Nature Reviews Rheumatology最新文献_第7页

Lipid nanoparticles with PDL1-encoding mRNA spread tolerance 带有 PDL1 编码 mRNA 的脂质纳米颗粒传播耐受性

IF 32.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-04-11 DOI: 10.1038/s41584-025-01251-8

Maria Papatriantafyllou

引用次数: 0

Decoding the adaptive immune repertoire for disease prediction 解码适应性免疫库以预测疾病

IF 32.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-04-10 DOI: 10.1038/s41584-025-01249-2

Laura F. Su

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Sex- and gender-based personalized medicine in rheumatology 风湿病学中的性别和基于性别的个性化医学

IF 32.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-04-07 DOI: 10.1038/s41584-025-01246-5

Elizabeth R. Volkmann, Carol Feghali-Bostwick

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IgG4-related disease and other fibro-inflammatory conditions igg4相关疾病和其他纤维炎性疾病

IF 32.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-04-07 DOI: 10.1038/s41584-025-01240-x

Francesco Peyronel, Emanuel Della-Torre, Federica Maritati, Maria L. Urban, Ingeborg Bajema, Nicolas Schleinitz, Augusto Vaglio

{"title":"IgG4-related disease and other fibro-inflammatory conditions","authors":"Francesco Peyronel, Emanuel Della-Torre, Federica Maritati, Maria L. Urban, Ingeborg Bajema, Nicolas Schleinitz, Augusto Vaglio","doi":"10.1038/s41584-025-01240-x","DOIUrl":"10.1038/s41584-025-01240-x","url":null,"abstract":"IgG4-related disease (IgG4-RD) is a fibro-inflammatory disorder usually characterized by multi-organ involvement. Its pathogenesis is complex and involves genetic and environmental factors, while immune responses usually mediate organ damage and promote fibrosis, which is a key feature of the disease. IgG4 responses, however, are not exclusive to IgG4-RD and can be encountered in other diseases with phenotypes that partially overlap that of IgG4-RD. Although IgG4-RD has clinical and histological hallmarks, the lack of validated diagnostic criteria often makes the diagnosis challenging, requiring a multi-dimensional approach that integrates clinical, radiological and serological data. The present Review covers recent advances in the understanding of disease drivers and its clinical phenotypes, mainly focusing on the differential diagnosis with potential IgG4-RD mimickers, namely histiocytoses, lymphoproliferative disorders, systemic vasculitides and other immune-mediated conditions. The Review also provides a schematic approach to IgG4-RD treatment, including a brief overview of glucocorticoid-sparing agents and emerging therapies, from B cell-depleting monoclonal antibodies to cytokine-targeting drugs, the majority of which are currently under investigation in randomized clinical trials. IgG4-related disease is a fibro-inflammatory disorder with a complex pathogenesis. Herein the authors review the latest developments in IgG4-related disease clinical phenotyping, pathophysiology and management, with a focus on the main mimics of this disease and how to approach issues related to differential diagnosis.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"21 5","pages":"275-290"},"PeriodicalIF":32.7,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex and gender matter for TNF inhibitor therapy in RA 性别和性别影响TNF抑制剂治疗RA

IF 32.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-04-02 DOI: 10.1038/s41584-025-01248-3

Holly Webster

引用次数: 0

Lupus ABC spearheading a new era of collaboration to advance lupus drug development 狼疮ABC率先合作推进狼疮药物开发的新时代

IF 32.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-04-01 DOI: 10.1038/s41584-025-01247-4

Hoang Nguyen, Teodora P. Staeva

引用次数: 0

The causal role of brain circuits in osteoarthritis pain 脑回路在骨关节炎疼痛中的因果作用

IF 32.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-03-31 DOI: 10.1038/s41584-025-01234-9

Joana Barroso, Paulo Branco, A. Vania Apkarian

{"title":"The causal role of brain circuits in osteoarthritis pain","authors":"Joana Barroso, Paulo Branco, A. Vania Apkarian","doi":"10.1038/s41584-025-01234-9","DOIUrl":"10.1038/s41584-025-01234-9","url":null,"abstract":"Osteoarthritis (OA) is a leading cause of chronic pain worldwide, resulting in substantial disability and placing a substantial burden on patients and society. The hallmark symptom of OA is joint pain. Despite extensive research, new treatments for OA pain remain limited, partly owing to a lack of understanding of underlying pain mechanisms. For a long time, OA pain was seen as a reflection of nociceptive activity at the joint level, and the brain has been viewed as a passive recipient of such information. In this Review, we challenge these concepts and discuss how, over time, the activation of peripheral nociceptors leads to adaptations in the brain that dictate the properties and experience of OA pain. These adaptations are further influenced by the inherent properties of the brain. We review general concepts that distinguish pain from nociception, present evidence on the incongruity between joint injury and experience of OA pain, and review brain circuits that are crucial in the perception of OA pain. Finally, we propose a model that integrates nociception, spinal-cord mechanisms, and central nervous system dynamics, each contributing uniquely to pain perception. This framework has the potential to inform the development of personalized treatment strategies. This Review discusses how pain in osteoarthritis might involve adaptations of brain circuits, and suggests that osteoarthritis pain management should consider targeting central mechanisms of pain in addition to nociceptive neuron activity.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"21 5","pages":"261-274"},"PeriodicalIF":32.7,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CXCL7 promotes bone erosion in RA CXCL7促进RA的骨侵蚀

IF 32.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-03-28 DOI: 10.1038/s41584-025-01245-6

Holly Webster

引用次数: 0

A role for TGFβ and EBV in MIS-C pathogenesis TGFβ和EBV在MIS-C发病机制中的作用

IF 32.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-03-28 DOI: 10.1038/s41584-025-01244-7

Maria Papatriantafyllou

引用次数: 0

Restoring articular cartilage: insights from structure, composition and development 修复关节软骨：从结构，组成和发展的见解

IF 32.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-03-28 DOI: 10.1038/s41584-025-01236-7

Alba Pueyo Moliner, Keita Ito, Frank Zaucke, Daniel J. Kelly, Mylène de Ruijter, Jos Malda

{"title":"Restoring articular cartilage: insights from structure, composition and development","authors":"Alba Pueyo Moliner, Keita Ito, Frank Zaucke, Daniel J. Kelly, Mylène de Ruijter, Jos Malda","doi":"10.1038/s41584-025-01236-7","DOIUrl":"10.1038/s41584-025-01236-7","url":null,"abstract":"Articular cartilage can withstand substantial compressive and shear forces within the joint and also reduces friction during motion. The exceptional mechanical properties of articular cartilage stem from its highly organized extracellular matrix (ECM). The ECM is composed mainly of collagen type II and is pivotal in conferring mechanical durability to the tissue within its proteoglycan-rich matrix. Articular cartilage is prone to injury and degeneration, and current treatments often fail to restore the mechanical function of this tissue. A key challenge is replicating the intricate collagen–proteoglycan network, which is essential for the long-lasting restoration and mechanical durability of the tissue. Understanding articular cartilage development, which arises between late embryonic and early juvenile development, is vital for the creation of durable therapeutic strategies. The development of the articular ECM involves the biosynthesis, fibrillogenesis and self-assembly of the collagen type II network, which, along with proteoglycans and minor ECM components, shapes the architecture of adult articular cartilage. A deeper understanding of these processes could inform biomaterial-based therapies aimed at improving therapeutic outcomes. Emerging biofabrication technologies offer new opportunities to integrate developmental principles into the creation of durable articular cartilage implants. Bridging fundamental biology with innovative engineering offers novel approaches to generating more-durable 3D implants for articular cartilage restoration. Insights from the composition, structure and development of articular cartilage are key for long-term therapeutic strategies to restore articular cartilage. The authors emphasize that future therapies should replicate the depth-dependent alignment of collagen and its interactions with the extracellular matrix to produce implants that mimic the biomechanical properties of cartilage.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"21 5","pages":"291-308"},"PeriodicalIF":32.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143723185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0