Nature Reviews Rheumatology最新文献_第4页

Restoring articular cartilage: insights from structure, composition and development 修复关节软骨：从结构，组成和发展的见解

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-03-28 DOI: 10.1038/s41584-025-01236-7

Alba Pueyo Moliner, Keita Ito, Frank Zaucke, Daniel J. Kelly, Mylène de Ruijter, Jos Malda

{"title":"Restoring articular cartilage: insights from structure, composition and development","authors":"Alba Pueyo Moliner, Keita Ito, Frank Zaucke, Daniel J. Kelly, Mylène de Ruijter, Jos Malda","doi":"10.1038/s41584-025-01236-7","DOIUrl":"https://doi.org/10.1038/s41584-025-01236-7","url":null,"abstract":"<p>Articular cartilage can withstand substantial compressive and shear forces within the joint and also reduces friction during motion. The exceptional mechanical properties of articular cartilage stem from its highly organized extracellular matrix (ECM). The ECM is composed mainly of collagen type II and is pivotal in conferring mechanical durability to the tissue within its proteoglycan-rich matrix. Articular cartilage is prone to injury and degeneration, and current treatments often fail to restore the mechanical function of this tissue. A key challenge is replicating the intricate collagen–proteoglycan network, which is essential for the long-lasting restoration and mechanical durability of the tissue. Understanding articular cartilage development, which arises between late embryonic and early juvenile development, is vital for the creation of durable therapeutic strategies. The development of the articular ECM involves the biosynthesis, fibrillogenesis and self-assembly of the collagen type II network, which, along with proteoglycans and minor ECM components, shapes the architecture of adult articular cartilage. A deeper understanding of these processes could inform biomaterial-based therapies aimed at improving therapeutic outcomes. Emerging biofabrication technologies offer new opportunities to integrate developmental principles into the creation of durable articular cartilage implants. Bridging fundamental biology with innovative engineering offers novel approaches to generating more-durable 3D implants for articular cartilage restoration.</p>","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"183 1","pages":""},"PeriodicalIF":33.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143723185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A role for TGFβ and EBV in MIS-C pathogenesis TGFβ和EBV在MIS-C发病机制中的作用

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-03-28 DOI: 10.1038/s41584-025-01244-7

Maria Papatriantafyllou

引用次数: 0

Profiling synovial tissue reveals OA subgroups 滑膜组织分析显示OA亚群

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-03-26 DOI: 10.1038/s41584-025-01241-w

Sarah Onuora

引用次数: 0

Z-DNA as an inflammatory trigger in lupus Z-DNA是狼疮的炎症诱因

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-03-26 DOI: 10.1038/s41584-025-01243-8

Maria Papatriantafyllou

引用次数: 0

Imaging inflammation with leukocyte-targeted PET tracers 用白细胞靶向PET示踪剂成像炎症

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-03-26 DOI: 10.1038/s41584-025-01239-4

Filippo Fagni

引用次数: 0

Oestrogens implicated in progression to arthritis 雌激素与关节炎的发展有关

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-03-25 DOI: 10.1038/s41584-025-01242-9

Sarah Onuora

引用次数: 0

Pentose phosphate pathway metabolite restores T cell balance in SLE 戊糖磷酸途径代谢物恢复SLE中的T细胞平衡

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-03-24 DOI: 10.1038/s41584-025-01238-5

Maria Papatriantafyllou

引用次数: 0

The role of the immune system in osteoarthritis: mechanisms, challenges and future directions 免疫系统在骨关节炎中的作用：机制、挑战和未来方向

IF 29.4 1区医学

Nature Reviews Rheumatology Pub Date : 2025-03-13 DOI: 10.1038/s41584-025-01223-y

David Moulin, Jérémie Sellam, Francis Berenbaum, Jérôme Guicheux, Marie-Astrid Boutet

{"title":"The role of the immune system in osteoarthritis: mechanisms, challenges and future directions","authors":"David Moulin, Jérémie Sellam, Francis Berenbaum, Jérôme Guicheux, Marie-Astrid Boutet","doi":"10.1038/s41584-025-01223-y","DOIUrl":"10.1038/s41584-025-01223-y","url":null,"abstract":"Osteoarthritis (OA) is a chronic joint disease that has long been considered a simple wear-and-tear condition. Over the past decade, research has revealed that various inflammatory features of OA, such as low-grade peripheral inflammation and synovitis, contribute substantially to the pathophysiology of the disease. Technological advances in the past 5 years have revealed a large diversity of innate and adaptive immune cells in the joints, particularly in the synovium and infrapatellar fat pad. Notably, the presence of synovial lymphoid structures, circulating autoantibodies and alterations in memory T cell and B cell populations have been documented in OA. These data indicate a potential contribution of self-reactivity to the disease pathogenesis, blurring the often narrow and inaccurate line between chronic inflammatory and autoimmune diseases. The diverse immune changes associated with OA pathogenesis can vary across disease phenotypes, and a better characterization of their underlying molecular endotypes will be key to stratifying patients, designing novel therapeutic approaches and ultimately ameliorating treatment allocation. Furthermore, examining both articular and systemic alterations, including changes in the gut–joint axis and microbial dysbiosis, could open up novel avenues for OA management. This Review provides an update on the role of innate and adaptive immune cells in the pathogenesis of osteoarthritis. The authors discuss emerging therapeutics that target the immune system in osteoarthritis and the challenges that limit the movement towards personalized medicine.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"21 4","pages":"221-236"},"PeriodicalIF":29.4,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143608050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treating inflammatory arthritis in individuals with concomitant cancer 治疗伴有癌症的炎症性关节炎

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-03-13 DOI: 10.1038/s41584-025-01235-8

Maria E. Suarez-Almazor

引用次数: 0

Delineating inflammatory from non-inflammatory mechanisms for therapy optimization in psoriatic arthritis 描述炎症和非炎症机制对银屑病关节炎的治疗优化

IF 29.4 1区医学

Nature Reviews Rheumatology Pub Date : 2025-03-12 DOI: 10.1038/s41584-025-01229-6

Alen Zabotti, Sibel Zehra Aydin, Paula David, Andrea Di Matteo, Dennis McGonagle

{"title":"Delineating inflammatory from non-inflammatory mechanisms for therapy optimization in psoriatic arthritis","authors":"Alen Zabotti, Sibel Zehra Aydin, Paula David, Andrea Di Matteo, Dennis McGonagle","doi":"10.1038/s41584-025-01229-6","DOIUrl":"10.1038/s41584-025-01229-6","url":null,"abstract":"Psoriatic arthritis (PsA) is anatomically much more heterogeneous than rheumatoid arthritis, as, beyond synovitis, it often also involves enthesitis, peritendinitis, tenosynovitis, osteitis and periostitis. This heterogeneity currently precludes a gold standard for objectively defining resolution of inflammation following treatment, with enthesitis posing a particular challenge. Despite these difficulties, we apply lessons learned from rheumatoid arthritis to describe how patients with PsA and an inadequate response to therapy can be designated within two patient subgroups, characterized by persistent inflammatory PsA (PIPsA) and non-inflammatory PsA (NIPsA), respectively. The NIPsA phenotype is defined by the lack of ongoing joint inflammation, as confirmed through clinical assessment and imaging, along with normalized inflammatory marker levels. NIPsA might be associated with obesity, biomechanical-related pain, osteoarthritis, fibromyalgia, secondary post-inflammatory damage and central pain mechanisms. In this article, we frame PsA composite outcomes measures in relationship to the PIPsA and NIPsA phenotypes and propose that this approach might help to minimize unnecessary or ineffective cycling of PsA therapy in patients who acquire dominant non-inflammatory mechanisms and might also inform future trial design. In this Perspective, the authors propose that patients with psoriatic arthritis and an inadequate response to therapy can be classified into two distinct subgroups, characterized by persistent inflammatory and non-inflammatory phenotypes, and discuss potential mechanisms underlying these phenotypes, as well as considerations for treatment strategies and trial design.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"21 4","pages":"237-248"},"PeriodicalIF":29.4,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0