Brown locusts, Locustana pardalina, host fluconazole resistant Candidozyma (Candida) auris, closely related to Clade III clinical strains.

IF 2.3 3区医学 Q3 INFECTIOUS DISEASES

Medical mycology Pub Date : 2025-07-24 DOI:10.1093/mmy/myaf069

Adepemi Ogundeji, Maryam Bello-Akinosho, Vaughn Swart, Jonathan Featherston, Errol D Cason, Armand Bolsenbroek, Carel Beneke, Jolly Musoke, Tyla Baker, Arshad Ismail, Olihile Sebolai, Jacobus Albertyn, Carolina Pohl

{"title":"Brown locusts, Locustana pardalina, host fluconazole resistant Candidozyma (Candida) auris, closely related to Clade III clinical strains.","authors":"Adepemi Ogundeji, Maryam Bello-Akinosho, Vaughn Swart, Jonathan Featherston, Errol D Cason, Armand Bolsenbroek, Carel Beneke, Jolly Musoke, Tyla Baker, Arshad Ismail, Olihile Sebolai, Jacobus Albertyn, Carolina Pohl","doi":"10.1093/mmy/myaf069","DOIUrl":null,"url":null,"abstract":"<p><p>The environmental niche and mode of transmission from the environment to humans of the emerging pathogenic yeast, Candidozyma (Candida) auris is a subject of speculation, with hypotheses including avian species and marine environments. Interestingly, yeasts related to C. auris have been repeatedly observed associated with various insects. This prompted us to investigate a thermophilic insect, Locustana pardalina as possible host for C. auris. Here we report the isolation and identification of three C. auris strains from the gut of L. pardalina as well as the phenotypic characterisation of one of these isolates. Interestingly, the isolate was able to survive at 50°C and grew at 15% NaCl. In addition, it was susceptible to the tested disinfectants and antifungals, except fluconazole. Genome sequencing and single-nucleotide polymorphism analyses placed the isolate in Clade III, which is common in South African hospitals. This highlights the potential role of thermotolerant insects in the evolution and dissemination of emerging pathogenic yeasts.</p>","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medical mycology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/mmy/myaf069","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 0

Abstract

The environmental niche and mode of transmission from the environment to humans of the emerging pathogenic yeast, Candidozyma (Candida) auris is a subject of speculation, with hypotheses including avian species and marine environments. Interestingly, yeasts related to C. auris have been repeatedly observed associated with various insects. This prompted us to investigate a thermophilic insect, Locustana pardalina as possible host for C. auris. Here we report the isolation and identification of three C. auris strains from the gut of L. pardalina as well as the phenotypic characterisation of one of these isolates. Interestingly, the isolate was able to survive at 50°C and grew at 15% NaCl. In addition, it was susceptible to the tested disinfectants and antifungals, except fluconazole. Genome sequencing and single-nucleotide polymorphism analyses placed the isolate in Clade III, which is common in South African hospitals. This highlights the potential role of thermotolerant insects in the evolution and dissemination of emerging pathogenic yeasts.

查看原文本刊更多论文

褐蝗，pardalina，宿主耐氟康唑假丝酵母菌（Candida） auris，与Clade III临床菌株密切相关。

新出现的致病性酵母菌耳念珠菌（Candidozyma auris）的环境生态位和从环境到人类的传播方式是一个猜测的主题，其假设包括鸟类和海洋环境。有趣的是，与金黄色葡萄球菌相关的酵母被反复观察到与各种昆虫有关。这促使我们研究了一种嗜热昆虫，pardalina蝗虫作为金黄色葡萄球菌的可能宿主。在这里，我们报告了从L. pardalina肠道中分离和鉴定的三株金黄色葡萄球菌菌株以及其中一株的表型特征。有趣的是，分离物能够在50°C下存活，在15% NaCl下生长。除氟康唑外，其它消毒剂和抗真菌剂均对其敏感。基因组测序和单核苷酸多态性分析将分离物定位为在南非医院常见的III型进化枝。这突出了耐热昆虫在新发致病性酵母的进化和传播中的潜在作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Medical mycology 医学-兽医学

CiteScore

5.70

自引率

3.40%

发文量

632

审稿时长

12 months

期刊介绍： Medical Mycology is a peer-reviewed international journal that focuses on original and innovative basic and applied studies, as well as learned reviews on all aspects of medical, veterinary and environmental mycology as related to disease. The objective is to present the highest quality scientific reports from throughout the world on divergent topics. These topics include the phylogeny of fungal pathogens, epidemiology and public health mycology themes, new approaches in the diagnosis and treatment of mycoses including clinical trials and guidelines, pharmacology and antifungal susceptibilities, changes in taxonomy, description of new or unusual fungi associated with human or animal disease, immunology of fungal infections, vaccinology for prevention of fungal infections, pathogenesis and virulence, and the molecular biology of pathogenic fungi in vitro and in vivo, including genomics, transcriptomics, metabolomics, and proteomics. Case reports are no longer accepted. In addition, studies of natural products showing inhibitory activity against pathogenic fungi are not accepted without chemical characterization and identification of the compounds responsible for the inhibitory activity.