Z-DNA是狼疮的炎症诱因

IF 29.4 1区医学 Q1 RHEUMATOLOGY

Nature Reviews Rheumatology Pub Date : 2025-03-26 DOI:10.1038/s41584-025-01243-8

Maria Papatriantafyllou

引用次数: 0

摘要

紫外线诱导的角质形成细胞线粒体损伤导致Z-DNA的积累，使I型干扰素反应在皮肤狼疮中持续存在。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Z-DNA as an inflammatory trigger in lupus

Ultraviolet light-induced mitochondrial damage in keratinocytes leads to accumulation of Z-DNA, perpetuating type I interferon responses in cutaneous lupus.

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来源期刊

Nature Reviews Rheumatology 医学-风湿病学

CiteScore

29.90

自引率

0.90%

发文量

137

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Rheumatology is part of the Nature Reviews portfolio of journals. The journal scope covers the entire spectrum of rheumatology research. We ensure that our articles are accessible to the widest possible audience.