Medical mycology最新文献_第3页

Correction to: Drug-resistance genes and antifungal susceptibility of Trichophyton verrucosum variants isolated from bovine skin lesions and farm environments. 修正：从牛皮损和农场环境中分离的疣状毛癣菌变异的耐药基因和抗真菌敏感性。

IF 2.7 3区医学

Medical mycology Pub Date : 2025-06-05 DOI: 10.1093/mmy/myaf053

引用次数: 0

Investigation of invasive fungal infection in tuberculosis/human immunodeficiency virus co-infected patients. 结核/hiv合并感染患者侵袭性真菌感染调查。

IF 2.7 3区医学

Medical mycology Pub Date : 2025-06-05 DOI: 10.1093/mmy/myaf045

Rejane Roncaglio, Dienefer Venske Bierhals, Emília Ferreira Andrade, Bianca Dos Santos Blan, Romina Buffarini, Andrea Von Groll, Rossana Patrícia Basso, Pedro Eduardo Almeida da Silva, Melissa Orzechowski Xavier, Ivy Bastos Ramis

{"title":"Investigation of invasive fungal infection in tuberculosis/human immunodeficiency virus co-infected patients.","authors":"Rejane Roncaglio, Dienefer Venske Bierhals, Emília Ferreira Andrade, Bianca Dos Santos Blan, Romina Buffarini, Andrea Von Groll, Rossana Patrícia Basso, Pedro Eduardo Almeida da Silva, Melissa Orzechowski Xavier, Ivy Bastos Ramis","doi":"10.1093/mmy/myaf045","DOIUrl":"10.1093/mmy/myaf045","url":null,"abstract":"Tuberculosis (TB) and human immunodeficiency virus (HIV) represent important public health problems. Suppression of the immune system, due to both diseases, predisposes to the development of opportunistic infections, such as invasive fungal infections (IFI). The aims of this study were to determine the frequency of investigation of IFI in TB/HIV co-infected patients, identify the most frequent IFI and evaluate the clinical-epidemiological characteristics of TB/HIV/IFI patients. A descriptive and retrospective study was conducted including patients assisted at Hospital Dr. Miguel Riet Corrêa Jr. (HU-FURG/Ebserh), in Rio Grande City, southern Brazil. All patients diagnosed with TB/HIV from 2017 to 2022 were included, and databases were analyzed for data regarding mycological exams for fungal disease investigation. Of the 194 TB/HIV co-infected patients, 77.8% (n = 151) were investigated for at least one IFI. Co-infection was confirmed in 13.9% (21/151), being 52.4% (n = 11) of the patients diagnosed with cryptococcosis, followed by histoplasmosis (47.6%; n = 10) and probable invasive aspergillosis (IA) (9.6%; n = 2). Furthermore, some patients presented more than one fungal co-infection (9.5%; n = 2). CD4 T cell count < 200 cells/mm3 represented a risk factor for the development of IFI (P = 0.006) and the outcome death was higher in the TB/HIV/IFI group, as well as 38% of patients died. Even without a systematic investigation for IFI in TB/HIV patients, a high rate of co-infection was shown. Therefore, it is necessary to investigate TB and IFI concomitantly, in people living with HIV, due to the worsening of the outcome when these infections are associated.","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Agricultural practices and biological characteristics as determinants of the prevalence of human pathogens A. fumigatus sensu stricto and A. udagawae. 农业实践和生物学特性作为人类病原体严格感烟曲霉和乌达川烟曲霉流行的决定因素。

IF 2.7 3区医学

Medical mycology Pub Date : 2025-06-05 DOI: 10.1093/mmy/myaf046

Freddy Villanueva-Cotrina, Guillermo García-Effron, Soledad Gamarra, Julieta Mariana Rojas, Heli Barron-Pastor, Melina Lorenzini, Gustavo Giusiano

{"title":"Agricultural practices and biological characteristics as determinants of the prevalence of human pathogens A. fumigatus sensu stricto and A. udagawae.","authors":"Freddy Villanueva-Cotrina, Guillermo García-Effron, Soledad Gamarra, Julieta Mariana Rojas, Heli Barron-Pastor, Melina Lorenzini, Gustavo Giusiano","doi":"10.1093/mmy/myaf046","DOIUrl":"10.1093/mmy/myaf046","url":null,"abstract":"Aspergillus section Fumigati (ASF) comprises saprophytic moulds that naturally inhabit a wide range of biomes including cultivated soils where climatic factors and agricultural practices can influence the composition of fungal communities. Aspergillus fumigatus sensu stricto is the leading cause of invasive aspergillosis in immunocompromised individuals, but closely related species have also emerged as important pathogens. We analyzed 29 soil samples (13 from orchards and 16 from conventional agricultural soils) collected at different times and seasons. Interestingly, the 48 ASF strains isolated matched to only two species, typified as A. fumigatus sensu stricto (28) and A. udagawae (20). Significant differences in the prevalence of both species were observed. A higher recovery of A. fumigatus sensu stricto was obtained in spring and A. udagawae in summer and winter. Considering the agricultural production system, A. fumigatus sensu stricto was more prevalent in agroecological orchards and A. udagawae in conventional agricultural soils. Our results suggest that the presence of only these two species may be attributed to their distinctive biological characteristics and the climatic conditions prevailing in the study area. While the prevalence of A. fumigatus sensu stricto in agroecological orchards and A. udagawae in conventional agriculture, may be a result of the ecological impact of agricultural production systems. Our study provides empirical evidence in support of a potential model whereby the presence and distribution of ASF species in agricultural soils may be driven by two key factors: their biological characteristics and the use of agrochemical compounds for crop production.","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Economic burden of fungal diseases in the United States. 真菌疾病在美国的经济负担。

IF 2.7 3区医学

Medical mycology Pub Date : 2025-06-05 DOI: 10.1093/mmy/myaf049

Kaitlin Benedict, Jeremy A W Gold, Tom Chiller, Meghan Lyman

引用次数: 0

Aspergillus latus: A cryptic causative agent of aspergillosis emerging in Japan. 曲霉：日本出现的一种曲霉病的隐性病原体。

IF 2.7 3区医学

Medical mycology Pub Date : 2025-06-05 DOI: 10.1093/mmy/myaf052

Saho Shibata, Momotaka Uchida, Sayaka Ban, Katsuhiko Kamei, Akira Watanabe, Takashi Yaguchi, Vit Hubka, Hiroki Takahashi

{"title":"Aspergillus latus: A cryptic causative agent of aspergillosis emerging in Japan.","authors":"Saho Shibata, Momotaka Uchida, Sayaka Ban, Katsuhiko Kamei, Akira Watanabe, Takashi Yaguchi, Vit Hubka, Hiroki Takahashi","doi":"10.1093/mmy/myaf052","DOIUrl":"10.1093/mmy/myaf052","url":null,"abstract":"Allodiploid hybrid species, Aspergillus latus, belonging to section Nidulantes, is a hybrid of A. spinulosporus and an unknown species closely related to A. quadrilineatus and A. sublatus. This hybrid has often been misidentified as the species in section Nidulantes, such as A. nidulans, A. spinulosporus, A. sublatus, or other cryptic species. Aspergillus latus has not been reported in Japan as well as Asia so far. In this study, we screened 23 clinical strains identified as A. spinulosporus isolated in Japan from 2012 to 2023 and found seven A. latus strains. To characterize the A. latus strains, we conducted comprehensive phenotyping including morphological observation, whole genome sequences, and phylogenetic analysis based on calmodulin (CaM) gene. In addition, we conducted antifungal susceptibility testing for A. latus strains. As a result, the morphological characters of A. latus were more similar to those of A. spinulosporus compared to A. sublatus. However, the ascospore of A. latus differed from that of A. spinulosporus. Phylogenetic analysis revealed that different CaM alleles from the same isolate clustered separately with A. spinulosporus and A. sublatus, consistent with its hybrid origin. Furthermore, A. latus strains showed reduced susceptibility to caspofungin and amphotericin B compared to A. spinulosporus, while they were susceptible to azoles. Our results suggest that A. latus has been a causative pathogen of aspergillosis in Japan since 2013.","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genome characterization of Trichophyton mentagrophytes genotype VII strain PG12DES from Italy. 意大利墨农毛癣菌基因型VII株PG12DES的基因组特征分析。

IF 2.7 3区医学

Medical mycology Pub Date : 2025-06-05 DOI: 10.1093/mmy/myaf054

Luca Rossi, Annarita Sorrentino, Prof Caterina Signoretto, Paolo Gaibani

引用次数: 0

Value of qPCR in the screening strategy for Candida auris. qPCR在耳念珠菌筛选中的应用价值。

IF 2.7 3区医学

Medical mycology Pub Date : 2025-04-30 DOI: 10.1093/mmy/myaf041

Sarah Jolivet, Sandra Fournier, Jeanne Bigot, Lokman Galal, Edith Le Roux, Mehdi Bonnet, Valérie Souyri, Pierre-Antoine Michel, Hélène Goulet, Gilles Pialoux, Marine Nadal, Muriel Fartoukh, Frédéric Barbut, Christophe Hennequin, Juliette Guitard

{"title":"Value of qPCR in the screening strategy for Candida auris.","authors":"Sarah Jolivet, Sandra Fournier, Jeanne Bigot, Lokman Galal, Edith Le Roux, Mehdi Bonnet, Valérie Souyri, Pierre-Antoine Michel, Hélène Goulet, Gilles Pialoux, Marine Nadal, Muriel Fartoukh, Frédéric Barbut, Christophe Hennequin, Juliette Guitard","doi":"10.1093/mmy/myaf041","DOIUrl":"https://doi.org/10.1093/mmy/myaf041","url":null,"abstract":"Candida auris has emerged as a major fungal pathogen responsible for persistent outbreaks, highlighting the importance of an effective screening strategy to control its spread in healthcare settings. Following a confirmed C. auris infection, we incorporated a specific qPCR assay into the screening process. Contact patients and environmental samples were screened weekly using culture and qPCR methods. We used these results to manage patients' cohorting, room disinfection, and new admissions in real time. The qPCR allowed us to identify 37 colonized patients and detect 47 contaminated environmental sites. While being specific, qPCR was more sensitive than culture in detecting C. auris colonization, enabling prompt infection control measures. This strategy was effective as the spread of C. auris in our institution was contained within 2 months. Our results support the inclusion of specific qPCR in the screening strategy for the early detection of C. auris in healthcare facilities.","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":"63 5","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 2.7 3区医学

Medical mycology Pub Date : 2025-04-30 DOI: 10.1093/mmy/myaf042

Haiming Yan, Xinrui Gao, Suling Chen, Yuanhui Jiang, Jian Chen, Siyi Cen, Xuwen Xu, Jie Peng, Shaohang Cai

{"title":"Inflammation-related indices as markers for mortality in people living with HIV co-infected with Talaromyces Marneffei: a retrospective analysis.","authors":"Haiming Yan, Xinrui Gao, Suling Chen, Yuanhui Jiang, Jian Chen, Siyi Cen, Xuwen Xu, Jie Peng, Shaohang Cai","doi":"10.1093/mmy/myaf042","DOIUrl":"10.1093/mmy/myaf042","url":null,"abstract":"Talaromyces marneffei (T. marneffei) co-infection remains a significant cause of mortality in people living with HIV (PLWH). Although early detection of individuals at high risk is essential, there remains a lack of markers to predict outcomes. This multicenter retrospective study analyzed 282 PLWH (95 treatment-naïve T. marneffei co-infected, 187 without opportunistic infections) to evaluate six inflammatory indices: systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), neutrophil-to-platelet ratio (NPR), and pan-immune inflammation value (PIV). Multivariate logistic regression and ROC analysis were performed to identify risk factors and prognostic performance. The results revealed that T. marneffei group exhibited significantly elevated levels of SII, NPR, NLR, and PLR (P <0.001), with lower LMR (P <0.001) and PIV levels (P =0.014). Logistic regression identified thrombocytopenia (P =0.026), hypoalbuminemia (P =0.031), and lower CD4+ T-cell counts (P =0.011) as independent predictors of HIV-TM coinfection. Among the T. marneffei group, survivors (n=80) and non-survivors (n=15) exhibited distinct inflammatory profiles: NLR demonstrated optimal mortality prediction (AUC=0.788, P <0.001), outperforming NPR (AUC=0.671, P <0.001). Multivariate analysis confirmed NLR as the sole mortality predictor (P =0.041), with restricted cubic spline analysis indicating a non-linear NLR-mortality relationship. In conclusion, we found that NLR represents a reliable prognostic marker for PLWH co-infected with T. marneffei.","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":"63 5","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanistic insights into granulocyte-macrophage colony-stimulating factor in combating fungal infections: Diverse fungal pathogens. 粒细胞-巨噬细胞集落刺激因子在对抗真菌感染中的机制见解：多种真菌病原体。

IF 2.7 3区医学

Medical mycology Pub Date : 2025-04-30 DOI: 10.1093/mmy/myaf044

Qi Dong, Weiwei Wu, Ruijun Zhang

引用次数: 0

A longitudinal study assessing Aspergillus polymerase chain reaction (PCR) performance through participation in external quality assessment schemes from 2019 to 2022. 一项通过参与2019 - 2022年外部质量评估方案评估曲霉聚合酶链反应（PCR）性能的纵向研究。

IF 2.7 3区医学

Medical mycology Pub Date : 2025-04-30 DOI: 10.1093/mmy/myaf036

Alastair Ricketts, Dorothy Montgomery, Juergen Loeffler, Rosemary Barnes, Mario Cruciani, J Peter Donnelly, P Lewis White

引用次数: 0