NanoImpact最新文献

{"title":"Probabilistic material flow analysis of released nano titanium dioxide in Mexico","authors":"Luis Mauricio Ortiz-Galvez ,&nbsp;Alejandro Caballero-Guzman ,&nbsp;Carla Lopes ,&nbsp;Ernesto Alfaro-Moreno","doi":"10.1016/j.impact.2024.100516","DOIUrl":"10.1016/j.impact.2024.100516","url":null,"abstract":"<div><p>Engineered Nanomaterials (ENMs) or products containing ENMs, known as nano-enabled products are commercialized globally by a large number of companies. Concern about the potential risks and negative impacts of releasing ENMs into the environment is under investigation. For this reason, methodologies to estimate the probable mass concentrations of ENMs released in different regions of the world have been developed. As a first attempt to estimate the probable mass flows of nanosized titanium dioxide (nano-TiO₂) released in Mexico, we developed a Probabilistic Material Flow Analysis (PMFA) for 2015.</p><p>The model describes probabilistic mass flows of released nano-TiO₂ during the life cycle of sunscreens, coatings, ceramic, and other nano-enabled products, including the flows through the solid waste and wastewater management systems, as well as the transfer of nano-TiO₂ to three environmental compartments (atmosphere, topsoil, and surface water). The PMFA incorporates the uncertainty related to the input data. We observed that the most significant nano-TiO₂ flows occur to the surface water, landfill, and soil compartments, targeted as the main “hot-spots”, where living organisms could be more exposed to this material. Further improvements in the model are needed due to some data gaps at some life cycle stages, for instance, solid waste management and reused wastewater manipulation for irrigation purposes. Finally, the model developed in this study can be adjusted to assess other ENM releases and can be beneficial for further investigation in fate modeling and environmental risk assessment.</p></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":"35 ","pages":"Article 100516"},"PeriodicalIF":4.9,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141262208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Governance of advanced materials: Shaping a safe and sustainable future","authors":"Monique Groenewold ,&nbsp;Eric A.J. Bleeker ,&nbsp;Cornelle W. Noorlander ,&nbsp;Adriënne J.A.M. Sips ,&nbsp;Margriet van der Zee ,&nbsp;Robert J. Aitken ,&nbsp;James H. Baker ,&nbsp;Martine I. Bakker ,&nbsp;Evert A. Bouman ,&nbsp;Shareen H. Doak ,&nbsp;Damjana Drobne ,&nbsp;Verónica I. Dumit ,&nbsp;Marie-Valentine Florin ,&nbsp;Wouter Fransman ,&nbsp;Mar M. Gonzalez ,&nbsp;Elisabeth Heunisch ,&nbsp;Panagiotis Isigonis ,&nbsp;Nina Jeliazkova ,&nbsp;Keld Alstrup Jensen ,&nbsp;Thomas Kuhlbusch ,&nbsp;Janeck J. Scott-Fordsmand","doi":"10.1016/j.impact.2024.100513","DOIUrl":"10.1016/j.impact.2024.100513","url":null,"abstract":"<div><p>The past few decades of managing the uncertain risks associated with nanomaterials have provided valuable insights (knowledge gaps, tools, methods, etc.) that are equally important to promote safe and sustainable development and use of advanced materials. Based on these insights, the current paper proposes several actions to optimize the risk and sustainability governance of advanced materials.</p><p>We emphasise the importance of establishing a European approach for risk and sustainability governance of advanced materials as soon as possible to keep up with the pace of innovation and to manage uncertainty among regulators, industry, SMEs and the public, regarding potential risks and impacts of advanced materials. Coordination of safe and sustainable advanced material research efforts, and data management according to the Findable, Accessible, Interoperable and Reusable (FAIR) principles will enhance the generation of regulatory-relevant knowledge. This knowledge is crucial to identify whether current regulatory standardised and harmonised test methods are adequate to assess advanced materials. At the same time, there is urgent need for responsible innovation beyond regulatory compliance which can be promoted through the Safe and Sustainable Innovation Approach. that combines the Safe and Sustainable by Design concept with Regulatory Preparedness, supported by a trusted environment. We further recommend consolidating all efforts and networks related to the risk and sustainability governance of advanced materials in a single, easy-to-use digital portal.</p><p>Given the anticipated complexity and tremendous efforts required, we identified the need of establishing an organisational structure dedicated to aligning the fast technological developments in advanced materials with proper risk and sustainability governance. Involvement of multiple stakeholders in a trusted environment ensures a coordinated effort towards the safe and sustainable development, production, and use of advanced materials. The existing infrastructures and network of experts involved in the governance of nanomaterials would form a solid foundation for such an organisational structure.</p></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":"35 ","pages":"Article 100513"},"PeriodicalIF":4.9,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141184166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analytical methods for quantifying PS and PVC Nanoplastic attachment to activated sludge Bacteria and their impact on community structure","authors":"Fazel Abdolahpur Monikh ,&nbsp;Nhung H.A. Nguyen ,&nbsp;Mandar Bandekar ,&nbsp;Jakub Riha ,&nbsp;Sara Bogialli ,&nbsp;Paolo Pastore ,&nbsp;Hans-Peter Grossart ,&nbsp;Alena Sevcu","doi":"10.1016/j.impact.2024.100514","DOIUrl":"10.1016/j.impact.2024.100514","url":null,"abstract":"<div><p>Nanoplastics are anticipated to be ubiquitous in various environmental compartments. However, challenges in analytical methods hinder our understanding of risks related to specific nanplastics characteristics such as size and chemical compositions, and interactions between nanoplastics and microorganisms. In this study, we applied fit-for-purpose analytical methods and techniques to understand how nanoplastic chemical composition influences their interaction with bacteria collected from activated sludge. When exposed to polystyrene (PS) and polyvinyl chloride (PVC) nanoplastics for 5 days, the nanoplastics attached to the bacteria. Specifically, on day 1, there was a significant predominance of PS nanoplastics over PVC ones of similar size and shape, possibly due to differences in their chemical composition. After 5 days, there is a substantial decrease in nanoplastics attached to bacteria, suggesting bacterial defence mechanisms may reduce particles attachment over time. The overall bacterial community structure demonstrated a high degree of resilience. This resilience highlights the ability of microbial communities to maintain their structure despite nanoplastic stressors, as evidenced by consistent alpha diversity, PCoA, and PERMANOVA results. Understanding these mechanisms is crucial for assessing nanoplastic fate and thus environmental impacts.</p></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":"35 ","pages":"Article 100514"},"PeriodicalIF":4.9,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452074824000247/pdfft?md5=e2327df1c115cfa349a1366b2d6a9b3b&pid=1-s2.0-S2452074824000247-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141184162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"(Re)imagining purpose: A framework for sustainable nanotechnology innovation","authors":"Paris Jeffcoat ,&nbsp;Cary Di Lernia ,&nbsp;Catherine Hardy ,&nbsp;Elizabeth J. New ,&nbsp;Wojciech Chrzanowski","doi":"10.1016/j.impact.2024.100511","DOIUrl":"10.1016/j.impact.2024.100511","url":null,"abstract":"<div><p>To fully understand and predict the impact of nanotechnologies, a truly multidisciplinary approach is required. However, the practicalities relating to <em>how</em> innovation, commercialisation, risk assessment, informatics, and governance in nanotechnology should intersect remain somewhat of a black box. To begin to shed light on this intersection, we identify a need to place ‘purpose’ at the heart of the nanotechnology innovation ecosystem. There is a growing appetite for responsible, sustainable, and purposeful innovation from business, financiers, regulators, consumers, and other stakeholders – an appetite that we foresee will permeate all spheres of commercialisation, including that of nanotechnology. Ultimately, nanotechnologies will only have the ability to sustainably address the global challenges of the 21st century if they are developed and implemented with purpose, and in full consideration of their social and environmental impacts. We (re)define purpose as it relates to sustainable nanotechnology innovation, in an effort to create a more-broadly shared language that can bridge the diverse stakeholder needs and perspectives that are required to address these challenges. To enable innovation, standardisation, promote interdisciplinarity, increase transparency, and enhance regulatory and corporate accountability, we propose a four stage, principles-based framework for purposeful nanotechnology development. This framework offers a practical way forward for nanotechnology innovation, shedding light on how nano-impact can be approached by multidisciplinary teams and describing how interrelated systems and stakeholders can interact successfully to achieve shared goals.</p></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":"35 ","pages":"Article 100511"},"PeriodicalIF":4.9,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452074824000211/pdfft?md5=3e744f248294742e3a2864173b8c04b3&pid=1-s2.0-S2452074824000211-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140944859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of micro(nano)plastics based on automated data interpretation and modeling: A review","authors":"Kwanyoung Ko ,&nbsp;Juhwan Lee ,&nbsp;Philipp Baumann ,&nbsp;Jaeho Kim ,&nbsp;Haegeun Chung","doi":"10.1016/j.impact.2024.100509","DOIUrl":"10.1016/j.impact.2024.100509","url":null,"abstract":"<div><p>The widespread presence of micro(nano)plastics (MNPs) in the environment threatens ecosystem integrity, and thus, it is necessary to determine and assess the occurrence, characteristics, and transport of MNPs between ecological components. However, most analytical approaches are cost- and time-inefficient in providing quantitative information with sufficient detail, and interpreting results can be difficult. Alternative analyses integrating novel measurements by imaging or proximal sensing with signal processing and machine learning may supplement these approaches. In this review, we examined published research on methods used for the automated data interpretation of MNPs found in the environment or those artificially prepared by fragmenting bulk plastics. We critically reviewed the primary areas of the integrated analytical process, which include sampling, data acquisition, processing, and modeling, applied in identifying, classifying, and quantifying MNPs in soil, sediment, water, and biological samples. We also provide a comprehensive discussion regarding model uncertainties related to estimating MNPs in the environment. In the future, the development of routinely applicable and efficient methods is expected to significantly contribute to the successful establishment of automated MNP monitoring systems.</p></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":"34 ","pages":"Article 100509"},"PeriodicalIF":4.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140909587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Algal growth inhibition test with TEMPO-oxidized cellulose nanofibers","authors":"Rie Tai ,&nbsp;Isamu Ogura ,&nbsp;Toshiya Okazaki ,&nbsp;Yoko Iizumi ,&nbsp;Hiroyuki Mano","doi":"10.1016/j.impact.2024.100504","DOIUrl":"10.1016/j.impact.2024.100504","url":null,"abstract":"<div><p>Ecotoxicity data on cellulose nanofibers (CNFs) are limited despite their wide potential applications prospects, such as structural and packaging materials, filters, coatings, foods, and cosmetics. In this study, toxicity tests of 2,2,6,6-tetramethylpiperidine-1-oxyl radical (TEMPO)-oxidized CNFs (TEMPO-CNFs), which are one of the major CNF products commercially available in Japan, on the green alga <em>Raphidocelis subcapitata</em> were conducted. As nanomaterials are considered difficult-to-test substances, the Organisation for Economic Co-operation and Development has released a guidance document that provides considerations regarding ecotoxicity tests of nanomaterials. In the algal growth inhibition tests of TEMPO-CNFs, there were specific issues to be examined, including the effects of medium components on the characteristics of TEMPO-CNFs, CNF interference with algal density measurements, algal interference with CNF measurements, and the effects of ion concentration changes in the test medium by the addition of CNFs on algal growth. To examine these issues, we conducted preliminary studies and established a suitable test method for algal growth inhibition tests of TEMPO-CNFs. We confirmed that the components in the medium for algal growth inhibition tests had negligible effects on the characteristics (zeta-potential, viscosity, and morphology) and concentration stability of TEMPO-CNFs and that <em>in vitro</em> and <em>in vivo</em> fluorescence measurements were applicable for estimating the algal densities, without interference by TEMPO-CNFs. In contrast, we observed that the grown algae interfered with the CNF concentration measurements. Therefore, we established a method to correct the measured CNF concentrations by estimating the algal contribution. Furthermore, we found that the nutrient salt concentrations in the medium changed due to interactions with CNFs; however, this change did not affect algal growth. Based on the results of the preliminary studies, algal growth inhibition tests of TEMPO-CNFs were conducted using <em>in vitro</em> and <em>in vivo</em> fluorescence measurements, along with measurements of CNFs and ion concentrations in the test dispersions. The test results showed that no growth inhibition was observed on growth rate or yield even at the maximum CNF concentration of 100 mg/L, suggesting that the ecological effect of TEMPO-CNFs on algae was relatively low. The results of this study will be valuable for conducting ecotoxicity assessments on additional CNFs and comparable nanomaterials in future studies.</p></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":"34 ","pages":"Article 100504"},"PeriodicalIF":4.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452074824000144/pdfft?md5=b227c55da85d42da6c0fdd69ff9db24e&pid=1-s2.0-S2452074824000144-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140306158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polyethylene terephthalate (PET) micro- and nanoplastic particles affect the mitochondrial efficiency of human brain vascular pericytes without inducing oxidative stress","authors":"Sean M. Gettings ,&nbsp;William Timbury ,&nbsp;Anna Dmochowska ,&nbsp;Riddhi Sharma ,&nbsp;Rebecca McGonigle ,&nbsp;Lewis E. MacKenzie ,&nbsp;Guillaume Miquelard-Garnier ,&nbsp;Nora Bourbia","doi":"10.1016/j.impact.2024.100508","DOIUrl":"https://doi.org/10.1016/j.impact.2024.100508","url":null,"abstract":"<div><p>The objective of this investigation was to evaluate the influence of micro- and nanoplastic particles composed of polyethylene terephthalate (PET), a significant contributor to plastic pollution, on human brain vascular pericytes. Specifically, we delved into their impact on mitochondrial functionality, oxidative stress, and the expression of genes associated with oxidative stress, ferroptosis and mitochondrial functions. Our findings demonstrate that the exposure of a monoculture of human brain vascular pericytes to PET particles in vitro at a concentration of 50 μg/ml for a duration of 3, 6 and 10 days did not elicit oxidative stress. Notably, we observed a reduction in various aspects of mitochondrial respiration, including maximal respiration, spare respiratory capacity, and ATP production in pericytes subjected to PET particles for 3 days, with a mitochondrial function recovery at 6 and 10 days. Furthermore, there were no statistically significant alterations in mitochondrial DNA copy number, or in the expression of genes linked to oxidative stress and ferroptosis, but an increase of the expression of the gene mitochondrial transcription factor A (<em>TFAM</em>) was noted at 3 days exposure.</p><p>These outcomes suggest that, at a concentration of 50 μg/ml, PET particles do not induce oxidative stress in human brain vascular pericytes. Instead, at 3 days exposure, PET exposure impairs mitochondrial functions, but this is recovered at 6-day exposure. This seems to indicate a potential mitochondrial hormesis response (mitohormesis) is incited, involving the gene <em>TFAM</em>. Further investigations are warranted to explore the stages of mitohormesis and the potential consequences of plastics on the integrity of the blood-brain barrier and intercellular interactions. This research contributes to our comprehension of the potential repercussions of nanoplastic pollution on human health and underscores the imperative need for ongoing examinations into the exposure to plastic particles.</p></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":"34 ","pages":"Article 100508"},"PeriodicalIF":4.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452074824000181/pdfft?md5=34e81013784dea8e9d4c13024e1925bd&pid=1-s2.0-S2452074824000181-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140645458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-dose cadmium telluride quantum dots trigger M1 polarization in macrophages through mTOR-mediated transcription factor EB activation","authors":"Tingting Wei,&nbsp;Na Liu,&nbsp;Yongshuai Yao,&nbsp;Xiaoquan Huang,&nbsp;Zhihui Wang,&nbsp;Tianshu Wu,&nbsp;Ting Zhang,&nbsp;Yuying Xue,&nbsp;Meng Tang","doi":"10.1016/j.impact.2024.100505","DOIUrl":"https://doi.org/10.1016/j.impact.2024.100505","url":null,"abstract":"<div><p>The increasing application of quantum dots (QDs) increases interactions with organisms. The inflammatory imbalance is a significant manifestation of immunotoxicity. Macrophages maintain inflammatory homeostasis. Using macrophages differentiated by phorbol 12-myristate 13-acetate-induced THP-1 cells as models, the study found that low-dose (5 μM) cadmium telluride QDs (CdTe-QDs) hindered monocyte-macrophage differentiation. CD11b is a surface marker of macrophage, and the addition of CdTe-QDs during induction resulted in a decrease in CD11b expression. Moreover, exposure of differentiated THP-1 macrophage (dTHP-1) to 5 μM CdTe-QDs led to the initiation of M1 polarization. This was indicated by the increased surface marker CD86 expression, along with elevated level of NF-κB and IL-1β proteins. The potential mechanisms are being explored. The transcription factor EB (TFEB) plays a significant role in immune regulation and serves as a crucial regulator of the autophagic lysosomal pathway. After exposed to CdTe-QDs, TFEB activation-mediated autophagy and M1 polarization were observed to occur simultaneously in dTHP-1. The mTOR signaling pathway contributed to TFEB activation induced by CdTe-QDs. However, mTOR-independent activation of TFEB failed to promote M1 polarization. These results suggest that mTOR-TFEB is an advantageous target to enhance the biocompatibility of CdTe-QDs.</p></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":"34 ","pages":"Article 100505"},"PeriodicalIF":4.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140559141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Responses of soil microbiome to copper-based materials (nano and bulk) for agricultural applications: An indoor-mesocosm experiment","authors":"Sara Peixoto ,&nbsp;Rui G. Morgado ,&nbsp;Marija Prodana ,&nbsp;Diogo N. Cardoso ,&nbsp;Catarina Malheiro ,&nbsp;Joana Neves ,&nbsp;Cátia Santos ,&nbsp;Zahra Khodaparast ,&nbsp;Maria D. Pavlaki ,&nbsp;Sandra Rodrigues ,&nbsp;Sónia M. Rodrigues ,&nbsp;Isabel Henriques ,&nbsp;Susana Loureiro","doi":"10.1016/j.impact.2024.100506","DOIUrl":"https://doi.org/10.1016/j.impact.2024.100506","url":null,"abstract":"<div><p>The foreseen increasing application of copper-based nanomaterials (Cu-NMs), replacing or complementing existing Cu-agrochemicals, may negatively impact the soil microbiome. Thus, we studied the effects on soil microbiome function and composition of nano copper oxide (nCuO) or copper hydroxide NMs in a commercial (Kocide®3000) or a lab-synthetized formulation (nCu(OH)₂) or bulk copper hydroxide (Cu(OH)₂-B), at the commonly recommended Cu dose of 50 mg(<em>Cu</em>)kg⁻¹ soil. Microbial responses were studied over 28 days in a designed indoor mesocosm. On day-28, in comparison to non-treated soil (CT), all Cu-treatments led to a reduction in dehydrogenase (95% to 68%), arylsulfatase (41% to 27%), and urease (40% to 20%) activity. There was a 32% increase in the utilization of carbon substrates in the nCuO-treatment and an increased abundance of viable bacteria in the nCu(OH)₂-treatment (75% of heterotrophic and 69% of P-solubilizing bacteria). The relative abundance of Acidobacteria [Kocide®3000, nCuO, and Cu(OH)₂-B treatments] and Flavobacteriia [nCu(OH)₂-treatment] was negatively affected by Cu exposure. The abundance of Cu-tolerant bacteria increased in soils treated with Kocide®3000 (Clostridia) and nCu(OH)₂ (Gemmatimonadetes). All Cu-treated soils exhibited a reduced abundance of denitrification-related genes (0.05% of <em>nosZ</em> gene). The DTPA-extractable pool of ionic Cu(II) varied among treatments: Cu(OH)₂-B &gt; Kocide®3000 ∼ nCuO&gt;nCu(OH)₂, which may explain changes on the soil microbiome composition, at the genera and OTU levels. Thus, our study revealed that Cu-materials (nano and bulk) influence the soil microbiome with implications on its ecological role. It highlights the importance of assessing the impact of Cu-materials under dynamic and complex exposure scenarios and emphasizes the need for specific regulatory frameworks for NMs.</p></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":"34 ","pages":"Article 100506"},"PeriodicalIF":4.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140619215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential mitigation of titanium dioxide nanoparticles against 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis through inhibiting the canonical NF-κB pathway","authors":"Yanjun Gao ,&nbsp;Langzhi He ,&nbsp;Shumin Duan ,&nbsp;Hasen Bilige ,&nbsp;Lizhi Lyu ,&nbsp;Zihui Li ,&nbsp;Hongbo Wang ,&nbsp;Chen Li ,&nbsp;Yun Wang","doi":"10.1016/j.impact.2024.100512","DOIUrl":"10.1016/j.impact.2024.100512","url":null,"abstract":"<div><p>Titanium dioxide nanoparticles (TiO₂ NPs) have been widely employed in various industry fields, which makes consumers concerned about their health impact. Our previous work displayed that TiO₂ NPs participated in the mitigation of TNBS-induced colitis, but the mechanism is still unknown. This work aimed to explore the role of oxidative stress and NF-κB pathway in the effect of TiO₂ NPs on TNBS-induced colitis. The results showed that TiO₂ NPs administration reduced the DAI score of colitis mice after TNBS enema. TiO₂ NPs did not alter oxidative stress status (GSH/GSSG), but repaired the gut dysbacteriosis and inhibited the canonical NF-κB pathway activation in TNBS-induced colitis mice, manifested as a decrease in pathogenic bacteria and an increase in beneficial bacteria, as well as down-regulation of toll-like receptors (TLRs), IKKα, IKKβ, p65 and pro-inflammatory cytokines (IL-1β, IL-6, TNF-α and IFN-γ) in mRNA level, and the increased transcription of anti-inflammatory cytokines (IL-10, TGF-β, and IL-12), along with the declined protein level of TNF-α in TiO₂ NPs treated colitis mice. The present study suggested that oral TiO₂ NPs administration inhibited the canonical NF-κB pathway activation by repairing gut dysbacteriosis, which made a predominant role in alleviating colitis. These findings provided a new perspective for exploring the safety of TiO₂ NPs.</p></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":"34 ","pages":"Article 100512"},"PeriodicalIF":4.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141071444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}