheumatoid arthritis.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"22 10","pages":"600-600"},"PeriodicalIF":33.7,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148888002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CDC42-pyrin interactions promote inflammasome activation and autoinflammatory disease. CDC42-pyrin相互作用促进炎性体活化和自身炎症性疾病。
IF 33.7 1区 医学
Nature Reviews Rheumatology Pub Date : 2026-09-02 DOI: 10.1038/s41584-026-01433-y
Holly Webster
{"title":"CDC42-pyrin interactions promote inflammasome activation and autoinflammatory disease.","authors":"Holly Webster","doi":"10.1038/s41584-026-01433-y","DOIUrl":"https://doi.org/10.1038/s41584-026-01433-y","url":null,"abstract":"","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":" ","pages":""},"PeriodicalIF":33.7,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Time to rethink clinical trial design in Sjögren disease. 是时候重新思考Sjögren疾病的临床试验设计了。
IF 33.7 1区 医学
Nature Reviews Rheumatology Pub Date : 2026-09-01 DOI: 10.1038/s41584-026-01429-8
Raphaèle Seror, Xavier Mariette
{"title":"Time to rethink clinical trial design in Sjögren disease.","authors":"Raphaèle Seror, Xavier Mariette","doi":"10.1038/s41584-026-01429-8","DOIUrl":"https://doi.org/10.1038/s41584-026-01429-8","url":null,"abstract":"","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":" ","pages":""},"PeriodicalIF":33.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148875369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ADAR1 variants define an interferon-related subtype of psoriatic disease ADAR1变异定义了银屑病的干扰素相关亚型。
IF 33.7 1区 医学
Nature Reviews Rheumatology Pub Date : 2026-09-01 DOI: 10.1038/s41584-026-01431-0
Holly Webster
{"title":"ADAR1 variants define an interferon-related subtype of psoriatic disease","authors":"Holly Webster","doi":"10.1038/s41584-026-01431-0","DOIUrl":"10.1038/s41584-026-01431-0","url":null,"abstract":"Researchers identified 11 ADAR1 variants in patients with psoriatic disease, which were associated with a strong type I interferon signature.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"22 10","pages":"599-599"},"PeriodicalIF":33.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148875393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Air pollution worsens disease activity in RA 空气污染使类风湿关节炎的疾病活动恶化。
IF 33.7 1区 医学
Nature Reviews Rheumatology Pub Date : 2026-08-27 DOI: 10.1038/s41584-026-01432-z
Jessica McHugh
{"title":"Air pollution worsens disease activity in RA","authors":"Jessica McHugh","doi":"10.1038/s41584-026-01432-z","DOIUrl":"10.1038/s41584-026-01432-z","url":null,"abstract":"Higher levels of air pollution are associated with increased disease activity and flare risk in patients with rheumatoid arthritis, according to findings from a prospective cohort study.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"22 10","pages":"598-598"},"PeriodicalIF":33.7,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148840815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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