Luciéle Pereira de Melo, Caroline Quintana Braga, Carolina Dos Santos Bermann, Lara Baccarin Ianiski, Jefferson Luiz Silva de Souza, Jéssica Rabelo de Oliveira Persichini, Angelita Dos Reis Gomes, Renata Osório de Faria, Maria Isabel de Azevedo, Sônia de Avila Botton, Daniela Isabel Brayer Pereira
{"title":"巴西孢子丝虫对盐酸阿莫罗芬和伊曲康唑的体外敏感性分析。","authors":"Luciéle Pereira de Melo, Caroline Quintana Braga, Carolina Dos Santos Bermann, Lara Baccarin Ianiski, Jefferson Luiz Silva de Souza, Jéssica Rabelo de Oliveira Persichini, Angelita Dos Reis Gomes, Renata Osório de Faria, Maria Isabel de Azevedo, Sônia de Avila Botton, Daniela Isabel Brayer Pereira","doi":"10.1093/mmy/myaf075","DOIUrl":null,"url":null,"abstract":"<p><p>Sporothrix brasiliensis is the leading cause of feline sporotrichosis in Brazil, an emerging zoonosis. Itraconazole (ITZ) is the first-line therapy; however, therapeutic failures and reports of ITZ-resistant isolates emphasize the need for new therapeutic options. This study evaluated the in vitro susceptibility profile of 25 Brazilian S. brasiliensis isolates to amorolfine hydrochloride (AMR) and ITZ. AMR evidenced fungicidal activity in 76% and fungistatic activity in 24% of isolates. All isolates were susceptible to ITZ. These findings support AMR as a promising antifungal candidate against S. brasiliensis and highlight the importance of continued surveillance of ITZ susceptibility, especially in endemic regions of Brazil.</p>","PeriodicalId":18586,"journal":{"name":"Medical mycology","volume":" ","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"In vitro susceptibility profile of Brazilian Sporothrix brasiliensis isolates to amorolfine hydrochloride and itraconazole.\",\"authors\":\"Luciéle Pereira de Melo, Caroline Quintana Braga, Carolina Dos Santos Bermann, Lara Baccarin Ianiski, Jefferson Luiz Silva de Souza, Jéssica Rabelo de Oliveira Persichini, Angelita Dos Reis Gomes, Renata Osório de Faria, Maria Isabel de Azevedo, Sônia de Avila Botton, Daniela Isabel Brayer Pereira\",\"doi\":\"10.1093/mmy/myaf075\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Sporothrix brasiliensis is the leading cause of feline sporotrichosis in Brazil, an emerging zoonosis. Itraconazole (ITZ) is the first-line therapy; however, therapeutic failures and reports of ITZ-resistant isolates emphasize the need for new therapeutic options. This study evaluated the in vitro susceptibility profile of 25 Brazilian S. brasiliensis isolates to amorolfine hydrochloride (AMR) and ITZ. AMR evidenced fungicidal activity in 76% and fungistatic activity in 24% of isolates. All isolates were susceptible to ITZ. These findings support AMR as a promising antifungal candidate against S. brasiliensis and highlight the importance of continued surveillance of ITZ susceptibility, especially in endemic regions of Brazil.</p>\",\"PeriodicalId\":18586,\"journal\":{\"name\":\"Medical mycology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2025-09-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medical mycology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/mmy/myaf075\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medical mycology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/mmy/myaf075","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
In vitro susceptibility profile of Brazilian Sporothrix brasiliensis isolates to amorolfine hydrochloride and itraconazole.
Sporothrix brasiliensis is the leading cause of feline sporotrichosis in Brazil, an emerging zoonosis. Itraconazole (ITZ) is the first-line therapy; however, therapeutic failures and reports of ITZ-resistant isolates emphasize the need for new therapeutic options. This study evaluated the in vitro susceptibility profile of 25 Brazilian S. brasiliensis isolates to amorolfine hydrochloride (AMR) and ITZ. AMR evidenced fungicidal activity in 76% and fungistatic activity in 24% of isolates. All isolates were susceptible to ITZ. These findings support AMR as a promising antifungal candidate against S. brasiliensis and highlight the importance of continued surveillance of ITZ susceptibility, especially in endemic regions of Brazil.
期刊介绍:
Medical Mycology is a peer-reviewed international journal that focuses on original and innovative basic and applied studies, as well as learned reviews on all aspects of medical, veterinary and environmental mycology as related to disease. The objective is to present the highest quality scientific reports from throughout the world on divergent topics. These topics include the phylogeny of fungal pathogens, epidemiology and public health mycology themes, new approaches in the diagnosis and treatment of mycoses including clinical trials and guidelines, pharmacology and antifungal susceptibilities, changes in taxonomy, description of new or unusual fungi associated with human or animal disease, immunology of fungal infections, vaccinology for prevention of fungal infections, pathogenesis and virulence, and the molecular biology of pathogenic fungi in vitro and in vivo, including genomics, transcriptomics, metabolomics, and proteomics. Case reports are no longer accepted. In addition, studies of natural products showing inhibitory activity against pathogenic fungi are not accepted without chemical characterization and identification of the compounds responsible for the inhibitory activity.