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Hyperuricaemia and gout in the Pacific 太平洋地区的高尿酸血症和痛风
IF 29.4 1区 医学
Nature Reviews Rheumatology Pub Date : 2025-03-11 DOI: 10.1038/s41584-025-01228-7
Baptiste Gérard, Megan Leask, Tony R. Merriman, Thomas Bardin, Erwan Oehler, Aniva Lawrence, Satupaitea Viali, Samuela ‘Ofanoa, Leanne Te Karu, Lisa K. Stamp, Nicola Dalbeth, Tristan Pascart
{"title":"Hyperuricaemia and gout in the Pacific","authors":"Baptiste Gérard, Megan Leask, Tony R. Merriman, Thomas Bardin, Erwan Oehler, Aniva Lawrence, Satupaitea Viali, Samuela ‘Ofanoa, Leanne Te Karu, Lisa K. Stamp, Nicola Dalbeth, Tristan Pascart","doi":"10.1038/s41584-025-01228-7","DOIUrl":"10.1038/s41584-025-01228-7","url":null,"abstract":"Gout is the most common form of inflammatory arthritis in adults worldwide. There has been a steady increase in prevalence, which varies across different geographic areas and is high in the Indigenous (First Nations) peoples of the Pacific region. Palaeo-archaeological studies demonstrate that gout was present in the Pacific region prior to European colonization, which is suggestive of genetic predisposition. Genetic risk factors, including population-specific genetic variants and genetic variants shared across populations, particularly those influencing urate transporters, have been identified in Indigenous peoples of the Pacific that partly explain the earlier age of onset of gout. Indigenous peoples of the Pacific experience severe gout, with frequent flares, high hospitalization rates and tophaceous gout, all aggravated by socio-cultural factors. Despite a specific need for effective gout management, Indigenous peoples of the Pacific are under-represented in gout research and inequities in care continue. Indigenous peoples-led, holistic gout management programmes are systematically and urgently required in this region, where gout is a major public health issue. Importantly, a foundation of cultural safety is necessary to underpin such programmes. In this Review, the authors provide an overview of gout and hyperuricaemia in Indigenous peoples of the Pacific region, including discussion of genetic, clinical and cultural aspects and how to address the inequitable health outcomes and suboptimal gout management in these populations.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"21 4","pages":"197-210"},"PeriodicalIF":29.4,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143589927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Obinutuzumab effective for lupus nephritis Obinutuzumab对狼疮性肾炎有效
IF 29.4 1区 医学
Nature Reviews Rheumatology Pub Date : 2025-03-07 DOI: 10.1038/s41584-025-01237-6
Sarah Onuora
{"title":"Obinutuzumab effective for lupus nephritis","authors":"Sarah Onuora","doi":"10.1038/s41584-025-01237-6","DOIUrl":"10.1038/s41584-025-01237-6","url":null,"abstract":"In a phase III trial, the addition of obinutuzumab to standard therapy for lupus nephritis led to an increase in the proportion of patients with a complete renal response.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"21 4","pages":"193-193"},"PeriodicalIF":29.4,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stem and progenitor cells in the synovial joint as targets for regenerative therapy 滑膜关节中的干细胞和祖细胞作为再生治疗的靶点
IF 29.4 1区 医学
Nature Reviews Rheumatology Pub Date : 2025-03-05 DOI: 10.1038/s41584-025-01222-z
Anke J. Roelofs, Jessica J. McClure, Elizabeth A. Hay, Cosimo De Bari
{"title":"Stem and progenitor cells in the synovial joint as targets for regenerative therapy","authors":"Anke J. Roelofs, Jessica J. McClure, Elizabeth A. Hay, Cosimo De Bari","doi":"10.1038/s41584-025-01222-z","DOIUrl":"10.1038/s41584-025-01222-z","url":null,"abstract":"Damage to articular cartilage, tendons, ligaments and entheses as a result of trauma, degeneration or inflammation in rheumatic diseases is prevalent. Regenerative medicine offers promising strategies for repairing damaged tissues, with the aim of restoring both their structure and function. While these strategies have traditionally relied on tissue engineering approaches using exogenous cells, interventions based on the activation of endogenous repair mechanisms are an attractive alternative. Key to advancing such approaches is a comprehensive understanding of the diversity of the stem and progenitor cells that reside in the adult synovial joint and how they function to repair damaged tissues. Advances in developmental biology have provided a lens through which to understand the origins, identities and functions of these cells, and insights into the roles of stem and progenitor cells in joint tissue repair, as well as their complex relationship with fibroblasts, have emerged. Integration of knowledge obtained through studies using advanced single-cell technologies will be crucial to establishing unified models of cell populations, lineage hierarchies and their molecular regulation. Ultimately, a more complete understanding of how cells repair tissues in adult life will guide the development of innovative pro-regenerative drugs, which are poised to enter clinical practice in musculoskeletal medicine. Stem and progenitor cells that contribute to tissue repair reside within various niches in the synovial joints of adult mammals. Understanding of the origins, identities and functions of these cells will guide the development of pro-regenerative therapeutic strategies.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"21 4","pages":"211-220"},"PeriodicalIF":29.4,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Joint location matters for TNF inhibitor treatment in PsA 关节位置对TNF抑制剂治疗PsA很重要
IF 29.4 1区 医学
Nature Reviews Rheumatology Pub Date : 2025-03-03 DOI: 10.1038/s41584-025-01233-w
Holly Webster
{"title":"Joint location matters for TNF inhibitor treatment in PsA","authors":"Holly Webster","doi":"10.1038/s41584-025-01233-w","DOIUrl":"10.1038/s41584-025-01233-w","url":null,"abstract":"Findings show that the resolution of joint swelling in response to treatment with TNF inhibitors varies depending on the location of the joint in psoriatic arthritis.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"21 4","pages":"193-193"},"PeriodicalIF":29.4,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Publisher Correction: An international perspective on the future of systemic sclerosis research 出版商更正：系统性硬化症研究未来的国际视角
IF 29.4 1区 医学
Nature Reviews Rheumatology Pub Date : 2025-03-03 DOI: 10.1038/s41584-025-01231-y
David J. Abraham, Carol M. Black, Christopher P. Denton, Jörg H. W. Distler, Robyn Domsic, Carol Feghali-Bostwick, Pravitt Gourh, Monique Hinchcliff, Fred Kolling IV, Masataka Kuwana, Robert Lafyatis, Ulf Landegren, J. Matthew Mahoney, Javier Martin, Marco Matucci-Cerinic, Zsuzsanna H. McMahan, Ana L. Mora, Luc Mouthon, Marlene Rabinovitch, Mauricio Rojas, Kristofer Rubin, Maria Trojanowska, John Varga, Michael L. Whitfield, Armando Gabrielli, Thomas Krieg
{"title":"Publisher Correction: An international perspective on the future of systemic sclerosis research","authors":"David J. Abraham, Carol M. Black, Christopher P. Denton, Jörg H. W. Distler, Robyn Domsic, Carol Feghali-Bostwick, Pravitt Gourh, Monique Hinchcliff, Fred Kolling IV, Masataka Kuwana, Robert Lafyatis, Ulf Landegren, J. Matthew Mahoney, Javier Martin, Marco Matucci-Cerinic, Zsuzsanna H. McMahan, Ana L. Mora, Luc Mouthon, Marlene Rabinovitch, Mauricio Rojas, Kristofer Rubin, Maria Trojanowska, John Varga, Michael L. Whitfield, Armando Gabrielli, Thomas Krieg","doi":"10.1038/s41584-025-01231-y","DOIUrl":"10.1038/s41584-025-01231-y","url":null,"abstract":"","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"21 4","pages":"249-249"},"PeriodicalIF":29.4,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41584-025-01231-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting T cell-activating NETs in uveitis 靶向T细胞活化NETs治疗葡萄膜炎
IF 29.4 1区 医学
Nature Reviews Rheumatology Pub Date : 2025-03-03 DOI: 10.1038/s41584-025-01230-z
Maria Papatriantafyllou
{"title":"Targeting T cell-activating NETs in uveitis","authors":"Maria Papatriantafyllou","doi":"10.1038/s41584-025-01230-z","DOIUrl":"10.1038/s41584-025-01230-z","url":null,"abstract":"Neutrophil extracellular traps might promote intraocular infiltration of effector CD4+ T cells by inducing endothelial cell senescence in autoimmune uveitis.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"21 4","pages":"191-191"},"PeriodicalIF":29.4,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TASL has a key role in SLE TASL 在系统性红斑狼疮中发挥关键作用
IF 29.4 1区 医学
Nature Reviews Rheumatology Pub Date : 2025-02-28 DOI: 10.1038/s41584-025-01232-x
Holly Webster
{"title":"TASL has a key role in SLE","authors":"Holly Webster","doi":"10.1038/s41584-025-01232-x","DOIUrl":"10.1038/s41584-025-01232-x","url":null,"abstract":"Two studies provide insights into the function of TASL in the pathogenesis of systemic lupus erythematosus and highlight the therapeutic potential of targeting this protein.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"21 4","pages":"192-192"},"PeriodicalIF":29.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143526271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Macrophages hit a nerve in painful joint venture 巨噬细胞在痛苦的合资企业中击中了神经
IF 33.7 1区 医学
Nature Reviews Rheumatology Pub Date : 2025-02-24 DOI: 10.1038/s41584-025-01227-8
Oumaima Ben Brahim, Stefan Uderhardt
{"title":"Macrophages hit a nerve in painful joint venture","authors":"Oumaima Ben Brahim, Stefan Uderhardt","doi":"10.1038/s41584-025-01227-8","DOIUrl":"https://doi.org/10.1038/s41584-025-01227-8","url":null,"abstract":"Hasegawa et al. reveal how synovial joints detect systemic inflammation through specialized fenestrated blood vessels at the synovial periphery. Three distinct macrophage populations and nociceptor neurons form a sentinel unit around these vessels, coordinating immune responses and pain signalling through interleukin-1β (IL-1β) and calcitonin gene-related peptide (CGRP) signalling.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"25 1","pages":""},"PeriodicalIF":33.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Towards better management of sterile bone inflammation 迈向更好地管理无菌骨炎症
IF 29.4 1区 医学
Nature Reviews Rheumatology Pub Date : 2025-02-20 DOI: 10.1038/s41584-025-01226-9
Jürgen Braun
{"title":"Towards better management of sterile bone inflammation","authors":"Jürgen Braun","doi":"10.1038/s41584-025-01226-9","DOIUrl":"10.1038/s41584-025-01226-9","url":null,"abstract":"The first expert consensus recommendations for the treatment and diagnosis of adult sterile bone inflammation have been developed, in which the term ‘chronic non-bacterial osteitis’ is proposed as a disease definition. Will these recommendations pave the way for better diagnosis, management and treatment of this rare disease?","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"21 4","pages":"195-196"},"PeriodicalIF":29.4,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Connecting the structure and function of cartilage using spatial omics 利用空间“组学”连接软骨的结构和功能
IF 29.4 1区 医学
Nature Reviews Rheumatology Pub Date : 2025-02-14 DOI: 10.1038/s41584-025-01225-w
Indira Prasadam, Xiwei Fan
{"title":"Connecting the structure and function of cartilage using spatial omics","authors":"Indira Prasadam, Xiwei Fan","doi":"10.1038/s41584-025-01225-w","DOIUrl":"10.1038/s41584-025-01225-w","url":null,"abstract":"Advances in spatial omics, such as transcriptomics and proteomics, have provided vital insights into cartilage microenvironments, revealing cellular diversity, zonal organization and links between cartilage structure and function. Analysing cartilage using spatial omics could deepen the understanding of diseases such as osteoarthritis and guide the development of targeted, disease-modifying therapies.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"21 4","pages":"189-190"},"PeriodicalIF":29.4,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143417254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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