基因组学对新加坡印朵毛癣菌的研究：抗性和传播动力学。

IF 2.3 3区医学 Q3 INFECTIOUS DISEASES

Medical mycology Pub Date : 2025-07-02 DOI:10.1093/mmy/myaf062

Jeanette W P Teo, Janet W S Cheng, Jamie S Wee, Douglas Chan, Ka Lip Chew

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引用次数: 0

摘要

在两家医院进行的为期11个月的研究中，对33株最初被归类为毛癣菌复合体的分离株进行了全基因组测序（WGS）。其中，24只（72.7%）鉴定为印趾踏虫，9只（27.3%）鉴定为趾间踏虫，未检出植地踏虫。在22例有临床资料的患者中，75%表现为多解剖部位受累；虽然只有两名患者报告最近旅行，但63.6%是农民工。只有4名患者的症状得到缓解，而5名患者出现复发。近80%的T. indotineae分离株显示与SQLE突变相关的特比萘芬耐药，而未观察到表型上的唑耐药，这与cyp51突变的缺失一致。indotineae（520 ~ 1531个SNP）和interdigitale（1 380 ~ 115 963个SNP）的单核苷酸多态性（SNP）分析均未发现系统发育聚类，可能是独立的引种。

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Genomic insights into the dermatophyte Trichophyton indotineae in Singapore: Resistance and transmission dynamics.

During an 11-month study at two hospital sites, 33 isolates initially classified as the Trichophyton mentagrophytes complex were subjected to whole-genome sequencing. Of these, 24 (72.7%) were identified as T. indotineae and 9 (27.3%) as T. interdigitale, with no T. mentagrophytes detected. Among the 22 patients with available clinical data, 75% exhibited involvement of multiple anatomical sites; although only two patients reported recent travel, 63.6% were migrant workers. Symptom resolution was documented in only four patients, whereas five experienced recurrences. Nearly 80% of T. indotineae isolates displayed terbinafine resistance linked to squalene epoxidase mutations, while no phenotypic azole resistance was observed, consistent with the absence of cyp51 mutations. Single-nucleotide polymorphism (SNP) analysis of both T. indotineae (520-1531 SNPs) and T. interdigitale (1380-115 963 SNPs) revealed no phylogenetic clustering, suggesting independent introductions.

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来源期刊

Medical mycology 医学-兽医学

CiteScore

5.70

自引率

3.40%

发文量

632

审稿时长

12 months

期刊介绍： Medical Mycology is a peer-reviewed international journal that focuses on original and innovative basic and applied studies, as well as learned reviews on all aspects of medical, veterinary and environmental mycology as related to disease. The objective is to present the highest quality scientific reports from throughout the world on divergent topics. These topics include the phylogeny of fungal pathogens, epidemiology and public health mycology themes, new approaches in the diagnosis and treatment of mycoses including clinical trials and guidelines, pharmacology and antifungal susceptibilities, changes in taxonomy, description of new or unusual fungi associated with human or animal disease, immunology of fungal infections, vaccinology for prevention of fungal infections, pathogenesis and virulence, and the molecular biology of pathogenic fungi in vitro and in vivo, including genomics, transcriptomics, metabolomics, and proteomics. Case reports are no longer accepted. In addition, studies of natural products showing inhibitory activity against pathogenic fungi are not accepted without chemical characterization and identification of the compounds responsible for the inhibitory activity.