NanoImpact最新文献

{"title":"Facile preparation of environmentally relevant nano- and microplastics for hazard assessment and ecotoxicological testing evaluation","authors":"J.J. Reinosa ,&nbsp;J.C. Guzmán ,&nbsp;M. Fernández-Álvarez ,&nbsp;A. Katsumiti ,&nbsp;M. Roldan ,&nbsp;M.Y. Hierhammer ,&nbsp;L. Deloch ,&nbsp;M. Rückert ,&nbsp;U.S. Gaipl ,&nbsp;F. Paulsen ,&nbsp;K. Jüngert ,&nbsp;M.V. Moreno-Arribas ,&nbsp;J.F. Fernández","doi":"10.1016/j.impact.2026.100622","DOIUrl":"10.1016/j.impact.2026.100622","url":null,"abstract":"<div><div>For years, a large proportion of plastics has been left behind in the environment and deteriorate in the form of nano- and microplastics (NMPs). These NMPs interact with living organisms. However, there are no established methods with which these NMPs can be reproduced, so their systemic study is limited. In this work, PET (polyethylene phthalate) nano- and microparticles are produced from commercially available polymer pellets by different grinding processes (top-down approach) that simulate environmental weathering. The developed process enables the production of plastic particles in the range of 20 nm to 300 μm in stable suspensions and free of impurities such as endotoxins. Relevant changes are detected in the NMPs related to the reduction of the particle size, their structural amorphization and the hydroxylation of the surface, which leads to an increase in the electrostatic charge affecting their stability in aquatic environment. This method allows the systematic study of plastic NMPs whose size and morphology are similar to those produced by erosion and transport in the environment. Down-streaming use of these suitable test materials for in vitro biological determinations related to human risk assessment is also evidenced in this work.</div></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":"42 ","pages":"Article 100622"},"PeriodicalIF":5.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147521509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A two-stage stacking machine learning framework for predicting metal oxide nanoparticle toxicity and biological outcomes","authors":"Tugba Muhlise Okyay ,&nbsp;Macit Koldas","doi":"10.1016/j.impact.2026.100633","DOIUrl":"10.1016/j.impact.2026.100633","url":null,"abstract":"<div><div>Metal oxide nanoparticles (MONPs) raise growing cytotoxicity concerns, yet experimental assessment requires multiple time-consuming biological assays. We developed a leakage-free two-stage machine learning framework predicting MONP toxicity and biological endpoints from physicochemical features. In Stage 1, a stacking ensemble (ExtraTrees + GradientBoosting + RandomForest + HistGradientBoosting → LogisticRegression meta-learner) trained on 304 KONA dataset records using out-of-fold (OOF) probability generation achieved Accuracy = 0.87 and ROC-AUC = 0.91 on held-out data, and ROC-AUC = 0.76 on an independent external validation set. A three-way ablation study revealed that IC₅₀-derived toxicity class substantially improves Stage 2 regression (ΔR² = +0.22 for ROS; +0.12 for Membrane Damage), while out-of-fold-predicted class provides negligible improvement with toxicity classification. In Stage 2, ordinal classification (Low/Moderate/High) with literature-based thresholds replaced continuous regression. BaggingClassifier and GradientBoostingClassifier achieved AUC = 0.82–0.86 across four endpoints. Grouped permutation importance and LIME identified nanoparticle composition, surface chemistry, core size, and surface area as dominant predictors, consistent with ion dissolution and ROS-mediated mechanisms. This framework reduces experimental burden while providing interpretable, generalizable MONP cytotoxicity predictions.</div></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":"42 ","pages":"Article 100633"},"PeriodicalIF":5.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147995482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-scale in-silico toxicological assessment of Ti₃C₂ and Cr₂C MXene nanoparticles at human biological interfaces","authors":"Sergio de-la-Huerta-Sainz ,&nbsp;Valentín Díez-Cabanes ,&nbsp;Pedro A. Marcos Villa ,&nbsp;Alfredo Bol ,&nbsp;Laura Gómez-Cuadrado ,&nbsp;Dalia de la Fuente-Vivas ,&nbsp;Javier Alcodori Ramos ,&nbsp;Carla F. Martins ,&nbsp;Inês T. Meireles ,&nbsp;Ana Rita Alberto ,&nbsp;Santiago Aparicio","doi":"10.1016/j.impact.2026.100624","DOIUrl":"10.1016/j.impact.2026.100624","url":null,"abstract":"<div><div>Despite their huge technological interest, practical application of MXene nanomaterials is somehow hampered by their potential toxicity. In this regard, the present work showcases the design and implementation of a full <em>in-silico</em> methodology for the toxicological analysis of nanoparticles (NPs) of two MXenes within a human cell environment, employing cost-effective computational approaches to achieve a preliminary hazard estimation in the absence of experimental data. This study combines computational methodologies of very different nature, from Density Functional Theory (DFT) calculations for a full quantum mechanics optimization of the system of interest and thermodynamical approximations like the COSMO-RS methodology for the analysis of the behaviour in membranes, to other, simpler methods like classic electrostatic Monte-Carlo calculations for the interaction with proteins, and machine-learning based methods for the development of simpler yet accurate predictive tools for a broader use. This multi-scale workflow was applied to a compendium of NPs derived from two MXenes of interest, Ti₃C₂ and Cr₂C, to understand the possible harm such materials could cause in the human body. As a result, an extremely low permeability and membrane-crossing potential was observed for the Ti₃C₂ NPs, and very weak and superficial interaction was observed for both MXenes with a library of critical human proteins. Two predictive docking energies models with R² of 0.85 were developed, and a low toxicological potential via the considered mechanisms was concluded as a result, thus paving the way of reaching accurate toxicological predictions for a wide range of MXene nanomaterials.</div></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":"42 ","pages":"Article 100624"},"PeriodicalIF":5.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147691111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using simple to more robust in vitro methods based on human pulmonary models to evaluate the acute and subacute toxicity of micro- and nanoplastics derived from 3D printing materials","authors":"Itziar Polanco-Garriz ,&nbsp;Juliana Carrillo-Romero ,&nbsp;Mari Venäläinen ,&nbsp;Jussi Lyyränen ,&nbsp;Hanna Pulli ,&nbsp;Satu Suhonen ,&nbsp;Jolanda Vermeulen ,&nbsp;Nienke Ruijter ,&nbsp;Ana Candalija Iserte ,&nbsp;Apostolos Salmatonidis ,&nbsp;Marie Carriere ,&nbsp;Morgan Lofty ,&nbsp;Matthew Boyles ,&nbsp;Davide Lotti ,&nbsp;Jesús C. Guzmán-Mínguez ,&nbsp;José F. Fernández ,&nbsp;Flemming Cassee ,&nbsp;Julia Catalán ,&nbsp;Isabel Rodríguez-Llopis ,&nbsp;Socorro Vázquez-Campos ,&nbsp;Alberto Katsumiti","doi":"10.1016/j.impact.2026.100631","DOIUrl":"10.1016/j.impact.2026.100631","url":null,"abstract":"<div><div>Mechanical recycling and other processes involved in the end-of-life treatment of 3D-printed plastic polymers can lead to the generation of micro- and nanoplastics (MNPs). As the use of these materials continues to grow, the mechanical degradation of plastics from 3D printing may increase human exposure to MNPs, raising concerns about potential health risks for users and environmental impacts. One of the main routes of exposure to MNPs is <em>via</em> inhalation. For regulatory purposes, most of inhalation studies have been performed using rodents and following the OECD TG 412, however, these models do not accurately mimic the physiology of the human pulmonary system. As alternative, New Approach Methodologies (NAMs) based on human <em>in vitro</em> models have been used lately, providing simple and valuable, and physiologically relevant tools for research. In this work, simple <em>in vitro</em> models using Calu-3 and TK6 cells were exposed for 24 h (acute) and the advanced primary human epithelial MucilAir™ model was exposed for 24 h (acute) and 28 days (sub-acute, adapting the OECD TG 412) to MNPs made of polypropylene (PP), polycarbonate (PC), PP + silver nanoparticles (PP + Ag) and PC + single wall carbon nanotubes (PC + SWCNT). The results showed no significant toxicity of MNPs in acute exposures using the Calu-3 and TK6 models. In contrast, significant effects were observed along time after acute and subacute exposure of MucilAir™ to the different MNPs. These results indicate that robust <em>in vitro</em> models such as MucilAir™ may represent a valuable NAM for acute and sub-acute inhalation toxicity studies.</div></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":"42 ","pages":"Article 100631"},"PeriodicalIF":5.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147941991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxicity of polycaprolactone nanoplastics, pristine or weathered in environmental conditions, to human intestinal epithelial cells, in vitro","authors":"M. Boulée ,&nbsp;V. Bard ,&nbsp;M. Papin ,&nbsp;D. Béal ,&nbsp;S. Devineau ,&nbsp;D. Fenel ,&nbsp;E. Dusacq ,&nbsp;V. Collin-Faure ,&nbsp;T. Rabilloud ,&nbsp;T. Douki ,&nbsp;M. Carriere","doi":"10.1016/j.impact.2026.100619","DOIUrl":"10.1016/j.impact.2026.100619","url":null,"abstract":"<div><div>Plastic, used in almost all everyday products, is a major source of pollution, particularly in the form of micro- and nanoplastics (MNPs). MNP impact on health, particularly on the digestive tract, is still poorly understood, especially in vulnerable populations such as those suffering from inflammatory bowel disease. The aim of this study was to assess the in vitro toxicity of nanoplastics (NPLs) from a biodegradable polymer, polycaprolactone (PCL), both in its pristine state and after accelerated weathering in environmental conditions, the latter resulting in the release of potentially toxic PCL oligomers. To do so, we used in vitro models of genetic susceptibility to Crohn's disease (CD), consisting in co-cultures of HT29-MTX cells with Caco-2 cells engineered to express either wild-type (WT) or mutated <em>nucleotide-binding oligomerization domain 2</em> (NOD2), representative of healthy individuals (Caco-2 NOD2^<em>WT</em>) or individuals with susceptibility to CD (Caco-2 NOD2^{<em>1007fs</em>}). Physicochemical transformation of PCL NPLs upon weathering were characterized. Cells were exposed to pristine and aged PCL NPLs and their cytotoxicity, genotoxicity, inflammatory potential, impact on the cells' redox balance and unfolded protein response, as well as on the epithelial barrier integrity were evaluated. Results show that accelerated weathering increases the crystallinity and leads to fusion of PCL NPLs. PCL NPLs accumulate inside cells where they degrade and release some PCL oligomers. However, in the tested conditions, PCL particles, both pristine and aged, do not show any overt toxicity in both cell systems, irrespective of particle size and weathering status. These data confirm that PCL NPLs, may they be intact or partially dissolved, show only mild toxicity to colon cells, upon acute, short-term exposure of Caco-2 / HT29-MTX cells.</div></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":"42 ","pages":"Article 100619"},"PeriodicalIF":5.5,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147378061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dustiness and aerosol characteristics of nanocellulose powders: Implications for workplace exposure and safety management","authors":"Isamu Ogura,&nbsp;Mari Kotake","doi":"10.1016/j.impact.2025.100610","DOIUrl":"10.1016/j.impact.2025.100610","url":null,"abstract":"<div><div>Nanocellulose materials, including cellulose nanofibers and cellulose nanocrystals, are promising renewable materials with diverse industrial applications. However, potential worker exposure during the handling of dry powders remains a concern. In this study, the dustiness and aerosol characteristics of nine nanocellulose powders were evaluated using the small rotating drum method specified in EN 17199. Aerosolized nanocellulose was characterized using real-time instruments, gravimetric analysis, and microscopic observation of filter-collected particles. All samples generated respirable particles, with mass-based dustiness indices ranging from 10 to 300 mg/kg, comparable to those of other nanomaterials. Aerosolized nanocellulose did not appear as isolated fibers but rather as aggregated or agglomerated particles approximately 0.1–10 μm in size. These findings suggest that, under conditions represented by the rotating drum method, aerosolized nanocellulose predominantly appears as particulate matter rather than isolated fibers. Nonetheless, emission and exposure control measures can be necessary when handling dry nanocellulose powders, given the magnitude of their mass-based dustiness indices. The performance and limitations of portable aerosol instruments were also assessed. Optical particle sizer measurements were occasionally influenced by artifacts that may arise from high concentrations of particles larger than the respirable size range, while dust monitors tended to underestimate concentrations for samples containing a large fraction of coarse particles. Despite these limitations, these instruments can provide useful information for workplace safety management when their constraints are taken into account. Overall, this study provides a scientific basis for developing effective exposure assessment and control strategies to support safe handling of nanocellulose powders in occupational environments.</div></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":"41 ","pages":"Article 100610"},"PeriodicalIF":5.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145843873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to ‘Multi-technique approach for the characterization of titanium dioxide color additive’ [NanoImpact Volume 40 October 2025 100599]","authors":"Sadia Afrin Khan ,&nbsp;Sheng Dong ,&nbsp;Martine Ferguson ,&nbsp;Betsy Jean Yakes ,&nbsp;Raymond P. Briñas","doi":"10.1016/j.impact.2025.100603","DOIUrl":"10.1016/j.impact.2025.100603","url":null,"abstract":"","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":"41 ","pages":"Article 100603"},"PeriodicalIF":5.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145677735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"nanoPharos: A case study on FAIR (Nano)material (Meta)data management","authors":"Anastasios G. Papadiamantis ,&nbsp;Andreas Tsoumanis ,&nbsp;Georgia Melagraki ,&nbsp;Iseult Lynch ,&nbsp;Antreas Afantitis","doi":"10.1016/j.impact.2025.100602","DOIUrl":"10.1016/j.impact.2025.100602","url":null,"abstract":"<div><div>Novel and advanced materials, including nanomaterials (NMs), are vital for diverse industrial and societal applications, yet conventional Research and Innovation (R&amp;I) and Research and Development (R&amp;D) can take decades to reach market deployment. Digitising these processes to support safe and sustainable material development, and reduce reliance on animal testing, requires large volumes of high-quality, interoperable data. The FAIR (Findable, Accessible, Interoperable, Reusable) Data Principles provide a framework for this, but demand domain-specific implementation strategies. We present nanoPharos, a repository offering ready-for-modelling NMs datasets integrating physicochemical characterisation, mechanistic toxicity, exposure, and risk assessment data, enriched with atomistic, structural, molecular, and periodic table-based descriptors. Built on an adapted ChemBL schema, nanoPharos captures NMs' complexity from unit cell to macroscopic properties, linking rich bibliographic, provenance, and scientific metadata. Case studies demonstrate scalability for advanced materials, while integration with platforms like nanodash and Zenodo enhances FAIRness. Evaluation via Joint Research Centre maturity indicators shows strong compliance, with ongoing work towards full ontology integration and advanced API queries.</div></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":"41 ","pages":"Article 100602"},"PeriodicalIF":5.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145654806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microplastic pollution in rivers and lakes of India: Sources, ecotoxicological impacts, and removal strategies","authors":"Avinash Kumar ,&nbsp;Vineet Kumar Poddar ,&nbsp;Sourav Sardar ,&nbsp;Arup Mistri ,&nbsp;Ayan Srivastava","doi":"10.1016/j.impact.2025.100604","DOIUrl":"10.1016/j.impact.2025.100604","url":null,"abstract":"<div><div>Microplastic pollution in freshwater ecosystems, particularly the rivers and lakes of India, has emerged as a significant environmental concern. This review synthesises the current understanding of microplastic pollution in these vital water bodies, encompassing their diverse sources, the ecotoxicological impacts on aquatic biota with a specific focus on Indian species, and the array of removal strategies being explored. The escalating production and consumption of plastics globally have led to the widespread presence of microplastics in various environmental compartments, posing threats to ecological integrity and potentially human health. Indian rivers and lakes, crucial for water supply, agriculture, and biodiversity, are increasingly affected by microplastic contamination from anthropogenic activities, including industrial discharge, domestic waste, agricultural runoff, and tourism. Studies on the eco-toxicology show negative impacts on aquatic organisms, such as bioaccumulation, oxidative stress, histopathological alterations, decreased growth rates, and changed behaviour in fish and other aquatic invertebrates. Additionally, this review critically examines the current literature, highlighting the abundance, distribution, and characteristics of microplastics in Indian freshwater systems, their adverse effects on aquatic organisms, and the efficacy and sustainability of existing and emerging remediation techniques. This thorough investigation further emphasizes the importance of tackling microplastic pollution in India's freshwater systems and points out the necessity of integrated management strategies that incorporate better waste management, and advanced treatment technologies. It also identifying critical knowledge gaps and proposing directions for future research to address this complex and growing environmental challenge.</div></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":"41 ","pages":"Article 100604"},"PeriodicalIF":5.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145715066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sample preparation now (2025) and then: Lessons from 13 years of nanomaterial regulatory safety testing","authors":"Kirsten Rasmussen ,&nbsp;Richard Handy ,&nbsp;Ivana Vinković Vrček ,&nbsp;Hubert Rauscher ,&nbsp;Mar González ,&nbsp;Tommaso Serchi","doi":"10.1016/j.impact.2026.100611","DOIUrl":"10.1016/j.impact.2026.100611","url":null,"abstract":"<div><div>The Organisation for Economic Co-operation and Development (OECD) has adapted or newly developed selected OECD test guidelines (TGs) and guidance documents (GDs) to address regulatory testing of nanomaterials. The “Guidance on Sample Preparation and Dosimetry for the Safety Testing of Manufactured Nanomaterials” (GSPD) is a cornerstone document in this context. It presents the general approach to sample preparation, whereas TGs and GDs often include information for the specific test. The GSPD addresses sample preparation of nanomaterials for testing physical and chemical properties, mammalian and environmental toxicity, and environmental fate. The third edition of the GSPD, published in 2025, integrates the substantial progress over the last decade in addressing issues related to sample preparation and dosimetry, <em>i.e.</em> the lessons learnt. The GSPD captures the progress in sample preparation protocols, noting that an overarching protocol is not available, and the deeper understanding of dosimetry and effective dose. Dose estimation is now underpinned by <em>in silico</em> tools. Across testing, medium composition is a key determinant of nanomaterial behaviour and should be systematically addressed. The sample preparation for physical and chemical properties includes one new endpoint, hydrophobicity. The GSPD reflects the growing consensus on the key practical issues for preparing nanomaterial samples in media for environmental studies. The information on sample preparation for <em>in vitro</em> testing is completely new, and the information on mammalian toxicity sample preparation reflects the leap in knowledge. The glossary has been significantly expanded. This paper provides an overview of the new elements in the updated GSPD.</div></div>","PeriodicalId":18786,"journal":{"name":"NanoImpact","volume":"41 ","pages":"Article 100611"},"PeriodicalIF":5.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146142878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}