Fumarate drives interferon release in systemic sclerosis monocytes

IF 29.4 1区医学 Q1 RHEUMATOLOGY

Nature Reviews Rheumatology Pub Date : 2025-04-16 DOI:10.1038/s41584-025-01261-6

Sarah Onuora

引用次数: 0

Abstract

Altered metabolism of the tricarboxylic acid cycle metabolite fumarate drives activation of interferon release in systemic sclerosis monocytes, suggesting a potential therapeutic approach.

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富马酸盐驱动系统性硬化症单核细胞释放干扰素

三羧酸循环代谢物富马酸酯代谢的改变驱动干扰素释放在系统性硬化症单核细胞的激活，提示一个潜在的治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Rheumatology 医学-风湿病学

CiteScore

29.90

自引率

0.90%

发文量

137

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Rheumatology is part of the Nature Reviews portfolio of journals. The journal scope covers the entire spectrum of rheumatology research. We ensure that our articles are accessible to the widest possible audience.