Medical mycology最新文献

{"title":"Molecular Epidemiology and Antifungal Susceptibility of Sporothrix Isolates from Shanxi, China: A Retrospective Study and National Comparison.","authors":"Ziping Song, Yujia Zhai, Long Zhou, Xiaorui Su, Xiao He, Ting Li, Kai Xu, Ruijun Zhang, Yuying Kang","doi":"10.1093/mmy/myaf090","DOIUrl":"https://doi.org/10.1093/mmy/myaf090","url":null,"abstract":"<p><p>This study characterizes the molecular epidemiology of Sporothrix species in Shanxi Province, a low-prevalence region in China, providing real data on genetic profiles and antifungal susceptibility patterns. Clinical records of sporotrichosis cases from a tertiary hospital in Shanxi (2019-2024) were retrospectively analyzed. Isolates were identified through multilocus sequencing targeting the internal transcribed spacer (ITS), calmodulin (CAL), β-tubulin (TUB), and mating-type locus (MAT) genes, with phylogenetic analysis. Antifungal susceptibility testing against seven agents was performed for both yeast and mycelial phases. Additionally, a review of Chinese case reports (2015-2025) was conducted to collect and summarize data on Sporothrix species identification across the country. All 11 isolates were confirmed as Sporothrix globosa, displaying high genetic similarity to the strains reported in most regions of China in previous studies. Terbinafine, ketoconazole, and itraconazole demonstrated good activity. Yeast-phase susceptibility was significantly higher for amphotericin B, itraconazole, and voriconazole (P<0.05, compared to the mycelial phase). Geospatial analysis indicated S. globosa dominance in reported areas, with persistent surveillance gaps in western China. This study from Shanxi provides a comprehensive overview of S. globosa as the predominant etiological agent in the region, consistent with the distribution pattern observed throughout China. Terbinafine demonstrated the highest in vitro activity against S. globosa.</p>","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145200226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of direct antifungal susceptibility testing using E-test for four antifungal agents in candidemia patients.","authors":"Grégoire Miaux, Ryane Benkhelil, Gisèle Dewulf, Séverine Loridant, Eric Dannaoui, Edith Mazars","doi":"10.1093/mmy/myaf077","DOIUrl":"10.1093/mmy/myaf077","url":null,"abstract":"<p><p>Candidemia is associated with high morbidity and mortality. Delayed initiation of effective and appropriate antifungal therapy correlates with increased patient mortality, emphasizing the importance of rapid antifungal susceptibility testing (AFST). Usual commercial methods, such as the standard E-test, are time-consuming, often requiring a minimum of 48 h. This study aimed to evaluate the performance of direct E-test (ET-dir) directly from positive blood culture bottles, with the goal of reducing turnaround time and improving clinical decision-making. A total of 160 yeast positive blood cultures were included over a 4-year period, comprising 85 Candida albicans. The minimum inhibitory concentrations (MICs) of fluconazole, voriconazole, amphotericin B, and anidulafungin were determined using ET-dir and compared to ET method (ET-sd). Essential agreement, categorical agreement, error rates, and bias were analyzed for all species and specifically for C. albicans. The essential agreement between ET-dir and ET-sd exceeded 87% for all antifungal agents and reached ≥90% for fluconazole. The categorical agreement was above 90% for all agents, and error rates remained within acceptable limits except for anidulafungin. For C. albicans, 23 of 24 performance data met acceptability criteria, with essential agreement ≥90% for all agents except fluconazole. ET-dir results were interpretable within 24 h for 93.7% of strains, providing at least a 24-h time gain over ET-sd. ET-dir is a reliable and rapid AFST method for candidemia, meeting most performance criteria compared to ET-sd while significantly reducing turnaround time. Its routine implementation could enable faster adaptation of antifungal therapy, ensuring that treatments are optimized based on susceptibility results.</p>","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144961052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Isavuconazole for Invasive Fungal Infections: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Ayano Kawasaki, Ryuya Shintani, Risa Takao, Yuka Nakazawa, Takayuki Mihara, Shintaro Ikegami, Sora Shimada, Yuri Matsumoto, Yuko Okamoto, Yuki Igarashi, Yuki Enoki, Kazuaki Taguchi, Kazuaki Matsumoto","doi":"10.1093/mmy/myaf089","DOIUrl":"https://doi.org/10.1093/mmy/myaf089","url":null,"abstract":"<p><strong>Background: </strong>Isavuconazole (ISA) is a treatment option for invasive fungal infections (IFIs) and is known for a favorable safety profile compared with other antifungal agents. However, comprehensive evidence regarding its efficacy and safety remains limited.</p><p><strong>Objectives: </strong>This study aimed to assess the efficacy and safety of ISA compared with other antifungal agents through a systematic review and meta-analysis restricted to randomized controlled trials (RCTs), to provide more reliable estimates of its clinical effects.</p><p><strong>Methods: </strong>Following PRISMA guidelines, a comprehensive literature search was conducted using PubMed, the Cochrane Library, Web of Science, and ClinicalTrials.gov to identify RCTs comparing ISA with other antifungal agents. The primary outcomes were clinical response and mortality. Secondary outcomes included the incidence of adverse events, including serious, drug-related, and organ-specific toxicities. A subgroup analysis was conducted focusing on filamentous fungal infections, comparing ISA and voriconazole.</p><p><strong>Results: </strong>Three RCTs met the inclusion criteria. No statistically significant differences were observed between ISA and comparator agents in terms of clinical response, mortality, or total and organ-specific adverse events. A trend toward fewer adverse events was noted in the ISA group. In the subgroup analysis, ISA and voriconazole showed similar efficacy and overall safety; however, the incidence of both drug-related adverse events and hepatobiliary disorders was significantly lower in the ISA group.</p><p><strong>Conclusions: </strong>ISA demonstrated efficacy comparable to that of other antifungal agents, with a favorable safety profile in patients with IFIs, including filamentous fungal infections. This meta-analysis of RCTs provide high-quality evidence to support antifungal drug selection in clinical practice.</p>","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145176554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Candidemia caused by Meyerozyma guilliermondii species complex in patients with cancer: A systematic review of case reports.","authors":"Jingchen Tang, Liuyang Cai, Haiyang He, Xiaohui Li, Siqin Liang, Li Zhang, Xiaochun Xue, Bin Xu, Weihua Pan","doi":"10.1093/mmy/myaf087","DOIUrl":"https://doi.org/10.1093/mmy/myaf087","url":null,"abstract":"<p><p>Meyerozyma guilliermondii represents an opportunistic pathogen complex threatening immunocompromised patients, notably those with cancer, leading to candidemia characterized by increasing incidence and high mortality risk. However, understanding of candidemia in cancer patients is limited. This study aims to elucidate the epidemiological and clinical features of candidemia by the M. guilliermondii species complex (MGSC) in cancer patients, thereby enhancing disease diagnosis and treatment. A systematic review was performed, analyzing cases from 1967 to 2024 documented in PubMed, Scopus, Embase, and Web of Science using specific terms related to M. guilliermondii and cancer. Additionally, two cancer-related invasive candidiasis cases by M. guilliermondii sensu stricto from Jiangxi Cancer Hospital were included. The review identified 282 cases, with 225 specifying tumor types: 114 hematologic malignancies and 111 solid tumors. A significant increase in cases was noted over the last two decades (92.2%). Predominantly adults were affected, with a male-to-female ratio of 97:53. Among the precisely identified species in recent years, M. guilliermondii sensu stricto was the most recorded species (83.6%), with nine cases of candidemia due to M. caribbica in cancer patients. The overall mortality was 33.0%. Common factors included central venous catheter (CVC) placement (75.8%), prior broad-spectrum antibiotics (68.5%), and parenteral nutrition (46.1%). Timely CVC removal is crucial for cancer patients with prolonged CVC placement to prevent MGSC-related candidemia. Cancer patients with multiple risk factors are highly susceptible to MGSC-caused candidemia, which is increasing in incidence and mortality risk. Prompt antifungal therapy is essential for improving prognosis.</p>","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in epidemiological and clinical findings between localized and systemic osteoarticular infection caused by Sporothrix: a systematic review of individual participant data.","authors":"Max Carlos Ramírez-Soto, Alexandro Bonifaz, Andrés Tirado-Sánchez, Yang Song, Alejandro Llanos-Cuentas","doi":"10.1093/mmy/myaf088","DOIUrl":"https://doi.org/10.1093/mmy/myaf088","url":null,"abstract":"<p><p>Knowledge of the clinical recognition and management of osteoarticular sporotrichosis is derived from case reports and limited series. Our aim was to perform a systematic review to evaluate the differences in epidemiologic and clinical findings between localized and systemic forms of osteoarticular sporotrichosis. We searched MEDLINE/PubMed, SCOPUS, Web of Science (WoS), Ovid, SCiELO, Cochrane, China National Knowledge Infrastructure (CNKI), Wanfang Data, CQVIP and xueshu.baidu.com on 31 December 2023. The retrieved case data was divided into two groups: (1) localized osteoarticular infection and (2) systemic osteoarticular infection. We estimated differences between the two groups using generalized linear models with Poisson distribution for robust variances to estimate prevalence ratios (PRs) with 95% confidence intervals (95% CIs). A total of 111 cases of localized infection and 100 cases of systemic infection were included. Individuals with systemic infection were more likely to be from hyperendemic areas (adjusted prevalence ratio (aPR) = 1.64; 95% CI, 1.24-2.18; p = 0.001), have HIV infection (aPR = 2.33; 95% CI, 1.42-3.82; p = 0.001), and have cancer (aPR = 1.90; 95% CI, 1.09-3.31; p = 0.023). Arthritis (50.4%) and osteomyelitis (46.0%) were predominant in localized and systemic infections, respectively. Osteomyelitis in 2 or more bones was more common in individuals with a systemic infection (aPR = 10.3; 95% CI, 3.38-31.7; p < 0.0001). Most cases of localized infection were treated with combination antifungals and surgery (32.2%), combination antifungals (25.3%) and amphotericin B monotherapy (19.1%), and systemic infection with combination antifungals (49.4%). As for the outcome, there were better outcomes in localized than in systemic infection. Therefore, Sporothrix infection should be considered in the differential diagnosis of osteomyelitis or arthritis, especially in immunocompromised patients from hyperendemic areas.</p>","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring virulence attributes in non-Cryptococcus Tremellomycetes.","authors":"Carolina Bermann, Caroline Quintana Braga, Luciéle Pereira de Melo, Augusto Brod, Henrique Zarnott Raatz, Isabella Rodrigues de Andrade, Lara Baccarin Ianiski, Aline Maciel Dos Santos, Sônia Avila Botton, Daniela Isabel Brayer Pereira","doi":"10.1093/mmy/myaf086","DOIUrl":"https://doi.org/10.1093/mmy/myaf086","url":null,"abstract":"<p><p>This study evaluated the virulence traits of non-Cryptococcus Tremellomycetes Papiliotrema flavescens (n = 5), Naganishia diffluens (n = 6), N. randhawae (n = 1), and Filobasidium magnum (n = 2). Virulence traits analyzed included capsule formation, melanin production, urease and phospholipase activity, hemolysin production, biofilm formation, and UV resistance. All yeasts produced capsule; melanin was detected in 78.6%, urease in 92.9%, and phospholipase in 85.7%; 42.9% were weak biofilm producers, and 33.3% survived UV exposure. These findings highlight that the fungi evaluated exhibit virulence attributes, underscoring the need for further research, including in vivo studies and genetic analyses, to clarify their pathogenic potential.</p>","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation and Clinical Impact of the Combination of Wako® (1,3)-β-D-Glucan in Serum and RT-PCR in Oral Wash for Pneumocystis jirovecii Infection Diagnosis: A Retrospective Cohort Study.","authors":"Alfredo Maldonado-Barrueco, Claudia Sanz-González, Eduardo Rubio-Mora, Inmaculada Quiles-Melero, Julio García-Rodríguez","doi":"10.1093/mmy/myaf085","DOIUrl":"https://doi.org/10.1093/mmy/myaf085","url":null,"abstract":"<p><p>Pneumocystis jirovecii pneumonia (PCP) is an opportunistic infection in immunocompromised patients, with a complex diagnosis due to its colonizing role. Current guidelines recommend microbiological confirmation through direct microscopy of lower respiratory tract samples, 1,3-β-D-glucan (BDG) serum testing, or RT-PCR detection in lower respiratory samples. However, non-invasive diagnostic alternatives, such as oral wash RT-PCR combined with BDG serum levels, could be an option for non-intubated and non-candidates to bronchoscopy patients in a real clinical setting. A retrospective study analysed 49 patients with suspected PCP at Hospital Universitario La Paz (Madrid, Spain) between January 2020-March 2025. Patients underwent to serum BDG (Wako®, ≥7 pg/mL) and P. jirovecii RT-PCR in oral wash tests. The study assessed the impact of time of symptoms and treatment on microbiological findings, and the clinical utility of combining test for PCP diagnosis. Among the 49 patients, 12 (24.5%) had a positive P. jirovecii RT-PCR in oral wash, and 12 of them (85.7%) also a positive BDG. Median BDG was 27.1 (IQR: 14.4-100.7) pg/mL for positive patients (p < 0.05). Patients with (+)BDG/RT-PCR showed a longer symptom duration compared to negative (p > 0.05). Previous PCP prophylaxis/treatment showed a reduce on P. jirovecii RT-PCR results (p > 0.05). Combining tests could be useful in patients who are not candidates for bronchoscopy (p < 0.05) and influenced treatment decisions, reducing unneeded PCP treatments in (-)RT-PCR/BDG in immunosuppressed patients with high pretest value. P. jirovecii RT-PCR in oral wash showed to be good screening assay in patients without PCP treatment/prophylaxis and BDG as appears to serve as a complementary diagnostic tool for confirming PCP infection, primarily in prolonged infectious conditions. This strategy could help optimize treatment decisions reducing the need for invasive procedures. Further multicentric studies are needed to validate the combination test results and assess cost-effectiveness in clinical practice.</p>","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology and outcomes of Candida-associated osteoarticular infections: A multicentre retrospective study from Turkey.","authors":"Özlem Güler, Murat Üzel, Dilşat Tepe, Firdevs Aksoy, Güle Çınar, Kemal Osman Memikoğlu, Bülent Durdu, Tülay Ünver Ulusoy, Aysun Benli̇, Zeynep Karakaşoğlu, Neşe Saltoğlu, Derya Seyman, Işıl Deniz Alıravcı, Hasibullah Yaqoobi, Ayça Aydın, Hatun Öztürk Çerik, Selin Özdemir, Betül Sümer, Azize Yetişgen, Ayşe Batırel, Ayşe Serra Özel, Seniha Şenbayrak, Yasemin Tezer Tekçe, Zehra Çağla Karakoç","doi":"10.1093/mmy/myaf080","DOIUrl":"10.1093/mmy/myaf080","url":null,"abstract":"<p><p>This multicentre retrospective study investigated the epidemiology, clinical characteristics, and fluconazole resistance rates of Candida species in osteoarticular infections across Turkey as well as the factors influencing complete recovery. Data were gathered from 73 adult patients diagnosed with proven or probable Candida-associated osteoarticular infections between 2015 and 2025 from 20 healthcare centres. The most common clinical presentation was spondylodiscitis, followed by the involvement of phalangeal bones in the hands and feet. Non-albicansCandida species accounted for 37/73 cases (50.7%), with Candida parapsilosis being the most frequent. Fluconazole resistance was low among C. albicans isolates (3%) but higher among non-albicans yeasts (27%). Bacterial co-infection, predominantly Gram-positive bacteria, was detected in 52.1% of cases. Diabetes was present in 50/73 patients (68.5%), particularly insulin-dependent diabetes, and was a prominent comorbidity that may have also contributed as a predisposing factor. Radiological detection of osteomyelitis was achieved in 69.9% of patients. Fluconazole was the most commonly used antifungal agent (74%) with a median treatment duration of 90 days. Multivariate analysis revealed that surgical debridement was significantly associated with a higher odds of clinical recovery (adjusted odds ratio [aOR], 5.764; 95% confidence interval [CI], 1.360-24.434; P = .017), whereas diabetes mellitus was significantly associated with a lower odds of total recovery (aOR, 0.205; 95% CI, 0.053-0.792; P = .022). In conclusion, this multicentre study provides epidemiological data and fluconazole resistance rates of Candida species causing osteoarticular infections in Turkey, highlights the occurrence of C. auris in this cohort, and identifies surgical intervention and diabetes mellitus as factors significantly associated with recovery.</p>","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12421878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144961010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro susceptibility profile of Brazilian Sporothrix brasiliensis isolates to amorolfine hydrochloride and itraconazole.","authors":"Luciéle Pereira de Melo, Caroline Quintana Braga, Carolina Dos Santos Bermann, Lara Baccarin Ianiski, Jefferson Luiz Silva de Souza, Jéssica Rabelo de Oliveira Persichini, Angelita Dos Reis Gomes, Renata Osório de Faria, Maria Isabel de Azevedo, Sônia de Avila Botton, Daniela Isabel Brayer Pereira","doi":"10.1093/mmy/myaf075","DOIUrl":"10.1093/mmy/myaf075","url":null,"abstract":"<p><p>Sporothrix brasiliensis is the leading cause of feline sporotrichosis in Brazil, an emerging zoonosis. Itraconazole (ITZ) is the first-line therapy; however, therapeutic failures and reports of ITZ-resistant isolates emphasize the need for new therapeutic options. This study evaluated the in vitro susceptibility profile of 25 Brazilian S. brasiliensis isolates to amorolfine hydrochloride (AMR) and ITZ. AMR evidenced fungicidal activity in 76% and fungistatic activity in 24% of isolates. All isolates were susceptible to ITZ. These findings support AMR as a promising antifungal candidate against S. brasiliensis and highlight the importance of continued surveillance of ITZ susceptibility, especially in endemic regions of Brazil.</p>","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144961082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malassezia japonica isolated from the cerumen of Cercopithecidae and Hylobatidae.","authors":"Ryuri Tachikawa, Koshiro Watanuki, Yuta Shintaku, Dai Hirose","doi":"10.1093/mmy/myaf078","DOIUrl":"10.1093/mmy/myaf078","url":null,"abstract":"<p><p>Species diversity of Malassezia in the cerumen of nonhuman primates (NHPs) belonging to the Cercopithecidae and Hylobatidae families was investigated. Isolates from cerumen samples collected from carcasses were identified at the species level using 26S rRNA sequence analysis, and intraspecific genetic variation was evaluated using internal transcribed spacer sequences. Fifteen strains were isolated from 30 cerumen samples. They were all identified as Malassezia japonica and clustered into three phylogenetic groups. Malassezia japonica is not a dominant species on human skin, but the results obtained suggest its adaptation to the skin of NHPs.</p>","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144961080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}