Nature Reviews Rheumatology最新文献_第8页

Profiling synovial tissue reveals OA subgroups 滑膜组织分析显示OA亚群

IF 32.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-03-26 DOI: 10.1038/s41584-025-01241-w

Sarah Onuora

引用次数: 0

Z-DNA as an inflammatory trigger in lupus Z-DNA是狼疮的炎症诱因

IF 32.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-03-26 DOI: 10.1038/s41584-025-01243-8

Maria Papatriantafyllou

引用次数: 0

Imaging inflammation with leukocyte-targeted PET tracers 用白细胞靶向PET示踪剂成像炎症

IF 32.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-03-26 DOI: 10.1038/s41584-025-01239-4

Filippo Fagni

引用次数: 0

Oestrogens implicated in progression to arthritis 雌激素与关节炎的发展有关

IF 32.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-03-25 DOI: 10.1038/s41584-025-01242-9

Sarah Onuora

引用次数: 0

Pentose phosphate pathway metabolite restores T cell balance in SLE 戊糖磷酸途径代谢物恢复SLE中的T细胞平衡

IF 32.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-03-24 DOI: 10.1038/s41584-025-01238-5

Maria Papatriantafyllou

引用次数: 0

The role of the immune system in osteoarthritis: mechanisms, challenges and future directions 免疫系统在骨关节炎中的作用：机制、挑战和未来方向

IF 29.4 1区医学

Nature Reviews Rheumatology Pub Date : 2025-03-13 DOI: 10.1038/s41584-025-01223-y

David Moulin, Jérémie Sellam, Francis Berenbaum, Jérôme Guicheux, Marie-Astrid Boutet

{"title":"The role of the immune system in osteoarthritis: mechanisms, challenges and future directions","authors":"David Moulin, Jérémie Sellam, Francis Berenbaum, Jérôme Guicheux, Marie-Astrid Boutet","doi":"10.1038/s41584-025-01223-y","DOIUrl":"10.1038/s41584-025-01223-y","url":null,"abstract":"Osteoarthritis (OA) is a chronic joint disease that has long been considered a simple wear-and-tear condition. Over the past decade, research has revealed that various inflammatory features of OA, such as low-grade peripheral inflammation and synovitis, contribute substantially to the pathophysiology of the disease. Technological advances in the past 5 years have revealed a large diversity of innate and adaptive immune cells in the joints, particularly in the synovium and infrapatellar fat pad. Notably, the presence of synovial lymphoid structures, circulating autoantibodies and alterations in memory T cell and B cell populations have been documented in OA. These data indicate a potential contribution of self-reactivity to the disease pathogenesis, blurring the often narrow and inaccurate line between chronic inflammatory and autoimmune diseases. The diverse immune changes associated with OA pathogenesis can vary across disease phenotypes, and a better characterization of their underlying molecular endotypes will be key to stratifying patients, designing novel therapeutic approaches and ultimately ameliorating treatment allocation. Furthermore, examining both articular and systemic alterations, including changes in the gut–joint axis and microbial dysbiosis, could open up novel avenues for OA management. This Review provides an update on the role of innate and adaptive immune cells in the pathogenesis of osteoarthritis. The authors discuss emerging therapeutics that target the immune system in osteoarthritis and the challenges that limit the movement towards personalized medicine.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"21 4","pages":"221-236"},"PeriodicalIF":29.4,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143608050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treating inflammatory arthritis in individuals with concomitant cancer 治疗伴有癌症的炎症性关节炎

IF 32.7 1区医学

Nature Reviews Rheumatology Pub Date : 2025-03-13 DOI: 10.1038/s41584-025-01235-8

Maria E. Suarez-Almazor

引用次数: 0

Delineating inflammatory from non-inflammatory mechanisms for therapy optimization in psoriatic arthritis 描述炎症和非炎症机制对银屑病关节炎的治疗优化

IF 29.4 1区医学

Nature Reviews Rheumatology Pub Date : 2025-03-12 DOI: 10.1038/s41584-025-01229-6

Alen Zabotti, Sibel Zehra Aydin, Paula David, Andrea Di Matteo, Dennis McGonagle

{"title":"Delineating inflammatory from non-inflammatory mechanisms for therapy optimization in psoriatic arthritis","authors":"Alen Zabotti, Sibel Zehra Aydin, Paula David, Andrea Di Matteo, Dennis McGonagle","doi":"10.1038/s41584-025-01229-6","DOIUrl":"10.1038/s41584-025-01229-6","url":null,"abstract":"Psoriatic arthritis (PsA) is anatomically much more heterogeneous than rheumatoid arthritis, as, beyond synovitis, it often also involves enthesitis, peritendinitis, tenosynovitis, osteitis and periostitis. This heterogeneity currently precludes a gold standard for objectively defining resolution of inflammation following treatment, with enthesitis posing a particular challenge. Despite these difficulties, we apply lessons learned from rheumatoid arthritis to describe how patients with PsA and an inadequate response to therapy can be designated within two patient subgroups, characterized by persistent inflammatory PsA (PIPsA) and non-inflammatory PsA (NIPsA), respectively. The NIPsA phenotype is defined by the lack of ongoing joint inflammation, as confirmed through clinical assessment and imaging, along with normalized inflammatory marker levels. NIPsA might be associated with obesity, biomechanical-related pain, osteoarthritis, fibromyalgia, secondary post-inflammatory damage and central pain mechanisms. In this article, we frame PsA composite outcomes measures in relationship to the PIPsA and NIPsA phenotypes and propose that this approach might help to minimize unnecessary or ineffective cycling of PsA therapy in patients who acquire dominant non-inflammatory mechanisms and might also inform future trial design. In this Perspective, the authors propose that patients with psoriatic arthritis and an inadequate response to therapy can be classified into two distinct subgroups, characterized by persistent inflammatory and non-inflammatory phenotypes, and discuss potential mechanisms underlying these phenotypes, as well as considerations for treatment strategies and trial design.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"21 4","pages":"237-248"},"PeriodicalIF":29.4,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hyperuricaemia and gout in the Pacific 太平洋地区的高尿酸血症和痛风

IF 29.4 1区医学

Nature Reviews Rheumatology Pub Date : 2025-03-11 DOI: 10.1038/s41584-025-01228-7

Baptiste Gérard, Megan Leask, Tony R. Merriman, Thomas Bardin, Erwan Oehler, Aniva Lawrence, Satupaitea Viali, Samuela ‘Ofanoa, Leanne Te Karu, Lisa K. Stamp, Nicola Dalbeth, Tristan Pascart

{"title":"Hyperuricaemia and gout in the Pacific","authors":"Baptiste Gérard, Megan Leask, Tony R. Merriman, Thomas Bardin, Erwan Oehler, Aniva Lawrence, Satupaitea Viali, Samuela ‘Ofanoa, Leanne Te Karu, Lisa K. Stamp, Nicola Dalbeth, Tristan Pascart","doi":"10.1038/s41584-025-01228-7","DOIUrl":"10.1038/s41584-025-01228-7","url":null,"abstract":"Gout is the most common form of inflammatory arthritis in adults worldwide. There has been a steady increase in prevalence, which varies across different geographic areas and is high in the Indigenous (First Nations) peoples of the Pacific region. Palaeo-archaeological studies demonstrate that gout was present in the Pacific region prior to European colonization, which is suggestive of genetic predisposition. Genetic risk factors, including population-specific genetic variants and genetic variants shared across populations, particularly those influencing urate transporters, have been identified in Indigenous peoples of the Pacific that partly explain the earlier age of onset of gout. Indigenous peoples of the Pacific experience severe gout, with frequent flares, high hospitalization rates and tophaceous gout, all aggravated by socio-cultural factors. Despite a specific need for effective gout management, Indigenous peoples of the Pacific are under-represented in gout research and inequities in care continue. Indigenous peoples-led, holistic gout management programmes are systematically and urgently required in this region, where gout is a major public health issue. Importantly, a foundation of cultural safety is necessary to underpin such programmes. In this Review, the authors provide an overview of gout and hyperuricaemia in Indigenous peoples of the Pacific region, including discussion of genetic, clinical and cultural aspects and how to address the inequitable health outcomes and suboptimal gout management in these populations.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"21 4","pages":"197-210"},"PeriodicalIF":29.4,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143589927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obinutuzumab effective for lupus nephritis Obinutuzumab对狼疮性肾炎有效

IF 29.4 1区医学

Nature Reviews Rheumatology Pub Date : 2025-03-07 DOI: 10.1038/s41584-025-01237-6

Sarah Onuora

引用次数: 0