Daniel Dang Hoang Nguyen, Gabrielle Louise Langron Chau, Savannah Reali, Matthew Richard Watts, Mark William Douglas, Justin Beardsley, Jan-Willem Cornelis Alffenaar
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引用次数: 0
Abstract
Antifungal stewardship is important for promoting quality care and tackling the emergence of drug resistance. Evaluation of the quantity and appropriateness of common antifungal prescriptions like fluconazole is essential in the development of these programmes. To perform a clinical audit of fluconazole prescribing and explore whether involvement of pharmacy students in this process was feasible and meaningful from both pharmacy student and health system perspectives. An audit was conducted of all fluconazole prescriptions from January 2024 to March 2024 at two Sydney hospitals. Trained pharmacy students, under the supervision of antimicrobial stewardship pharmacists and physicians, completed the audit using the Antifungal National Antimicrobial Prescribing Survey audit tool. Prescriptions were assessed for their compliance to guidelines and appropriateness. Data on pharmacy students' educational experience was collected by a 5-point Likert scale survey. A total of 145 fluconazole prescriptions were audited: 34 for empiric therapy, 56 for directed therapy, and 56 for prophylaxis. A total of 91 (62.8%) prescriptions were assessed as appropriate, 46 (31.7%) were inappropriate, and 8 (5.5%) were not assessable. Potential drug-drug interactions were identified in 17 patients receiving fluconazole doses of 200 mg or greater, of which three were clinically significant, requiring intervention. Students had positive experiences contributing to quality use of medicines, in terms of enjoyment, support, and education. Inappropriate fluconazole use was common. Pharmacy students made a positive contribution to the antifungal audit, promoting good stewardship practises for the hospital while accessing enhanced learning and development opportunities.
期刊介绍：
Medical Mycology is a peer-reviewed international journal that focuses on original and innovative basic and applied studies, as well as learned reviews on all aspects of medical, veterinary and environmental mycology as related to disease. The objective is to present the highest quality scientific reports from throughout the world on divergent topics. These topics include the phylogeny of fungal pathogens, epidemiology and public health mycology themes, new approaches in the diagnosis and treatment of mycoses including clinical trials and guidelines, pharmacology and antifungal susceptibilities, changes in taxonomy, description of new or unusual fungi associated with human or animal disease, immunology of fungal infections, vaccinology for prevention of fungal infections, pathogenesis and virulence, and the molecular biology of pathogenic fungi in vitro and in vivo, including genomics, transcriptomics, metabolomics, and proteomics. Case reports are no longer accepted. In addition, studies of natural products showing inhibitory activity against pathogenic fungi are not accepted without chemical characterization and identification of the compounds responsible for the inhibitory activity.
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