Medical mycology最新文献_第10页

Histoplasma antigens as novel players for the development of new enzyme immunoassays for the serodiagnosis of histoplasmosis: A comparative study of their analytical performance. 将组织胞浆菌抗原作为开发用于组织胞浆菌病血清诊断的新型酶免疫测定的新型参与者：对其分析性能的比较研究。

IF 2.9 3区医学

Medical mycology Pub Date : 2024-03-28 DOI: 10.1093/mmy/myae023

Carolina Rodríguez Laboccetta, Víctor J Briceño Fernández, Agustín Videla Garrido, Gladys B Posse, María L Cuestas, Alejandro D Nusblat

{"title":"Histoplasma antigens as novel players for the development of new enzyme immunoassays for the serodiagnosis of histoplasmosis: A comparative study of their analytical performance.","authors":"Carolina Rodríguez Laboccetta, Víctor J Briceño Fernández, Agustín Videla Garrido, Gladys B Posse, María L Cuestas, Alejandro D Nusblat","doi":"10.1093/mmy/myae023","DOIUrl":"10.1093/mmy/myae023","url":null,"abstract":"Definitive diagnosis of histoplasmosis relies on culture and/or cytology/histopathology; however, these procedures have limited sensitivity and cultures are time-consuming. Antibodies detection by immunodiffusion has low sensitivity in immunocompromised individuals and uses histoplasmin (HMN), a crude antigenic extract, as reagent. Novel protein antigen candidates have been recently identified and produced by DNA-recombinant techniques to obtain standardized and specific reagents for diagnosing histoplasmosis. To compare the analytical performance of novel enzyme-linked immunosorbent assays (ELISAs) for antibodies testing for diagnosing histoplasmosis using different Histoplasma capsulatum antigens as reagents. The H. capsulatum 100 kDa protein (Hcp100), the M antigen and its immunoreactive fragment F1 were produced by DNA-recombinant techniques. Galactomannan was purified from both the yeast and mycelial cell walls (yGM and mGM, respectively). The analytical performance of the ELISA tests for the serological detection of antibodies against these antigens was evaluated and compared with those obtained using HMN as reagent. Antibodies detection by the Hcp100 ELISA demonstrated 90.0% sensitivity and 92.0% specificity, versus 43.3% sensitivity and 95.0% specificity of the M ELISA, 33.3% sensitivity and 84.0% specificity of the F1 ELISA, 96.7% sensitivity and 94.0% specificity of the yGM ELISA, 83.3% sensitivity and 88.0% specificity of the mGM ELISA, and 70.0% sensitivity and 86.0% specificity for the HMN ELISA. In summary, Hcp100 is proposed as the most promising candidate for the serodiagnosis of histoplasmosis. The primary immunoreactive element in HMN proved to be GM rather than the M antigen. Nevertheless, a higher incidence of cross-reactions was noted with GM compared to M.","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140120071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COVID-19 associated candidemia: From a shift in fungal epidemiology to a rise in azole drug resistance. 与 COVID -19 相关的念珠菌血症：从真菌流行病学的转变到唑类药物耐药性的上升。

IF 2.9 3区医学

Medical mycology Pub Date : 2024-03-28 DOI: 10.1093/mmy/myae031

Mohammad Javad Najafzadeh, Tahmineh Shaban, Hossein Zarrinfar, Alireza Sedaghat, Neginsadat Hosseinikargar, Fariba Berenji, Mahsa Jalali, Michaela Lackner, Jasper Elvin James, Macit Ilkit, Cornelia Lass-Flörl

{"title":"COVID-19 associated candidemia: From a shift in fungal epidemiology to a rise in azole drug resistance.","authors":"Mohammad Javad Najafzadeh, Tahmineh Shaban, Hossein Zarrinfar, Alireza Sedaghat, Neginsadat Hosseinikargar, Fariba Berenji, Mahsa Jalali, Michaela Lackner, Jasper Elvin James, Macit Ilkit, Cornelia Lass-Flörl","doi":"10.1093/mmy/myae031","DOIUrl":"10.1093/mmy/myae031","url":null,"abstract":"Our understanding of fungal epidemiology and the burden of antifungal drug resistance in COVID-19-associated candidemia (CAC) patients is limited. Therefore, we conducted a retrospective multicenter study in Iran to explore clinical and microbiological profiles of CAC patients. Yeast isolated from blood, were identified by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and subjected to antifungal susceptibility testing (AFST) using the broth microdilution method M27-A3 protocol. A total of 0.6% of the COVID-19 patients acquired CAC (43/6174). Fluconazole was the most widely used antifungal, and 37% of patients were not treated. Contrary to historic candidemia patients, Candida albicans and C. tropicalis were the most common species. In vitro resistance was high and only noted for azoles; 50%, 20%, and 13.6% of patients were infected with azole-non-susceptible (ANS) C. tropicalis, C. parapsilosis, and C. albicans isolates, respectively. ERG11 mutations conferring azole resistance were detected for C. parapsilosis isolates (Y132F), recovered from an azole-naïve patient. Our study revealed an unprecedented rise in ANS Candida isolates, including the first C. parapsilosis isolate carrying Y132F, among CAC patients in Iran, which potentially threatens the efficacy of fluconazole, the most widely used drug in our centers. Considering the high mortality rate and 37% of untreated CAC cases, our study underscores the importance of infection control strategies and antifungal stewardship to minimize the emergence of ANS Candida isolates during COVID-19.","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140194164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of the antifungal activity of the pyrimidine analogs flucytosine and carmofur against human-pathogenic dematiaceous fungi. 嘧啶类似物氟胞嘧啶和卡莫氟对人类致病性脱霉真菌的抗真菌活性比较。

IF 2.9 3区医学

Medical mycology Pub Date : 2024-03-28 DOI: 10.1093/mmy/myae029

Rowena Alves Coelho, Fernando Almeida-Silva, Maria Helena Galdino Figueiredo-Carvalho, Vanessa Brito de Souza Rabello, Gabriela Rodrigues de Souza, Maria Cristina da Silva Lourenço, Marcio L Rodrigues, Rodrigo Almeida-Paes

{"title":"Comparison of the antifungal activity of the pyrimidine analogs flucytosine and carmofur against human-pathogenic dematiaceous fungi.","authors":"Rowena Alves Coelho, Fernando Almeida-Silva, Maria Helena Galdino Figueiredo-Carvalho, Vanessa Brito de Souza Rabello, Gabriela Rodrigues de Souza, Maria Cristina da Silva Lourenço, Marcio L Rodrigues, Rodrigo Almeida-Paes","doi":"10.1093/mmy/myae029","DOIUrl":"10.1093/mmy/myae029","url":null,"abstract":"Chromoblastomycosis (CBM) and pheohyphomycosis (PHM) are the most common implantation mycoses caused by dematiaceous fungi. In the past, flucytosine (5-FC) has been used to treat CBM, but development of resistance is common. Carmofur belongs to the same class as 5-FC and has in vitro inhibitory activity against the main agents of CBM and PHM. The aim of this study was to compare the action of these two pyrimidine analog drugs against CBM and PHM agents. The minimum inhibitory concentration (MIC) and the selectivity index based on cytotoxicity tests of these two drugs against some agents of these mycoses were determined, with carmofur presenting a higher selectivity index than 5-FC. Carmofur demonstrated here synergistic interactions with itraconazole and amphotericin B against Exophiala heteromorpha, Fonsecaea pedrosoi, Fonsecaea monophora, and Fonsecaea nubica strains. Additionally, carmofur plus itraconazole demonstrated here synergism against a Phialophora verrucosa strain. To evaluate the development of carmofur resistance, passages in culture medium containing subinhibitory concentrations of this pyrimidine analog were carried out, followed by in vitro susceptibility tests. Exophiala dermatitidis quickly developed resistance, whereas F. pedrosoi took seven passages in carmofur-supplemented medium to develop resistance. Moreover, resistance was permanent in E. dermatitidis but transient in F. pedrosoi. Hence, carmofur has exhibited certain advantages, albeit accompanied by limitations such as the development of resistance, which was expected as with 5-FC. This underscores its therapeutic potential in combination with other drugs, emphasizing the need for a meticulous evaluation of its application in the fight against dematiaceous fungi.","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11008743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140294041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection and genotyping of zoonotic microsporidia in the endangered Iberian lynx (Lynx pardinus). 濒危伊比利亚猞猁（Lynx pardinus）人畜共患小孢子虫的检测和基因分型。

IF 2.9 3区医学

Medical mycology Pub Date : 2024-03-28 DOI: 10.1093/mmy/myae027

Gabriel Ávalos, Javier Caballero-Gómez, Pablo Matas-Méndez, Sabrina Castro-Scholten, Débora Jiménez-Martín, Pamela C Köster, Mónica Santín, Begoña Bailo, David Cano-Terriza, David González-Barrio, Marta Mateo, Ignacio García-Bocanegra, Alejandro Dashti, Fernando Nájera, David Carmena

{"title":"Detection and genotyping of zoonotic microsporidia in the endangered Iberian lynx (Lynx pardinus).","authors":"Gabriel Ávalos, Javier Caballero-Gómez, Pablo Matas-Méndez, Sabrina Castro-Scholten, Débora Jiménez-Martín, Pamela C Köster, Mónica Santín, Begoña Bailo, David Cano-Terriza, David González-Barrio, Marta Mateo, Ignacio García-Bocanegra, Alejandro Dashti, Fernando Nájera, David Carmena","doi":"10.1093/mmy/myae027","DOIUrl":"10.1093/mmy/myae027","url":null,"abstract":"Microsporidia is a diverse group of obligate, intracellular, and spore-forming parasites that infect a wide range of animals. Among them, Enterocytozoon bieneusi and Encephalitozoon spp. are the most frequently reported species in humans. Limited information is available about the presence and molecular diversity of microsporidian species in the endangered Iberian lynx (Lynx pardinus). Presence of Enterocytozoon bieneusi and Encephalitozoon spp. was investigated by molecular methods in wild and captive Iberian lynxes from Spain. Overall, E. bieneusi was detected in 3.2% (8/251) of the animals examined. None of the samples tested were positive for Encephalitozoon spp. Four known (D, EbfelA, PigEBITS7, and Type IV) and a novel (named as LynxSpEb1) E. bieneusi genotypes were identified. All the genotypes found belonged to the zoonotic Group 1 of E. bieneusi. This study provides the first genotyping data of E. bieneusi in Iberian lynx in Spain. Our result indicate that the Iberian lynx does not seem to play a relevant role in the epidemiology of Encephalitozoon spp., and that this endangered felid is likely acting as spillover host rather than a true reservoir of E. bieneusi. Additional studies should be conducted to assess the impact of this parasite in the health status of the endangered Iberian lynx.","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140158444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revealing the hidden interplay: The unexplored relationship between fungi and viruses beyond HIV, SARS-CoV-2, and influenza. 揭示隐藏的相互作用：除艾滋病毒、SARS-CoV-2 和流感之外，真菌与病毒之间尚未探索的关系。

IF 2.9 3区医学

Medical mycology Pub Date : 2024-03-28 DOI: 10.1093/mmy/myae021

Théo Ghelfenstein-Ferreira, Alexandra Serris, Maud Salmona, Fanny Lanternier, Alexandre Alanio

{"title":"Revealing the hidden interplay: The unexplored relationship between fungi and viruses beyond HIV, SARS-CoV-2, and influenza.","authors":"Théo Ghelfenstein-Ferreira, Alexandra Serris, Maud Salmona, Fanny Lanternier, Alexandre Alanio","doi":"10.1093/mmy/myae021","DOIUrl":"10.1093/mmy/myae021","url":null,"abstract":"The complex interaction between viruses and fungi has profound implications, especially given the significant impact of these microorganisms on human health. While well-known examples such as HIV, influenza, and SARS-CoV-2 are recognized as risk factors for invasive fungal diseases, the relationship between viruses and fungi remains largely underexplored outside of these cases. Fungi and viruses can engage in symbiotic or synergistic interactions. Remarkably, some viruses, known as mycoviruses, can directly infect fungi, may influencing their phenotype and potentially their virulence. In addition, viruses and fungi can coexist within the human microbiome, a complex ecosystem of microorganisms. Under certain conditions, viral infection might predispose the host to an invasive fungal infection, as observed with influenza-associated pulmonary aspergillosis or COVID-19 associated pulmonary aspergillosis. We aim in this review to highlight potential connections between fungi and viruses (CMV and other herpesviruses, HTLV-1 and respiratory viruses), excluding SARS-CoV-2 and influenza.","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140110633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular detection of Enterocytozoon bieneusi in bats from Portugal. 全标题：葡萄牙蝙蝠肠虫的分子检测。

IF 2.9 3区医学

Medical mycology Pub Date : 2024-03-07 DOI: 10.1093/mmy/myae019

Andreia V S Cruz, Pedro López-López, Sérgio Santos-Silva, Antonio Rivero-Juárez, Hugo Rebelo, João R Mesquita

{"title":"Molecular detection of Enterocytozoon bieneusi in bats from Portugal.","authors":"Andreia V S Cruz, Pedro López-López, Sérgio Santos-Silva, Antonio Rivero-Juárez, Hugo Rebelo, João R Mesquita","doi":"10.1093/mmy/myae019","DOIUrl":"10.1093/mmy/myae019","url":null,"abstract":"Enterocytozoon bieneusi is a microsporidia commonly found in the gastrointestinal tract of humans and a wide range of other animals, constituting a major cause of microsporidiosis in humans. Although E. bieneusi has been detected in humans, domestic, and wild animals in Portugal, and its presence in bats has been linked to zoonotic characteristics, its occurrence in bats within the country has not been reported. In this study, we investigated the presence of E. bieneusi in 380 bat fecal samples collected in mainland Portugal through a nested PCR assay targeting the internal transcribed spacer region and the flanking small and large subunits of the ribosomal RNA. Enterocytozoon bieneusi was detected in one bat sample (i.e., 0.26%; Pipistrellus pipistrellus). Additionally, another sample tested positive for Enterocytozoon sp. Phylogenetic analysis of the obtained ITS sequence of E. bieneusi revealed clustering within the potentially zoonotic Group 1. This study represents the first report of E. bieneusi in a bat from Europe. Findings presented here contribute to an enhanced understanding of E. bieneusi epidemiology.","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139983316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Neutrophil extracellular traps (NETs) and Th-2 dominant immune responses in chronic granulomatous chromoblastomycosis. 更正：慢性肉芽肿嗜铬细胞瘤病中的中性粒细胞胞外陷阱（NET）和 Th-2 主导免疫反应。

IF 2.9 3区医学

Medical mycology Pub Date : 2024-03-07 DOI: 10.1093/mmy/myae025

引用次数: 0

Evaluation of the drug-drug interaction between triazole antifungals and cystic fibrosis transmembrane conductance regulator modulators in a real-life cohort. 在现实生活队列中评估三唑类抗真菌药与囊性纤维化跨膜传导调节剂之间的药物相互作用。

IF 2.9 3区医学

Medical mycology Pub Date : 2024-03-07 DOI: 10.1093/mmy/myae020

Anouk M E Jansen, Margot N Eggermont, Erik B Wilms, Sami Aziz, Monique Reijers, Jolt Roukema, Adilia Warris, Roger J M Brüggemann, Renske van der Meer

引用次数: 0

A diverse spectrum of mycoses histologically diagnosed in Ghana: Insights from a 10-year retrospective study. 加纳组织学诊断的多种霉菌病：一项十年回顾性研究的启示。

IF 2.9 3区医学

Medical mycology Pub Date : 2024-03-07 DOI: 10.1093/mmy/myae015

Bright Ocansey, Isaac Erskine, Leonard Okine, Daniel Potakey, Prince Pappoe-Ashong, Isaac Sraku, Solomon Quayson, Japheth Opintan, Chris Kosmidis, David Denning

{"title":"A diverse spectrum of mycoses histologically diagnosed in Ghana: Insights from a 10-year retrospective study.","authors":"Bright Ocansey, Isaac Erskine, Leonard Okine, Daniel Potakey, Prince Pappoe-Ashong, Isaac Sraku, Solomon Quayson, Japheth Opintan, Chris Kosmidis, David Denning","doi":"10.1093/mmy/myae015","DOIUrl":"10.1093/mmy/myae015","url":null,"abstract":"In Ghana, most laboratory diagnoses of severe mycoses are based on histopathology findings due to inadequate availability of serology, culture, and molecular tests. The aim of this study was to evaluate the spectrum of mycoses diagnosed in Ghana. We retrospectively reviewed reports from 2012 to 2021 from three major pathology laboratories in Ghana to identify reports indicating the presence of fungal elements and diagnosis of a mycosis, then extracted demographic, clinical history, site of infection, stain(s), used and diagnosed mycosis details. Over the 10-year period, 107 cases were found. No apparent increasing and decreasing trend in the number of cases per year or in a period was observed. The age range of affected patients was from 4 to 86 years. Special stains for fungi were only used in 22 of 107 (20.6%) of cases. The most frequently affected site was the sino-nasal area (34%). Mycosis type was determined for 58 (54.2%) cases, comprising aspergillosis (21), candidiasis (14), dermatophytosis (6), mucormycosis (3), two cases each of chromoblastomycosis, histoplasmosis, eumycetoma, entomophthoromycosis, sporotrichosis, and Malassezia infection and a single case each of cryptococcosis and deep onychomycosis. Of the 53 (49.5%) cases with presumptive diagnosis data, only seven (13.2%) had a pre-biopsy suspicion of mycosis. There is a wide spectrum of mycoses in Ghana, including endemic mycoses not previously reported. Improving the use of special fungal stains could increase yield and mycoses identification. Laboratory diagnostic capacity needs enhancement to complement histopathology investigations with serology, culture, and molecular methods.","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10919345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139931933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fusariosis in burn patients: A systematic review of case reports. 烧伤患者的镰刀菌病：病例报告的系统回顾。

IF 2.7 3区医学

Medical mycology Pub Date : 2024-03-07 DOI: 10.1093/mmy/myae013

Paola Piccoli, Fabíola Lucini, Abdullah M S Al-Hatmi, Luana Rossato

{"title":"Fusariosis in burn patients: A systematic review of case reports.","authors":"Paola Piccoli, Fabíola Lucini, Abdullah M S Al-Hatmi, Luana Rossato","doi":"10.1093/mmy/myae013","DOIUrl":"10.1093/mmy/myae013","url":null,"abstract":"Burns can cause skin damage, facilitating the entry of fungi and other microorganisms into the body, leading to infections. Fusarium is a fungus capable of infecting individuals with burn injuries. Diagnosing and treating Fusarium infections in burn patients can be challenging due to the manifestation of nonspecific symptoms. This study aims to investigate case reports and case series from published literature describing Fusarium infection in burned patients, in order to assess treatment regimens, clinical outcomes, and make recommendations for future management. We conducted searches on Web of Science, PubMed, ScienceDirect, and Medline for all case reports and case series containing keywords 'Burn', 'Burns', 'Burned', 'Fusarium', or 'Fusariosis' in the title or abstract. All burn patients who developed Fusarium fungal infections between January 1974 and March 2023 were included in the study. Demographic and clinical data were analyzed retrospectivity. The final analysis incorporates 24 case reports encompassing a total of 87 burn patients with Fusarium infection. Patient ages ranged from one to 85 years, with the majority being male (53%). The median percentage of burn surface area was 78%, and the skin in the face, upper limbs, and lower limbs were the most commonly infected sites. Fungal infections appeared around 10 days after the burn injury on average. The majority of the patients were identified through culture or histopathology. The Fusarium dimerum species complex, which was found in nine patients, was the most frequently identified Fusarium species complex. Amphotericin B was the most preferred treatment drug, followed by voriconazole, and 62% of patients underwent debridement. In our study, 23 patients (37%) died from fungal infections. Implementing early and effective treatment protocols targeting Fusarium spp. in burn treatment units can significantly reduce mortality rates. It is critical to enhance the understanding of fusariosis epidemiology and emphasize the importance of maintaining a high clinical suspicion for this condition in burn patients.","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139913045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0