Nature Reviews Rheumatology最新文献

Antibiotic-induced loss of gut SCFAs exacerbates alphavirus arthritis. 抗生素诱导的肠道SCFAs丢失会加剧甲病毒关节炎。

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2026-09-04 DOI: 10.1038/s41584-026-01435-w

Holly Webster

引用次数: 0

Vaccination considerations in autoimmune rheumatic diseases. 自身免疫性风湿病的疫苗接种考虑。

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2026-09-03 DOI: 10.1038/s41584-026-01427-w

Meliha C Kapetanovic

{"title":"Vaccination considerations in autoimmune rheumatic diseases.","authors":"Meliha C Kapetanovic","doi":"10.1038/s41584-026-01427-w","DOIUrl":"https://doi.org/10.1038/s41584-026-01427-w","url":null,"abstract":"Patients with autoimmune rheumatic diseases (ARDs) are at increased risk of numerous vaccine-preventable infections owing to a combination of disease-related immune dysregulation, immunosuppressive therapies - including glucocorticoids - and comorbidities. Age-related immunosenescence further increases this susceptibility in older patients. The SARS-CoV-2 (COVID-19) pandemic and measles outbreaks have underscored the importance of optimizing vaccination strategies and improving adherence to recommendations. Nevertheless, coverage for routinely recommended vaccines, including influenza and pneumococcal vaccines, remains suboptimal in this population. Vaccine hesitancy is an important barrier driven by concerns regarding safety, tolerability, disease flares and the potential induction of new autoimmune phenomena. Advanced therapies - including B cell-depleting agents, chimeric antigen receptor T cell therapy and bispecific T cell engagers - can substantially impair vaccine-induced immune responses, highlighting the importance of optimizing vaccination timing in relation to treatment. Although most studies focus on humoral and cellular immune responses, evidence on the long-term durability of vaccine-induced immunity, the need for booster doses and real-world vaccine effectiveness in patients with ARDs remains limited. Ethical considerations are important. Although vaccination in adults is generally not mandatory, improving vaccine uptake reduces the burden of infections in patients with ARDs, contributes to herd immunity and provides indirect protection for other vulnerable populations.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":" ","pages":""},"PeriodicalIF":33.7,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148888020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondrial succinate sensing promotes macrophage inflammation in RA. 线粒体琥珀酸感知促进类风湿关节炎的巨噬细胞炎症。

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2026-09-03 DOI: 10.1038/s41584-026-01434-x

Jessica McHugh

引用次数: 0

CDC42-pyrin interactions promote inflammasome activation and autoinflammatory disease. CDC42-pyrin相互作用促进炎性体活化和自身炎症性疾病。

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2026-09-02 DOI: 10.1038/s41584-026-01433-y

Holly Webster

引用次数: 0

Time to rethink clinical trial design in Sjögren disease. 是时候重新思考Sjögren疾病的临床试验设计了。

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2026-09-01 DOI: 10.1038/s41584-026-01429-8

Raphaèle Seror, Xavier Mariette

引用次数: 0

ADAR1 variants define an interferon-related subtype of psoriatic disease. ADAR1变异定义了银屑病的干扰素相关亚型。

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2026-09-01 DOI: 10.1038/s41584-026-01431-0

Holly Webster

引用次数: 0

Air pollution worsens disease activity in RA. 空气污染使类风湿关节炎的疾病活动恶化。

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2026-08-27 DOI: 10.1038/s41584-026-01432-z

Jessica McHugh

引用次数: 0

Hepatic control of immunometabolism: implications for the pathogenesis, diagnosis and treatment of rheumatic diseases. 肝脏对免疫代谢的控制：对风湿性疾病的发病机制、诊断和治疗的意义。

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2026-08-26 DOI: 10.1038/s41584-026-01421-2

Andras Perl, Katalin Banki

{"title":"Hepatic control of immunometabolism: implications for the pathogenesis, diagnosis and treatment of rheumatic diseases.","authors":"Andras Perl, Katalin Banki","doi":"10.1038/s41584-026-01421-2","DOIUrl":"https://doi.org/10.1038/s41584-026-01421-2","url":null,"abstract":"Autoimmune rheumatic diseases, including systemic lupus erythematosus and antiphospholipid syndrome, arise from interactions between genetic susceptibility and environmental triggers that drive metabolic dysregulation. The liver, a central metabolic and immunological organ, has a key role in initiating and amplifying systemic autoimmunity and organ damage. It functions as an interface between the gut microbiome, nutrients, drugs and environmental toxins. The liver regulates immune cell development, coordinates systemic immune responses through metabolite and cytokine production and modifies self-antigens via oxidation, glycosylation and lipidation. These changes can transform normal molecules into autoantigens. Hepatocytes also produce coagulation, complement factors and apolipoproteins, such as β2-glycoprotein I, a major target of antiphospholipid antibodies. In addition, the liver secretes antioxidants such as glutathione, albumin and paraoxonase-1, which protect lipoproteins from becoming antigenic and reduce risks of atherosclerosis and thrombosis. Liver diseases such as steatosis and steatohepatitis have bidirectional relationships with systemic lupus erythematosus, antiphospholipid syndrome and other rheumatic conditions. Liver cells can also be direct targets of autoimmune responses. Delineating the role of the liver in metabolic control of autoimmunity and inflammation can lead to better understanding of disease pathogenesis, improved clinical diagnosis and identification of new therapeutic targets in rheumatic diseases.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":" ","pages":""},"PeriodicalIF":33.7,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148830454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Towards a global collaborative approach to living guideline development in rheumatology. 迈向风湿病生活指南制定的全球合作方法。

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2026-08-24 DOI: 10.1038/s41584-026-01422-1

Laurent Arnaud, Guillermo J Pons-Estel

引用次数: 0

Author Correction: Diagnostic, prognostic and therapeutic biomarkers in rheumatoid arthritis. 作者更正：类风湿关节炎的诊断、预后和治疗生物标志物。

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2026-08-24 DOI: 10.1038/s41584-026-01430-1

Zoltán Szekanecz, Lilla Gunkl-Tóth, Szilvia Szamosi, Diane van der Woude, Iain McInnes, György Nagy

引用次数: 0