Nature Reviews Rheumatology最新文献_第8页

Adropin inhibits fibrosis in SSc 阿托品能抑制 SSc 的纤维化

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2024-05-03 DOI: 10.1038/s41584-024-01121-9

Robert Phillips

引用次数: 0

Relapsing polychondritis: clinical updates and new differential diagnoses 复发性多软骨炎：临床更新和新的鉴别诊断

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2024-05-02 DOI: 10.1038/s41584-024-01113-9

Philippe Mertz, Nathalie Costedoat-Chalumeau, Marcela A. Ferrada, Guillaume Moulis, Arsène Mekinian, Peter C. Grayson, Laurent Arnaud

{"title":"Relapsing polychondritis: clinical updates and new differential diagnoses","authors":"Philippe Mertz, Nathalie Costedoat-Chalumeau, Marcela A. Ferrada, Guillaume Moulis, Arsène Mekinian, Peter C. Grayson, Laurent Arnaud","doi":"10.1038/s41584-024-01113-9","DOIUrl":"10.1038/s41584-024-01113-9","url":null,"abstract":"Relapsing polychondritis is a rare inflammatory disease characterized by recurrent inflammation of cartilaginous structures, mainly of the ears, nose and respiratory tract, with a broad spectrum of accompanying systemic features. Despite its rarity, prompt recognition and accurate diagnosis of relapsing polychondritis is crucial for appropriate management and optimal outcomes. Our understanding of relapsing polychondritis has changed markedly in the past couple of years with the identification of three distinct patient clusters that have different clinical manifestations and prognostic outcomes. With the progress of pangenomic sequencing and the discovery of new somatic and monogenic autoinflammatory diseases, new differential diagnoses have emerged, notably the vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome, autoinflammatory diseases and immune checkpoint inhibitor-related adverse events. In this Review, we present a detailed update of the newly identified clusters and highlight red flags that should raise suspicion of these alternative diagnoses. The identification of these different clusters and mimickers has a direct impact on the management, follow-up and prognosis of patients with relapsing polychondritis and autoinflammatory syndromes. Relapsing polychondritis, a rare inflammatory disorder that affects cartilaginous structures, presents challenges in diagnosis owing to overlapping symptoms with other conditions. This Review provides a clinical update on relapsing polychondritis, emphasizing the importance of distinguishing this disease from similar conditions.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"20 6","pages":"347-360"},"PeriodicalIF":33.7,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140819419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Granzyme serine proteases in inflammation and rheumatic diseases 炎症和风湿病中的颗粒酶丝氨酸蛋白酶

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2024-04-30 DOI: 10.1038/s41584-024-01109-5

Alexandre Aubert, Karen Jung, Sho Hiroyasu, Julian Pardo, David J. Granville

{"title":"Granzyme serine proteases in inflammation and rheumatic diseases","authors":"Alexandre Aubert, Karen Jung, Sho Hiroyasu, Julian Pardo, David J. Granville","doi":"10.1038/s41584-024-01109-5","DOIUrl":"10.1038/s41584-024-01109-5","url":null,"abstract":"Granzymes (granule-secreted enzymes) are a family of serine proteases that have been viewed as redundant cytotoxic enzymes since their discovery more than 30 years ago. Predominantly produced by cytotoxic lymphocytes and natural killer cells, granzymes are delivered into the cytoplasm of target cells through immunological synapses in cooperation with the pore-forming protein perforin. After internalization, granzymes can initiate cell death through the cleavage of intracellular substrates. However, evidence now also demonstrates the existence of non-cytotoxic, pro-inflammatory, intracellular and extracellular functions that are granzyme specific. Under pathological conditions, granzymes can be produced and secreted extracellularly by immune cells as well as by non-immune cells. Depending on the granzyme, accumulation in the extracellular milieu might contribute to inflammation, tissue injury, impaired wound healing, barrier dysfunction, osteoclastogenesis and/or autoantigen generation. Granzyme serine proteases are known for their perforin-dependent cytotoxic activities, but evidence also indicates that they have a range of non-cytotoxic, pro-inflammatory intracellular and extracellular functions. In this Review, the authors discuss granzyme biology with an emphasis on its involvement in rheumatic disease pathology.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"20 6","pages":"361-376"},"PeriodicalIF":33.7,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140817695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treat-to-target or treat-to-dissolve strategy to improve gout treatment 采取 "靶向治疗 "或 "溶解治疗 "策略改进痛风治疗

IF 29.4 1区医学

Nature Reviews Rheumatology Pub Date : 2024-04-26 DOI: 10.1038/s41584-024-01117-5

Pascal Richette, Nicola Dalbeth

引用次数: 0

Advancing precision rheumatology through tissue and blood profiling 通过组织和血液分析推进精准风湿病学的发展

IF 29.4 1区医学

Nature Reviews Rheumatology Pub Date : 2024-04-12 DOI: 10.1038/s41584-024-01115-7

George D. Kalliolias, Athanasios G. Papavassiliou

引用次数: 0

Molecular biomarker approaches to prevention of post-traumatic osteoarthritis 预防创伤后骨关节炎的分子生物标记方法

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2024-04-11 DOI: 10.1038/s41584-024-01102-y

Virginia Byers Kraus, Ming-Feng Hsueh

{"title":"Molecular biomarker approaches to prevention of post-traumatic osteoarthritis","authors":"Virginia Byers Kraus, Ming-Feng Hsueh","doi":"10.1038/s41584-024-01102-y","DOIUrl":"10.1038/s41584-024-01102-y","url":null,"abstract":"Up to 50% of individuals develop post-traumatic osteoarthritis (PTOA) within 10 years following knee-joint injuries such as anterior cruciate ligament rupture or acute meniscal tear. Lower-extremity PTOA prevalence is estimated to account for ≥12% of all symptomatic osteoarthritis (OA), or approximately 5.6 million cases in the USA. With knowledge of the inciting event, it might be possible to ‘catch PTOA in the act’ with sensitive imaging and soluble biomarkers and thereby prevent OA sequelae by early intervention. Existing biomarker data in the joint-injury literature can provide insights into the pathogenesis and early risk trajectory related to PTOA and can help to elucidate a research agenda for preventing or slowing the onset of PTOA. Non-traumatic OA and PTOA have many clinical, radiological and genetic similarities, and efforts to understand early risk trajectories in PTOA might therefore contribute to the identification and classification of early non-traumatic OA, which is the most prevalent form of OA. Early identification of osteoarthritis (OA) prior to the development of symptoms is challenging. Post-traumatic OA provides a model for the development of OA following a defined event. In this Review, the authors describe the existing knowledge relating to the biomarkers of post-traumatic OA, which might also be applicable to the identification of early non-traumatic OA.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"20 5","pages":"272-289"},"PeriodicalIF":33.7,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140544740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Joint-specific memory, resident memory T cells and the rolling window of opportunity in arthritis 关节特异性记忆、常驻记忆 T 细胞和关节炎的滚动机会之窗

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2024-04-10 DOI: 10.1038/s41584-024-01107-7

Margaret H. Chang, Robert C. Fuhlbrigge, Peter A. Nigrovic

{"title":"Joint-specific memory, resident memory T cells and the rolling window of opportunity in arthritis","authors":"Margaret H. Chang, Robert C. Fuhlbrigge, Peter A. Nigrovic","doi":"10.1038/s41584-024-01107-7","DOIUrl":"10.1038/s41584-024-01107-7","url":null,"abstract":"In rheumatoid arthritis, juvenile idiopathic arthritis and other forms of inflammatory arthritis, the immune system targets certain joints but not others. The pattern of joints affected varies by disease and by individual, with flares most commonly involving joints that were previously inflamed. This phenomenon, termed joint-specific memory, is difficult to explain by systemic immunity alone. Mechanisms of joint-specific memory include the involvement of synovial resident memory T cells that remain in the joint during remission and initiate localized disease recurrence. In addition, arthritis-induced durable changes in synovial fibroblasts and macrophages can amplify inflammation in a site-specific manner. Together with ongoing systemic processes that promote extension of arthritis to new joints, these local factors set the stage for a stepwise progression in disease severity, a paradigm for arthritis chronicity that we term the joint accumulation model. Although durable drug-free remission through early treatment remains elusive for most forms of arthritis, the joint accumulation paradigm defines new therapeutic targets, emphasizes the importance of sustained treatment to prevent disease extension to new joints, and identifies a rolling window of opportunity for altering the natural history of arthritis that extends well beyond the initiation phase of disease. This Review discusses joint-specific memory (the tendency of arthritis to recur in previously inflamed joints), explores the involvement of resident memory T cells and other contributors, and evaluates how arthritis might spread to new joints, emphasizing the important of sustained treatment.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"20 5","pages":"258-271"},"PeriodicalIF":33.7,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140545057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Benralizumab noninferior to mepolizumab for EGPA 本拉珠单抗治疗 EGPA 的疗效不劣于麦泊珠单抗

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2024-04-09 DOI: 10.1038/s41584-024-01116-6

Sarah Onuora

引用次数: 0

Author Correction: Therapeutic potential in rheumatic diseases of extracellular vesicles derived from mesenchymal stromal cells 作者更正：源自间充质基质细胞的细胞外囊泡对风湿病的治疗潜力。

IF 33.7 1区医学

Nature Reviews Rheumatology Pub Date : 2024-04-05 DOI: 10.1038/s41584-024-01114-8

Giuliana Minani Bertolino, Marie Maumus, Christian Jorgensen, Danièle Noël