Targeting osteoarthritis where it hurts: the osteochondral junction

IF 29.4 1区医学 Q1 RHEUMATOLOGY

Nature Reviews Rheumatology Pub Date : 2025-04-22 DOI:10.1038/s41584-025-01257-2

Anne-Marie Malfait, Alia M. Obeidat

引用次数: 0

Abstract

In joints with osteoarthritis, angiogenesis and neuronal growth occur at the osteochondral junction, a process that can contribute to structural joint damage and pain. Targeting this neurovascularization process represents a possible strategy for the development of disease-modifying drugs for osteoarthritis.

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针对骨关节炎的痛处，骨软骨连接处

在患有骨关节炎的关节中，骨软骨交界处会出现血管生成和神经元生长，这一过程会导致关节结构性损伤和疼痛。以这种神经血管化过程为靶点是开发骨关节炎疾病调节药物的一种可能策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Rheumatology 医学-风湿病学

CiteScore

29.90

自引率

0.90%

发文量

137

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Rheumatology is part of the Nature Reviews portfolio of journals. The journal scope covers the entire spectrum of rheumatology research. We ensure that our articles are accessible to the widest possible audience.