Medical mycology最新文献

{"title":"First draft genome sequence of the emerging sexually transmitted dermatophyte Trichophyton mentagrophytes genotype VII.","authors":"Charlotte Reid, Mohamed Adnan Asif Ali, Lara Saivanya, Nicolas Helmstetter, Yaiza Gutierrez Vazquez, Peter Ashton, Rhys A Farrer, Johanna Rhodes, Alireza Abdolrasouli, Andrew M Borman","doi":"10.1093/mmy/myag065","DOIUrl":"10.1093/mmy/myag065","url":null,"abstract":"<p><p>Trichophyton mentagrophytes ITS-genotype VII (TMVII) is a globally emerging sexually transmitted dermatophyte causing severe skin infections characterised by painful, pustular lesions on the face, public area, genitalia, and trunk. To inform the prevention efforts, we present the first draft genomes of four TMVII isolates obtained from patients in the United Kingdom diagnosed between 2021 and 2025. We performed whole-genome sequencing and phylogenetic analysis based on single-nucleotide polymorphisms. We analysed the genetic relatedness of four TMVII isolates collected from UK patients, two had travel links to Spain and the Middle East. Two further isolates, including T. mentagrophytes ITS-genotype I/II obtained from a canine infection in the United Kingdom in 2025 and Trichophyton indotineae were sequenced for contextual analysis. We confirm that the TMVII strains studied here represent a highly clonal population, distinct from both zoophilic T. mentagrophytes genotype I/II and anthropophilic T. indotineae.</p>","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148875518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical profile and outcomes of persistent candidemia: A matched case-control study.","authors":"David R Bayless, Omar M Abu Saleh, Douglas W Challener, Paschalis Vergidis, Jack W McHugh","doi":"10.1093/mmy/myag090","DOIUrl":"10.1093/mmy/myag090","url":null,"abstract":"<p><p>Although candidemia is among the most common invasive fungal infections in hospitalized patients, the persistence of bloodstream infection despite antifungal therapy remains poorly characterized. We performed a retrospective, matched case-control study of persistent candidemia (PC) across three tertiary care centers in the United States over a 7-year period (2018-2025). PC was defined as at least 72 h of positive blood cultures with the same Candida species from the start of active antifungal therapy. Cases were matched 1:2 to controls with non-PC by diagnosis date. Associations were evaluated using conditional logistic regression within matched strata. The cohort included 47 PC cases and 94 matched controls. Compared with controls, cases were more likely to have a central venous catheter (CVC) at candidemia onset and be in the intensive care unit at diagnosis. Intra-abdominal sources were more common with PC. In multivariable analyses, CVC presence (adjusted odds ratio (aOR) 4.58, 95% CI 1.39-15.09) and ICU status (aOR 3.10, 95% CI 1.10-8.72) were associated with persistence, while male sex was inversely associated (aOR 0.21, 95% CI 0.08-0.60; P = .004). PC was associated with longer duration of hospitalization (median 36 vs 19 days; P < .001) and higher 30-day all-cause mortality (40.4% vs 22.3%; P = .040). In summary, PC was associated with higher mortality and longer hospital stays than non-PC. CVC presence and intensive care unit status were independently associated with persistence.</p>","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148906615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kinetics of anti-Aspergillus spp. IgG antibodies in COVID-19-associated pulmonary aspergillosis.","authors":"Camille Cordier, Chloë Lemaire, Fanny Vuotto, Mahdi Ouafi, Séverine Loridant, Gaetan Piga, Jordan Leroy, Julien Poissy, Boualem Sendid, Anahita Rouzé, Marjorie Cornu","doi":"10.1093/mmy/myag089","DOIUrl":"10.1093/mmy/myag089","url":null,"abstract":"<p><p>COVID-19-associated pulmonary aspergillosis (CAPA) is a recognized fungal superinfection, but diagnosis remains difficult due to non-specific clinical and radiological findings. While anti-Aspergillus spp. IgG antibodies (AspAb) are used for chronic aspergillosis diagnosis, their role in this context is unclear. We described AspAb kinetics in CAPA patients hospitalized in intensive care unit (ICU). We performed a retrospective study at Lille University Hospital from February 2020 to December 2021, enrolling ICU SARS-CoV-2 patients. Patients were included if they had at least one positive mycological marker-direct examination, culture, galactomannan antigen (GM) or Aspergillus fumigatus qPCR in bronchoalveolar lavage and/or serum-along with clinical and radiological findings consistent with CAPA, as defined by the 2020 European Confederation of Medical Mycology and the International Society for Human and Animal Mycology consensus criteria. Among 898 patients, 95 (10.6%) had at least one positive mycological marker; 47 fulfilled CAPA criteria (5.2%), and 43 had at least one AspAb measurement. One-quarter of CAPA patients (23.3%, 10 patients) had at least one positive AspAb measurement (one of whom had only one measurement). Among AspAb-positive patients, seven (70.0%) seroconverted a mean of 8.3 days (standard deviation, 8.5) after CAPA diagnosis; one had documented positivity prior to hospitalization. Seven patients (70.0%) reached AspAb rate ≥ 80 AU/ml. These results are the first observed in CAPA patients and need to be confirmed in a larger cohort of non-neutropenic patients hospitalized in ICU with viral pneumonia.</p>","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urine detection of Histoplasma antigens among symptomatic people living with HIV (PLWH) in Mato Grosso do Sul, Brazil: A comparative study of EIA and lateral flow assay.","authors":"Danielle G da Silva, Pedro A L Lemke, Randolph E S Paredes, Arthur P Dos Santos, Barbara C Amorim, Thaynara Azevedo Dos Santos, Leilane Souza do Prado Tair, Vinícius Lopes Teodoro Felix, Taynara Nogueira Martins, Nathalia Antunes Maciel, Wesllaine Milanezi Rosa, Diego H Cáceres, Alexandre A Bertucci, Fernanda Paes Reis, Wellington S Fava, Marcia de C S Melhem, Rinaldo P Mendes, Anamaria M M Paniago, James Venturini","doi":"10.1093/mmy/myag088","DOIUrl":"10.1093/mmy/myag088","url":null,"abstract":"<p><p>Histoplasma spp., thermally dimorphic fungus acquired from environmental exposure, is associated with high mortality in people with advanced HIV disease. Early diagnosis remains challenging because conventional mycological methods have limited sensitivity, reinforcing the importance of urinary antigen detection. We conducted a cross-sectional study between 2022 and 2023 at a tertiary referral hospital in Campo Grande, Mato Grosso do Sul, Brazil, to assess the agreement between two urinary Histoplasma antigen detection platforms and to evaluate Histoplasma antigenuria among symptomatic people living with HIV (PLWH) with suspected disseminated histoplasmosis (DH). During the study period, 241 PLWH underwent urinary Histoplasma antigen testing with both an enzyme immunoassay (EIA; IMMY Clarus® Histoplasma Galactomannan Antigen) and a lateral flow assay (LFA; MiraVista Histoplasma LFA) at our laboratory. Of these, 78 fulfilled the predefined clinical eligibility criteria for suspected DH and were included in the study. Additional immunodiagnostic assays for paracoccidioidomycosis, aspergillosis, and cryptococcosis were also performed. Urinary Histoplasma antigen was detected in 18 patients, corresponding to a frequency of 23.1% (95% confidence interval [CI], 14.6%-34.2%) among symptomatic PLWH with suspected DH. The most frequent clinical manifestations were weight loss (84.6%), fever (80.8%), and cough (71.8%). Coinfections were common, and the case fatality rate among antigen-positive patients was 27.8% (5/18; 95% CI, 10.7-53.6). Inter-assay agreement between EIA and LFA was high (93.6%). Our findings demonstrate a substantial frequency of urinary Histoplasma antigen positivity in this selected cohort of symptomatic PLWH with suspected DH and support further evaluation of antigen-based diagnostic strategies in similar tertiary-care settings.</p>","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148795294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The future of fungal diagnostics: What's next in laboratory testing for invasive fungal infection?","authors":"Rachel Southern-Thomas, Simran Goyal, Anna Louise Wild, Neil Robert Hope Stone","doi":"10.1093/mmy/myag085","DOIUrl":"10.1093/mmy/myag085","url":null,"abstract":"<p><p>Invasive fungal infection (IFI) is responsible for millions of deaths globally each year. Prompt diagnosis of IFI is critical, with delay associated with increased mortality. Traditional, culture-based diagnostics are relatively slow and insensitive. Novel molecular techniques, biomarkers and point-of-care tests hope to overcome these limitations. However, these newer methods come with issues of cost, accessibility, and standardisation. This review briefly lays out the current diagnostic landscape, highlights important changes to standards of care, then explores new developments and the future of fungal laboratory diagnosis.</p>","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13543316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148795275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposure to Coccidioides spp. and silent infection in Sonora, Mexico: A cross-sectional serological and environmental analysis.","authors":"Edith Sánchez-Paredes, Diego H Cáceres, Rodrigo Reyes-Macías, Sandra Miranda-Mauricio, José M Galeana-Pizaña, Laura R Castañón-Olivares","doi":"10.1093/mmy/myag087","DOIUrl":"10.1093/mmy/myag087","url":null,"abstract":"<p><p>Coccidioidomycosis is an endemic fungal disease in arid regions of the Americas, yet population-level exposure in Mexico remains poorly defined. This study aimed to evaluate the frequency and spatial distribution of asymptomatic individuals with anti-Coccidioides IgG antibodies residing in different municipalities of Sonora, Mexico, and to evaluate the environmental factors associated with the seropositivity presented. A cross-sectional serosurvey was conducted using 534 serum samples collected from 15 laboratories at different municipalities of Sonora. Anti-Coccidioides IgG antibodies were detected using a commercial enzyme immunoassay. Seroprevalence was analyzed by demographic characteristics, and to evaluate whether environmental conditions differed between municipalities with and without evidence of Coccidioides spp. exposure, mean values of 19 bioclimatic variables were calculated. Overall, IgG seropositivity was 7.3%, with an additional 15% showing indeterminate results. Higher seropositivity was observed among young adults and in individuals that reported no travel to endemic regions in the United States of America. The Mann-Whitney U test identified a significant difference only for temperature seasonality (BIO4) between municipalities with and without seropositive individuals; this difference remained significant after correction for multiple comparisons. These findings provide serological evidence of exposure to Coccidioides spp. in nine municipalities of Sonora. The indeterminate percentage of 15% in an area considered endemic is striking and given that the chosen test is designed for diagnosis, lower cut-off points should be considered for serological surveillance or prevalence studies in asymptomatic populations to provide more information on the hidden burden of coccidioidomycosis in endemic regions.</p>","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148725107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Candida bloodstream infection in left ventricular assist device recipients: Case series and review of the literature.","authors":"Jacob Sama, Saira Butt, Abdalla Eltayeb A A, Roopa Rao, Marina Shariff, Ravi K Misra, Kashif Saleem, Sujal Modi, Maya Guglin, Onyedika J Ilonze","doi":"10.1093/mmy/myag095","DOIUrl":"10.1093/mmy/myag095","url":null,"abstract":"<p><p>Candida (C-BSI) is a rare infection in patients with left ventricular assist devices (LVADs). We aim to describe the characteristics and outcomes of C-BSI. We performed a retrospective search for C-BSI in patients with LVADs at our institution from January 2012 to May 2024. We performed a literature review using the keywords 'fungemia ventricular assist device', 'candidemia ventricular assist device', 'Candida ventricular assist device,' or 'Candida endocarditis ventricular assist device' from 1990 to 2024. Clinical characteristics and outcomes were extracted. We identified three institutional cases along with 21 additional cases from the literature. The incidence of candidemia was 3.1% (3/97) and 1.8% (16/867), respectively, in the case series and literature review. The mean age was 45.6 years (range 19-73 years), and the average body mass index (BMI) was 31.8 kg/m². There was a 100% mortality rate in our cohort and 62.5% mortality rate in the literature review cohort. Among the surviving patients in the literature review, 66.7% underwent heart transplantation, and 33.3% were discharged on antifungal therapy. About 41.2% of patients experienced right heart failure, with four requiring temporary mechanical circulatory support post-operatively. Obesity was present in 75.0% of patients, and 42.1% had an LVAD-related infection. C-BSI developed after an average of 426 days of LVAD support, with 33.3% occurring within 30 days postoperatively. The average duration of C-BSI was 29 days. Candida auris was the most common species. C-BSI is a rare fatal complication in LVAD patients. Obesity, delayed sternal wound closure, and right heart failure may contribute to these poor outcomes.</p>","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148912839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Entomophthoromycosis: A systematic analysis of 405 cases.","authors":"Dinesh Reddy Gangavaram, Snigdha Reddy, Kalaiselvi Vinayagamoorthy, Hariprasath Prakash","doi":"10.1093/mmy/myag097","DOIUrl":"10.1093/mmy/myag097","url":null,"abstract":"<p><p>Entomophthoromycosis is a chronic fungal granulomatous disease caused by Basidiobolus and Conidiobolus species. This disease is associated with significant morbidity and prolonged treatment. This systematic review aims to address the epidemiology, clinical features, diagnostic methods, therapeutic strategies, and clinical outcomes of entomophthoromycosis. The MEDLINE, Embase, Scopus, and Web of Science databases were searched using appropriate keywords for entomophthoromycosis from 1 January 2000 to 31 December 2023. A total of 405 cases of entomophthoromycosis were included; of those, basidiobolomycosis (n = 241/405, 59.5%) was the most common, followed by conidiobolomycosis (n = 123/405, 30.4%) and unclassified entomophthoromycosis (n = 41/405, 10.1%). Distinct epidemiological patterns were observed: basidiobolomycosis was most commonly reported from Middle Eastern countries (n = 139/241, 57.7%), whereas conidiobolomycosis was most commonly reported from Southeast Asian countries (n = 97/123, 78.9%). The common clinical forms seen in basidiobolomycosis were gastrointestinal (n = 164/241, 68%) and cutaneous (n = 64/241, 26.6%) disease, and rhino-facial disease (n = 114/123, 92.7%) in conidiobolomycosis. Demonstration of fungal hyphae by histopathology or by direct microscopy is the most common diagnostic method (n = 377/405, 93.1%). Culture positivity was higher in conidiobolomycosis (n = 94/123, 76.4%) than in basidiobolomycosis (n = 108/241, 44.8%). Antifungal treatment with surgery (n = 129/231, 55.8%) was the common treatment strategy for basidiobolomycosis. Antifungal therapy alone (n = 77/112, 68.8%) was the most commonly used treatment for conidiobolomycosis. Itraconazole was the most common antifungal used in treatment (n = 228/357, 63.9%), followed by potassium iodide (n = 104/357, 29.1%). Overall mortality of the cohort is 10.93% (n = 40/366). Gastrointestinal basidiobolomycosis has a higher mortality (n = 28/150, 18.7%). Both these diseases exhibit different geographic patterns and clinical forms. The disease mimics malignancies and other inflammatory diseases; high clinical suspicion is essential for prompt diagnosis and initiation of therapy to improve clinical outcomes.</p>","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148912844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of virulence factors with antifungal resistance and clinical outcomes in Candida species isolated from bloodstream infections.","authors":"Wanshisha Daphi Wanswett, Sheetal Goenka, Manisha Jain, Poonam Loomba, Anirban Hom Choudhuri, Abha Sharma, Shivani Tyagi","doi":"10.1093/mmy/myag096","DOIUrl":"10.1093/mmy/myag096","url":null,"abstract":"<p><p>Candidemia represent a significant cause of morbidity and mortality in hospitalized patients. Mortality depends on the virulence and resistance profile of the organism. This study aimed to evaluate virulence factors in Candida species isolated from bloodstream infections and correlate them with antifungal resistance patterns and clinical outcomes. 100 Candida isolates from blood cultures were collected over 1 year. Virulence factors including hemolysin, phospholipase, and proteinase activities, along with biofilm formation, were assessed. Susceptibility to antifungal was assessed using the VITEK®2 system. Clinical data and outcomes were analysed in relation to virulence factors and resistance patterns. Non-albicans Candida species (NAC) predominated (90%) over Candida albicans (10%). Candida parapsilosis (32%), and C. tropicalis (30%) were the most common NAC species. Overall, hemolysin activity was detected in 79% of isolates, phospholipase in 51%, proteinase in 43%, and biofilm formation in 87%. Candida auris and C. duobushaemulonii demonstrated the strongest virulence factor expression. Fluconazole resistance was observed in 22% of isolates, with C. auris showing 100% resistance. Isolates with stronger enzymatic activities and biofilm formation showed significantly higher antifungal resistance (P < .0001). The crude mortality rate was 27%, with significantly higher mortality in patients infected with resistant isolates and those expressing strong virulence factors (P < .05). NAC species have emerged as predominant causative agents of candidemia, demonstrating higher virulence factor expression and antifungal resistance compared to C. albicans. The correlation between virulence factors, antifungal resistance, and mortality highlights the importance of species-level identification and antifungal susceptibility testing for optimal management of candidemia.</p>","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148919607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diversity of ITS genotypes in Trichophyton mentagrophytes species complex isolates causing tinea corporis and tinea capitis: a multicenter study in France.","authors":"Arnaud Jabet, Noémie Coron, Christine Schuttler, Cyrille Valin, Elodie Pernot-Marino, Bruno Colin, Gina Cosentino, Gentiane Monsel, Renaud Piarroux, Arnaud Fekkar, Anne-Cécile Normand","doi":"10.1093/mmy/myag098","DOIUrl":"10.1093/mmy/myag098","url":null,"abstract":"<p><p>The Trichophyton mentagrophytes complex currently comprises three species (T. mentagrophytes, T. interdigitale, and T. indotineae) and exhibits substantial diversity in internal transcribed spacer (ITS) region sequences. Within this complex, Trichophyton indotineae and T. mentagrophytes ITS genotype VII have recently emerged as important public health concerns. The aim of the study was to describe the diversity of species and ITS genotypes among human clinical isolates belonging to the T. mentagrophytes complex recovered from glabrous skin and scalp samples in France. All isolates belonging to the T. mentagrophytes complex obtained from glabrous skin and scalp samples collected by three private clinical laboratories located in three French regions were sequenced for the ITS region. Clinical data were collected to compare patient characteristics according to ITS genotype. Among the 92 isolates, 62 (67.4%) corresponded to T. mentagrophytes sensu stricto, 21 (22.8%) to T. indotineae, and 9 (9.8%) to T. interdigitale. Among T. mentagrophytes sensu stricto isolates, five ITS genotypes were identified, in decreasing order of frequency: II*, III*, VII, III, and IV. Trichophyton mentagrophytes ITS genotype VII accounted for 16.3% of isolates within the T. mentagrophytes species complex and was isolated exclusively from adult men, unlike the other ITS genotypes. Twelve of the 21 T. indotineae isolates grew on a terbinafine screening medium and harbored the F397L or L393S substitution in the SQLE sequence. The emerging pathogens T. indotineae and T. mentagrophytes ITS genotype VII together account for 39.1% of T. mentagrophytes species-complex isolates identified in three private laboratories in France and infecting glabrous skin or scalp.</p>","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148944898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}