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Nature Reviews Rheumatology最新文献

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Targeting anti-PAD4 autoantibodies in RA 针对RA的抗pad4自身抗体
IF 32.7 1区 医学
Nature Reviews Rheumatology Pub Date : 2025-05-06 DOI: 10.1038/s41584-025-01264-3
Holly Webster
{"title":"Targeting anti-PAD4 autoantibodies in RA","authors":"Holly Webster","doi":"10.1038/s41584-025-01264-3","DOIUrl":"10.1038/s41584-025-01264-3","url":null,"abstract":"Findings implicate anti-PAD4 antibodies in the pathogenesis of rheumatoid arthritis.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"21 7","pages":"373-373"},"PeriodicalIF":32.7,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143909896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Arterial and venous thrombosis in systemic and monogenic vasculitis 全身和单源性血管炎的动脉和静脉血栓形成。
IF 32.7 1区 医学
Nature Reviews Rheumatology Pub Date : 2025-05-06 DOI: 10.1038/s41584-025-01252-7
Federica Bello, Filippo Fagni, Giacomo Bagni, Catherine L. Hill, Aladdin J. Mohammad, Sergey Moiseev, Iacopo Olivotto, Emire Seyahi, Giacomo Emmi
{"title":"Arterial and venous thrombosis in systemic and monogenic vasculitis","authors":"Federica Bello, Filippo Fagni, Giacomo Bagni, Catherine L. Hill, Aladdin J. Mohammad, Sergey Moiseev, Iacopo Olivotto, Emire Seyahi, Giacomo Emmi","doi":"10.1038/s41584-025-01252-7","DOIUrl":"10.1038/s41584-025-01252-7","url":null,"abstract":"Systemic vasculitis, common forms of which include anti-neutrophil cytoplasmic antibody-associated small-vessel vasculitis, large-vessel vasculitis and Behçet syndrome, are frequently complicated by arterial or venous thrombotic events (AVTEs). Newly identified entities such as DADA2 (deficiency of adenosine deaminase 2) and VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome, which are driven by genetic mutations, also exhibit vasculitic features and are associated with a high risk of AVTEs. AVTEs in systemic vasculitis, including monogenic forms of vasculitis, are due to the complex interaction of inflammation and coagulation. New insights into the pathogenetic mechanisms implicate endothelial dysfunction, immune complex deposition and the interplay of pro-inflammatory cytokines with prothrombotic factors, which collectively promote thrombus formation. AVTEs impose a substantial disease burden, complicate diagnosis and negatively affect prognosis by increasing the risk of morbidity and mortality. Early diagnosis and treatment are crucial to prevent lasting damage. Management strategies should target both thrombosis and underlying inflammation. Antithrombotic therapies, including low-dose aspirin, or oral anticoagulants should be used on the basis of individual thrombotic risk assessment. Immunosuppressive therapy is the cornerstone of treatment for arterial and venous thrombosis, particularly in Behçet syndrome, in which vascular inflammation has a crucial role in thrombotic complications. Systemic vasculitis, including monogenic forms, is associated with an increased risk of arterial and venous thromboembolic events (AVTEs). This Review highlights the latest advances in the understanding of the pathogenesis, clinical features and management of AVTEs in systemic and monogenic vasculitis.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"21 6","pages":"355-369"},"PeriodicalIF":32.7,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143915091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risks and benefits of immunosuppressant withdrawal in systemic lupus erythematosus 系统性红斑狼疮患者停用免疫抑制剂的风险和益处
IF 32.7 1区 医学
Nature Reviews Rheumatology Pub Date : 2025-05-02 DOI: 10.1038/s41584-025-01262-5
Catriona A. Wagner, Judith A. James
{"title":"Risks and benefits of immunosuppressant withdrawal in systemic lupus erythematosus","authors":"Catriona A. Wagner, Judith A. James","doi":"10.1038/s41584-025-01262-5","DOIUrl":"10.1038/s41584-025-01262-5","url":null,"abstract":"Withdrawing immunosuppressive treatment in systemic lupus erythematosus offers reduced toxicity and improved quality of life for patients in remission but carries a risk of disease reactivation. Emerging studies emphasize the importance of identifying patients who can safely discontinue therapy using clinical criteria and molecular profiling to guide personalized strategies.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"21 8","pages":"439-440"},"PeriodicalIF":32.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143901314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding the causes of treatment failure is crucial for the management of axial spondyloarthritis 了解治疗失败的原因对治疗轴性脊柱炎至关重要
IF 32.7 1区 医学
Nature Reviews Rheumatology Pub Date : 2025-04-23 DOI: 10.1038/s41584-025-01254-5
Denis Poddubnyy, Xenofon Baraliakos
{"title":"Understanding the causes of treatment failure is crucial for the management of axial spondyloarthritis","authors":"Denis Poddubnyy, Xenofon Baraliakos","doi":"10.1038/s41584-025-01254-5","DOIUrl":"10.1038/s41584-025-01254-5","url":null,"abstract":"Although numerous therapies are available for axial spondyloarthritis, more than half of patients do not achieve remission or respond to treatment. Understanding the reasons for non-response in axial spondyloarthritis is essential for effective management of this disease.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"21 6","pages":"309-311"},"PeriodicalIF":32.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143866446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors beyond urate levels for managing gout flares 管理痛风耀斑的因素超出了准确水平
IF 32.7 1区 医学
Nature Reviews Rheumatology Pub Date : 2025-04-23 DOI: 10.1038/s41584-025-01255-4
Hang Korng Ea, Pascal Richette
{"title":"Factors beyond urate levels for managing gout flares","authors":"Hang Korng Ea, Pascal Richette","doi":"10.1038/s41584-025-01255-4","DOIUrl":"10.1038/s41584-025-01255-4","url":null,"abstract":"Urate crystals alone are required but not sufficient to trigger gout flares; they can also be modulated by environmental, metabolic, genetic and epigenetic factors. Avoiding large variation in urate levels, maintaining prophylaxis until crystal clearance and initiating low-dose urate-lowering therapy are efficient strategies for disease management.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"21 7","pages":"371-372"},"PeriodicalIF":32.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143866445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glycosylation switch in synovial fibroblasts promotes ECM degradation 滑膜成纤维细胞中的糖基化转换促进了 ECM 降解
IF 32.7 1区 医学
Nature Reviews Rheumatology Pub Date : 2025-04-23 DOI: 10.1038/s41584-025-01258-1
Holly Webster
{"title":"Glycosylation switch in synovial fibroblasts promotes ECM degradation","authors":"Holly Webster","doi":"10.1038/s41584-025-01258-1","DOIUrl":"10.1038/s41584-025-01258-1","url":null,"abstract":"Activation of N-acetylgalactosaminyltransferases in synovial fibroblasts promotes the degradation of the extracellular matrix in arthritis.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"21 6","pages":"317-317"},"PeriodicalIF":32.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143862087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting osteoarthritis where it hurts: the osteochondral junction 针对骨关节炎的痛处，骨软骨连接处
IF 32.7 1区 医学
Nature Reviews Rheumatology Pub Date : 2025-04-22 DOI: 10.1038/s41584-025-01257-2
Anne-Marie Malfait, Alia M. Obeidat
{"title":"Targeting osteoarthritis where it hurts: the osteochondral junction","authors":"Anne-Marie Malfait, Alia M. Obeidat","doi":"10.1038/s41584-025-01257-2","DOIUrl":"10.1038/s41584-025-01257-2","url":null,"abstract":"In joints with osteoarthritis, angiogenesis and neuronal growth occur at the osteochondral junction, a process that can contribute to structural joint damage and pain. Targeting this neurovascularization process represents a possible strategy for the development of disease-modifying drugs for osteoarthritis.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"21 6","pages":"319-320"},"PeriodicalIF":32.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143857903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current challenges in understanding the epidemiology of calcium pyrophosphate crystal deposition 了解焦磷酸钙晶体沉积流行病学的当前挑战
IF 32.7 1区 医学
Nature Reviews Rheumatology Pub Date : 2025-04-17 DOI: 10.1038/s41584-025-01256-3
Charlotte Jauffret, Tristan Pascart
{"title":"Current challenges in understanding the epidemiology of calcium pyrophosphate crystal deposition","authors":"Charlotte Jauffret, Tristan Pascart","doi":"10.1038/s41584-025-01256-3","DOIUrl":"10.1038/s41584-025-01256-3","url":null,"abstract":"Calcium pyrophosphate deposition (CPPD) disease is secondary to the pathological accumulation of calcium pyrophosphate (CPP) crystals inside joints and involves acute or chronic inflammatory arthritis. Epidemiological research on CPPD has been slow despite the suspected high prevalence of this condition. Here we highlight key challenges in CPPD imaging, diagnosis and nomenclature that need to be addressed for epidemiological research to progress at a faster pace.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"21 6","pages":"312-313"},"PeriodicalIF":32.7,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143841199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fumarate drives interferon release in systemic sclerosis monocytes 富马酸盐驱动系统性硬化症单核细胞释放干扰素
IF 32.7 1区 医学
Nature Reviews Rheumatology Pub Date : 2025-04-16 DOI: 10.1038/s41584-025-01261-6
Sarah Onuora
{"title":"Fumarate drives interferon release in systemic sclerosis monocytes","authors":"Sarah Onuora","doi":"10.1038/s41584-025-01261-6","DOIUrl":"10.1038/s41584-025-01261-6","url":null,"abstract":"Altered metabolism of the tricarboxylic acid cycle metabolite fumarate drives activation of interferon release in systemic sclerosis monocytes, suggesting a potential therapeutic approach.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"21 6","pages":"316-316"},"PeriodicalIF":32.7,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143836708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Upadacitinib effective for GCA in phase III trial 奥达帕替尼在 III 期试验中对 GCA 有效
IF 32.7 1区 医学
Nature Reviews Rheumatology Pub Date : 2025-04-15 DOI: 10.1038/s41584-025-01260-7
Sarah Onuora
{"title":"Upadacitinib effective for GCA in phase III trial","authors":"Sarah Onuora","doi":"10.1038/s41584-025-01260-7","DOIUrl":"10.1038/s41584-025-01260-7","url":null,"abstract":"In the phase III SELECT-GCA trial, upadacitinib at a dose of 15 mg daily was superior to placebo with respect to achievement of sustained remission of giant cell arteritis at 52 weeks.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"21 7","pages":"373-373"},"PeriodicalIF":32.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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