Nature Reviews Rheumatology最新文献

STING-driven necroptosis linked to autoinflammatory disease. 与自身炎症性疾病相关的sting驱动的坏死性上睑下垂。

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-10-02 DOI: 10.1038/s41584-025-01315-9

Sarah Onuora

引用次数: 0

Glucagon-like peptide-1 receptor agonists in arthritis: current insights and future directions. 胰高血糖素样肽-1受体激动剂在关节炎中的作用：当前的见解和未来的方向。

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-10-01 DOI: 10.1038/s41584-025-01302-0

Derin Karacabeyli,Diane Lacaille

{"title":"Glucagon-like peptide-1 receptor agonists in arthritis: current insights and future directions.","authors":"Derin Karacabeyli,Diane Lacaille","doi":"10.1038/s41584-025-01302-0","DOIUrl":"https://doi.org/10.1038/s41584-025-01302-0","url":null,"abstract":"Obesity affects nearly one in six adults worldwide. Excess adiposity is a pro-inflammatory state associated with increased risk of several types of arthritis, increased arthritis disease activity and/or severity, and poorer response to certain treatments. Obesity is a major risk factor for cardiovascular disease, the leading cause of death in people with common arthritides such as osteoarthritis (OA), gout, rheumatoid arthritis, psoriatic arthritis and axial spondyloarthritis. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are a promising therapeutic option for people with arthritis and obesity or type 2 diabetes mellitus owing to their pleiotropic effects, including weight loss, improved survival and reduced risk of major cardiovascular and renal events. In vitro and preclinical in vivo experiments in arthritis have uncovered weight-loss-independent anti-inflammatory and chondroprotective properties of GLP-1RAs. In knee OA, clinical data suggest that GLP-1RAs improve pain and function and reduce the risk of surgical intervention; however, their effects on OA incidence remain incompletely understood. Evidence suggests that GLP-1RAs do not directly prevent gout attacks, but are effective in managing cardiometabolic conditions commonly associated with gout and other arthritides. More research is needed to clarify the effects of GLP-1RAs on incidence, disease activity, and progression of rheumatoid arthritis, psoriatic arthritis and axial spondyloarthritis.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"100 1","pages":""},"PeriodicalIF":33.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145203712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vivo CAR-T cell engineering in refractory SLE. 体内CAR-T细胞工程治疗难治性SLE。

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-10-01 DOI: 10.1038/s41584-025-01313-x

Maria Papatriantafyllou

引用次数: 0

DADA2 as an autosomal dominant disease. DADA2是常染色体显性遗传病。

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-10-01 DOI: 10.1038/s41584-025-01312-y

Holly Webster

引用次数: 0

The role of the patient in rheumatology. 病人在风湿病学中的作用。

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-10-01 DOI: 10.1038/s41584-025-01303-z

Jeanette Andersen,Janet Church,Seth Durrant,Sue Farrington,Noriko Okochi,Natasha Trehan

引用次数: 0

Author Correction: Parathyroid hormone receptor agonists in the management of osteoporosis. 作者更正：甲状旁腺激素受体激动剂在骨质疏松症的管理。

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-09-30 DOI: 10.1038/s41584-025-01314-w

Nicholas Fuggle,René Rizzoli,Charlotte Beaudart,Bernard Cortet,Elizabeth M Curtis,Mickaël Hiligsmann,Jean-Marc Kaufman,Nicola Veronese,Ben Hur Albergaria,Nasser Al-Daghri,Majed Alokail,Maria Luisa Brandi,Olivier Bruyère,Nansa Burlet,Claudia Campusano,Enrique Casado,Etienne Cavalier,Manju Chandran,Cyrus Cooper,Patrizia D'Amelio,Bess Dawson-Hughes,Peter R Ebeling,John A Kanis,Andreas Kurth,Radmila Matijevic,Eugene McCloskey,Michael McClung,Ouafa Mkinsi,Ngozi Njeze,Régis P Radermecker,François Rannou,Stuart Silverman,Şansın Tüzün,Leith Zakraoui,Jean-Yves Reginster,Nicholas C Harvey

引用次数: 0

20 years of Nature Reviews Rheumatology. 20年自然评论风湿病学。

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-09-29 DOI: 10.1038/s41584-025-01308-8

Peter E Lipsky

引用次数: 0

A firm grip on hand OA: 20 years of progress and prospects. 紧握手中OA：二十年的进步与展望。

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-09-25 DOI: 10.1038/s41584-025-01304-y

Francis Berenbaum,Emmanuel Maheu

引用次数: 0

A 20-year reflection on women in rheumatology. 20年来风湿病学女性的反思。

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-09-23 DOI: 10.1038/s41584-025-01307-9

Ashira D Blazer,Grace C Wright

引用次数: 0

Global epidemiology of spondyloarthritis 脊柱炎的全球流行病学

IF 32.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-09-15 DOI: 10.1038/s41584-025-01286-x

John D. Reveille, Lihi Eder, Nelly Ziade, Percival D. Sampaio-Barros, Tae-Hwan Kim, Nurullah Akkoç, Matthew A. Brown

{"title":"Global epidemiology of spondyloarthritis","authors":"John D. Reveille, Lihi Eder, Nelly Ziade, Percival D. Sampaio-Barros, Tae-Hwan Kim, Nurullah Akkoç, Matthew A. Brown","doi":"10.1038/s41584-025-01286-x","DOIUrl":"10.1038/s41584-025-01286-x","url":null,"abstract":"The worldwide epidemiology of axial spondyloarthritis (axSpA), psoriatic arthritis (PsA) and peripheral spondyloarthritis, as well as of HLA-B27 and other MHC and non-MHC genes in these diseases, is reviewed herein. The frequency of axSpA is highest in circumpolar groups (such as Sami people and certain Indigenous American groups) and lowest in those of Japanese and African ancestry. The same pattern holds for PsA, although the overall prevalence of PsA seems much lower in East Asia, where it is less frequent than axSpA. The prevalence of PsA in people with psoriasis is increased where rheumatological assessment was carried out and seems to be increasing over time. HLA-B27 remains the most important genetic factor in axSpA susceptibility, although its frequency is lower in African American, South American and Middle Eastern populations than in others. The presence of HLA-B27 and other HLA alleles seems to be important in discerning clinical subsets of SpA and PsA, particularly those characterized by acute anterior uveitis or by axSpA with psoriasis, although these HLA-B27 and other MHC and non-MHC associations are derived from genome-wide association studies and other chip-based studies in large populations. These studies have been carried out mainly in populations of European and East Asian ancestry, and similar data from Latin America, sub-Saharan Africa and South Asia are lacking. This under-representation is an unmet need in applying genetic factors to understand the pathogenesis, diagnosis and classification of SpA and PsA. This article provides a comprehensive overview of the epidemiology of spondyloarthritis — including axial spondyloarthritis, psoriatic arthritis and peripheral spondyloarthritis — worldwide, as well as the epidemiology of genetic factors implicated in these diseases.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"21 10","pages":"580-598"},"PeriodicalIF":32.7,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145059336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0