A 40-year antifungal susceptibility surveillance of Talaromyces marneffei (1984-2024) at a tertiary hospital in Guangxi, China.

IF 2.3 3区 医学 Q3 INFECTIOUS DISEASES
Xinyu Zhou, Yanqing Zheng, Dongyan Zheng, Zhiwen Jiang, Kaisu Pan, Guoqun Liu, Saroj Karki, Xiaojuan He, Cunwei Cao
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Abstract

Long-term trends in the antifungal susceptibility of Talaromyces marneffei isolates have not been well characterized. We conducted a 40-year surveillance study analyzing the antifungal susceptibility of 131 T. marneffei isolates collected from the clinical laboratory of the First Affiliated Hospital of Guangxi Medical University between 1984 and 2024. In vitro susceptibilities to conventional antifungal agents, including itraconazole, voriconazole, fluconazole, and amphotericin B, were analyzed using the Clinical and Laboratory Standards Institute broth microdilution method. We also explored the potential influence of host Human Immunodeficiency Virus (HIV) status and fungal mating type (MAT) on susceptibility patterns. The minimum inhibitory concentrations (MICs) for itraconazole, voriconazole, fluconazole, and amphotericin B ranged from 0.015 to 0.06 μg/ml, 0.008 to 0.03 μg/ml, 1 to 8 μg/ml, and 0.25 to 1 μg/ml, respectively. Fluconazole showed a significant decline in susceptibility over time (P < .01), whereas the susceptibilities to the other antifungals remained stable (P > .05). The correlations observed between the MICs of different triazoles (P < .01) suggest potential cross-resistance among triazoles. MAT and HIV infection status did not significantly affect antifungal susceptibility patterns (P > .05). These findings underscore the importance of ongoing antifungal susceptibility surveillance in T. marneffei, considering the changes in fluconazole susceptibility and potential triazole cross-resistance, while other antifungals remain stable.

广西某三级医院马尔尼菲Talaromyces marneffei药敏监测(1984-2024)
马尔尼菲Talaromyces marneffei分离株抗真菌敏感性的长期趋势尚未得到很好的表征。对1984年至2024年广西医科大学第一附属医院临床实验室采集的131株马尼菲t菌进行了40年的药敏监测研究。采用美国临床与实验室标准协会(CLSI)肉汤微量稀释法对伊曲康唑、伏立康唑、氟康唑和两性霉素B等常规抗真菌药物进行体外敏感性分析。我们还探讨了宿主HIV状态和真菌交配类型(MAT)对易感性模式的潜在影响。对伊曲康唑、伏立康唑、氟康唑和两性霉素B的最低抑菌浓度分别为0.015 ~ 0.06 μg/mL、0.008 ~ 0.03 μg/mL、1 ~ 8 μg/mL和0.25 ~ 1 μg/mL。随着时间的推移,氟康唑的易感性明显下降(p < 0.05)。不同三唑类药物的mic之间存在相关性(p < 0.05)。这些发现强调了在其他抗真菌药物保持稳定的情况下,考虑到氟康唑敏感性和潜在的三唑交叉耐药性的变化,对马尼菲t进行持续的抗真菌药敏监测的重要性。
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来源期刊
Medical mycology
Medical mycology 医学-兽医学
CiteScore
5.70
自引率
3.40%
发文量
632
审稿时长
12 months
期刊介绍: Medical Mycology is a peer-reviewed international journal that focuses on original and innovative basic and applied studies, as well as learned reviews on all aspects of medical, veterinary and environmental mycology as related to disease. The objective is to present the highest quality scientific reports from throughout the world on divergent topics. These topics include the phylogeny of fungal pathogens, epidemiology and public health mycology themes, new approaches in the diagnosis and treatment of mycoses including clinical trials and guidelines, pharmacology and antifungal susceptibilities, changes in taxonomy, description of new or unusual fungi associated with human or animal disease, immunology of fungal infections, vaccinology for prevention of fungal infections, pathogenesis and virulence, and the molecular biology of pathogenic fungi in vitro and in vivo, including genomics, transcriptomics, metabolomics, and proteomics. Case reports are no longer accepted. In addition, studies of natural products showing inhibitory activity against pathogenic fungi are not accepted without chemical characterization and identification of the compounds responsible for the inhibitory activity.
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