Medical mycology最新文献

Malassezia yeast population dynamics on the skin of patients living with HIV.

IF 2.7 3区医学

Medical mycology Pub Date : 2024-12-14 DOI: 10.1093/mmy/myae120

Abdourahim Abdillah, Isabelle Ravaux, Saadia Mokhtari, Stéphane Ranque

{"title":"Malassezia yeast population dynamics on the skin of patients living with HIV.","authors":"Abdourahim Abdillah, Isabelle Ravaux, Saadia Mokhtari, Stéphane Ranque","doi":"10.1093/mmy/myae120","DOIUrl":"https://doi.org/10.1093/mmy/myae120","url":null,"abstract":"Malassezia species are lipid-dependent yeasts of the normal skin mycobiota in humans and some animals. Yet, both the dynamic of Malassezia skin colonization and the associated fungal and bacterial skin microbiome remain unknown in HIV+ patients. This study aimed to compare Malassezia yeast community structure and associated microbiome on the healthy skin of HIV+ patients and healthy controls. A total of 23 HIV+ patients and 10 healthy controls were included and followed-up for a maximum of 5 visits over 10 to 17 months. At each visit, chest, face, nasolabial fold, and scalp skin samples were subjected to both culture and MALDI-TOF MS identification, and ITS/16S metabarcoding. The participants were categorized according to their Malassezia colony forming unit (CFU) abundance. Malassezia were cultured from each participant at each visit. HIV+ patients were highly colonized on all visits with CFU >100. M. sympodialis and M. globosa were the most dominant species. M. furfur and M. dermatis were more prevalent in HIV+ than in healthy participants. M. sympodialis prevalence was stable at each sampling sites over time. M. furfur prevalence was stable and more abundant over time on HIV+ patients' chest. The metabarcoding analysis suggested a higher fungal and bacterial diversity and an increased abundance of Cladosporium halotolerans and Streptococcus in HIV+ patients than in controls. Overall, HIV+ patients display a high skin colonization by Malassezia yeasts and a dysbiosis of both fungal and bacterial communities.","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of the cell-surface lectin domain-containing protein expressed in the adhesive colony morphology of Trichosporon asahii.

IF 2.7 3区医学

Medical mycology Pub Date : 2024-12-13 DOI: 10.1093/mmy/myae119

Tomoe Ichikawa, Yoshio Ishibashi

{"title":"Identification of the cell-surface lectin domain-containing protein expressed in the adhesive colony morphology of Trichosporon asahii.","authors":"Tomoe Ichikawa, Yoshio Ishibashi","doi":"10.1093/mmy/myae119","DOIUrl":"https://doi.org/10.1093/mmy/myae119","url":null,"abstract":"Trichosporon asahii is a yeast pathogen that causes a deep-seated infection. In fungal infections, molecules involved in adhesion to host tissues or catheters are one of the pathogenic factors. A single strain of T. asahii produces various colony morphologies, including highly adhesive colony types, but the molecules involved in the adhesiveness have not been identified. This study compared proteins in cell-surface extracts from weakly and highly adherent colony types and identified a protein abundantly expressed in highly adherent cells, which was named T. asahii R-type lectin domain-containing protein (TAL). TAL was a predicted 48 kDa protein with a carbohydrate-binding region, but a band was detected at ∼250 kDa in sodium dodecyl sulfate-polyacrylamide gel electrophoresis, suggesting that it was highly glycosylated. When TAL was overexpressed in mammalian cells and deglycosylated, the protein size decreased, confirming that it was glycosylated. In weakly adherent colony-type cells, the bands detected by anti-TAL antiserum were barely noted. The absence of bands indicates that the protein expression was low and does not suggest that the degree of glycosylation was different. These results suggested that multiple colony types derived from a single strain have different pathogenic properties.","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical characteristics and outcomes of colonization and infection by yeast species in solid organ transplant recipients: molecular identification and antifungal susceptibility patterns of isolates.

IF 2.7 3区医学

Medical mycology Pub Date : 2024-12-11 DOI: 10.1093/mmy/myae118

Somayeh Yazdanpanah, Mojtaba Shafiekhani, Mohammad Ahmadi, Zahra Zare, Hamed Nikoupour, Sara Arabsheybani, Bita Geramizadeh, Mohammad-Hossein Anbardar, Parisa Chamanpara, Hamid Badali, Mohsen Moghadami, Keyvan Pakshir, Kamiar Zomorodian

{"title":"Clinical characteristics and outcomes of colonization and infection by yeast species in solid organ transplant recipients: molecular identification and antifungal susceptibility patterns of isolates.","authors":"Somayeh Yazdanpanah, Mojtaba Shafiekhani, Mohammad Ahmadi, Zahra Zare, Hamed Nikoupour, Sara Arabsheybani, Bita Geramizadeh, Mohammad-Hossein Anbardar, Parisa Chamanpara, Hamid Badali, Mohsen Moghadami, Keyvan Pakshir, Kamiar Zomorodian","doi":"10.1093/mmy/myae118","DOIUrl":"https://doi.org/10.1093/mmy/myae118","url":null,"abstract":"Fungal infections are serious complications after solid organ transplantation, with high mortality and morbidity. Given the importance of the local epidemiological data, and also extensive prophylactic regimens in solid organ transplant (SOT) recipients, this study aimed to investigate the clinical characteristics and resistance patterns of yeast isolates in SOT recipients at a main referral transplant center in Iran. Of the 275 recipients enrolled, 22 (8%) had at least one positive yeast culture at a median of 5 days after transplantation. Bacterial infection and reoperation were significantly associated with colonization or infection caused by yeast species (P:0.001). Moreover, mortality and length of ICU/hospital stay were significantly higher in patients with positive yeast cultures (P < 0.05). The most frequent species isolated was Candida albicans (50%), followed by C. glabrata (22.7%). Of species with definite breakpoints, the fluconazole- resistant rate was 23%. Caspofungin and amphotericin B showed potent activity against all isolates. Regarding the high risk of fungal infections, awareness of local epidemiological trends and resistance patterns can help improve outcomes in SOT recipients.","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between preoperative antifungal therapy and postoperative complications in patients with pulmonary aspergilloma: a national database study in Japan.

IF 2.7 3区医学

Medical mycology Pub Date : 2024-12-09 DOI: 10.1093/mmy/myae117

Keita Takeda, Akira Yokoyama, Takeshi Fukami, Yuya Kimura, Maho Suzukawa, Taisuke Jo, Junko Suzuki, Yuka Sasaki, Akihisa Mitani, Goh Tanaka, Asahi Fujita, Hiroki Matsui, Kiyohide Fushimi, Takahide Nagase, Hideo Yasunaga

{"title":"Association between preoperative antifungal therapy and postoperative complications in patients with pulmonary aspergilloma: a national database study in Japan.","authors":"Keita Takeda, Akira Yokoyama, Takeshi Fukami, Yuya Kimura, Maho Suzukawa, Taisuke Jo, Junko Suzuki, Yuka Sasaki, Akihisa Mitani, Goh Tanaka, Asahi Fujita, Hiroki Matsui, Kiyohide Fushimi, Takahide Nagase, Hideo Yasunaga","doi":"10.1093/mmy/myae117","DOIUrl":"https://doi.org/10.1093/mmy/myae117","url":null,"abstract":"Postoperative complications of pulmonary resection in patients with pulmonary aspergilloma are common. Preoperative antifungal therapy is a perioperative management strategy to reduce postoperative complications; however, the benefit of the treatment remains controversial. A retrospective cohort study was conducted using data from the Diagnosis Procedure Combination database (July 2010-March 2021), a national inpatient database in Japan. Patients with pulmonary aspergilloma with or without chronic necrotizing pulmonary aspergillosis who underwent pulmonary resection were identified and divided into two groups based on whether they received preoperative antifungal therapy. Propensity-score overlap weighting was performed to compare the occurrence of composite postoperative complications and postoperative length of hospital stay between the two groups. We identified 98 patients with pulmonary aspergilloma who received preoperative antifungal therapy and 399 patients who did not. After propensity-score overlap weighting, the preoperative antifungal therapy group had a significantly lower proportion of composite postoperative complications than the non-preoperative antifungal therapy group (6.8% vs. 14.2%, P = 0.038). There was no significant difference in postoperative length of stay between the groups with and without preoperative antifungal therapy (median 14.6 vs. 15.8 days, P = 0.41). Preoperative antifungal therapy was associated with a reduction in postoperative complications in patients with pulmonary aspergilloma. Preoperative treatment with antifungals may be beneficial in reducing the risk of postoperative complications in patients with pulmonary aspergilloma undergoing pulmonary resection.","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the diagnostic performance of a semi-quantitative lateral flow assay for the detection of Cryptococcus antigen in serum and cerebrospinal fluid specimens.

IF 2.7 3区医学

Medical mycology Pub Date : 2024-12-06 DOI: 10.1093/mmy/myae116

Maria Camila Castañeda-Torres, Julián Arango, Alejandra Zuluaga, Álvaro Rúa-Giraldo, Diego H Caceres

{"title":"Evaluation of the diagnostic performance of a semi-quantitative lateral flow assay for the detection of Cryptococcus antigen in serum and cerebrospinal fluid specimens.","authors":"Maria Camila Castañeda-Torres, Julián Arango, Alejandra Zuluaga, Álvaro Rúa-Giraldo, Diego H Caceres","doi":"10.1093/mmy/myae116","DOIUrl":"https://doi.org/10.1093/mmy/myae116","url":null,"abstract":"Cryptococcosis predominantly affects immunocompromised individuals, particularly those with advanced HIV disease, with meningitis being the most severe form and linked to high mortality. Diagnosis typically relies on rapid Cryptococcus antigen (CrAg) testing, and antigen titer quantification helps in early detection and assessing disease severity. However, conventional titer methods are often more expensive than qualitative antigen detection. This study assessed the diagnostic performance of a semi-quantitative Lateral Flow Assay (CrAgSQ LFA, IMMY™) for CrAg detection in serum and cerebrospinal fluid (CSF) collected between 2014-2022. The CrAgSQ LFA was compared to the standard CrAg LFA (IMMY™) and Clarus Cryptococcal Ag enzyme immunoassay (EIA-CrAg, IMMY™). The CrAgSQ LFA demonstrated 100% sensitivity and specificity in both serum and CSF, with perfect agreement (kappa 1.00) with the CrAg LFA. Comparing the CrAgSQ LFA with the titer measurement results obtained using CrAg LFA, in category 1+, titers ranged from 1:2-1:20; in 2+, from 1:5-1:40; in 3+, from 1:20-1:2560; and in category 4+, from 1:320-1:2560.Titer results for the CrAgSQ LFA aligned well with CrAg LFA, and operator agreement was strong, with weighted kappa values of 0.926 and 0.966. The CrAg-EIA showed a sensitivity of 84% and specificity of 100% using the manufacture cut-off (> 0.265), which improved to 96% sensitivity with an optimized cut-off value (>0.145). Overall, the CrAgSQ LFA demonstrated high accuracy and reliability, suggesting it could be a valuable tool for diagnosing cryptococcosis in the Americas.","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical utility of pharmacogenomic testing for patients with coccidioidal meningitis. 球虫脑膜炎患者药物基因组学检测的临床实用性。

IF 2.7 3区医学

Medical mycology Pub Date : 2024-12-05 DOI: 10.1093/mmy/myae113

Rawan Elkurdi, Marie F Grill, Adrijana Kekic, Janis E Blair

引用次数: 0

Pulmonary aspergillosis in green sea turtles (Chelonia mydas): A case series. 绿海龟（Chelonia mydas）肺曲霉菌病：绿海龟曲霉菌病病例系列。

IF 2.7 3区医学

Medical mycology Pub Date : 2024-12-05 DOI: 10.1093/mmy/myae114

Vanice Rodrigues Poester, Jessica E Dávila Hidalgo, Lívia Silveira Munhoz, Mariana Rodrigues Trápaga, Emília Ferreira Andrade, Paula Lima Canabarro, Pamela Parmigiani, Eduarda Corrêa Freitas, Mariana Martins Flores, Éryca Ceolin Lamego, Andréa Corrado Adornes, Alessandro Comarú Pasqualotto, David A Stevens, Melissa Orzechowski Xavier

引用次数: 0

Antemortem diagnostic tests for the detection of Aspergillus infection in birds: A systematic review. 用于检测鸟类曲霉菌感染的尸检诊断测试：系统综述。

IF 2.7 3区医学

Medical mycology Pub Date : 2024-11-12 DOI: 10.1093/mmy/myae112

Sabrina Vieu, Jacques Guillot, François Beaudeau

{"title":"Antemortem diagnostic tests for the detection of Aspergillus infection in birds: A systematic review.","authors":"Sabrina Vieu, Jacques Guillot, François Beaudeau","doi":"10.1093/mmy/myae112","DOIUrl":"10.1093/mmy/myae112","url":null,"abstract":"Aspergillosis remains a common and life-threatening disease in captive and wild birds all over the world. The diagnosis is currently based on clinical signs or lesions, diagnostic imaging, and a variety of biological tests. This systematic review aimed to compare the accuracy of antemortem diagnostic tests for Aspergillus infection in birds. According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a search was conducted on PubMed, Scopus, Web of Science, and CAB until January 2024. The methodological quality was assessed with QUADAS 2 risk of bias tool. The 13 studies, selected for the review, included results from a wide variety of birds (mainly Spheniciformes but also Falconiformes, Psittaciformes, and Galliformes) from wildlife rehabilitation centers, zoological parks, or veterinary practices. Aspergillus infection was mainly confirmed by fungal culture and/or histopathology. Serum markers included Aspergillus components (galactomannan, β-d-glucan, mannoproteins, and gliotoxin), anti-Aspergillus antibodies, 3-hydroxybutyrate, as well as protein electrophoresis and acute phase molecules. Sensitivity and specificity displayed a large amount of variation despite threshold arrangement. Disparities in the number of individuals per study did not allow for reliable comparison. Platelia Ag Assay (Bio-Rad), the most commonly used test in the studies, demonstrated moderate specificity and low sensitivity. Overall, non-specific tests demonstrated more consistent performance, whereas specific tests showed greater variability. Based on current knowledge, none of these tests provide sufficient accuracy to reliably detect Aspergillus infection in birds in clinical practice.","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142623845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Geraniol inhibits both planktonic cells and biofilms of the Candida parapsilosis species complex: Highlight for the improved efficacy of amphotericin B, caspofungin and fluconazole plus Geraniol. 香叶醇可抑制副丝状念珠菌菌种群的浮游细胞和生物膜：两性霉素 B、卡泊芬净和氟康唑加香叶醇可提高疗效的亮点。

IF 2.7 3区医学

Medical mycology Pub Date : 2024-11-12 DOI: 10.1093/mmy/myae105

José Júlio Costa Sidrim, Daniel Vieira Martins, Maria Gleiciane da Rocha, Géssica Dos Santos Araújo, Rossana de Aguiar Cordeiro, Glaucia Morgana de Melo Guedes, Waldemiro de Aquino Pereira-Neto, Débora de Souza Collares Maia Castelo-Branco, Marcos Fábio Gadelha Rocha

{"title":"Geraniol inhibits both planktonic cells and biofilms of the Candida parapsilosis species complex: Highlight for the improved efficacy of amphotericin B, caspofungin and fluconazole plus Geraniol.","authors":"José Júlio Costa Sidrim, Daniel Vieira Martins, Maria Gleiciane da Rocha, Géssica Dos Santos Araújo, Rossana de Aguiar Cordeiro, Glaucia Morgana de Melo Guedes, Waldemiro de Aquino Pereira-Neto, Débora de Souza Collares Maia Castelo-Branco, Marcos Fábio Gadelha Rocha","doi":"10.1093/mmy/myae105","DOIUrl":"10.1093/mmy/myae105","url":null,"abstract":"The Candida parapsilosis species complex poses a recognized threat to the nosocomial environment. In the scenario of the global rise of resistant strains to antifungals, geraniol, a terpene isolated from different essential oils, has shown promising antimicrobial activity. We evaluated: (1) the effects of geraniol against the C. parapsilosis species complex, in planktonic and biofilm forms; (2) the strains' susceptibility to clinical antifungals and (3) the geraniol interaction with antifungals. Eighteen isolates were subjected to in vitro susceptibility testing by the broth microdilution protocol, using geraniol, amphotericin B, caspofungin, itraconazole and fluconazole to determine the minimum inhibitory concentration (MIC) and subsequently, we measured the fungicidal activity. Geraniol was tested against biofilms by the measurement of the metabolic activity and biomass. Pharmacological interactions were performed by the checkerboard method. Geraniol's MIC range was between 256 and 512 µg/ml. MIC range for clinical antifungals was ≤ 0.031-4 µg/ml. Geraniol also showed antibiofilm activity with average reductions of metabolic activity (38.33%) and biomass (30.69%), at MIC concentration. Furthermore, geraniol showed synergistic/additive effects with antifungals. Briefly, geraniol inhibits both planktonic cells and biofilms of the C. parapsilosis species complex and besides it improves the efficacy of amphotericin B, caspofungin and fluconazole.","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High histoplasmosis incidence in kidney transplant recipients in Santa Fe city, Argentina. 阿根廷圣菲市肾移植受者组织胞浆菌病发病率高。

IF 2.7 3区医学

Medical mycology Pub Date : 2024-11-12 DOI: 10.1093/mmy/myae099

Manuela Loaiza-Oliva, Soledad Gamarra, Joaquín Agusti, Luis Gaite, José Hugo Paladini, Valeria Martínez, Mariano Arriola, Judith Ana Gaite, Guillermo Garcia-Effron

{"title":"High histoplasmosis incidence in kidney transplant recipients in Santa Fe city, Argentina.","authors":"Manuela Loaiza-Oliva, Soledad Gamarra, Joaquín Agusti, Luis Gaite, José Hugo Paladini, Valeria Martínez, Mariano Arriola, Judith Ana Gaite, Guillermo Garcia-Effron","doi":"10.1093/mmy/myae099","DOIUrl":"10.1093/mmy/myae099","url":null,"abstract":"Histoplasmosis is endemic in the central/northeast region of Argentina. It is estimated that the incidence of this mycosis is low in solid organ transplant recipients. This work aims to describe the epidemiology, clinical forms, and evolution of kidney transplant recipients diagnosed with histoplasmosis in Santa Fe city, Argentina. A retrospective study was carried out between 2015 and 2020 on kidney transplant patients with symptoms associated with histoplasmosis in Santa Fe. Histoplasmosis diagnosis was performed through histopathology, recovery of Histoplasma spp., by culture, and/or positive nested Polimerase Chain Reaction (PCR) specific for the Histoplasma Hc100 gene. During the study period, 360 kidney transplantations were performed. Of these patients, 12 were diagnosed with histoplasmosis (3.3%). The patients' median age was 51 years, and 75% were male. Eleven patients (92%) presented the disseminated form of the disease. Thirty-three percent were diagnosed with histoplasmosis in their first year post-transplantation (mostly 6-12 months), while 42% received their diagnosis 3 years after transplantation. Laboratory diagnosis was performed by histopathology, culture, and PCR in four cases (33%), by culture and PCR in three cases (25%), and by PCR alone in three cases (25%). Thus, all 12 patients showed positive nested PCR results. All patients received amphotericin B as initial treatment. A good response was observed in 83% of patients. We found a high incidence of histoplasmosis in kidney transplant recipients (up to 10 times higher than reports from other endemic areas). Diagnosis by histopathology/culture showed 75% sensitivity, while nested PCR showed better sensitivity and diagnostic speed.","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142623848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0