Nature Reviews Rheumatology最新文献_第2页

Current understanding and management of cardiovascular involvement in rheumatic immune-mediated inflammatory diseases 目前对风湿免疫介导的炎症性疾病累及心血管的认识和处理方法

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2024-09-02 DOI: 10.1038/s41584-024-01149-x

Maya H. Buch, Ziad Mallat, Marc R. Dweck, Jason M. Tarkin, Declan P. O’Regan, Vanessa Ferreira, Taryn Youngstein, Sven Plein

{"title":"Current understanding and management of cardiovascular involvement in rheumatic immune-mediated inflammatory diseases","authors":"Maya H. Buch, Ziad Mallat, Marc R. Dweck, Jason M. Tarkin, Declan P. O’Regan, Vanessa Ferreira, Taryn Youngstein, Sven Plein","doi":"10.1038/s41584-024-01149-x","DOIUrl":"https://doi.org/10.1038/s41584-024-01149-x","url":null,"abstract":"<p>Immune-mediated inflammatory diseases (IMIDs) are a spectrum of disorders of overlapping immunopathogenesis, with a prevalence of up to 10% in Western populations and increasing incidence in developing countries. Although targeted treatments have revolutionized the management of rheumatic IMIDs, cardiovascular involvement confers an increased risk of mortality and remains clinically under-recognized. Cardiovascular pathology is diverse across rheumatic IMIDs, ranging from premature atherosclerotic cardiovascular disease (ASCVD) to inflammatory cardiomyopathy, which comprises myocardial microvascular dysfunction, vasculitis, myocarditis and pericarditis, and heart failure. Epidemiological and clinical data imply that rheumatic IMIDs and associated cardiovascular disease share common inflammatory mechanisms. This concept is strengthened by emergent trials that indicate improved cardiovascular outcomes with immune modulators in the general population with ASCVD. However, not all disease-modifying therapies that reduce inflammation in IMIDs such as rheumatoid arthritis demonstrate equally beneficial cardiovascular effects, and the evidence base for treatment of inflammatory cardiomyopathy in patients with rheumatic IMIDs is lacking. Specific diagnostic protocols for the early detection and monitoring of cardiovascular involvement in patients with IMIDs are emerging but are in need of ongoing development. This Review summarizes current concepts on the potentially targetable inflammatory mechanisms of cardiovascular pathology in rheumatic IMIDs and discusses how these concepts can be considered for the diagnosis and management of cardiovascular involvement across rheumatic IMIDs, with an emphasis on the potential of cardiovascular imaging for risk stratification, early detection and prognostication.</p>","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":null,"pages":null},"PeriodicalIF":33.7,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142130734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Macrophage-coated nanocarriers for gouty arthritis 治疗痛风性关节炎的巨噬细胞包裹纳米载体

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2024-08-23 DOI: 10.1038/s41584-024-01161-1

Holly Webster

引用次数: 0

Advancing equity in genomic medicine for rheumatology. 促进风湿病基因组医学的公平性。

IF 29.4 1区医学

Nature Reviews Rheumatology Pub Date : 2024-08-22 DOI: 10.1038/s41584-024-01156-y

Roberto Díaz-Peña, Olufemi Adelowo

引用次数: 0

PDZK1 downregulation linked to mitochondrial dysfunction in OA. PDZK1 下调与 OA 线粒体功能障碍有关。

IF 29.4 1区医学

Nature Reviews Rheumatology Pub Date : 2024-08-20 DOI: 10.1038/s41584-024-01157-x

Maria Papatriantafyllou

引用次数: 0

Ion channels in osteoarthritis: emerging roles and potential targets 骨关节炎中的离子通道：新出现的作用和潜在靶点

IF 29.4 1区医学

Nature Reviews Rheumatology Pub Date : 2024-08-09 DOI: 10.1038/s41584-024-01146-0

Renpeng Zhou, Wenyu Fu, Dmytro Vasylyev, Stephen G. Waxman, Chuan-ju Liu

{"title":"Ion channels in osteoarthritis: emerging roles and potential targets","authors":"Renpeng Zhou, Wenyu Fu, Dmytro Vasylyev, Stephen G. Waxman, Chuan-ju Liu","doi":"10.1038/s41584-024-01146-0","DOIUrl":"10.1038/s41584-024-01146-0","url":null,"abstract":"Osteoarthritis (OA) is a highly prevalent joint disease that causes substantial disability, yet effective approaches to disease prevention or to the delay of OA progression are lacking. Emerging evidence has pinpointed ion channels as pivotal mediators in OA pathogenesis and as promising targets for disease-modifying treatments. Preclinical studies have assessed the potential of a variety of ion channel modulators to modify disease pathways involved in cartilage degeneration, synovial inflammation, bone hyperplasia and pain, and to provide symptomatic relief in models of OA. Some of these modulators are currently being evaluated in clinical trials. This review explores the structures and functions of ion channels, including transient receptor potential channels, Piezo channels, voltage-gated sodium channels, voltage-dependent calcium channels, potassium channels, acid-sensing ion channels, chloride channels and the ATP-dependent P2XR channels in the osteoarthritic joint. The discussion spans channel-targeting drug discovery and potential clinical applications, emphasizing opportunities for further research, and underscoring the growing clinical impact of ion channel biology in OA. Ion channels have key functions in chondrocytes, bone cells, immune cells and neurons. Liu and colleagues discuss how these functions might contribute to cartilage degeneration, bone formation inflammation and pain in osteoarthritis, and highlight the therapeutic potential of ion channel modulators.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":null,"pages":null},"PeriodicalIF":29.4,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141909158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Behavioural therapy app for fibromyalgia 纤维肌痛的行为疗法应用程序

IF 29.4 1区医学

Nature Reviews Rheumatology Pub Date : 2024-08-08 DOI: 10.1038/s41584-024-01151-3

Sarah Onuora

引用次数: 0

The past 25 years in paediatric rheumatology: insights from monogenic diseases 过去 25 年的儿科风湿病学：单基因疾病的启示

IF 29.4 1区医学

Nature Reviews Rheumatology Pub Date : 2024-08-07 DOI: 10.1038/s41584-024-01145-1

Seza Ozen, Ivona Aksentijevich

{"title":"The past 25 years in paediatric rheumatology: insights from monogenic diseases","authors":"Seza Ozen, Ivona Aksentijevich","doi":"10.1038/s41584-024-01145-1","DOIUrl":"10.1038/s41584-024-01145-1","url":null,"abstract":"The past 25 years have seen major novel developments in the field of paediatric rheumatology. The concept of autoinflammation was introduced to this field, and medicine more broadly, with studies of familial Mediterranean fever, the most common autoinflammatory disease globally. New data on the positive evolutionary selection of familial Mediterranean fever-associated genetic variants might be pertinent to mild gain-of-function variants reported in other disease-associated genes. Genetic studies have unveiled the complexity of human heritability to inflammation and flourishing data from rare monogenic disorders have contributed to a better understanding of general disease mechanisms in paediatric rheumatic conditions. Beyond genomics, the application of other ‘omics’ technologies, including transcriptomics, proteomics and metabolomics, has generated an enormous dataset that can be applied to the development of new therapies and in the practice of precision medicine. Novel biomarkers for monitoring disease activity and progression have also emerged. A surge in the development of targeted biologic therapies has led to durable remission and improved prognosis for many diseases that in the past caused major complications. Last but not least, the COVID-19 pandemic has affected paediatric rheumatology practice and has sparked new investigations into the link between viral infections and unregulated inflammatory responses in children. Paediatric rheumatology has seen many notable developments in the past 25 years, including the introduction of the concept of autoinflammation and a greater understanding of the genetics and pathogenesis of inflammatory diseases. In this Perspective, Ozen and Aksentijevich discuss how these and other discoveries have transformed the field and herald improvements in patient care.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":null,"pages":null},"PeriodicalIF":29.4,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141899447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of obesity and adipose tissue dysfunction in osteoarthritis pain 肥胖和脂肪组织功能障碍在骨关节炎疼痛中的作用。

IF 29.4 1区医学

Nature Reviews Rheumatology Pub Date : 2024-08-07 DOI: 10.1038/s41584-024-01143-3

Marie Binvignat, Jérémie Sellam, Francis Berenbaum, David T. Felson

{"title":"The role of obesity and adipose tissue dysfunction in osteoarthritis pain","authors":"Marie Binvignat, Jérémie Sellam, Francis Berenbaum, David T. Felson","doi":"10.1038/s41584-024-01143-3","DOIUrl":"10.1038/s41584-024-01143-3","url":null,"abstract":"Obesity has a pivotal and multifaceted role in pain associated with osteoarthritis (OA), extending beyond the mechanistic influence of BMI. It exerts its effects both directly and indirectly through various modifiable risk factors associated with OA-related pain. Adipose tissue dysfunction is highly involved in OA-related pain through local and systemic inflammation, immune dysfunction, and the production of pro-inflammatory cytokines and adipokines. Adipose tissue dysfunction is intricately connected with metabolic syndrome, which independently exerts specific effects on OA-related pain, distinct from its association with BMI. The interplay among obesity, adipose tissue dysfunction and metabolic syndrome influences OA-related pain through diverse pain mechanisms, including nociceptive pain, peripheral sensitization and central sensitization. These complex interactions contribute to the heightened pain experience observed in individuals with OA and obesity. In addition, pain management strategies are less efficient in individuals with obesity. Importantly, therapeutic interventions targeting obesity and metabolic syndrome hold promise in managing OA-related pain. A deeper understanding of the intricate relationship between obesity, metabolic syndrome and OA-related pain is crucial and could have important implications for improving pain management and developing innovative therapeutic options in OA. In this Review, the authors explore the complex interactions between osteoarthritis-related pain and obesity, adipose tissue dysfunction and metabolic syndrome, and discuss how knowledge of these relationships could help improve pain management and identify new therapeutic options.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":null,"pages":null},"PeriodicalIF":29.4,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141902409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancements and challenges in CAR T cell therapy in autoimmune diseases 自身免疫性疾病 CAR T 细胞疗法的进展与挑战

IF 29.4 1区医学

Nature Reviews Rheumatology Pub Date : 2024-08-06 DOI: 10.1038/s41584-024-01139-z

Georg Schett, Fabian Müller, Jule Taubmann, Andreas Mackensen, Wei Wang, Rich A. Furie, Ralf Gold, Aiden Haghikia, Peter A. Merkel, Roberto Caricchio, Maria-Antonietta D’Agostino, Franco Locatelli, Carl H. June, Dimitrios Mougiakakos

{"title":"Advancements and challenges in CAR T cell therapy in autoimmune diseases","authors":"Georg Schett, Fabian Müller, Jule Taubmann, Andreas Mackensen, Wei Wang, Rich A. Furie, Ralf Gold, Aiden Haghikia, Peter A. Merkel, Roberto Caricchio, Maria-Antonietta D’Agostino, Franco Locatelli, Carl H. June, Dimitrios Mougiakakos","doi":"10.1038/s41584-024-01139-z","DOIUrl":"10.1038/s41584-024-01139-z","url":null,"abstract":"Chimeric antigen receptor (CAR) T cells are highly effective at targeting and eliminating cells of the B cell lineage. CAR T cell therapy has become a standard-of-care treatment for patients with relapsed or refractory B cell malignancies. In addition, the administration of genetically modified T cells with the capacity to deplete B cells and/or plasma cells has tremendous therapeutic potential in autoimmune diseases. In the past few years, CD19-based and B cell maturation antigen (BCMA)-based CAR T cell therapies have been applied to various B cell-mediated autoimmune diseases including systemic lupus erythematosus, idiopathic inflammatory myopathy, systemic sclerosis, neuromyelitis optica spectrum disorder, myasthenia gravis and multiple sclerosis. The scientific rationale behind this approach is that deep depletion of B cells, including autoreactive B cell clones, could restore normal immune function, referred to as an immune reset. In this Review, we discuss important aspects of CAR T cell therapy in autoimmune disease, including considerations relating to patient selection, safety, efficacy and medical management. These considerations are based on the early experiences of CAR T cell therapy in autoimmune diseases, and as the field of CAR T cell therapy in autoimmune diseases continues to rapidly evolve, these issues will remain subject to ongoing refinement and adaptation. CAR T cell therapy shows promise for achieving long-term drug-free remission in various autoimmune diseases. This Review discusses the ongoing challenges and unanswered questions of CAR T cell therapy in autoimmune diseases, including pre-procedural, procedural and post-procedural considerations.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":null,"pages":null},"PeriodicalIF":29.4,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141895485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shedding light onto the immunometabolic effects of glucocorticoids 揭示糖皮质激素的免疫代谢作用。

IF 29.4 1区医学

Nature Reviews Rheumatology Pub Date : 2024-08-01 DOI: 10.1038/s41584-024-01144-2

Luis M. Franco

引用次数: 0