Medical mycology最新文献_第4页

A global perspective of the changing epidemiology of invasive fungal disease and real-world experience with the use of isavuconazole. 从全球角度看侵袭性真菌病流行病学的变化以及使用异黄酮唑的实际经验。

IF 2.7 3区医学

Medical mycology Pub Date : 2024-09-06 DOI: 10.1093/mmy/myae083

George R Thompson, Sharon C-A Chen, Wadha Ahmed Alfouzan, Koichi Izumikawa, Arnaldo L Colombo, Johan Maertens

{"title":"A global perspective of the changing epidemiology of invasive fungal disease and real-world experience with the use of isavuconazole.","authors":"George R Thompson, Sharon C-A Chen, Wadha Ahmed Alfouzan, Koichi Izumikawa, Arnaldo L Colombo, Johan Maertens","doi":"10.1093/mmy/myae083","DOIUrl":"10.1093/mmy/myae083","url":null,"abstract":"Global epidemiological data show that the incidence of invasive fungal disease (IFD) has increased in recent decades, with the rising frequency of infections caused by Aspergillus and Mucorales order species. The number and variety of patients at risk of IFD has also expanded, owing in part to advances in the treatment of hematologic malignancies and other serious diseases, including hematopoietic stem cell transplantation (HCT) and other therapies causing immune suppression. Isavuconazonium sulfate (active moiety: isavuconazole) is an advanced-generation triazole antifungal approved for the treatment of invasive aspergillosis and mucormycosis that has demonstrated activity against a variety of yeasts, moulds, and dimorphic fungi. While real-world clinical experience with isavuconazole is sparse in some geographic regions, it has been shown to be effective and well tolerated in diverse patient populations, including those with multiple comorbidities who may have failed to respond to prior triazole antifungal therapy. Isavuconazole may be suitable for patients with IFD receiving concurrent QTc-prolonging therapy, as well as those on venetoclax or ruxolitinib. Data from clinical trials are not available to support the use of isavuconazole prophylactically for the prevention of IFD or for the treatment of endemic IFD, such as those caused by Histoplasma spp., but real-world evidence from case studies suggests that it has clinical utility in these settings. Isavuconazole is an option for patients at risk of IFD, particularly when the use of alternative antifungal therapies is not possible because of toxicities, pharmacokinetics, or drug interactions.","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11382804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141976086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Landscape of in situ cytokine expression, soluble C-type lectin receptors, and vitamin D in patients with recurrent vulvovaginal candidiasis. 复发性外阴阴道念珠菌病患者原位细胞因子表达、可溶性 C 型凝集素受体和维生素 D 的分布。

IF 2.7 3区医学

Medical mycology Pub Date : 2024-09-06 DOI: 10.1093/mmy/myae091

Jeiser Marcelo Consuegra-Asprilla, Manuela Chaverra-Osorio, Brajhan Torres, Yuliana Cabrera-Chingal, Angelica Mancera-Mieles, Carolina Rodríguez-Echeverri, Beatriz L Gómez, Ángel González

{"title":"Landscape of in situ cytokine expression, soluble C-type lectin receptors, and vitamin D in patients with recurrent vulvovaginal candidiasis.","authors":"Jeiser Marcelo Consuegra-Asprilla, Manuela Chaverra-Osorio, Brajhan Torres, Yuliana Cabrera-Chingal, Angelica Mancera-Mieles, Carolina Rodríguez-Echeverri, Beatriz L Gómez, Ángel González","doi":"10.1093/mmy/myae091","DOIUrl":"10.1093/mmy/myae091","url":null,"abstract":"The immunopathogenesis of recurrent vulvovaginal candidiasis (RVVC) is poorly understood. Recently, it was reported that patients with RVVC present a decrease in both the fungicidal capacity of neutrophils and the proliferative capability of peripheral blood mononuclear cells in response to Candida albicans infection, suggesting an alteration in the innate and adaptive immune response. The aim of this study was to determine the in-situ expression, in the vaginal mucosa, of genes associated with the immune response, as well as the serum concentrations of dectin-1, mannose-binding lectin (MBL), and vitamin D in patients with RVVC. A study was carried out on 40 patients with a diagnosis of RVVC and 26 healthy women. Vaginal scrapings were obtained, and the expression of genes that encode cytokines and transcription factors specific for Th1, Th2, Th17, Treg, pro-inflammatory profiles, and enzymes related to oxidative/microbicidal mechanisms was evaluated by quantitiative polymerase chain reaction (qPCR). Additionally, serum levels of vitamin D and the soluble receptors dectin-1 and MBL were determined by enzyme-linked immunosorbent assay (ELISA). In patients with RVVC, a decreased expression of T-bet, RORγ-T, IL-1β, and IL-17, and an increase in the expression of FOXP3, IL-4, IL-8, IL-10, and IL-18 were observed when compared to healthy women: moreover, decreased levels of MBL were also observed in these patients. These results confirm that patients with RVVC present in-situ alterations in both the specific and adaptive immune response against Candida spp., a fact that could be associated with the exaggerated vaginal inflammatory response.","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142140532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular epidemiology and antifungal susceptibility of dermatophytes and Candida isolates in superficial fungal infections at a grade A tertiary hospital in Northern China. 华北某甲级三甲医院浅部真菌感染中皮真菌和念珠菌分离物的分子流行病学和抗真菌敏感性

IF 2.7 3区医学

Medical mycology Pub Date : 2024-09-06 DOI: 10.1093/mmy/myae087

Ruijun Zhang, Ziping Song, Xiaorui Su, Ting Li, Juan Xu, Xiao He, Yuanwen Yang, Bingmei Chang, Yuying Kang

{"title":"Molecular epidemiology and antifungal susceptibility of dermatophytes and Candida isolates in superficial fungal infections at a grade A tertiary hospital in Northern China.","authors":"Ruijun Zhang, Ziping Song, Xiaorui Su, Ting Li, Juan Xu, Xiao He, Yuanwen Yang, Bingmei Chang, Yuying Kang","doi":"10.1093/mmy/myae087","DOIUrl":"10.1093/mmy/myae087","url":null,"abstract":"This study analyzed the prevalence and antifungal susceptibility of superficial fungal infections in 295 cases from 2019 to 2020 at a dermatology clinic. Dermatophytes were the predominant pathogens (69.5%), including Trichophytonrubrum, T. interdigitale, Microsporum canis, et al., followed by Candida spp. (29.5%), including Candidaalbicans, Ca. parapsilosis, and Ca. glabrata. The most common infections were onychomycosis (36.3%), tinea cruris (30.5%), and tinea corporis (18.6%). The distribution of SFI types showed variations based on gender, age, and season. Common antifungal agents, including terbinafine, voriconazole, ciclopiroxamine, amphotericin B, itraconazole, and ketoconazole have exhibited low minimum inhibitory concentrations against dermatophytes, especially terbinafine, which has been potent against superficial fungal infections caused by dermatophytes in the local area. Candida spp. strains were generally susceptible or classified as wild-type to 5-flucytosine and amphotericin B, with 92.0% being wild-type for itraconazole. However, resistance to fluconazole and voriconazole was observed in a small percentage of Ca. albicans and Ca. parapsilosis strains. The emergence of drug-resistant Candida underscores the importance of prudent antifungal use and continuous surveillance.","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142036340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deciphering prognostic indicators in non-HIV cryptococcal meningitis: Constructing and validating a predictive Nomogram model. 解密非艾滋病毒隐球菌脑膜炎的预后指标：构建并验证预测性提名图模型

IF 2.7 3区医学

Medical mycology Pub Date : 2024-09-06 DOI: 10.1093/mmy/myae092

Feng Liang, Runyang Li, Make Yao, Jing Wang, Yunhong Li, Lijian Lei, Junhong Guo, Xueli Chang

{"title":"Deciphering prognostic indicators in non-HIV cryptococcal meningitis: Constructing and validating a predictive Nomogram model.","authors":"Feng Liang, Runyang Li, Make Yao, Jing Wang, Yunhong Li, Lijian Lei, Junhong Guo, Xueli Chang","doi":"10.1093/mmy/myae092","DOIUrl":"10.1093/mmy/myae092","url":null,"abstract":"Cryptococcal meningitis (CM) is a well-recognized fungal infection, with substantial mortality in individuals infected with the human immunodeficiency virus (HIV). However, the incidence, risk factors, and outcomes in non-HIV adults remain poorly understood. This study aims to investigate the characteristics and prognostic indicators of CM in non-HIV adult patients, integrating a novel predictive model to guide clinical decision-making. A retrospective cohort of 64 non-HIV adult CM patients, including 51 patients from previous studies and 13 from the First Hospital of Shanxi Medical University, was analyzed. We assessed demographic features, underlying diseases, intracranial pressure, cerebrospinal fluid characteristics, and brain imaging. Using the least absolute shrinkage and selection operator (LASSO) method, and multivariate logistic regression, we identified significant variables and constructed a Nomogram prediction model. The model's calibration, discrimination, and clinical value were evaluated using the Bootstrap method, calibration curve, C index, goodness-of-fit test, receiver operating characteristic (ROC) analysis, and decision curve analysis. Age, brain imaging showing parenchymal involvement, meningeal and ventricular involvement, and previous use of immunosuppressive agents were identified as significant variables. The Nomogram prediction model displayed satisfactory performance with an akaike information criterion (AIC) value of 72.326, C index of 0.723 (0.592-0.854), and area under the curve (AUC) of 0.723, goodness-of-fit test P = 0.995. This study summarizes the clinical and imaging features of adult non-HIV CM and introduces a tailored Nomogram prediction model to aid in patient management. The identification of predictive factors and the development of the nomogram enhance our understanding and capacity to treat this patient population. The insights derived have potential clinical implications, contributing to personalized care and improved patient outcomes.","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142140531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Comparison of Candida colonization in intensive care unit patients with and without COVID-19: First prospective cohort study from Turkey. 更正：有 COVID-19 和没有 COVID-19 的重症监护室患者念珠菌定植情况比较：土耳其首次前瞻性队列研究。

IF 2.7 3区医学

Medical mycology Pub Date : 2024-08-02 DOI: 10.1093/mmy/myae078

引用次数: 0

Molecular characterisation of Histoplasma capsulatum sensu lato from Ethiopian horses reveals two distinct phylogenetic clades. 埃塞俄比亚马的荚膜组织胞浆菌（Histoplasma capsulatum sensu lato）的分子特征揭示了两个不同的系统发育支系。

IF 2.7 3区医学

Medical mycology Pub Date : 2024-08-02 DOI: 10.1093/mmy/myae079

Patrick C Y Woo, Fatma Al Mheiri, Jessika Cavalleri, Sunitha Joseph, James Y M Tang, Marina Joseph, Chi-Ching Tsang, Susanna K P Lau, Ulrich Wernery

{"title":"Molecular characterisation of Histoplasma capsulatum sensu lato from Ethiopian horses reveals two distinct phylogenetic clades.","authors":"Patrick C Y Woo, Fatma Al Mheiri, Jessika Cavalleri, Sunitha Joseph, James Y M Tang, Marina Joseph, Chi-Ching Tsang, Susanna K P Lau, Ulrich Wernery","doi":"10.1093/mmy/myae079","DOIUrl":"10.1093/mmy/myae079","url":null,"abstract":"Epizootic lymphangitis (EL) is a highly prevalent and contagious infectious disease affecting horses in many parts of Ethiopia caused by Histoplasma capsulatum sensu lato ('var. farciminosum'). In this study, 12 suspected isolates of H. capsulatum sensu lato or yeasts unidentified by conventional biochemical tests isolated from Ethiopian horses with EL were characterised by internal transcribed spacer sequencing. Six of the 12 isolates were identified to be members of H. capsulatum sensu lato and the other six were Pichia kudriavzevii (synonym: Candida krusei) (n = 3), Trichosporon asahii (n = 1), Geotrichum silvicola (n = 1) and Moesziomyces aphidis (n = 1), respectively. The six H. capsulatum sensu lato isolates were further characterised by multilocus sequence analysis. Four distinct gene loci (arf [462 bases], H-anti [410 bases], ole1 [338 bases] and tub1 [272 bases]) of these six isolates as well as those of two H. capsulatum sensu lato ('var. farciminosum') reference strains (ATCC 58332 and ATCC 28798) were polymerase chain reaction (PCR)-amplified and sequenced. Phylogenetic analyses of their concatenated nucleotide sequences showed that three of the isolates and the reference strain ATCC 58332 were identical and belonged to the Eurasia clade within Latin American (LAm) A (H. suramericanum), and those of the other three isolates and the reference strain ATCC 28798 were identical and belonged to the Africa clade. At least two distinct phylogenetic clades of H. capsulatum sensu lato were circulating in Ethiopian horses with EL. Advanced molecular technologies and bioinformatics tools are crucial for the accurate identification and typing of pathogens as well as the discovery of novel microorganisms in veterinary microbiology.","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification and antifungal susceptibility profile of uncommon yeast species at Fattouma Bourguiba University Hospital in Tunisia. 突尼斯 Fattouma Bourguiba 大学医院不常见酵母菌种的鉴定和抗真菌药敏谱。

IF 2.7 3区医学

Medical mycology Pub Date : 2024-08-02 DOI: 10.1093/mmy/myae070

Sameh Belgacem, Wissal Chebil, Safa Ben Salem, Oussama Babba, Maha Mastouri, Hamouda Babba

{"title":"Identification and antifungal susceptibility profile of uncommon yeast species at Fattouma Bourguiba University Hospital in Tunisia.","authors":"Sameh Belgacem, Wissal Chebil, Safa Ben Salem, Oussama Babba, Maha Mastouri, Hamouda Babba","doi":"10.1093/mmy/myae070","DOIUrl":"10.1093/mmy/myae070","url":null,"abstract":"Despite the severe impact of uncommon yeast fungal infections and the pressing need for more research on the topic, there are still few studies available on the identification, epidemiology, and susceptibility profile of those pathogens. The aims of the current study were to define the profile of uncommon yeast species at Fattouma Bourguiba University Hospital using phenotypic, molecular, and proteomic methods and to study their antifungal susceptibility profile. Pre-identified uncommon yeast species were collected from 2018 to 2021. These isolates were further identified using phenotypic methods (ID32C® system and Vitek2® YST), matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS), and sequencing. The antifungal susceptibility profile was studied using the reference CLSI broth microdilution method. In total, 30 strains were collected during the study period. Referring to the sequencing, the most isolated uncommon species were Saprochaete capitata, Candida lusitaniae, Candida kefyr, Candida inconspicua, and Candida guilliermondii. A total of 90% of isolates were correctly identified by MALDI-TOF MS compared to 76.7% and 63.3% by ID32® C and VITEK® 2 YST, respectively. The isolated species showed variable responses to antifungals. Candida guilliermondii showed increased azole minimum inhibitory concentrations. Misidentification of uncommon yeast species was common using commercial phenotypic methods. The high percentage of concordance of MALDI-TOF results with sequencing highlights its high performance and usefulness as a routine diagnosis tool.","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141580225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Candida albicans-A systematic review to inform the World Health Organization Fungal Priority Pathogens List. 更正：白念珠菌--为世界卫生组织真菌优先病原体清单提供信息的系统性综述。

IF 2.7 3区医学

Medical mycology Pub Date : 2024-08-02 DOI: 10.1093/mmy/myae074

引用次数: 0

Mycology laboratory diagnostic capacity for invasive fungal diseases in public hospitals in Vietnam. 越南公立医院真菌学实验室对侵袭性真菌疾病的诊断能力。

IF 2.7 3区医学

Medical mycology Pub Date : 2024-08-02 DOI: 10.1093/mmy/myae082

Vu Ngoc Hieu, Nguyen Le Hiep, Le Minh Hang, Bianca A Lau-Goodchild, Nguyen Van Duong, Nguyen Thuy Linh, Justin Beardsley, Vu Quoc Dat

引用次数: 0

Sporothrix brasiliensis-specific polymerase chain reaction for the diagnosis of cat and human sporotrichosis through non-invasive samples. 通过非侵入性样本诊断猫和人孢子丝菌病的巴西孢子丝菌特异性 PCR。

IF 2.7 3区医学

Medical mycology Pub Date : 2024-08-02 DOI: 10.1093/mmy/myae075

Mariana Rodrigues Trápaga, Vanice Rodrigues Poester, Karine Ortiz Sanchotene, Rossana Patrícia Basso, Fabiana Fedatto Bernardon, Rejane Luvielmo, Cecília Bittencourt Severo, Rodrigo Almeida-Paes, Rosely Maria Zancopé Oliveira, Andrea von Groll, Melissa Orzechowski Xavier

{"title":"Sporothrix brasiliensis-specific polymerase chain reaction for the diagnosis of cat and human sporotrichosis through non-invasive samples.","authors":"Mariana Rodrigues Trápaga, Vanice Rodrigues Poester, Karine Ortiz Sanchotene, Rossana Patrícia Basso, Fabiana Fedatto Bernardon, Rejane Luvielmo, Cecília Bittencourt Severo, Rodrigo Almeida-Paes, Rosely Maria Zancopé Oliveira, Andrea von Groll, Melissa Orzechowski Xavier","doi":"10.1093/mmy/myae075","DOIUrl":"10.1093/mmy/myae075","url":null,"abstract":"Zoonotic sporotrichosis caused by Sporothrix brasiliensis is an emerging mycosis in Latin America. One of the problems to quickly treat infected animals and break the transmission chain is associated with the time-consuming gold-standard diagnosis method (culture). We aimed to evaluate a species-specific polymerase chain reaction (PCR) for the diagnosis of sporotrichosis caused by S. brasiliensis using non-invasive samples. We performed a retrospective cross-sectional study using samples collected with swabs from humans and cats with clinical suspicion of sporotrichosis. Deoxyribonucleic acid (DNA) was extracted using a commercial kit, and a species-specific PCR for S. brasiliensis detection was performed. One hundred ten samples were included. PCR showed a good concordance with culture (86% of agreement) for human and cat samples (Kappa coefficient = 0.722, and 0.727, respectively). In conclusion, our data shows that this adapted PCR using non-invasive samples can be applied to sporotrichosis diagnosis, being a good alternative mainly in regions with a lack of mycologists to identify the fungus in culture, contributing to the control of this emergent zoonosis.","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141752106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0