JAK抑制剂如何改变类风湿关节炎的血栓形成平衡

IF 29.4 1区医学 Q1 RHEUMATOLOGY

Nature Reviews Rheumatology Pub Date : 2025-05-16 DOI:10.1038/s41584-025-01263-4

Vibeke Strand

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引用次数: 0

摘要

深静脉血栓形成和肺栓塞发生率的增加在类风湿关节炎中早已被注意到，并被归因于慢性炎症和疾病活动的影响，以及特定的生物dmard和JAK抑制剂。在ACR Open Rheumatology上，Zavoriti和Miossec的报告提供了可能解释JAK抑制剂tofacitinib的血栓前作用的数据。

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How JAK inhibitors tip the prothrombotic balance in rheumatoid arthritis

The increased incidence of deep vein thromboses and pulmonary emboli has long been noted in rheumatoid arthritis and has been ascribed to the effects of chronic inflammation and disease activity, as well as to specific biologic DMARDs and JAK inhibitors. Reporting in ACR Open Rheumatology, Zavoriti and Miossec provide data that might explain the prothrombotic effects of the JAK inhibitor tofacitinib.

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来源期刊

Nature Reviews Rheumatology 医学-风湿病学

CiteScore

29.90

自引率

0.90%

发文量

137

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Rheumatology is part of the Nature Reviews portfolio of journals. The journal scope covers the entire spectrum of rheumatology research. We ensure that our articles are accessible to the widest possible audience.