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Predicting the dissolution of metal-based nanoparticles by means of QSPRs and the effect of data augmentation 利用QSPRs预测金属基纳米颗粒的溶解及数据增强效应
IF 4.7 3区 环境科学与生态学
NanoImpact Pub Date : 2025-01-01 DOI: 10.1016/j.impact.2025.100547
Yuchao Song , Surendra Balraadjsing , Willie J.G.M. Peijnenburg , Martina G. Vijver
{"title":"Predicting the dissolution of metal-based nanoparticles by means of QSPRs and the effect of data augmentation","authors":"Yuchao Song ,&nbsp;Surendra Balraadjsing ,&nbsp;Willie J.G.M. Peijnenburg ,&nbsp;Martina G. Vijver","doi":"10.1016/j.impact.2025.100547","DOIUrl":"10.1016/j.impact.2025.100547","url":null,"abstract":"<div><div>Particle dissolution is a critical process in the environmental fate assessment of metal-based nanoparticles (MNPs). Numerous attempts have been made previously to adequately quantify dissolution (kinetics), however, existing dissolution data and models are generally limited to a few nanomaterials or specific time points. Hence, they only capture phases of the process. This study aimed to develop a Quantitative Structure-Property Relationship (QSPR) model to predict the ion release (in %) of MNPs for different time points and water chemistry conditions. Furthermore, many machine learning models are frequently plagued by a lack of data and recently data augmentation has been suggested as a method to mitigate this issue. Therefore, we also investigated the effects of data augmentation on QSPRs. Following data collection from literature, QSPR models were generated and results indicate models with adequate performance (R<sup>2</sup> &gt; 0.7). Results also demonstrated significant improvements in model performance with increasing amounts of applied data augmentation. However, a deeper evaluation of the results also highlighted that data augmentation can lead to misleading and overoptimistic model evaluation. Thus, proper model assessment is necessary when evaluating QSPRs. Variable importance analysis results revealed that the “initial concentration” and features related to the size and shape of MNPs were the most critical factors in the dissolution process. The predictive models generated here for MNP dissolution can improve nanomaterial testing efficiency and guide experimental design.</div></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":"37 ","pages":"Article 100547"},"PeriodicalIF":4.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143378928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nano-sized polystyrene plastics toxicity: Necroptosis pathway caused by autophagy blockade and lysosomal dysfunction 纳米聚苯乙烯塑料毒性:自噬阻断和溶酶体功能障碍引起的坏死坏死途径。
IF 4.7 3区 环境科学与生态学
NanoImpact Pub Date : 2025-01-01 DOI: 10.1016/j.impact.2024.100537
Haiyan Wu , Runqiu Cai , Chaoyu Zhou , Yifei Yang , Xinyuan Tian , Zhongling Zhao , Qianyu Bai , Xuejiao Qiu , Qingyi Song , Lei Zhang , Huihui Bao , Tianlong Liu
{"title":"Nano-sized polystyrene plastics toxicity: Necroptosis pathway caused by autophagy blockade and lysosomal dysfunction","authors":"Haiyan Wu ,&nbsp;Runqiu Cai ,&nbsp;Chaoyu Zhou ,&nbsp;Yifei Yang ,&nbsp;Xinyuan Tian ,&nbsp;Zhongling Zhao ,&nbsp;Qianyu Bai ,&nbsp;Xuejiao Qiu ,&nbsp;Qingyi Song ,&nbsp;Lei Zhang ,&nbsp;Huihui Bao ,&nbsp;Tianlong Liu","doi":"10.1016/j.impact.2024.100537","DOIUrl":"10.1016/j.impact.2024.100537","url":null,"abstract":"<div><div>The persistent detection of nano-sized plastic particles in humans, animals, and animal-derived products underscores the potential impact of these particles on living organisms. Consequently, the toxicology of such particles has emerged as a pivotal research interests in recent years. In this study, NP was synthesized successfully with an average particle size of 100 nm using a emulsion polymerization method as model particles. Following co-incubation of IEC-6 cells with NP for 24–168 h, a notable inhibition of cell viability and proliferation was observed. The significant activation of autophagy and a concomitant blockage of autophagic flux in IEC-6 cells after 24–72 h of co-incubation with NP were unveiled by transmission electron microscopy, western blotting, and double-fluorescent autophagy analysis. A significant increase in the number of lysosomes and an increase in the expression of hydrolase CTSB were detected, indicating dysregulation of lysosomal function. The subsequent transcriptomic and metabolomics analyses, coupled with the observation of activated lysosomes and the RIPK1-RIPK3-MLKL/PYGL pathway, led us to posit that the blockade of autophagy and lysosomal dysfunction, culminating in lysosomal membrane permeabilization (LMP) induced necroptosis, constitutes one of the mechanisms contributing to the cytotoxicity of NP.</div></div><div><h3>Synopsis</h3><div>The cytotoxicity and its related mechanisms of nano-plastic is still unclear. This study found that nano-plastics may induce necroptosis in cells, and autophagy blockade and lysosomal dysfunction are prodromal manifestations.</div></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":"37 ","pages":"Article 100537"},"PeriodicalIF":4.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The risk of short-term microplastic exposure on female reproductive function: A rat model study 短期微塑料暴露对雌性生殖功能的影响:大鼠模型研究。
IF 4.7 3区 环境科学与生态学
NanoImpact Pub Date : 2025-01-01 DOI: 10.1016/j.impact.2025.100545
Zihan Wang , Ruiqing Zhang , Yuanzhen Zhang , Yao Xiong , Ming Zhang
{"title":"The risk of short-term microplastic exposure on female reproductive function: A rat model study","authors":"Zihan Wang ,&nbsp;Ruiqing Zhang ,&nbsp;Yuanzhen Zhang ,&nbsp;Yao Xiong ,&nbsp;Ming Zhang","doi":"10.1016/j.impact.2025.100545","DOIUrl":"10.1016/j.impact.2025.100545","url":null,"abstract":"<div><div>Long-term effects of microplastics (MPs) exposure have been demonstrated to impair reproductive function. However, in real world, the exposure level of MP is not constant and it may vary in different individuals. This study aims to evaluate the impact of short-term exposure to MPs on ovarian and endometrial function in rat models. Serum steroid hormone concentrations and the expression of ovarian steroid hormone receptor were disturbed. We found that as MPs exposure concentration increased, thickness of the endometrial glandular epithelial layer and the number of endometrial glands decreased; the number of primordial follicles decreased, while the numbers of primary and secondary oocytes significantly increased, indicating a potential oocyte overactivation. Although short-term MP exposure appears to not influence embryo implantation and hormone functions, the results of this study highlight the potential of MPs to disrupt reproductive health in women.</div></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":"37 ","pages":"Article 100545"},"PeriodicalIF":4.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143040296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Absolute quantitative lipidomics reveals the disturbance of lipid metabolism induced by oral exposure of titanium dioxide nanoparticles 绝对定量脂质组学揭示了口服二氧化钛纳米颗粒引起的脂质代谢紊乱。
IF 4.7 3区 环境科学与生态学
NanoImpact Pub Date : 2025-01-01 DOI: 10.1016/j.impact.2025.100554
Nairui Yu , Jiaqi Shi , Ying Ma , Yi Zhang , Li Guan , Zhangjian Chen , Guang Jia
{"title":"Absolute quantitative lipidomics reveals the disturbance of lipid metabolism induced by oral exposure of titanium dioxide nanoparticles","authors":"Nairui Yu ,&nbsp;Jiaqi Shi ,&nbsp;Ying Ma ,&nbsp;Yi Zhang ,&nbsp;Li Guan ,&nbsp;Zhangjian Chen ,&nbsp;Guang Jia","doi":"10.1016/j.impact.2025.100554","DOIUrl":"10.1016/j.impact.2025.100554","url":null,"abstract":"<div><div>The widespread use of titanium dioxide nanoparticles (TiO<sub>2</sub> NPs) as a white pigment in consumer goods increases the possibility of its release into the environment, which poses a great health risk to human beings. Many studies have proved the liver damage caused by TiO<sub>2</sub> NPs, but the research about the potential effects of TiO<sub>2</sub> NPs on liver lipid metabolism has been limited. Therefore, we selected Sprague-Dawley (SD) rats to explore the effects of long-term exposure to TiO<sub>2</sub> NPs on lipid metabolism. Rats were exposed to TiO<sub>2</sub> NPs at 0, 2, 10, 50 mg/kg body weight daily for 90 consecutive days. Subsequently, absolute quantitative lipidomics was used to ascertain variation of differential lipid metabolites in rat liver and serum. The results showed that TiO<sub>2</sub> NPs (50 mg/kg) changed 22 lipid metabolites such as DAG (18:2/20:5) and TAG (58:10/FA18:2) in rat liver. In the serum, the alteration of 119 lipid metabolites such as DAG (18:0/18:2) were more significant. There was a significant correlation between the different lipid metabolites in liver and serum. At the same time, it was observed that the relative expression levels of oxidative stress-related genes <em>Nrf-2</em> and <em>Ho-1</em> changed significantly, and they were closely related to differential metabolites. In conclusion, oral exposure of TiO<sub>2</sub> NPs has changed the lipid metabolomics of liver and serum, and the strong induction of oxidative stress may be related to it. TAG and DAG are key metabolites and metabolic pathways in two distinct biological samples, serving as potential indicators of liver injury to a certain extent.</div></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":"37 ","pages":"Article 100554"},"PeriodicalIF":4.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gastrointestinal dysfunction as the main performance of the oral toxicity of titanium dioxide nanoparticle on gastric ulcer rats 胃肠功能紊乱是纳米二氧化钛颗粒对胃溃疡大鼠口服毒性的主要表现。
IF 4.7 3区 环境科学与生态学
NanoImpact Pub Date : 2025-01-01 DOI: 10.1016/j.impact.2025.100551
Yun Wang , Chen Li , Te Ba , Shengyuan Wang , Langzhi He , Zhangjian Chen , Ji Pu , Xiaoxing Cui , Guang Jia
{"title":"Gastrointestinal dysfunction as the main performance of the oral toxicity of titanium dioxide nanoparticle on gastric ulcer rats","authors":"Yun Wang ,&nbsp;Chen Li ,&nbsp;Te Ba ,&nbsp;Shengyuan Wang ,&nbsp;Langzhi He ,&nbsp;Zhangjian Chen ,&nbsp;Ji Pu ,&nbsp;Xiaoxing Cui ,&nbsp;Guang Jia","doi":"10.1016/j.impact.2025.100551","DOIUrl":"10.1016/j.impact.2025.100551","url":null,"abstract":"<div><div>Titanium dioxide nanoparticles (TiO<sub>2</sub> NPs) have promising applications in food additives and pharmaceutical dressings, raising concerns about their oral safety. The current studies mainly focus on healthy groups, and the effect of TiO<sub>2</sub> NPs on the patient population is rarely known. Here, a comprehensive toxicity study of TiO<sub>2</sub> NPs (75 ± 15 nm, anatase) in gastric ulcer rats <em>(</em>male 8-week old <em>Sprague-Dawley</em> rats) is reported following oral exposure at dose of 0, 10, 50, 200 mg/kg body weight per day for 30 days. The gastric ulcer rats were produced by submucosal injection of acetic acid solution into the rat stomach. The healthy rats were used as the normal control. We evaluated nanoparticle biodistribution, systemic toxicity, and gastrointestinal function indices in the rats. Our findings indicate that oral administration of TiO<sub>2</sub> NPs resulted in minimal intestinal absorption and transport with limited systemic organ toxicity. The internalization of TiO<sub>2</sub> NPs and activation of mast cells in the stomach tissues, along with the low serum levels of histamine and IgE, suggest a localized allergic reaction rather than a systemic one. Furthermore, the notably reduced plasma levels of D-lactate and the activity of diamine oxidase (DAO) indicated the upregulation of intestinal barrier function. These statistically significant results indicated that gastrointestinal dysfunction was the main performance of the oral toxicity of TiO<sub>2</sub> NPs on gastric ulcer rats, emphasizing the importance of controlling the intake of TiO<sub>2</sub> NPs in patients with gastric ulcers.</div></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":"37 ","pages":"Article 100551"},"PeriodicalIF":4.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mixtures of polystyrene micro and nanoplastics affects fat and glucose metabolism in 3T3-L1 adipocytes and zebrafish larvae 聚苯乙烯微塑料和纳米塑料的混合物影响3T3-L1脂肪细胞和斑马鱼幼虫的脂肪和葡萄糖代谢。
IF 4.7 3区 环境科学与生态学
NanoImpact Pub Date : 2025-01-01 DOI: 10.1016/j.impact.2025.100549
Jung Eun Kim , Narayan Sah Sonar , Laxmi Sen Thakuri , Jin Woo Park , Ki-Tae Kim , Dong Young Rhyu
{"title":"Mixtures of polystyrene micro and nanoplastics affects fat and glucose metabolism in 3T3-L1 adipocytes and zebrafish larvae","authors":"Jung Eun Kim ,&nbsp;Narayan Sah Sonar ,&nbsp;Laxmi Sen Thakuri ,&nbsp;Jin Woo Park ,&nbsp;Ki-Tae Kim ,&nbsp;Dong Young Rhyu","doi":"10.1016/j.impact.2025.100549","DOIUrl":"10.1016/j.impact.2025.100549","url":null,"abstract":"<div><div>Microplastics (MPs) and nanoplastics (NPs) are pervasive pollutants that pose a hazard to human health. Although most previous studies have investigated the effects of MPs and NPs on digestion, oxidative stress, and inflammation in diverse models, the combined effect of plastic mixtures (PM) containing MPs and NPs on obesity and type 2 diabetes mellitus (T2DM) remains unknown. The hypothesis of our study is to verify the association between PM exposure and clinical features of metabolic diseases such as lipogenesis and insulin resistance. Therefore, we investigated the effects of PM on fat and glucose metabolism in 3T3-L1 cells and high-fat diet (HFD)-induced zebrafish larvae. PM exposure increased cell viability, differentiation, adipogenesis (<em>PPARγ</em> and <em>C/EBPα</em>), and lipogenesis (<em>FAS</em> and <em>SREBP-1c</em>), while it decreased glucose uptake and inhibited insulin signal (<em>IRS1</em>, <em>PI3K</em>, <em>AKT,</em> and <em>GLUT4</em>) expression 3T3-L1 cells. In zebrafish larvae, PM mainly bioaccumulated in the intestine and pancreatic tissue, reducing glucose uptake and increasing body weight and blood glucose compared to controls. Moreover, PM significantly increased adipogenic differentiation (<em>PPARγ</em>) and synthesis (<em>FASN</em> and <em>FABP</em>), proinflammatory cytokines (<em>TNF-α</em> and <em>IL-6</em>), and gluconeogenesis (<em>PCK1</em> and <em>G6Pase</em>). Conversely, energy and fat metabolism (<em>AMPKα</em> and <em>adiponectin</em>), insulin production (<em>INSα</em>), signaling pathway (<em>IRS1</em>, <em>AKT,</em> and <em>GLUT2</em>), and anti-inflammatory cytokines (<em>IL-10</em> and <em>IL-4</em>) were suppressed. Overall, this study sheds light on the mechanisms responsible for the detrimental effects of PM exposure on fat and glucose metabolism, providing insights into metabolic disorders, like type 2 diabetes, in both in vitro and in vivo models.</div></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":"37 ","pages":"Article 100549"},"PeriodicalIF":4.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolomics reveals the toxicity of polystyrene nanoplastics in the gills of Acrossocheilus yunnanensis 代谢组学揭示了聚苯乙烯纳米塑料在云南对虾鳃中的毒性
IF 4.7 3区 环境科学与生态学
NanoImpact Pub Date : 2025-01-01 DOI: 10.1016/j.impact.2025.100552
Qianqian Xiang , Ruisi Yang , Zexiang Hua , Peng Wang , Jilai Zhang , Wenyu Long , Xuexiu Chang
{"title":"Metabolomics reveals the toxicity of polystyrene nanoplastics in the gills of Acrossocheilus yunnanensis","authors":"Qianqian Xiang ,&nbsp;Ruisi Yang ,&nbsp;Zexiang Hua ,&nbsp;Peng Wang ,&nbsp;Jilai Zhang ,&nbsp;Wenyu Long ,&nbsp;Xuexiu Chang","doi":"10.1016/j.impact.2025.100552","DOIUrl":"10.1016/j.impact.2025.100552","url":null,"abstract":"<div><div>Although the ecotoxicity of polystyrene nanoplastics (PS-NP) to fish has been widely reported, their impact on the metabolic processes in fish gills and the underlying mechanisms remains unclear. Here, we investigated the effects of PS-NP on the morphology, oxidative stress, and metabolism of <em>Acrossocheilus yunnanensis</em> gills using conventional physicochemical indicators and metabolomics analysis. The results showed that PS-NP caused oxidative stress, and resulted in gill tissue lesions (e.g., proliferation and sloughing of gill epithelial cells). Metabolomics results showed that PS-NP exposure induced 75–164 differentially expressed metabolites (DEMs) in fish gills, and they were mainly related to lipid metabolism. DEMs induced by high concentration of PS-NP compared with low concentration of PS-NP were not only significantly enriched in glycerophospholipid metabolism, but also in sphingolipid metabolism, nucleic acid metabolism, and a variety of signaling pathways. In conclusion, the results of this work suggest that PS-NP cause disruption of phospholipid metabolism mainly by disrupting the integrity of gill tissue, which provides a new perspective for understanding the impact mechanism of PS-NP on fish gills. Given that fish play essential roles in maintaining ecological balance, the adverse effects of PS-NP on fish gills could ultimately disrupt the stability and health of the aquatic ecosystem.</div></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":"37 ","pages":"Article 100552"},"PeriodicalIF":4.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143480368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nano versus bulk: Evaluating the toxicity of lanthanum, yttrium, and cerium oxides on Enchytraeus crypticus 纳米与体积:评估镧、钇和铈氧化物对隐斑斑腹虫的毒性。
IF 4.7 3区 环境科学与生态学
NanoImpact Pub Date : 2025-01-01 DOI: 10.1016/j.impact.2024.100540
Joana Santos , Inês Neca , Ana Capitão , João Nogueira , José A.S. Santos , Edgar Pinto , Angela Barreto , Ana L. Daniel-da-Silva , Vera L. Maria
{"title":"Nano versus bulk: Evaluating the toxicity of lanthanum, yttrium, and cerium oxides on Enchytraeus crypticus","authors":"Joana Santos ,&nbsp;Inês Neca ,&nbsp;Ana Capitão ,&nbsp;João Nogueira ,&nbsp;José A.S. Santos ,&nbsp;Edgar Pinto ,&nbsp;Angela Barreto ,&nbsp;Ana L. Daniel-da-Silva ,&nbsp;Vera L. Maria","doi":"10.1016/j.impact.2024.100540","DOIUrl":"10.1016/j.impact.2024.100540","url":null,"abstract":"<div><div>Considering the increase in demand for rare earth elements (REEs) and their accumulation in soil ecosystems, it is crucial to understand their toxicity. However, the impact of lanthanum, yttrium and cerium oxides (La<sub>2</sub>O<sub>3</sub>, Y<sub>2</sub>O<sub>3</sub> and CeO<sub>2</sub>, respectively) on soil organisms remains insufficiently studied. This study aims to unravel the effects of La<sub>2</sub>O<sub>3</sub>, Y<sub>2</sub>O<sub>3</sub> and CeO<sub>2</sub> nanoparticles (NPs) and their corresponding bulk forms (0, 156, 313, 625, 1250 and 2500 mg/kg) on the terrestrial species <em>Enchytraeus crypticus</em>. The effects on survival, reproduction (21 days (d)), avoidance behavior (2 d) and DNA integrity (2 and 7 d) of <em>E. crypticus</em> were evaluated. No significant effects on survival were observed. For La<sub>2</sub>O<sub>3</sub>, the bulk form affected more endpoints than the NPs, inducing avoidance behavior (1250 mg/kg) and DNA damage (1250 mg/kg - 2 d; 2500 mg/kg - 7 d). The Y<sub>2</sub>O<sub>3</sub> NPs demonstrated higher toxicity than the bulk form: decreased reproduction (≥ 1250 mg/kg); induced avoidance behavior (≥ 625 mg/kg) and DNA damage (≥ 156 mg/kg - 2 d; 2500 mg/kg - 7 d). For CeO<sub>2</sub>, both forms exhibited similar toxicity, decreasing reproduction (625 mg/kg for bulk and 2500 mg/kg for NPs) and inducing DNA damage at all tested concentrations for both forms. REEs oxides toxicity was influenced by the REEs type and concentration, exposure time and material form, suggesting different modes of action. This study highlights the distinct responses of <em>E. crypticus</em> after exposure to REEs oxides and shows that REEs exposure may differently affect soil organisms, emphasizing the importance of risk assessment.</div></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":"37 ","pages":"Article 100540"},"PeriodicalIF":4.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bayesian network modelling for predicting the environmental hazard of silver nanomaterials in soils 土壤中银纳米材料环境危害的贝叶斯网络预测。
IF 4.7 3区 环境科学与生态学
NanoImpact Pub Date : 2025-01-01 DOI: 10.1016/j.impact.2025.100553
Irini Furxhi , Sarah Roberts , Richard Cross , Elise Morel , Anna Costa , Elma Lahive
{"title":"Bayesian network modelling for predicting the environmental hazard of silver nanomaterials in soils","authors":"Irini Furxhi ,&nbsp;Sarah Roberts ,&nbsp;Richard Cross ,&nbsp;Elise Morel ,&nbsp;Anna Costa ,&nbsp;Elma Lahive","doi":"10.1016/j.impact.2025.100553","DOIUrl":"10.1016/j.impact.2025.100553","url":null,"abstract":"<div><div>In alignment with the European Union's Green Deal, which directs safe and sustainable practices for all chemicals, including nanomaterials (NMs) and advanced materials (AdMa), this study addresses the environmental hazard of silver NMs to terrestrial ecosystems. In the context of safe and sustainable by design (SSbD) framework, there is a need for methodologies that integrate pHysicochemical characteristics and experimental conditions to reliably predict their hazards to exposed species. Bayesian Networks (BN) represent a pivotal machine-learning (ML) tool with the potential to accelerate the SSbD process by leveraging predictive capabilities. In this study, we employed BN models trained on a literature-derived dataset capturing the ecotoxicity of silver (Ag) NMs in soils, focusing on predicting chronic no-observed effect concentrations (chronic NOECs). The model incorporates physicochemical characteristics such as surface treatment, nominal particle diameter and particle shape as provided by manufacturers, species information such as life stage and taxonomic class, and exposure medium characteristics. The BN, refined through expert insights, achieved an average predictive accuracy of approximately 82 % across the output labels. The study also extracted interpretable rules from the BN, outlining environmental safety criteria and identified key factors influencing NM hazard for terrestrial organisms. The critical need for experimental datasets that provide fuller details of physiochemical characteristics and experimental conditions, as well as current limitations, are highlighted. This modelling approach facilitates the rapid screening of the potential hazards of AgNMs to terrestrial ecosystems, with the potential to accelerate safety evaluations and rationalise experimental demands.</div></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":"37 ","pages":"Article 100553"},"PeriodicalIF":4.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A catalytic perspective to nanomaterials reactivity-based toxicity; implications for single- and multiple-component nanomaterials (nanocomposites) 纳米材料反应毒性的催化研究对单组分和多组分纳米材料(纳米复合材料)的影响。
IF 4.7 3区 环境科学与生态学
NanoImpact Pub Date : 2025-01-01 DOI: 10.1016/j.impact.2025.100542
Miguel A. Bañares, Victor Alcolea-Rodriguez , Raquel Portela
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