Titanium dioxide nanoparticles - physicochemical characterization and cytotoxic risk

IF 4.7 3区 环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES
Filip Kunc , Xiaomei Du , Andre Zborowski , Linda J. Johnston , David C. Kennedy
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引用次数: 0

Abstract

Titanium dioxide (TiO2) nanoparticles (NPs) are incorporated into numerous consumer products yet data as to potential adverse health effects remains inconclusive. In this paper we physically characterize 16 nanoforms of TiO2 from different manufacturers of different size, crystalline structure and surface chemistry. Physical measurements of the particles were performed and compared with those provided by manufacturers revealing several discrepancies. We then examined the biological effects of these particles in cell culture in 3 commonly used cell lines for testing materials. We were unable to validate that anatase particles are more cytotoxic than rutile particles as has been reported, and generally found that the particles produced few effects and no significant production of reactive oxygen species under the conditions used. While some particles do exhibit a dose dependent cytotoxicity that increases over time in some cell lines, the effects were not consistent between cell lines and do not appear to be linked to crystalline structure or any of the specific physical characteristics that were measured including, size, charge and surface composition, nor a correlation with the production of reactive oxygen species.
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来源期刊
NanoImpact
NanoImpact Social Sciences-Safety Research
CiteScore
11.00
自引率
6.10%
发文量
69
审稿时长
23 days
期刊介绍: NanoImpact is a multidisciplinary journal that focuses on nanosafety research and areas related to the impacts of manufactured nanomaterials on human and environmental systems and the behavior of nanomaterials in these systems.
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