NanoImpact最新文献

{"title":"Polyethylene terephthalate (PET) micro- and nanoplastic particles affect the mitochondrial efficiency of human brain vascular pericytes without inducing oxidative stress","authors":"Sean M. Gettings ,&nbsp;William Timbury ,&nbsp;Anna Dmochowska ,&nbsp;Riddhi Sharma ,&nbsp;Rebecca McGonigle ,&nbsp;Lewis E. MacKenzie ,&nbsp;Guillaume Miquelard-Garnier ,&nbsp;Nora Bourbia","doi":"10.1016/j.impact.2024.100508","DOIUrl":"https://doi.org/10.1016/j.impact.2024.100508","url":null,"abstract":"<div><p>The objective of this investigation was to evaluate the influence of micro- and nanoplastic particles composed of polyethylene terephthalate (PET), a significant contributor to plastic pollution, on human brain vascular pericytes. Specifically, we delved into their impact on mitochondrial functionality, oxidative stress, and the expression of genes associated with oxidative stress, ferroptosis and mitochondrial functions. Our findings demonstrate that the exposure of a monoculture of human brain vascular pericytes to PET particles in vitro at a concentration of 50 μg/ml for a duration of 3, 6 and 10 days did not elicit oxidative stress. Notably, we observed a reduction in various aspects of mitochondrial respiration, including maximal respiration, spare respiratory capacity, and ATP production in pericytes subjected to PET particles for 3 days, with a mitochondrial function recovery at 6 and 10 days. Furthermore, there were no statistically significant alterations in mitochondrial DNA copy number, or in the expression of genes linked to oxidative stress and ferroptosis, but an increase of the expression of the gene mitochondrial transcription factor A (<em>TFAM</em>) was noted at 3 days exposure.</p><p>These outcomes suggest that, at a concentration of 50 μg/ml, PET particles do not induce oxidative stress in human brain vascular pericytes. Instead, at 3 days exposure, PET exposure impairs mitochondrial functions, but this is recovered at 6-day exposure. This seems to indicate a potential mitochondrial hormesis response (mitohormesis) is incited, involving the gene <em>TFAM</em>. Further investigations are warranted to explore the stages of mitohormesis and the potential consequences of plastics on the integrity of the blood-brain barrier and intercellular interactions. This research contributes to our comprehension of the potential repercussions of nanoplastic pollution on human health and underscores the imperative need for ongoing examinations into the exposure to plastic particles.</p></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452074824000181/pdfft?md5=34e81013784dea8e9d4c13024e1925bd&pid=1-s2.0-S2452074824000181-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140645458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Responses of soil microbiome to copper-based materials (nano and bulk) for agricultural applications: An indoor-mesocosm experiment","authors":"Sara Peixoto ,&nbsp;Rui G. Morgado ,&nbsp;Marija Prodana ,&nbsp;Diogo N. Cardoso ,&nbsp;Catarina Malheiro ,&nbsp;Joana Neves ,&nbsp;Cátia Santos ,&nbsp;Zahra Khodaparast ,&nbsp;Maria D. Pavlaki ,&nbsp;Sandra Rodrigues ,&nbsp;Sónia M. Rodrigues ,&nbsp;Isabel Henriques ,&nbsp;Susana Loureiro","doi":"10.1016/j.impact.2024.100506","DOIUrl":"https://doi.org/10.1016/j.impact.2024.100506","url":null,"abstract":"<div><p>The foreseen increasing application of copper-based nanomaterials (Cu-NMs), replacing or complementing existing Cu-agrochemicals, may negatively impact the soil microbiome. Thus, we studied the effects on soil microbiome function and composition of nano copper oxide (nCuO) or copper hydroxide NMs in a commercial (Kocide®3000) or a lab-synthetized formulation (nCu(OH)₂) or bulk copper hydroxide (Cu(OH)₂-B), at the commonly recommended Cu dose of 50 mg(<em>Cu</em>)kg⁻¹ soil. Microbial responses were studied over 28 days in a designed indoor mesocosm. On day-28, in comparison to non-treated soil (CT), all Cu-treatments led to a reduction in dehydrogenase (95% to 68%), arylsulfatase (41% to 27%), and urease (40% to 20%) activity. There was a 32% increase in the utilization of carbon substrates in the nCuO-treatment and an increased abundance of viable bacteria in the nCu(OH)₂-treatment (75% of heterotrophic and 69% of P-solubilizing bacteria). The relative abundance of Acidobacteria [Kocide®3000, nCuO, and Cu(OH)₂-B treatments] and Flavobacteriia [nCu(OH)₂-treatment] was negatively affected by Cu exposure. The abundance of Cu-tolerant bacteria increased in soils treated with Kocide®3000 (Clostridia) and nCu(OH)₂ (Gemmatimonadetes). All Cu-treated soils exhibited a reduced abundance of denitrification-related genes (0.05% of <em>nosZ</em> gene). The DTPA-extractable pool of ionic Cu(II) varied among treatments: Cu(OH)₂-B &gt; Kocide®3000 ∼ nCuO&gt;nCu(OH)₂, which may explain changes on the soil microbiome composition, at the genera and OTU levels. Thus, our study revealed that Cu-materials (nano and bulk) influence the soil microbiome with implications on its ecological role. It highlights the importance of assessing the impact of Cu-materials under dynamic and complex exposure scenarios and emphasizes the need for specific regulatory frameworks for NMs.</p></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140619215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential mitigation of titanium dioxide nanoparticles against 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis through inhibiting the canonical NF-κB pathway","authors":"Yanjun Gao ,&nbsp;Langzhi He ,&nbsp;Shumin Duan ,&nbsp;Hasen Bilige ,&nbsp;Lizhi Lyu ,&nbsp;Zihui Li ,&nbsp;Hongbo Wang ,&nbsp;Chen Li ,&nbsp;Yun Wang","doi":"10.1016/j.impact.2024.100512","DOIUrl":"10.1016/j.impact.2024.100512","url":null,"abstract":"<div><p>Titanium dioxide nanoparticles (TiO₂ NPs) have been widely employed in various industry fields, which makes consumers concerned about their health impact. Our previous work displayed that TiO₂ NPs participated in the mitigation of TNBS-induced colitis, but the mechanism is still unknown. This work aimed to explore the role of oxidative stress and NF-κB pathway in the effect of TiO₂ NPs on TNBS-induced colitis. The results showed that TiO₂ NPs administration reduced the DAI score of colitis mice after TNBS enema. TiO₂ NPs did not alter oxidative stress status (GSH/GSSG), but repaired the gut dysbacteriosis and inhibited the canonical NF-κB pathway activation in TNBS-induced colitis mice, manifested as a decrease in pathogenic bacteria and an increase in beneficial bacteria, as well as down-regulation of toll-like receptors (TLRs), IKKα, IKKβ, p65 and pro-inflammatory cytokines (IL-1β, IL-6, TNF-α and IFN-γ) in mRNA level, and the increased transcription of anti-inflammatory cytokines (IL-10, TGF-β, and IL-12), along with the declined protein level of TNF-α in TiO₂ NPs treated colitis mice. The present study suggested that oral TiO₂ NPs administration inhibited the canonical NF-κB pathway activation by repairing gut dysbacteriosis, which made a predominant role in alleviating colitis. These findings provided a new perspective for exploring the safety of TiO₂ NPs.</p></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141071444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-dose cadmium telluride quantum dots trigger M1 polarization in macrophages through mTOR-mediated transcription factor EB activation","authors":"Tingting Wei,&nbsp;Na Liu,&nbsp;Yongshuai Yao,&nbsp;Xiaoquan Huang,&nbsp;Zhihui Wang,&nbsp;Tianshu Wu,&nbsp;Ting Zhang,&nbsp;Yuying Xue,&nbsp;Meng Tang","doi":"10.1016/j.impact.2024.100505","DOIUrl":"https://doi.org/10.1016/j.impact.2024.100505","url":null,"abstract":"<div><p>The increasing application of quantum dots (QDs) increases interactions with organisms. The inflammatory imbalance is a significant manifestation of immunotoxicity. Macrophages maintain inflammatory homeostasis. Using macrophages differentiated by phorbol 12-myristate 13-acetate-induced THP-1 cells as models, the study found that low-dose (5 μM) cadmium telluride QDs (CdTe-QDs) hindered monocyte-macrophage differentiation. CD11b is a surface marker of macrophage, and the addition of CdTe-QDs during induction resulted in a decrease in CD11b expression. Moreover, exposure of differentiated THP-1 macrophage (dTHP-1) to 5 μM CdTe-QDs led to the initiation of M1 polarization. This was indicated by the increased surface marker CD86 expression, along with elevated level of NF-κB and IL-1β proteins. The potential mechanisms are being explored. The transcription factor EB (TFEB) plays a significant role in immune regulation and serves as a crucial regulator of the autophagic lysosomal pathway. After exposed to CdTe-QDs, TFEB activation-mediated autophagy and M1 polarization were observed to occur simultaneously in dTHP-1. The mTOR signaling pathway contributed to TFEB activation induced by CdTe-QDs. However, mTOR-independent activation of TFEB failed to promote M1 polarization. These results suggest that mTOR-TFEB is an advantageous target to enhance the biocompatibility of CdTe-QDs.</p></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140559141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of TiO2 (nano)particles migration from food packaging materials to food simulants by single particle ICP-MS/MS using a high efficiency sample introduction system","authors":"Isabel Bastardo-Fernández ,&nbsp;Rachida Chekri ,&nbsp;Caroline Oster ,&nbsp;Valentin Thoury ,&nbsp;Paola Fisicaro ,&nbsp;Petru Jitaru ,&nbsp;Johanna Noireaux","doi":"10.1016/j.impact.2024.100503","DOIUrl":"10.1016/j.impact.2024.100503","url":null,"abstract":"<div><p>TiO₂ is the most widely used white pigment in plastics and food packaging industry, thus the question of its migration towards food and hence the impact on consumers is raised. Since recent research indicate its potential toxicity, it is necessary to study TiO₂ contamination as a consequence of food storage. For this purpose, plastic containers from commercially-available dairy products and custom-made TiO₂-spiked polypropylene materials were put in contact with 50% (<em>v/v</em>) ethanol and 3% (<em>w/v</em>) acetic acid, which were used here as food simulants. The migration assays were carried out under standard contact conditions of packaging use (as recommended by Commission Regulation (EU) N° 10/2011 for food contact migration testing), and under conditions of extreme mechanical degradation of the packaging. The TiO₂ (nano)particles released in the food simulants were analysed by single particle inductively coupled plasma-tandem mass spectrometry in mass-shift mode and using a high efficiency sample introduction system (APEX™ Ω) to avoid matrix effects from food simulants. For the dairy product containers and for the spiked polypropylene, results showed release of TiO₂ particles of rather large sizes (average size: 164 and 175 nm, respectively) under mechanical degradation conditions, i.e. when the polymeric structure is damaged. The highest amounts of TiO₂ were observed in 50% ethanol after 10 days of storage at 50 °C (0.62 ng cm⁻²) for the dairy product containers and after 1 day of storage at 50 °C (0.68 ng cm⁻²) for the spiked polypropylene. However, the level of Ti released in particle form was very small compared to the total Ti content in the packaging and far below the acceptable migration limits set by European legislation. Release under standard contact conditions of use of the container was not measurable, thus the migration of TiO₂ particles from this packaging to dairy products among storage is expected to be negligible.</p></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140184867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Everything falls apart: How solids degrade and release nanomaterials, composite fragments, and microplastics","authors":"Wendel Wohlleben ,&nbsp;Nathan Bossa ,&nbsp;Denise M. Mitrano ,&nbsp;Keana Scott","doi":"10.1016/j.impact.2024.100510","DOIUrl":"10.1016/j.impact.2024.100510","url":null,"abstract":"<div><p>To ensure the safe use of materials, one must assess the identity and quantity of exposure. Solid materials, such as plastics, metals, coatings and cements, degrade to some extent during their life cycle, and releases can occur during manufacturing, use and end-of-life. Releases (e.g., what is released, how does release happen, and how much material is released) depend on the composition and internal (nano)structures of the material as well as the applied stresses during the lifecycle. We consider, in some depth, releases from mechanical, weathering and thermal stresses and specifically address the use cases of fused-filament 3D printing, dermal contact, food contact and textile washing. Solid materials can release embedded nanomaterials, composite fragments, or micro- and nanoplastics, as well as volatile organics, ions and dissolved organics. The identity of the release is often a heterogenous mixture and requires adapted strategies for sampling and analysis, with suitable quality control measures. Control materials enhance robustness by enabling comparative testing, but reference materials are not always available as yet. The quantity of releases is typically described by time-dependent rates that are modulated by the nature and intensity of the applied stress, the chemical identity of the polymer or other solid matrix, and the chemical identity and compatibility of embedded engineered nanomaterials (ENMs) or other additives. Standardization of methods and the documentation of metadata, including all the above descriptors of the tested material, applied stresses, sampling and analytics, are identified as important needs to advance the field and to generate robust, comparable assessments. In this regard, there are strong methodological synergies between the study of all solid materials, including the study of micro- and nanoplastics. From an outlook perspective, we review the hazard of the released entities, and show how this informs risk assessment. We also address the transfer of methods to related issues such as tyre wear, advanced materials and advanced manufacturing, biodegradable polymers, and non-solid matrices. As the consideration of released entities will become more routine in industry via lifecycle assessment in Safe-and-Sustainable-by-Design practices, release assessments will require careful design of the study with quality controls, the use of agreed-on test materials and standardized methods where these exist and the adoption of clearly defined data reporting practices that enable data reuse, meta-analyses, and comparative studies.</p></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140957933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the potential of daily intake of polystyrene microplastics via drinking water in inducing PCOS and its ovarian fibrosis progression using female zebrafish","authors":"Madhuchhanda Adhikari ,&nbsp;Chayan Biswas ,&nbsp;Piyali Mazumdar ,&nbsp;Shampa Sarkar (Biswas) ,&nbsp;Kousik Pramanick","doi":"10.1016/j.impact.2024.100507","DOIUrl":"10.1016/j.impact.2024.100507","url":null,"abstract":"<div><p>Polystyrene microplastics, extensively considered endocrine disrupting chemicals, disturb the reproductive system of living organisms. Polycystic ovary syndrome (PCOS), the reproductive endocrinopathy, is longstanding concern due to its eternal impacts as reproductive disorder and infertility. Despite several reports in reproductive and endocrine toxicity, there is inadequate literature regarding the daily intake of polystyrene-microplastics <em>via</em> drinking water in causing PCOS and leading to ovarian fibrosis in long-term. The present study investigated whether daily consumption of polystyrene-microplastics at doses equivalent to human exposure can cause PCOS and progress to ovarian fibrosis, using female zebrafish as model. Resembling letrozole-PCOS zebrafish model, daily intake of polystyrene-microplastics displayed hallmark PCOS pathophysiology; like excess body weight and %Gonadosomatic index, decreased Follicle Stimulating Hormone and β-estradiol, increased Luteinising Hormone, brain and ovarian Testosterone (39.3% and 75% respectively). Correspondingly, ovarian histology revealed more developing (stage I and II) oocytes and less mature oocytes alongwith cystic lesions; like follicular membrane disorganization, zona pellucida invagination, theca hypertrophy, basophilic granular accumulation and oocyte buddings. Lipid deposition in intestinal and ovarian tissues was evidenced and increased fasting blood glucose manifesting insulin resistance. The expression of PCOS biomarkers (<em>tox3, dennd1a, fem1a</em>) was significantly disturbed. Polystyrene microplastics played vital role in inducing PCOS further enhancing oxidative stress, which positively influences inflammation and aggravate ovarian mitophagy, shedding light on its ability to harshen PCOS into ovarian fibrosis, which is characterized by collagen deposition and upregulation of pro-fibrogenic biomarker genes. These findings illustrate the potential of daily microplastics intake <em>via</em> drinking water in triggering PCOS and its progression to ovarian fibrosis.</p></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140777842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanotechnology in agriculture: A solution to global food insecurity in a changing climate?","authors":"Shital Vaidya,&nbsp;Chaoyi Deng,&nbsp;Yi Wang,&nbsp;Nubia Zuverza-Mena,&nbsp;Christian Dimkpa,&nbsp;Jason C. White","doi":"10.1016/j.impact.2024.100502","DOIUrl":"10.1016/j.impact.2024.100502","url":null,"abstract":"<div><p>Although the Green Revolution dramatically increased food production, it led to non- sustainable conventional agricultural practices, with productivity in general declining over the last few decades. Maintaining food security with a world population exceeding 9 billion in 2050, a changing climate, and declining arable land will be exceptionally challenging. In fact, nothing short of a revolution in how we grow, distribute, store, and consume food is needed. In the last ten years, the field of nanotoxicology in plant systems has largely transitioned to one of sustainable nano-enabled applications, with recent discoveries on the use of this advanced technology in agriculture showing tremendous promise. The range of applications is quite extensive, including direct application of nanoscale nutrients for improved plant health, nutrient biofortification, increased photosynthetic output, and greater rates of nitrogen fixation. Other applications include nano-facilitated delivery of both fertilizers and pesticides; nano-enabled delivery of genetic material for gene silencing against viral pathogens and insect pests; and nanoscale sensors to support precision agriculture. Recent efforts have demonstrated that nanoscale strategies increase tolerance to both abiotic and biotic stressors, offering realistic potential to generate climate resilient crops. Considering the efficiency of nanoscale materials, there is a need to make their production more economical, alongside efficient use of incumbent resources such as water and energy. The hallmark of many of these approaches involves much greater impact with far less input of material. However, demonstrations of efficacy at field scale are still insufficient in the literature, and a thorough understanding of mechanisms of action is both necessary and often not evident. Although nanotechnology holds great promise for combating global food insecurity, there are far more ways to do this poorly than safely and effectively. This review summarizes recent work in this space, calling out existing knowledge gaps and suggesting strategies to alleviate those concerns to advance the field of sustainable nano-enabled agriculture.</p></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140175614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of airborne dust emissions from three types of crushed multi-walled carbon nanotube-enhanced concretes","authors":"Camilla Abrahamsson ,&nbsp;Jenny Rissler ,&nbsp;Monica Kåredal ,&nbsp;Maria Hedmer ,&nbsp;Jan Suchorzewski ,&nbsp;Miguel Prieto ,&nbsp;Ojas Arun Chaudhari ,&nbsp;Anders Gudmundsson ,&nbsp;Christina Isaxon","doi":"10.1016/j.impact.2024.100500","DOIUrl":"10.1016/j.impact.2024.100500","url":null,"abstract":"<div><p>Dispersing Multi-Walled Carbon Nanotubes (MWCNTs) into concrete at low (&lt;1 wt% in cement) concentrations may improve concrete performance and properties and provide enhanced functionalities. When MWCNT-enhanced concrete is fragmented during remodelling or demolition, the stiff, fibrous and carcinogenic MWCNTs will, however, also be part of the respirable particulate matter released in the process. Consequently, systematic aerosolizing of crushed MWCNT-enhanced concretes in a controlled environment and measuring the properties of this aerosol can give valuable insights into the characteristics of the emissions such as concentrations, size range and morphology. These properties impact to which extent the emissions can be inhaled as well as where they are expected to deposit in the lung, which is critical to assess whether these materials might constitute a future health risk for construction and demolition workers. In this work, the impact from MWCNTs on aerosol characteristics was assessed for samples of three concrete types with various amounts of MWCNT, using a novel methodology based on the continuous drop method. MWCNT-enhanced concretes were crushed, aerosolized and the emitted particles were characterized with online and offline techniques. For light-weight porous concrete, the addition of MWCNT significantly reduced the respirable mass fraction (RESP) and particle number concentrations (PNC) across all size ranges (7 nm – 20 μm), indicating that MWCNTs dampened the fragmentation process by possibly reinforcing the microstructure of brittle concrete. For normal concrete, the opposite could be seen, where MWCNTs resulted in drastic increases in RESP and PNC, suggesting that the MWCNTs may be acting as defects in the concrete matrix, thus enhancing the fragmentation process. For the high strength concrete, the fragmentation decreased at the lowest MWCNT concentration, but increased again for the highest MWCNT concentration. All tested concrete types emitted &lt;100 nm particles, regardless of CNT content. SEM imaging displayed CNTs protruding from concrete fragments, but no free fibres were detected.</p></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452074824000107/pdfft?md5=2c842636786b9e5781b2be1ec2a669d2&pid=1-s2.0-S2452074824000107-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139924124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stool titanium dioxide is positively associated with stool alpha-1 antitrypsin and calprotectin in young healthy adults","authors":"Christianto Putra, Dhimiter Bello, Shannon L. Kelleher, Katherine L. Tucker, Kelsey M. Mangano","doi":"10.1016/j.impact.2024.100498","DOIUrl":"https://doi.org/10.1016/j.impact.2024.100498","url":null,"abstract":"","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139816258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}