Medical mycology最新文献_第8页

Molecular characterisation of Histoplasma capsulatum sensu lato from Ethiopian horses reveals two distinct phylogenetic clades. 埃塞俄比亚马的荚膜组织胞浆菌（Histoplasma capsulatum sensu lato）的分子特征揭示了两个不同的系统发育支系。

IF 2.7 3区医学

Medical mycology Pub Date : 2024-08-02 DOI: 10.1093/mmy/myae079

Patrick C Y Woo, Fatma Al Mheiri, Jessika Cavalleri, Sunitha Joseph, James Y M Tang, Marina Joseph, Chi-Ching Tsang, Susanna K P Lau, Ulrich Wernery

{"title":"Molecular characterisation of Histoplasma capsulatum sensu lato from Ethiopian horses reveals two distinct phylogenetic clades.","authors":"Patrick C Y Woo, Fatma Al Mheiri, Jessika Cavalleri, Sunitha Joseph, James Y M Tang, Marina Joseph, Chi-Ching Tsang, Susanna K P Lau, Ulrich Wernery","doi":"10.1093/mmy/myae079","DOIUrl":"10.1093/mmy/myae079","url":null,"abstract":"Epizootic lymphangitis (EL) is a highly prevalent and contagious infectious disease affecting horses in many parts of Ethiopia caused by Histoplasma capsulatum sensu lato ('var. farciminosum'). In this study, 12 suspected isolates of H. capsulatum sensu lato or yeasts unidentified by conventional biochemical tests isolated from Ethiopian horses with EL were characterised by internal transcribed spacer sequencing. Six of the 12 isolates were identified to be members of H. capsulatum sensu lato and the other six were Pichia kudriavzevii (synonym: Candida krusei) (n = 3), Trichosporon asahii (n = 1), Geotrichum silvicola (n = 1) and Moesziomyces aphidis (n = 1), respectively. The six H. capsulatum sensu lato isolates were further characterised by multilocus sequence analysis. Four distinct gene loci (arf [462 bases], H-anti [410 bases], ole1 [338 bases] and tub1 [272 bases]) of these six isolates as well as those of two H. capsulatum sensu lato ('var. farciminosum') reference strains (ATCC 58332 and ATCC 28798) were polymerase chain reaction (PCR)-amplified and sequenced. Phylogenetic analyses of their concatenated nucleotide sequences showed that three of the isolates and the reference strain ATCC 58332 were identical and belonged to the Eurasia clade within Latin American (LAm) A (H. suramericanum), and those of the other three isolates and the reference strain ATCC 28798 were identical and belonged to the Africa clade. At least two distinct phylogenetic clades of H. capsulatum sensu lato were circulating in Ethiopian horses with EL. Advanced molecular technologies and bioinformatics tools are crucial for the accurate identification and typing of pathogens as well as the discovery of novel microorganisms in veterinary microbiology.","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification and antifungal susceptibility profile of uncommon yeast species at Fattouma Bourguiba University Hospital in Tunisia. 突尼斯 Fattouma Bourguiba 大学医院不常见酵母菌种的鉴定和抗真菌药敏谱。

IF 2.7 3区医学

Medical mycology Pub Date : 2024-08-02 DOI: 10.1093/mmy/myae070

Sameh Belgacem, Wissal Chebil, Safa Ben Salem, Oussama Babba, Maha Mastouri, Hamouda Babba

{"title":"Identification and antifungal susceptibility profile of uncommon yeast species at Fattouma Bourguiba University Hospital in Tunisia.","authors":"Sameh Belgacem, Wissal Chebil, Safa Ben Salem, Oussama Babba, Maha Mastouri, Hamouda Babba","doi":"10.1093/mmy/myae070","DOIUrl":"10.1093/mmy/myae070","url":null,"abstract":"Despite the severe impact of uncommon yeast fungal infections and the pressing need for more research on the topic, there are still few studies available on the identification, epidemiology, and susceptibility profile of those pathogens. The aims of the current study were to define the profile of uncommon yeast species at Fattouma Bourguiba University Hospital using phenotypic, molecular, and proteomic methods and to study their antifungal susceptibility profile. Pre-identified uncommon yeast species were collected from 2018 to 2021. These isolates were further identified using phenotypic methods (ID32C® system and Vitek2® YST), matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS), and sequencing. The antifungal susceptibility profile was studied using the reference CLSI broth microdilution method. In total, 30 strains were collected during the study period. Referring to the sequencing, the most isolated uncommon species were Saprochaete capitata, Candida lusitaniae, Candida kefyr, Candida inconspicua, and Candida guilliermondii. A total of 90% of isolates were correctly identified by MALDI-TOF MS compared to 76.7% and 63.3% by ID32® C and VITEK® 2 YST, respectively. The isolated species showed variable responses to antifungals. Candida guilliermondii showed increased azole minimum inhibitory concentrations. Misidentification of uncommon yeast species was common using commercial phenotypic methods. The high percentage of concordance of MALDI-TOF results with sequencing highlights its high performance and usefulness as a routine diagnosis tool.","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141580225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sporothrix brasiliensis-specific polymerase chain reaction for the diagnosis of cat and human sporotrichosis through non-invasive samples. 通过非侵入性样本诊断猫和人孢子丝菌病的巴西孢子丝菌特异性 PCR。

IF 2.7 3区医学

Medical mycology Pub Date : 2024-08-02 DOI: 10.1093/mmy/myae075

Mariana Rodrigues Trápaga, Vanice Rodrigues Poester, Karine Ortiz Sanchotene, Rossana Patrícia Basso, Fabiana Fedatto Bernardon, Rejane Luvielmo, Cecília Bittencourt Severo, Rodrigo Almeida-Paes, Rosely Maria Zancopé Oliveira, Andrea von Groll, Melissa Orzechowski Xavier

{"title":"Sporothrix brasiliensis-specific polymerase chain reaction for the diagnosis of cat and human sporotrichosis through non-invasive samples.","authors":"Mariana Rodrigues Trápaga, Vanice Rodrigues Poester, Karine Ortiz Sanchotene, Rossana Patrícia Basso, Fabiana Fedatto Bernardon, Rejane Luvielmo, Cecília Bittencourt Severo, Rodrigo Almeida-Paes, Rosely Maria Zancopé Oliveira, Andrea von Groll, Melissa Orzechowski Xavier","doi":"10.1093/mmy/myae075","DOIUrl":"10.1093/mmy/myae075","url":null,"abstract":"Zoonotic sporotrichosis caused by Sporothrix brasiliensis is an emerging mycosis in Latin America. One of the problems to quickly treat infected animals and break the transmission chain is associated with the time-consuming gold-standard diagnosis method (culture). We aimed to evaluate a species-specific polymerase chain reaction (PCR) for the diagnosis of sporotrichosis caused by S. brasiliensis using non-invasive samples. We performed a retrospective cross-sectional study using samples collected with swabs from humans and cats with clinical suspicion of sporotrichosis. Deoxyribonucleic acid (DNA) was extracted using a commercial kit, and a species-specific PCR for S. brasiliensis detection was performed. One hundred ten samples were included. PCR showed a good concordance with culture (86% of agreement) for human and cat samples (Kappa coefficient = 0.722, and 0.727, respectively). In conclusion, our data shows that this adapted PCR using non-invasive samples can be applied to sporotrichosis diagnosis, being a good alternative mainly in regions with a lack of mycologists to identify the fungus in culture, contributing to the control of this emergent zoonosis.","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141752106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasma itraconazole concentrations during treatment of feline sporotrichosis. 治疗猫孢子丝虫病期间的血浆伊曲康唑浓度。

IF 2.7 3区医学

Medical mycology Pub Date : 2024-08-02 DOI: 10.1093/mmy/myae076

Gabriela Reis Pereira-Oliveira, Isabella Dib Ferreira Gremião, Maria Lopes Corrêa, Cindy Caroline Dos Santos Honorato, Paula Gonçalves Viana, Anna Barreto Fernandes Figueiredo, Jéssica Sepúlveda Boechat, Érica Guerino Dos Reis, Raquel de Vasconcelos Carvalhaes Oliveira, Aline Campos de Azevedo da Silva, Thiago Santana Novotny, Lusiele Guaraldo, Sandro Antonio Pereira

{"title":"Plasma itraconazole concentrations during treatment of feline sporotrichosis.","authors":"Gabriela Reis Pereira-Oliveira, Isabella Dib Ferreira Gremião, Maria Lopes Corrêa, Cindy Caroline Dos Santos Honorato, Paula Gonçalves Viana, Anna Barreto Fernandes Figueiredo, Jéssica Sepúlveda Boechat, Érica Guerino Dos Reis, Raquel de Vasconcelos Carvalhaes Oliveira, Aline Campos de Azevedo da Silva, Thiago Santana Novotny, Lusiele Guaraldo, Sandro Antonio Pereira","doi":"10.1093/mmy/myae076","DOIUrl":"10.1093/mmy/myae076","url":null,"abstract":"Itraconazole (ITZ) is the most used drug to treat feline sporotrichosis; however, little is known about its pharmacokinetics in cats with this mycosis. The aim of this study was to determine plasma ITZ concentrations in cats with sporotrichosis treated with ITZ as monotherapy or in combination with potassium iodide (KI). Cats diagnosed with sporotrichosis received orally ITZ (100 mg/cat/day) or combination therapy with ITZ (100 mg/cat/day) and KI (2.5-5 mg/kg/day) in the case of worsening or stagnation of the clinical condition. At each monthly visit, blood samples were collected at an interval of 4 h for analysis of trough and peak plasma ITZ concentrations by HPLC. Clinical features and laboratory parameters were evaluated during follow-up. Sixteen cats were included in the study. The median plasma ITZ concentration of all cats was 0.75 µg/mL. The median plasma ITZ concentration was 0.5 µg/mL in cats that received ITZ monotherapy (n = 12) and 1.0 µg/mL in those treated with ITZ + KI (n = 4). The clinical cure rate was 56.3% (n = 9) and the median treatment duration was 8 weeks. Nine cats (56.3%) developed adverse clinical reactions, and hyporexia was the most frequent (n = 8; 88.9%). Serum alanine aminotransferase was elevated in four cats (25%). The median plasma ITZ concentration detected in cats was considered to be therapeutic (>0.5 µg/mL) and was reached after 4 weeks of treatment. Plasma ITZ concentrations were higher in cats that received ITZ + KI compared to those treated only with ITZ, suggesting pharmacokinetic synergism between these drugs.","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141759748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Candida albicans-A systematic review to inform the World Health Organization Fungal Priority Pathogens List. 更正：白念珠菌--为世界卫生组织真菌优先病原体清单提供信息的系统性综述。

IF 2.7 3区医学

Medical mycology Pub Date : 2024-08-02 DOI: 10.1093/mmy/myae074

引用次数: 0

Mycology laboratory diagnostic capacity for invasive fungal diseases in public hospitals in Vietnam. 越南公立医院真菌学实验室对侵袭性真菌疾病的诊断能力。

IF 2.7 3区医学

Medical mycology Pub Date : 2024-08-02 DOI: 10.1093/mmy/myae082

Vu Ngoc Hieu, Nguyen Le Hiep, Le Minh Hang, Bianca A Lau-Goodchild, Nguyen Van Duong, Nguyen Thuy Linh, Justin Beardsley, Vu Quoc Dat

引用次数: 0

Aspergillosis coinfection in patients with proven mucormycosis. 已证实患有粘孢子菌病的患者合并曲霉菌病。

IF 2.7 3区医学

Medical mycology Pub Date : 2024-08-02 DOI: 10.1093/mmy/myae081

Sang Hyun Ra, Ji Yeun Kim, Joon Seon Song, Hyeon Mu Jang, Euijin Chang, Seongman Bae, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Sung-Han Kim

{"title":"Aspergillosis coinfection in patients with proven mucormycosis.","authors":"Sang Hyun Ra, Ji Yeun Kim, Joon Seon Song, Hyeon Mu Jang, Euijin Chang, Seongman Bae, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Sung-Han Kim","doi":"10.1093/mmy/myae081","DOIUrl":"10.1093/mmy/myae081","url":null,"abstract":"Although research on aspergillosis and mucormycosis confection is important to optimize antifungal therapy, data on this issue is scarce. Thus, we systematically investigated aspergillosis coinfection in patients with proven mucormycosis. Medical records of adult patients with proven mucormycosis whose formalin-fixed paraffin-embedded (FFPE) tissue sections were available, in a tertiary hospital from August 2007 to July 2023 were retrospectively reviewed to assess coinfection with aspergillosis. We noted cultures of fungi from sterile and non-sterile sites and performed polymerase chain reaction (PCR) assays on FFPE tissues to detect Aspergillus- and Mucorales-specific DNA. Sixty-seven patients with proven mucormycosis, including 12 (18%) with a positive culture of the mucormycosis agent from sterile site cultures, were enrolled. Fungal cultures from sterile and non-sterile sites revealed Aspergillus spp. growth in nine (13%) of the 67 patients, including two sterile and seven non-sterile cultures. The fungal PCR analysis from the FFPE sections was positive for Aspergillus-specific PCR in five (7%) and positive for both Aspergillus- and Mucorales-specific PCR results in eight (12%). Overall, 21 (31%) of the 67 patients with proven mucormycosis had microbiologic and/or molecular evidence of aspergillosis coinfection. Positive blood or bronchoalveolar lavage fluid galactomannan results were more common in the coinfection group (67% [14/21]) than in the mucormycosis group (37% [17/46], P = .024). No significant difference in mortality between the two groups was observed. Approximately one-third of patients with proven mucormycosis exhibited molecular and/or microbiologic evidence of aspergillosis coinfection. Further research is needed to identify patients with aspergillosis and mucormycosis coinfections, for optimal antifungal therapy.","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141976087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic performance of the (1-3)-β-d-glucan assay in patients with different risks for invasive fungal diseases. (1-3)-β-D-葡聚糖检测法在不同侵袭性真菌疾病风险患者中的诊断性能。

IF 2.7 3区医学

Medical mycology Pub Date : 2024-08-02 DOI: 10.1093/mmy/myae071

Eliel Nham, Si-Ho Kim, Jae-Hoon Ko, Kyungmin Huh, Sun Young Cho, Cheol-In Kang, Doo Ryeon Chung, Kyong Ran Peck

{"title":"Diagnostic performance of the (1-3)-β-d-glucan assay in patients with different risks for invasive fungal diseases.","authors":"Eliel Nham, Si-Ho Kim, Jae-Hoon Ko, Kyungmin Huh, Sun Young Cho, Cheol-In Kang, Doo Ryeon Chung, Kyong Ran Peck","doi":"10.1093/mmy/myae071","DOIUrl":"10.1093/mmy/myae071","url":null,"abstract":"We evaluated the diagnostic performance of the β-d-glucan (BDG) test (Beijing Gold Mountain River Tech) in diagnosing invasive fungal disease (IFD) and its variations among patients with different risks. Patients ≥18 years old who underwent a serum BDG test (positive cutoff value >80 pg/ml) from April 2017 through May 2018 were collected consecutively. Patients were classified into three groups: group 1, patients with host factors as defined by the prior 2008 European Organization for Research and Treatment (EORTC) criteria; group 2, those with extended host factors in 2020 EORTC criteria; and group 3, those without any risk factor mentioned in the criteria. IFD was defined by 2020 EORTC criteria, but BDG was not considered. Diagnostic performance of the serum BDG test was measured by the area under the curve (AUC) of the receiver-operating characteristic curve. Among 469 patients, 15.4% (72/469) were diagnosed with IFD (48/191 [25.1%], 14/144 [9.7%], and 10/134 [7.5%] in groups 1, 2, and 3, respectively). The BDG assay showed fair performance (AUC 0.748 [95% CI: 0.688-0.810]). Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were 77.8%, 60.7%, 26.4%, and 93.8%, respectively. PPV was higher in group 1, and NPV was higher in group 3. Additionally, diagnostic odds ratios were 6.73, 2.88, and 5.92 in groups 1, 2, and 3. Immunosuppressant use, non-IFD/Candida colonization, and central venous catheter were associated with false positivity. Clinicians should cautiously interpret the BDG assay, considering the various diagnostic performances depending on the different levels of risk.","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141727428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design of Cryptococcus neoformans multi-epitope vaccine based on immunoinformatics method. 基于免疫信息学方法设计新型隐球菌多位点疫苗

IF 2.7 3区医学

Medical mycology Pub Date : 2024-08-02 DOI: 10.1093/mmy/myae080

Ziyou Zhou, Fei Zhu, Shiyang Ma, Caixia Tan, Hang Yang, Peipei Zhang, Yizhong Xu, Rongliu Qin, Yuying Luo, Jie Chen, Pinhua Pan

{"title":"Design of Cryptococcus neoformans multi-epitope vaccine based on immunoinformatics method.","authors":"Ziyou Zhou, Fei Zhu, Shiyang Ma, Caixia Tan, Hang Yang, Peipei Zhang, Yizhong Xu, Rongliu Qin, Yuying Luo, Jie Chen, Pinhua Pan","doi":"10.1093/mmy/myae080","DOIUrl":"10.1093/mmy/myae080","url":null,"abstract":"Cryptococcus neoformans is a widely distributed opportunistic pathogenic fungus. While C. neoformans commonly infects immunocompromised individuals, it can also affect those who are immunocompetent. Transmission of C. neoformans primarily occurs through the respiratory tract, leading to the development of meningitis. The mortality rate of Cryptococcal meningitis is high, and treatment options are limited. Cryptococcus neoformans infections pose a significant public health threat and currently lack targeted and effective response strategies. This study aimed to screen T lymphocyte (cytotoxic T lymphocyte and helper T lymphocyte) and B lymphocyte epitopes derived from four C. neoformans antigens and develop two multi-epitope vaccines by combining them with various adjuvants. Molecular docking results demonstrated that the vaccines bind stably to Toll-like receptor 4 ( and induce innate immunity. The credibility of the molecular docking results was validated through subsequent molecular dynamics simulations. Furthermore, the results of immune simulation analyses underscored the multi-epitope vaccine's capability to effectively induce robust humoral and cellular immune responses within the host organism. These two vaccines have demonstrated theoretical efficacy against C. neoformans infection as indicated by computer analysis. Nevertheless, additional experimental validation is essential to substantiate the protective efficacy of the vaccines.","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141913293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Direct antiglobulin (Coombs) test in HIV-positive Talaromycosis marneffei patients. HIV 阳性 Talaromycosis marneffei 患者的直接抗球蛋白（库姆斯）试验。

IF 2.7 3区医学

Medical mycology Pub Date : 2024-08-02 DOI: 10.1093/mmy/myae077

Mengyan Wang, Yujiao Jin, Biao Zhu

{"title":"Direct antiglobulin (Coombs) test in HIV-positive Talaromycosis marneffei patients.","authors":"Mengyan Wang, Yujiao Jin, Biao Zhu","doi":"10.1093/mmy/myae077","DOIUrl":"10.1093/mmy/myae077","url":null,"abstract":"Talaromycosis marneffei (T.M) is the primary opportunistic infection of AIDS patients, and its morbidity and mortality are extremely high. To further clarify the disease characteristics of patients and provide a solid basis for in-depth exploration of their pathogenic mechanisms, we retrospectively summarized and analyzed their clinical data. We included all T.M patients tested for direct antiglobulin test (DAT) in the study. Interestingly, we found that AIDS-T.M patients had an extremely high rate of DAT positivity (92/127, 72.44%). In univariate analysis, a positive DAT was associated with blood culture of TM (P = .021), hypoproteinemia (P = .001), anemia (P = .001), thrombocytopenia (P = .003), sepsis (P = .007), and Sequential Organ Failure Assessment (SOFA) (P = .001). Hypoproteinemia, anemia, SOFA, APTT > 32.6 s, and AST > 40 U/l were studied by logistic regression. Logistic regression revealed that SOFA (OR = 1.311, P = .043), hypoproteinemia (OR = 0.308, P = .021), and anemia (OR = 0.19, P = .044) were associated with positive DAT. Positive DAT was associated with severe disease manifestations such as sepsis, and the DAT test is crucial in patients with fungemia.","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11319930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141913294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0