Nature Reviews Rheumatology最新文献_第2页

Region-specific, data-driven guidelines are needed for rheumatic diseases in LMICs 中低收入国家需要针对特定区域、以数据为导向的风湿病指南

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-05-12 DOI: 10.1038/s41584-025-01265-2

Amita Aggarwal

引用次数: 0

Understanding rheumatic disease through continuous cell state analysis 通过连续的细胞状态分析了解风湿病

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-05-07 DOI: 10.1038/s41584-025-01253-6

Lysette Marshall, Soumya Raychaudhuri, Sebastien Viatte

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引用次数: 0

Targeting anti-PAD4 autoantibodies in RA 针对RA的抗pad4自身抗体

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-05-06 DOI: 10.1038/s41584-025-01264-3

Holly Webster

引用次数: 0

Arterial and venous thrombosis in systemic and monogenic vasculitis. 全身和单源性血管炎的动脉和静脉血栓形成。

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-05-06 DOI: 10.1038/s41584-025-01252-7

Federica Bello,Filippo Fagni,Giacomo Bagni,Catherine L Hill,Aladdin J Mohammad,Sergey Moiseev,Iacopo Olivotto,Emire Seyahi,Giacomo Emmi

{"title":"Arterial and venous thrombosis in systemic and monogenic vasculitis.","authors":"Federica Bello,Filippo Fagni,Giacomo Bagni,Catherine L Hill,Aladdin J Mohammad,Sergey Moiseev,Iacopo Olivotto,Emire Seyahi,Giacomo Emmi","doi":"10.1038/s41584-025-01252-7","DOIUrl":"https://doi.org/10.1038/s41584-025-01252-7","url":null,"abstract":"Systemic vasculitis, common forms of which include anti-neutrophil cytoplasmic antibody-associated small-vessel vasculitis, large-vessel vasculitis and Behçet syndrome, are frequently complicated by arterial or venous thrombotic events (AVTEs). Newly identified entities such as DADA2 (deficiency of adenosine deaminase 2) and VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome, which are driven by genetic mutations, also exhibit vasculitic features and are associated with a high risk of AVTEs. AVTEs in systemic vasculitis, including monogenic forms of vasculitis, are due to the complex interaction of inflammation and coagulation. New insights into the pathogenetic mechanisms implicate endothelial dysfunction, immune complex deposition and the interplay of pro-inflammatory cytokines with prothrombotic factors, which collectively promote thrombus formation. AVTEs impose a substantial disease burden, complicate diagnosis and negatively affect prognosis by increasing the risk of morbidity and mortality. Early diagnosis and treatment are crucial to prevent lasting damage. Management strategies should target both thrombosis and underlying inflammation. Antithrombotic therapies, including low-dose aspirin, or oral anticoagulants should be used on the basis of individual thrombotic risk assessment. Immunosuppressive therapy is the cornerstone of treatment for arterial and venous thrombosis, particularly in Behçet syndrome, in which vascular inflammation has a crucial role in thrombotic complications.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"56 3 1","pages":""},"PeriodicalIF":33.7,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143915091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risks and benefits of immunosuppressant withdrawal in systemic lupus erythematosus 系统性红斑狼疮患者停用免疫抑制剂的风险和益处

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-05-02 DOI: 10.1038/s41584-025-01262-5

Catriona A. Wagner, Judith A. James

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Glycosylation switch in synovial fibroblasts promotes ECM degradation 滑膜成纤维细胞中的糖基化转换促进了 ECM 降解

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-04-23 DOI: 10.1038/s41584-025-01258-1

Holly Webster

引用次数: 0

Factors beyond urate levels for managing gout flares 管理痛风耀斑的因素超出了准确水平

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-04-23 DOI: 10.1038/s41584-025-01255-4

Hang Korng Ea, Pascal Richette

引用次数: 0

Understanding the causes of treatment failure is crucial for the management of axial spondyloarthritis 了解治疗失败的原因对治疗轴性脊柱炎至关重要

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-04-23 DOI: 10.1038/s41584-025-01254-5

Denis Poddubnyy, Xenofon Baraliakos

引用次数: 0

Targeting osteoarthritis where it hurts: the osteochondral junction 针对骨关节炎的痛处，骨软骨连接处

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-04-22 DOI: 10.1038/s41584-025-01257-2

Anne-Marie Malfait, Alia M. Obeidat

引用次数: 0

Current challenges in understanding the epidemiology of calcium pyrophosphate crystal deposition 了解焦磷酸钙晶体沉积流行病学的当前挑战

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-04-17 DOI: 10.1038/s41584-025-01256-3

Charlotte Jauffret, Tristan Pascart

引用次数: 0