Nature Reviews Rheumatology最新文献

{"title":"Stem and progenitor cells in the synovial joint as targets for regenerative therapy","authors":"Anke J. Roelofs, Jessica J. McClure, Elizabeth A. Hay, Cosimo De Bari","doi":"10.1038/s41584-025-01222-z","DOIUrl":"10.1038/s41584-025-01222-z","url":null,"abstract":"Damage to articular cartilage, tendons, ligaments and entheses as a result of trauma, degeneration or inflammation in rheumatic diseases is prevalent. Regenerative medicine offers promising strategies for repairing damaged tissues, with the aim of restoring both their structure and function. While these strategies have traditionally relied on tissue engineering approaches using exogenous cells, interventions based on the activation of endogenous repair mechanisms are an attractive alternative. Key to advancing such approaches is a comprehensive understanding of the diversity of the stem and progenitor cells that reside in the adult synovial joint and how they function to repair damaged tissues. Advances in developmental biology have provided a lens through which to understand the origins, identities and functions of these cells, and insights into the roles of stem and progenitor cells in joint tissue repair, as well as their complex relationship with fibroblasts, have emerged. Integration of knowledge obtained through studies using advanced single-cell technologies will be crucial to establishing unified models of cell populations, lineage hierarchies and their molecular regulation. Ultimately, a more complete understanding of how cells repair tissues in adult life will guide the development of innovative pro-regenerative drugs, which are poised to enter clinical practice in musculoskeletal medicine. Stem and progenitor cells that contribute to tissue repair reside within various niches in the synovial joints of adult mammals. Understanding of the origins, identities and functions of these cells will guide the development of pro-regenerative therapeutic strategies.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"21 4","pages":"211-220"},"PeriodicalIF":29.4,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Joint location matters for TNF inhibitor treatment in PsA","authors":"Holly Webster","doi":"10.1038/s41584-025-01233-w","DOIUrl":"10.1038/s41584-025-01233-w","url":null,"abstract":"Findings show that the resolution of joint swelling in response to treatment with TNF inhibitors varies depending on the location of the joint in psoriatic arthritis.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"21 4","pages":"193-193"},"PeriodicalIF":29.4,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Publisher Correction: An international perspective on the future of systemic sclerosis research","authors":"David J. Abraham, Carol M. Black, Christopher P. Denton, Jörg H. W. Distler, Robyn Domsic, Carol Feghali-Bostwick, Pravitt Gourh, Monique Hinchcliff, Fred Kolling IV, Masataka Kuwana, Robert Lafyatis, Ulf Landegren, J. Matthew Mahoney, Javier Martin, Marco Matucci-Cerinic, Zsuzsanna H. McMahan, Ana L. Mora, Luc Mouthon, Marlene Rabinovitch, Mauricio Rojas, Kristofer Rubin, Maria Trojanowska, John Varga, Michael L. Whitfield, Armando Gabrielli, Thomas Krieg","doi":"10.1038/s41584-025-01231-y","DOIUrl":"10.1038/s41584-025-01231-y","url":null,"abstract":"","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"21 4","pages":"249-249"},"PeriodicalIF":29.4,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41584-025-01231-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting T cell-activating NETs in uveitis","authors":"Maria Papatriantafyllou","doi":"10.1038/s41584-025-01230-z","DOIUrl":"10.1038/s41584-025-01230-z","url":null,"abstract":"Neutrophil extracellular traps might promote intraocular infiltration of effector CD4+ T cells by inducing endothelial cell senescence in autoimmune uveitis.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"21 4","pages":"191-191"},"PeriodicalIF":29.4,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TASL has a key role in SLE","authors":"Holly Webster","doi":"10.1038/s41584-025-01232-x","DOIUrl":"10.1038/s41584-025-01232-x","url":null,"abstract":"Two studies provide insights into the function of TASL in the pathogenesis of systemic lupus erythematosus and highlight the therapeutic potential of targeting this protein.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"21 4","pages":"192-192"},"PeriodicalIF":29.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143526271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macrophages hit a nerve in painful joint venture","authors":"Oumaima Ben Brahim, Stefan Uderhardt","doi":"10.1038/s41584-025-01227-8","DOIUrl":"10.1038/s41584-025-01227-8","url":null,"abstract":"Hasegawa et al. reveal how synovial joints detect systemic inflammation through specialized fenestrated blood vessels at the synovial periphery. Three distinct macrophage populations and nociceptor neurons form a sentinel unit around these vessels, coordinating immune responses and pain signalling through interleukin-1β (IL-1β) and calcitonin gene-related peptide (CGRP) signalling.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"21 5","pages":"257-258"},"PeriodicalIF":32.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards better management of sterile bone inflammation","authors":"Jürgen Braun","doi":"10.1038/s41584-025-01226-9","DOIUrl":"10.1038/s41584-025-01226-9","url":null,"abstract":"The first expert consensus recommendations for the treatment and diagnosis of adult sterile bone inflammation have been developed, in which the term ‘chronic non-bacterial osteitis’ is proposed as a disease definition. Will these recommendations pave the way for better diagnosis, management and treatment of this rare disease?","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"21 4","pages":"195-196"},"PeriodicalIF":29.4,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Connecting the structure and function of cartilage using spatial omics","authors":"Indira Prasadam, Xiwei Fan","doi":"10.1038/s41584-025-01225-w","DOIUrl":"10.1038/s41584-025-01225-w","url":null,"abstract":"Advances in spatial omics, such as transcriptomics and proteomics, have provided vital insights into cartilage microenvironments, revealing cellular diversity, zonal organization and links between cartilage structure and function. Analysing cartilage using spatial omics could deepen the understanding of diseases such as osteoarthritis and guide the development of targeted, disease-modifying therapies.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"21 4","pages":"189-190"},"PeriodicalIF":29.4,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143417254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An international perspective on the future of systemic sclerosis research","authors":"David J. Abraham, Carol M. Black, Christopher P. Denton, Jörg H. W. Distler, Robyn Domsic, Carol Feghali-Bostwick, Pravitt Gourh, Monique Hinchcliff, Fred Kolling IV, Masataka Kuwana, Robert Lafyatis, Ulf Landegren, J. Matthew Mahoney, Javier Martin, Marco Matucci-Cerinic, Zsuzsanna H. McMahan, Ana L. Mora, Luc Mouthon, Marlene Rabinovitch, Mauricio Rojas, Kristofer Rubin, Maria Trojanowska, John Varga, Michael L. Whitfield, Armando Gabrielli, Thomas Krieg","doi":"10.1038/s41584-024-01217-2","DOIUrl":"10.1038/s41584-024-01217-2","url":null,"abstract":"Systemic sclerosis (SSc) remains a challenging and enigmatic systemic autoimmune disease, owing to its complex pathogenesis, clinical and molecular heterogeneity, and the lack of effective disease-modifying treatments. Despite a century of research in SSc, the interconnections among microvascular dysfunction, autoimmune phenomena and tissue fibrosis in SSc remain unclear. The absence of validated biomarkers and reliable animal models complicates diagnosis and treatment, contributing to high morbidity and mortality. Advances in the past 5 years, such as single-cell RNA sequencing, next-generation sequencing, spatial biology, transcriptomics, genomics, proteomics, metabolomics, microbiome profiling and artificial intelligence, offer new avenues for identifying the early pathogenetic events that, once treated, could change the clinical history of SSc. Collaborative global efforts to integrate these approaches are crucial to developing a comprehensive, mechanistic understanding and enabling personalized therapies. Challenges include disease classification, clinical heterogeneity and the establishment of robust biomarkers for disease activity and progression. Innovative clinical trial designs and patient-centred approaches are essential for developing effective treatments. Emerging therapies, including cell-based and fibroblast-targeting treatments, show promise. Global cooperation, standardized protocols and interdisciplinary research are vital for advancing SSc research and improving patient outcomes. The integration of advanced research techniques holds the potential for important breakthroughs in the diagnosis, treatment and care of individuals with SSc. The diagnosis, treatment and management of systemic sclerosis (SSc) remains challenging, owing to the complexity of this disease. In this Perspective, an international group of experts discuss the future of SSc research and how the advent of innovative technologies will advance research into and understanding of SSc.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"21 3","pages":"174-187"},"PeriodicalIF":29.4,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143418361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A direct link between SARS-CoV-2 and bone loss","authors":"Sarah Onuora","doi":"10.1038/s41584-025-01224-x","DOIUrl":"10.1038/s41584-025-01224-x","url":null,"abstract":"Research demonstrates that the SARS-CoV-2 protein ORF8 drives osteoclastogenesis, establishing a direct link between viral infection and bone loss.","PeriodicalId":18810,"journal":{"name":"Nature Reviews Rheumatology","volume":"21 3","pages":"128-128"},"PeriodicalIF":29.4,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}