Medical mycology最新文献

{"title":"A clinically actionable nomogram for predicting invasive pulmonary aspergillosis: A nested case-control study.","authors":"Lunfang Tan, Qiaorui Zhou, Xiang Luo, Rui Li, Zhengtu Li, Huanyao Zhang, Ronger Zhang, Jinping Zheng, Feng Ye, Yun Li","doi":"10.1093/mmy/myag078","DOIUrl":"10.1093/mmy/myag078","url":null,"abstract":"<p><p>Invasive pulmonary aspergillosis (IPA) is a life-threatening infection with high mortality, often misdiagnosed due to non-specific symptoms. The lack of effective early prediction models delays treatment and worsens outcomes. To identify independent IPA risk factors and develop a clinically actionable nomogram for early prediction, we conducted a nested case-control study within a 10-year cohort of 27 100 pulmonary infection patients. The cohort was split into training (70%) and testing (30%) sets. In the training set, 1002 IPA cases (proven or probable, as defined by European Organization for Research and Treatment of Cancer and Mycosis Research Group Education and Research Consortium 2020 criteria) were included, alongside 2004 randomly selected pneumonia controls (1:2 ratio). A nomogram was developed using multivariable logistic regression in the training set and was evaluated by held-out internal validation in the testing set. Model performance was primarily assessed via area under the curve (AUC), calibration, and decision curve analysis (DCA). Nine independent IPA predictors were identified: bronchiectasis (odds ratio [OR]= 7.07), pulmonary tuberculosis (OR = 2.20), diabetes (OR = 2.09), positive serum galactomannan (GM) test (OR = 1.76), mechanical ventilation (OR = 1.74), connective tissue disease (OR = 1.73), positive serum (1,3)-β-d-glucan (G) test (OR = 1.48), sputum (OR = 1.33), and neutrophil-to-lymphocyte ratio (OR = 1.01). The nomogram demonstrated moderate stable discrimination (training AUC: 0.73; testing AUC: 0.75), with excellent calibration (Brier scores: 0.183 and 0.110). DCA confirmed clinical utility across wide risk thresholds. In conclusion, this novel nine-variable nomogram using routine clinical data provides a practical tool for early IPA risk estimation, potentially guiding timely decisions and improving outcomes. External validation is warranted.</p>","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148631048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective study comparing the severe cutaneous adverse reactions in patients receiving triazole antifungal therapy and literature analysis.","authors":"Cheng-Tao Jin, Qian-Qian Jiang, Ping Chen, Wei Jiang","doi":"10.1093/mmy/myag084","DOIUrl":"10.1093/mmy/myag084","url":null,"abstract":"<p><p>Triazole antifungal drugs (TADs) are widely used in clinical practice but carry a risk of severe cutaneous adverse reactions (SCARs). However, comprehensive real-world evidence regarding the comparative safety profiles of individual TADs remains limited. This research aimed to investigate and compare the real-world risk, clinical characteristics, and time-to-onset of SCARs associated with individual TADs. The SCAR cases with TADs as the primary suspect drug were identified in the FDA Adverse Event Reporting System. Disproportionality analysis and Bayesian methods were employed to detect safety signals with Reporting Odds Ratio (ROR), Proportional Reporting Ratio (PRR), Bayesian Confidence Propagation Neural Network (BCPNN), and Empirical Bayes Geometric Mean (EBGM). Differences of clinical features, outcomes, time-to-onset (TTO), and signal strength at the preferred term (PT) level were analyzed. A total of 1429 SCAR cases with five TADs were identified. Fluconazole showed the strongest and most consistent statistical association across all four algorithms (ROR = 5.2), followed by itraconazole. Voriconazole yielded mixed signals (positive by ROR and BCPNN only), while Posaconazole and Isavuconazole exhibited no significant SCAR signals. Voriconazole was associated with the highest mortality proportion (12.8%), followed by posaconazole (10%). The median TTO for SCARs was 8 days, with voriconazole having the longest delay (16 days). At the PT level, 45 distinct signals were identified, including high-risk manifestations such as fixed eruption (ROR = 24.43), mucosal ulceration, and SJS/TEN overlap. This study identified significant variability of SCARs signals among triazole antifungals. These findings support early risk recognition and informed antifungal selection in clinical practice.</p>","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13502895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148760732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short tandem repeat genotyping of Pichia kudriavzevii isolates reveals long-standing clinical clade with high transmission potential.","authors":"Bram Spruijtenburg, Kusum Jain, Merlijn H I van Haren, Jacques F Meis, Theun de Groot, Eelco F J Meijer, Anuradha Chowdhary","doi":"10.1093/mmy/myag082","DOIUrl":"10.1093/mmy/myag082","url":null,"abstract":"<p><p>Pichia kudriavzevii (previously known as Candida krusei) is among the top five causative agents of candidemia, mainly affecting neonates. The yeast is intrinsically resistant to fluconazole, and nosocomial transmission has been reported. Recently, whole genome sequencing (WGS) analysis on 24 out of 165 clinical P. kudriavzevii isolates from Delhi, India showed two clusters, indicating nosocomial transmission. To further increase our insight into the transmission of this fungus in healthcare settings, we performed short tandem repeat (STR) genotyping of 106 isolates from Delhi, India, and compared outcomes to STR genotypes and WGS data of isolates originating from various countries. A total of 52 unique genotypes were identified, in addition to five clusters comprising two to 22 isolates. Four of these clusters were restricted to a single hospital, while the largest cluster included six hospitals. Interestingly, when compared to a global collection, Iranian clinical isolates were identical to the multicenter cluster and also related to isolates from the Netherlands and Sri Lanka, the latter isolate being collected in 1935. WGS analysis on a selection of isolates confirmed the clusters identified by STR analysis, underscoring the high discriminatory power of the STR genotyping scheme. In short, we report several events of single-center nosocomial transmission of P. kudriavzevii in India. One multicenter cluster was found, which was closely related to isolates originating from diverse countries, suggesting a fitness advantage or elevated transmission potential for this lineage.</p>","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13482982/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148679212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Captive lizards (Squamata: Sauria) as reservoirs of medically important and antifungal-resistant yeasts.","authors":"Rossella Samarelli, Nicola Pugliese, Jairo Alfonso Mendoza-Roldan, Mara Miglianti, Renata Fagundes-Moreira, Pietro Laricchiuta, Matteo Legrottaglie, Patrizia Danesi, Domenico Otranto, Gustavo Giusiano","doi":"10.1093/mmy/myag083","DOIUrl":"10.1093/mmy/myag083","url":null,"abstract":"<p><p>Zoological collections represent unique environments in which captivity-related alterations of host microbiota may increase susceptibility to infectious diseases. While reptiles are recognized reservoirs of microorganisms, data on quantitative yeast colonization and antifungal susceptibility in captive lizards remain limited. This study assessed 28 lizards belonging to nine species housed in a zoological park in southern Italy. Skin and cloacal swabs (n = 56) revealed yeast growth in 75% of animals and 57.1% of samples, with positivity rates of 60.7% and 53.6% for skin and cloacal samples, respectively. MALDI-TOF MS and ITS region sequencing identified 113 isolates belonging to 17 distinct fungal species, including Arthrographis spp., Meyerozyma spp., Candida spp., Pichia spp., Trichosporon spp., and others. Arthrographis kalrae was the predominant species (i.e., 36.3%), followed by Meyerozyma guilliermondii (i.e., 16.8%). Mean colonization loads were 4.25 CFU/swab for skin and 10.50 CFU/swab for cloacal samples. Eight species were considered clinically relevant, including the Candida parapsilosis complex, Pichia kudriavzevii, and Trichosporon asahii. Antifungal susceptibility testing performed according to Clinical and Laboratory Standards Institute (CLSI, 2022) guidelines revealed marked phenotypic heterogeneity and frequent elevation of minimum inhibitory concentration (MIC). Above-threshold MICs differed significantly according to yeast species, antifungal compound, and sampling site. Non-wild-type phenotypes and elevated MICs were observed across multiple antifungal classes, with amphotericin B >64 µg/ml and fluconazole >256 µg/ml in several isolates (i.e., 92.3% and 75.0%, respectively). Reduced susceptibility or resistance was evident in Clavispora lusitaniae, M. guilliermondii, and Wickerhamomyces anomalus. These findings support the hypothesis that captive lizards may represent asymptomatic reservoirs of opportunistic and potentially antifungal-resistant yeasts, emphasizing the importance of hygiene measures and microbiological surveillance in zoological settings.</p>","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13499607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148761476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenotypic and genotypic analysis of clonal clinical isolates of Nakaseomyces glabratus (Candida glabrata).","authors":"Ana L López-Marmolejo, Marco J Hernández-Chávez, Guadalupe Gutiérrez-Escobedo, Paulina Varela-Castillo, M Selene Herrera-Basurto, R Areli Martínez-Gamboa, María F González-Lara, José Sifuentes-Osornio, Alejandro De Las Peñas, Irene Castaño","doi":"10.1093/mmy/myag077","DOIUrl":"10.1093/mmy/myag077","url":null,"abstract":"<p><p>Nakaseomyces glabratus (formerly Candida glabrata) is an emerging and opportunistic fungal pathogen that possesses a set of virulence attributes allowing it to survive and colonize new niches within its host. The objective of this study is to determine patterns of phenotypic and genotypic variation in clonal clinical isolates from different patients that occur during an infection. We analyzed 35 clonal clinical isolates of N. glabratus from 10 patients, which we first identified with species-specific primers and genotyped with six polymorphic molecular markers. We characterized the susceptibility to three classes of antifungals, the ability to adhere and form biofilms on polystyrene, the response to thermal stress and oxidative stress caused by different oxidizing agents, and the enzymatic activity of the catalase. We found that the N. glabratus clinical isolates analyzed from each patient share a clonal origin but differ from isolates from other patients. We found that the isolates can grow in a wide range of temperatures and acute and chronic stress conditions such as oxidative stress. Isolates from patient 9 displayed higher resistance to acute exposure to H2O2 in stationary-phase cells than the standard laboratory strain BG14, and this correlates with a higher activity of the only catalase enzyme of N. glabratus. In addition, we identified a case of phenotypic variation among clonal isolates derived from the same patient.</p>","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148605206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical, epidemiological and mycological characteristics of pediatric kerion celsi in Eastern Turkey: A retrospective study of 65 cases.","authors":"Hatice Uce Özkol, Ziya İlhan, İlknur Yorğun Özdemir","doi":"10.1093/mmy/myag076","DOIUrl":"10.1093/mmy/myag076","url":null,"abstract":"<p><p>Kerion celsi remains a significant public health concern in eastern Turkey. This study aimed to evaluate the clinical, demographic, and mycological characteristics of patients diagnosed with kerion celsi, a condition that continues to be relatively common in this region. A total of 65 pediatric patients who were hospitalized in our dermatology clinic between December 2015 and December 2016 were included in the study. During epilation, which is routinely performed as part of the treatment, hair and skin samples were collected to identify the causative agents. All samples underwent standard microbiological procedures for fungal identification. Of the patients, 51 (78.5%) were male and 14 (21.5%) were female. The ages ranged from 1 to 13 years, with a mean age of 6.45 years. Regarding seasonal distribution, 6 patients (9.2%) were admitted in summer, 10 (15.4%) in autumn, 27 (41.5%) in winter, and 22 (33.8%) in spring. The majority of patients (56; 86.2%) were from rural areas, while only 9 (13.8%) resided in urban settings. Fungal growth was detected in 23 samples (35.3%), whereas no growth was observed in 42 samples (64.7%). Among the culture-positive cases, Trichophyton (T.) verrucosum was the most frequently identified species, accounting for 9 cases (38.7%). In conclusion, our findings indicate that T. verrucosum was the predominant etiological agent of kerion celsi in eastern Turkey. Additionally, the study reported the presence of fungal species not previously described in Turkey.</p>","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148536260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics, antifungal exposure, and 90-day mortality of PCR-identified candidemia according to presumed species-level fluconazole susceptibility.","authors":"Isabel Campa, Molly Studebaker, Andrés F Henao-Martínez, Martin Krsak, Daniel B Chastain","doi":"10.1093/mmy/myag080","DOIUrl":"10.1093/mmy/myag080","url":null,"abstract":"<p><p>Rapid species identification frequently informs early antifungal decision-making before isolate-level antifungal susceptibility testing (AFST) becomes available. Clinicians therefore commonly rely on presumed species-level fluconazole susceptibility to guide initial therapy. Whether these presumed susceptibility categories identify clinically distinct patient populations with different treatment patterns and outcomes remains uncertain. We conducted a retrospective cohort study using TriNetX Research Network (May 2017-November 2023) including adults with PCR-identified candidemia. Patients were categorized as presumed fluconazole susceptible (FS) (Candida albicans, C. parapsilosis, and C. tropicalis) or presumed fluconazole nonsusceptible (FNS) (Nakaseomyces glabratus, Pichia kudriavzevii, and C. auris). Clinical characteristics, antifungal treatment patterns, and 90-day all-cause mortality were evaluated using inverse probability of treatment weighting (IPTW) and Cox proportional hazards models. Among 1171 patients, 43% were categorized in the FNS group. Compared with the FS group, patients in the FNS group were older, had greater comorbidity burden, and more frequently received echinocandins, whereas azole exposure was more common in the FS group. Despite similar crude 90-day mortality (23.9% vs 23.3%), IPTW-adjusted analysis demonstrated lower survival among patients in the FS group (adjusted hazard ratio 1.41, 95% confidence interval 1.09-1.82, P = .009). Within-group analyses identified variables independently associated with mortality. Species categorized as presumed FNS accounted for nearly half of PCR-identified candidemia cases and were associated with clinically distinct patient populations characterized by different baseline characteristics and mortality associations. Rapid species identification conveys clinically relevant information beyond anticipated fluconazole susceptibility while awaiting isolate-level AFST.</p>","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148631014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Copper-only Superoxide dismutase 6 contributes to reactive oxygen species regulation, genotoxic stress tolerance, and virulence in Candida albicans.","authors":"Zhiwei Liu, Mengxue Li, Jiule Wang, Biao Chen","doi":"10.1093/mmy/myag063","DOIUrl":"10.1093/mmy/myag063","url":null,"abstract":"<p><p>Superoxide dismutase (SOD) is a major antioxidant enzyme that protects cells against reactive oxygen species (ROS)-mediated oxidative stress. The identification of a fungal-specific copper-only SOD family in Candida albicans (C. albicans) has revealed a previously unrecognized component of fungal oxidative stress defence, yet the role of SOD6 remains unclear. Here, we generated a sod6Δ/Δ mutant in C. albicans using a transient CRISPR/Cas9 approach and examined the contribution of SOD6 to virulence, ROS homeostasis, oxidative stress resistance, and genome maintenance. Compared with the wild-type (WT) strain, the sod6Δ/Δ mutant showed attenuated virulence in both the Galleria mellonella (G. mellonell) infection model and a murine systemic candidiasis model. This virulence defect occurred without detectable alterations in hyphal formation or other major pathogenicity-associated traits. Instead, the mutant accumulated higher intracellular and extracellular ROS levels and displayed increased sensitivity to hydrogen peroxide, zeocin, and camptothecin (CPT), consistent with impaired oxidative stress adaptation and genome maintenance. Transcriptomic analysis further revealed downregulation of genes involved in DNA replication and repair, with dpb4, which encodes a subunit of DNA polymerase epsilon required for DNA replication and genome stability, showing the greatest reduction. Together, these findings identify SOD6 as an important determinant of oxidative stress adaptation, genome maintenance, and pathogenic fitness in C. albicans.</p>","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148283950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genotype structure of Trichophyton mentagrophytes complex from companion animals in France reveals restricted diversity.","authors":"Arnaud Jabet, Anne-Cécile Normand, Nicolas Soetart, Maxime Kittel, Caroline Dumont, Floriane Hubert, Sara Gonzalez-Munoz, Thomas Guilmin, Gentiane Monsel, Arnaud Fekkar, Renaud Piarroux, Jacques Guillot","doi":"10.1093/mmy/myag057","DOIUrl":"10.1093/mmy/myag057","url":null,"abstract":"<p><p>The Trichophyton mentagrophytes complex includes pathogens of major relevance in both human and veterinary medicine. Despite growing knowledge of the rDNA Internal Transcribed Spacer (ITS) region diversity within the complex, data on circulating genotypes in animals remain scarce. We analyzed 348 T. mentagrophytes isolates obtained from companion animals in France in 2020 to describe ITS genotype distribution and assess the presence of T. indotineae and T. mentagrophytes ITS-genotype VII. Eight ITS genotypes were identified, with genotype III* largely predominant (62.4%), followed by genotypes III (22.4%) and II* (8.6%). No significant difference in genotype distribution was observed between cats and dogs. Genotype XXIV was exclusively detected in the three chinchilla isolates, while genotype XXVI-Uhrlass was identified in 17 cases. Three previously undescribed ITS genotypes were also recorded. Sequencing of tef1-α and tubb in a subset of isolates showed limited diversity within each ITS genotype, except for genotype III*, which exhibited several sequence variants. Mating-type analysis revealed both idiomorphs in the collection, although a single idiomorph was detected within each ITS genotype except genotype III*. Genotypes III and XXVI exhibited a restricted geographical distribution. Neither T. indotineae, T. mentagrophytes ITS-genotype VII, nor T. interdigitale ITS genotypes were identified. Our results highlight restricted genetic diversity among companion animal-derived isolates in France and support reduced genetic mixing among ITS genotypes, consistent with ongoing speciation processes within T. mentagrophytes species complex.</p>","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148157005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human-to-animal transmission cases of the anthropophilic dermatophyte species Trichophyton tonsurans in France, 2021-2025.","authors":"Arnaud Jabet, Anne-Cécile Normand, Nicolas Soetart, Mansala Mukoko, Veronica Risco-Castillo, Arnaud Fekkar, Renaud Piarroux, Jacques Guillot","doi":"10.1093/mmy/myag066","DOIUrl":"10.1093/mmy/myag066","url":null,"abstract":"<p><p>Veterinary infections caused by anthropophilic dermatophytes are extremely rare and, until now, have mainly involved Trichophyton rubrum. The present investigation documents 22 cases of positive culture for the anthropophilic dermatophyte species T. tonsurans in companion animals identified in France from 2021 to 2025. Trichophyton tonsurans was isolated from 13 cats and 9 dogs. Eleven animals showed symptomatic infection, whereas the others were asymptomatic carriers. Contamination most likely followed owner-to-animal transmission, suggesting a new route of spread for T. tonsurans, an increasingly reported species. Patients infected with T. tonsurans should therefore be informed of the risk of transmission to their companion animals.</p>","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148283917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}