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Nature Reviews Rheumatology最新文献

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Factors beyond urate levels for managing gout flares 管理痛风耀斑的因素超出了准确水平
IF 33.7 1区 医学
Nature Reviews Rheumatology Pub Date : 2025-04-23 DOI: 10.1038/s41584-025-01255-4
Hang Korng Ea, Pascal Richette
{"title":"Factors beyond urate levels for managing gout flares","authors":"Hang Korng Ea, Pascal Richette","doi":"10.1038/s41584-025-01255-4","DOIUrl":"https://doi.org/10.1038/s41584-025-01255-4","url":null,"abstract":"Urate crystals alone are required but not sufficient to trigger gout flares; they can also be modulated by environmental, metabolic, genetic and epigenetic factors. Avoiding large variation in urate levels, maintaining prophylaxis until crystal clearance and initiating low-dose urate-lowering therapy are efficient strategies for disease management.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"69 1","pages":""},"PeriodicalIF":33.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143866445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding the causes of treatment failure is crucial for the management of axial spondyloarthritis 了解治疗失败的原因对治疗轴性脊柱炎至关重要
IF 33.7 1区 医学
Nature Reviews Rheumatology Pub Date : 2025-04-23 DOI: 10.1038/s41584-025-01254-5
Denis Poddubnyy, Xenofon Baraliakos
{"title":"Understanding the causes of treatment failure is crucial for the management of axial spondyloarthritis","authors":"Denis Poddubnyy, Xenofon Baraliakos","doi":"10.1038/s41584-025-01254-5","DOIUrl":"https://doi.org/10.1038/s41584-025-01254-5","url":null,"abstract":"Although numerous therapies are available for axial spondyloarthritis, more than half of patients do not achieve remission or respond to treatment. Understanding the reasons for non-response in axial spondyloarthritis is essential for effective management of this disease.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"5 1","pages":""},"PeriodicalIF":33.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143866446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting osteoarthritis where it hurts: the osteochondral junction 针对骨关节炎的痛处，骨软骨连接处
IF 33.7 1区 医学
Nature Reviews Rheumatology Pub Date : 2025-04-22 DOI: 10.1038/s41584-025-01257-2
Anne-Marie Malfait, Alia M. Obeidat
{"title":"Targeting osteoarthritis where it hurts: the osteochondral junction","authors":"Anne-Marie Malfait, Alia M. Obeidat","doi":"10.1038/s41584-025-01257-2","DOIUrl":"https://doi.org/10.1038/s41584-025-01257-2","url":null,"abstract":"In joints with osteoarthritis, angiogenesis and neuronal growth occur at the osteochondral junction, a process that can contribute to structural joint damage and pain. Targeting this neurovascularization process represents a possible strategy for the development of disease-modifying drugs for osteoarthritis.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"15 1","pages":""},"PeriodicalIF":33.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143857903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current challenges in understanding the epidemiology of calcium pyrophosphate crystal deposition 了解焦磷酸钙晶体沉积流行病学的当前挑战
IF 33.7 1区 医学
Nature Reviews Rheumatology Pub Date : 2025-04-17 DOI: 10.1038/s41584-025-01256-3
Charlotte Jauffret, Tristan Pascart
{"title":"Current challenges in understanding the epidemiology of calcium pyrophosphate crystal deposition","authors":"Charlotte Jauffret, Tristan Pascart","doi":"10.1038/s41584-025-01256-3","DOIUrl":"https://doi.org/10.1038/s41584-025-01256-3","url":null,"abstract":"Calcium pyrophosphate deposition (CPPD) disease is secondary to the pathological accumulation of calcium pyrophosphate (CPP) crystals inside joints and involves acute or chronic inflammatory arthritis. Epidemiological research on CPPD has been slow despite the suspected high prevalence of this condition. Here we highlight key challenges in CPPD imaging, diagnosis and nomenclature that need to be addressed for epidemiological research to progress at a faster pace.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"20 1","pages":""},"PeriodicalIF":33.7,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143841199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fumarate drives interferon release in systemic sclerosis monocytes 富马酸盐驱动系统性硬化症单核细胞释放干扰素
IF 33.7 1区 医学
Nature Reviews Rheumatology Pub Date : 2025-04-16 DOI: 10.1038/s41584-025-01261-6
Sarah Onuora
{"title":"Fumarate drives interferon release in systemic sclerosis monocytes","authors":"Sarah Onuora","doi":"10.1038/s41584-025-01261-6","DOIUrl":"https://doi.org/10.1038/s41584-025-01261-6","url":null,"abstract":"Altered metabolism of the tricarboxylic acid cycle metabolite fumarate drives activation of interferon release in systemic sclerosis monocytes, suggesting a potential therapeutic approach.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"40 1","pages":""},"PeriodicalIF":33.7,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143836708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Upadacitinib effective for GCA in phase III trial 奥达帕替尼在 III 期试验中对 GCA 有效
IF 33.7 1区 医学
Nature Reviews Rheumatology Pub Date : 2025-04-15 DOI: 10.1038/s41584-025-01260-7
Sarah Onuora
{"title":"Upadacitinib effective for GCA in phase III trial","authors":"Sarah Onuora","doi":"10.1038/s41584-025-01260-7","DOIUrl":"https://doi.org/10.1038/s41584-025-01260-7","url":null,"abstract":"In the phase III SELECT-GCA trial, upadacitinib at a dose of 15 mg daily was superior to placebo with respect to achievement of sustained remission of giant cell arteritis at 52 weeks.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"26 1","pages":""},"PeriodicalIF":33.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lipid nanoparticles with PDL1-encoding mRNA spread tolerance 带有 PDL1 编码 mRNA 的脂质纳米颗粒传播耐受性
IF 33.7 1区 医学
Nature Reviews Rheumatology Pub Date : 2025-04-11 DOI: 10.1038/s41584-025-01251-8
Maria Papatriantafyllou
{"title":"Lipid nanoparticles with PDL1-encoding mRNA spread tolerance","authors":"Maria Papatriantafyllou","doi":"10.1038/s41584-025-01251-8","DOIUrl":"https://doi.org/10.1038/s41584-025-01251-8","url":null,"abstract":"Lipid nanoparticle carriers of immunosuppressive mRNA shape tolerogenic antigen-presenting cells that inhibit arthritis progression in mice.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"1 1","pages":""},"PeriodicalIF":33.7,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143819080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decoding the adaptive immune repertoire for disease prediction 解码适应性免疫库以预测疾病
IF 33.7 1区 医学
Nature Reviews Rheumatology Pub Date : 2025-04-10 DOI: 10.1038/s41584-025-01249-2
Laura F. Su
{"title":"Decoding the adaptive immune repertoire for disease prediction","authors":"Laura F. Su","doi":"10.1038/s41584-025-01249-2","DOIUrl":"https://doi.org/10.1038/s41584-025-01249-2","url":null,"abstract":"A simple blood test that can diagnose or predict one’s risk for autoimmune diseases would revolutionize medicine and transform patient care. Published in Science, Zaslavsky et al. advance this vision with a powerful machine learning framework that leverages immune receptor sequences from T cells and B cells for disease classification.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"183 1","pages":""},"PeriodicalIF":33.7,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex- and gender-based personalized medicine in rheumatology 风湿病学中的性别和基于性别的个性化医学
IF 33.7 1区 医学
Nature Reviews Rheumatology Pub Date : 2025-04-07 DOI: 10.1038/s41584-025-01246-5
Elizabeth R. Volkmann, Carol Feghali-Bostwick
{"title":"Sex- and gender-based personalized medicine in rheumatology","authors":"Elizabeth R. Volkmann, Carol Feghali-Bostwick","doi":"10.1038/s41584-025-01246-5","DOIUrl":"https://doi.org/10.1038/s41584-025-01246-5","url":null,"abstract":"Although autoimmune rheumatic diseases are more prevalent in women than men, few clinical trials report findings on the basis of sex and gender. Future clinical trials should report sex and gender differences in treatment and safety outcomes in a standardized manner to improve outcomes for all patients.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"6 1","pages":""},"PeriodicalIF":33.7,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IgG4-related disease and other fibro-inflammatory conditions igg4相关疾病和其他纤维炎性疾病
IF 33.7 1区 医学
Nature Reviews Rheumatology Pub Date : 2025-04-07 DOI: 10.1038/s41584-025-01240-x
Francesco Peyronel, Emanuel Della-Torre, Federica Maritati, Maria L. Urban, Ingeborg Bajema, Nicolas Schleinitz, Augusto Vaglio
{"title":"IgG4-related disease and other fibro-inflammatory conditions","authors":"Francesco Peyronel, Emanuel Della-Torre, Federica Maritati, Maria L. Urban, Ingeborg Bajema, Nicolas Schleinitz, Augusto Vaglio","doi":"10.1038/s41584-025-01240-x","DOIUrl":"https://doi.org/10.1038/s41584-025-01240-x","url":null,"abstract":"<p>IgG4-related disease (IgG4-RD) is a fibro-inflammatory disorder usually characterized by multi-organ involvement. Its pathogenesis is complex and involves genetic and environmental factors, while immune responses usually mediate organ damage and promote fibrosis, which is a key feature of the disease. IgG4 responses, however, are not exclusive to IgG4-RD and can be encountered in other diseases with phenotypes that partially overlap that of IgG4-RD. Although IgG4-RD has clinical and histological hallmarks, the lack of validated diagnostic criteria often makes the diagnosis challenging, requiring a multi-dimensional approach that integrates clinical, radiological and serological data. The present Review covers recent advances in the understanding of disease drivers and its clinical phenotypes, mainly focusing on the differential diagnosis with potential IgG4-RD mimickers, namely histiocytoses, lymphoproliferative disorders, systemic vasculitides and other immune-mediated conditions. The Review also provides a schematic approach to IgG4-RD treatment, including a brief overview of glucocorticoid-sparing agents and emerging therapies, from B cell-depleting monoclonal antibodies to cytokine-targeting drugs, the majority of which are currently under investigation in randomized clinical trials.</p>","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"1715 1","pages":""},"PeriodicalIF":33.7,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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