Nature Reviews Rheumatology最新文献

Insights into Lyme arthritis 深入了解莱姆病

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-05-28 DOI: 10.1038/s41584-025-01269-y

Holly Webster

引用次数: 0

How JAK inhibitors tip the prothrombotic balance in rheumatoid arthritis JAK抑制剂如何改变类风湿关节炎的血栓形成平衡

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-05-16 DOI: 10.1038/s41584-025-01263-4

Vibeke Strand

引用次数: 0

Fibroblasts in immune responses, inflammatory diseases and therapeutic implications 成纤维细胞在免疫反应、炎症性疾病及其治疗意义

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-05-14 DOI: 10.1038/s41584-025-01259-0

Angela E. Zou, Suppawat Kongthong, Alisa A. Mueller, Michael B. Brenner

{"title":"Fibroblasts in immune responses, inflammatory diseases and therapeutic implications","authors":"Angela E. Zou, Suppawat Kongthong, Alisa A. Mueller, Michael B. Brenner","doi":"10.1038/s41584-025-01259-0","DOIUrl":"https://doi.org/10.1038/s41584-025-01259-0","url":null,"abstract":"Once regarded as passive bystander cells of the tissue stroma, fibroblasts have emerged as active orchestrators of tissue homeostasis and disease. From regulating immunity and controlling tissue remodelling to governing cell growth and differentiation, fibroblasts assume myriad roles in guiding normal tissue development, maintenance and repair. By comparison, in chronic inflammatory diseases such as rheumatoid arthritis, fibroblasts recruit and sustain inflammatory leukocytes, become dominant producers of pro-inflammatory factors and catalyse tissue destruction. In other disease contexts, fibroblasts promote fibrosis and impair host control of cancer. Single-cell studies have uncovered striking transcriptional and functional heterogeneity exhibited by fibroblasts in both normal tissues and diseased tissues. In particular, advances in the understanding of fibroblast pathology in rheumatoid arthritis have shed light on pathogenic fibroblast states in other chronic diseases. The differentiation and activation of these fibroblast states is driven by diverse physical and chemical cues within the tissue microenvironment and by cell-intrinsic signalling and epigenetic mechanisms. These insights into fibroblast behaviour and regulation have illuminated therapeutic opportunities for the targeted deletion or modulation of pathogenic fibroblasts across many diseases.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"122 1","pages":""},"PeriodicalIF":33.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The pathogenesis, clinical presentations and treatment of monogenic systemic vasculitis 单基因系统性血管炎的发病机制、临床表现及治疗

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-05-14 DOI: 10.1038/s41584-025-01250-9

Ahmet Gül, Ivona Aksentijevich, Paul Brogan, Marco Gattorno, Peter C. Grayson, Seza Ozen

{"title":"The pathogenesis, clinical presentations and treatment of monogenic systemic vasculitis","authors":"Ahmet Gül, Ivona Aksentijevich, Paul Brogan, Marco Gattorno, Peter C. Grayson, Seza Ozen","doi":"10.1038/s41584-025-01250-9","DOIUrl":"https://doi.org/10.1038/s41584-025-01250-9","url":null,"abstract":"Many monogenic autoinflammatory diseases, including DADA2 (deficiency of adenosine deaminase 2), HA20 (haploinsufficiency of A20), SAVI (STING-associated vasculopathy with onset in infancy), COPA syndrome, LAVLI (LYN kinase-associated vasculopathy and liver fibrosis) and VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome, present predominantly with vasculitis and constitute a substantial subgroup of vasculitic conditions associated with a ‘probable aetiology’. The spectrum of monogenic vasculitis encompasses all sizes and types of blood vessel, ranging from large vessels to medium-size and small vessels, and from the arterial side to the venous side of the vasculature. Monogenic vasculitis typically starts early in life during infancy or childhood; VEXAS syndrome, which presents in late adulthood, is an exception. The activation of myeloid cells via inflammasome and nuclear factor-κB pathways, type I interferon-enhanced autoimmune mechanisms and/or dysregulated adaptive immune responses have an important role in the development of immune-mediated endothelial dysfunction and vascular damage. Genetic testing is essential for the diagnosis of underlying monogenic autoinflammatory diseases; however, the penetrance of genetic variants can vary. Increased awareness and recognition of distinctive clinical findings could facilitate earlier diagnosis and allow for more-targeted treatments.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"3 1","pages":""},"PeriodicalIF":33.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143945762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Region-specific, data-driven guidelines are needed for rheumatic diseases in LMICs 中低收入国家需要针对特定区域、以数据为导向的风湿病指南

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-05-12 DOI: 10.1038/s41584-025-01265-2

Amita Aggarwal

引用次数: 0

Understanding rheumatic disease through continuous cell state analysis 通过连续的细胞状态分析了解风湿病

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-05-07 DOI: 10.1038/s41584-025-01253-6

Lysette Marshall, Soumya Raychaudhuri, Sebastien Viatte

{"title":"Understanding rheumatic disease through continuous cell state analysis","authors":"Lysette Marshall, Soumya Raychaudhuri, Sebastien Viatte","doi":"10.1038/s41584-025-01253-6","DOIUrl":"https://doi.org/10.1038/s41584-025-01253-6","url":null,"abstract":"Autoimmune rheumatic diseases are a heterogeneous group of conditions, including rheumatoid arthritis (RA) and systemic lupus erythematosus. With the increasing availability of large single-cell datasets, novel disease-associated cell types continue to be identified and characterized at multiple omics layers, for example, ‘T peripheral helper’ (TPH) (CXCR5− PD-1hi) cells in RA and systemic lupus erythematosus and MerTK+ myeloid cells in RA. Despite efforts to define disease-relevant cell atlases, the very definition of a ‘cell type’ or ‘lineage’ has proven controversial as higher resolution assays emerge. This Review explores the cell types and states involved in disease pathogenesis, with a focus on the shifting perspectives on immune and stromal cell taxonomy. These understandings of cell identity are closely related to the computational methods adopted for analysis, with implications for the interpretation of single-cell data. Understanding the underlying cellular architecture of disease is also crucial for therapeutic research as ambiguity hinders translation to the clinical setting. We discuss the implications of different frameworks for cell identity for disease treatment and the discovery of predictive biomarkers for stratified medicine — an unmet clinical need for autoimmune rheumatic diseases.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"12 1","pages":""},"PeriodicalIF":33.7,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143920033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting anti-PAD4 autoantibodies in RA 针对RA的抗pad4自身抗体

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-05-06 DOI: 10.1038/s41584-025-01264-3

Holly Webster

引用次数: 0

Arterial and venous thrombosis in systemic and monogenic vasculitis. 全身和单源性血管炎的动脉和静脉血栓形成。

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-05-06 DOI: 10.1038/s41584-025-01252-7

Federica Bello,Filippo Fagni,Giacomo Bagni,Catherine L Hill,Aladdin J Mohammad,Sergey Moiseev,Iacopo Olivotto,Emire Seyahi,Giacomo Emmi

{"title":"Arterial and venous thrombosis in systemic and monogenic vasculitis.","authors":"Federica Bello,Filippo Fagni,Giacomo Bagni,Catherine L Hill,Aladdin J Mohammad,Sergey Moiseev,Iacopo Olivotto,Emire Seyahi,Giacomo Emmi","doi":"10.1038/s41584-025-01252-7","DOIUrl":"https://doi.org/10.1038/s41584-025-01252-7","url":null,"abstract":"Systemic vasculitis, common forms of which include anti-neutrophil cytoplasmic antibody-associated small-vessel vasculitis, large-vessel vasculitis and Behçet syndrome, are frequently complicated by arterial or venous thrombotic events (AVTEs). Newly identified entities such as DADA2 (deficiency of adenosine deaminase 2) and VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome, which are driven by genetic mutations, also exhibit vasculitic features and are associated with a high risk of AVTEs. AVTEs in systemic vasculitis, including monogenic forms of vasculitis, are due to the complex interaction of inflammation and coagulation. New insights into the pathogenetic mechanisms implicate endothelial dysfunction, immune complex deposition and the interplay of pro-inflammatory cytokines with prothrombotic factors, which collectively promote thrombus formation. AVTEs impose a substantial disease burden, complicate diagnosis and negatively affect prognosis by increasing the risk of morbidity and mortality. Early diagnosis and treatment are crucial to prevent lasting damage. Management strategies should target both thrombosis and underlying inflammation. Antithrombotic therapies, including low-dose aspirin, or oral anticoagulants should be used on the basis of individual thrombotic risk assessment. Immunosuppressive therapy is the cornerstone of treatment for arterial and venous thrombosis, particularly in Behçet syndrome, in which vascular inflammation has a crucial role in thrombotic complications.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"56 3 1","pages":""},"PeriodicalIF":33.7,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143915091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risks and benefits of immunosuppressant withdrawal in systemic lupus erythematosus 系统性红斑狼疮患者停用免疫抑制剂的风险和益处

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-05-02 DOI: 10.1038/s41584-025-01262-5

Catriona A. Wagner, Judith A. James

引用次数: 0

Glycosylation switch in synovial fibroblasts promotes ECM degradation 滑膜成纤维细胞中的糖基化转换促进了 ECM 降解

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-04-23 DOI: 10.1038/s41584-025-01258-1

Holly Webster

引用次数: 0