Microsystems & Nanoengineering最新文献_第6页

Patterning silver nanowire network via the Gibbs-Thomson effect. 利用吉布斯-汤姆逊效应绘制银纳米线网络。

IF 7.3 1区工程技术

Microsystems & Nanoengineering Pub Date : 2025-05-19 DOI: 10.1038/s41378-025-00945-z

Hongteng Wang, Haichuan Li, Yijia Xin, Weizhen Chen, Haogeng Liu, Ying Chen, Yaofei Chen, Lei Chen, Yunhan Luo, Zhe Chen, Gui-Shi Liu

{"title":"Patterning silver nanowire network via the Gibbs-Thomson effect.","authors":"Hongteng Wang, Haichuan Li, Yijia Xin, Weizhen Chen, Haogeng Liu, Ying Chen, Yaofei Chen, Lei Chen, Yunhan Luo, Zhe Chen, Gui-Shi Liu","doi":"10.1038/s41378-025-00945-z","DOIUrl":"10.1038/s41378-025-00945-z","url":null,"abstract":"As transparent electrodes, patterned silver nanowire (AgNW) networks suffer from noticeable pattern visibility, which is an unsettled issue for practical applications such as display. Here, we introduce a Gibbs-Thomson effect (GTE)-based patterning method to effectively reduce pattern visibility. Unlike conventional top-down and bottom-up strategies that rely on selective etching, removal, or deposition of AgNWs, our approach focuses on fragmenting nanowires primarily at the junctions through the GTE. This is realized by modifying AgNWs with a compound of diphenyliodonium nitrate and silver nitrate, which aggregates into nanoparticles at the junctions of AgNWs. These nanoparticles can boost the fragmentation of nanowires at the junctions under an ultralow temperature (75 °C), allow pattern transfer through a photolithographic masking operation, and enhance plasmonic welding during UV exposure. The resultant patterned electrodes have trivial differences in transmittance (ΔT = 1.4%) and haze (ΔH = 0.3%) between conductive and insulative regions, with high-resolution patterning size down to 10 μm. To demonstrate the practicality of this novel method, we constructed a highly transparent, optoelectrical interactive tactile e-skin using the patterned AgNW electrodes.","PeriodicalId":18560,"journal":{"name":"Microsystems & Nanoengineering","volume":"11 1","pages":"96"},"PeriodicalIF":7.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultra-small millimeter-wave filter chips based on high-K single-crystal lithium niobate. 基于高钾单晶铌酸锂的超小型毫米波滤波芯片。

IF 7.3 1区工程技术

Microsystems & Nanoengineering Pub Date : 2025-05-19 DOI: 10.1038/s41378-025-00947-x

Qun Li, Junyan Zheng, Yansong Yang

{"title":"Ultra-small millimeter-wave filter chips based on high-K single-crystal lithium niobate.","authors":"Qun Li, Junyan Zheng, Yansong Yang","doi":"10.1038/s41378-025-00947-x","DOIUrl":"10.1038/s41378-025-00947-x","url":null,"abstract":"Next-generation communication systems require the mass deployment of ultra-small, high-performance filters that integrate multi-physical domains. However, achieving an optimal balance between miniaturization, low insertion loss, high selectivity, and low cost of millimeter-wave filters remains a challenge for existing technologies. Herein, we propose and demonstrate ultra-small millimeter-wave filters based on the multifunctional lithium niobate (LN) with outstanding nonlinear optical, electro-optic, piezoelectric, ferroelectric, and thermoelectric characteristics. As a high-K material with low dielectric loss and straightforward fabrication, LN provides an ideal platform for integrating photonic, acoustic, and electromagnetic functionalities. Notably, while LN is already proven for acoustic and optical signal processing, its potential for electromagnetic signal processing remains largely unexplored. In this work, we introduce second-order and fourth-order LN-based millimeter-wave bandpass filters (BPFs) tailored for narrowband and wideband millimeter-wave applications, respectively. Through careful optimization of the LN thickness, we elevate the cutoff frequencies of high-order modes, enhancing frequency selectivity while maintaining compactness. The LN-based BPFs exhibit record-breaking performance metrics, including minimal insertion loss, high selectivity, and compatibility with microfabrication processes. The LN-based BPFs fulfill the critical demands of millimeter-wave wireless communications, sensing, imaging, and emerging quantum information systems, paving the way for scalable, multi-physical integrated circuits.","PeriodicalId":18560,"journal":{"name":"Microsystems & Nanoengineering","volume":"11 1","pages":"95"},"PeriodicalIF":7.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cantilever beam-based piezoelectric micromachined ultrasonic transducer with post processing soft interconnecting strategy for in-air rangefinding. 基于悬臂梁的压电微机械超声换能器及其后处理软互连策略的空中测距。

IF 7.3 1区工程技术

Microsystems & Nanoengineering Pub Date : 2025-05-19 DOI: 10.1038/s41378-025-00939-x

Yan Wang, Peng Chen, Junning Zhang, Zihan Li, Hongbin Yu

{"title":"Cantilever beam-based piezoelectric micromachined ultrasonic transducer with post processing soft interconnecting strategy for in-air rangefinding.","authors":"Yan Wang, Peng Chen, Junning Zhang, Zihan Li, Hongbin Yu","doi":"10.1038/s41378-025-00939-x","DOIUrl":"10.1038/s41378-025-00939-x","url":null,"abstract":"Despite of good performance immunity to stress and high transmitting/receiving sensitivity advantages, the fabrication imperfection induced asynchronous vibration and the resultant prolonged ring-down tail severely limit the potential of the cantilever beam-based piezoelectric micromachined ultrasonic transducer (PMUT) in pulse-echo applications as transceiver. To address this issue, a novel post processing soft interconnecting strategy is presented. In this case, specific reservoir structure is intentionally integrated into the cantilever-beam based PMUT design, under the assistance of which the liquid PDMS can be accurately applied and spontaneously driven to seal the air gaps between the already released cantilever beams via the capillary effect. After curing, the PDMS will be transformed from liquid to solid and serve as soft interconnecting spring between adjacent cantilever beams so as to force them to vibrate in synchronous mode. At the same time, this treatment does not change the existing fabrication process and has little effect on the original PMUT performance. From both of the mechanical and acoustic response measurement results, effective suppression for the asynchronous vibration and significant reduction of the ring-down tail have been successfully demonstrated for the treated PMUT device. In the subsequent pulse-echo rangefinding experiment, a distance detection range covering from 270.8 mm to 3.8 m with a divergence angle close to 170° has been achieved when it is driven at resonant frequency of 69.2 kHz with 40 Vpp, 40-cycles sinusoidal signal. Given the simple yet effective treatment, the proposed strategy shows great prospective in developing high performance PMUT for in-air rangefinding applications.","PeriodicalId":18560,"journal":{"name":"Microsystems & Nanoengineering","volume":"11 1","pages":"97"},"PeriodicalIF":7.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A wearable self-aid microneedle chip based on actively transdermal delivery of epinephrine. 一种基于肾上腺素主动透皮输送的可穿戴自助微针芯片。

IF 7.3 1区工程技术

Microsystems & Nanoengineering Pub Date : 2025-05-16 DOI: 10.1038/s41378-025-00941-3

Chenxi Jin, Peng Guo, Wenjun Li, Wangwang Zhu, Chengcheng Li, Jing Ma, Jun Li, Dachao Li, Jing He, Zhihua Pu

{"title":"A wearable self-aid microneedle chip based on actively transdermal delivery of epinephrine.","authors":"Chenxi Jin, Peng Guo, Wenjun Li, Wangwang Zhu, Chengcheng Li, Jing Ma, Jun Li, Dachao Li, Jing He, Zhihua Pu","doi":"10.1038/s41378-025-00941-3","DOIUrl":"10.1038/s41378-025-00941-3","url":null,"abstract":"Epinephrine is important for first aid and usually applied via injection, which is painful and problematic in operation, thereby making it difficult to self-delivery. In this study, a method to actively transdermal delivery of epinephrine is proposed based on incorporating microneedles with iontophoresis, and then a wearable device is fabricated for rapid and controllable self-delivery of epinephrine. The device consists of a hydrogel microneedle array, a conductive drug delivery hydrogel, iontophoresis electrodes, and an encapsulated cartridge with a spring and self-locking micro-mechanism. The microneedles create subcutaneous microchannels, allowing the epinephrine contained in the hydrogel to enter the body under the control of iontophoretic currents. The dosage and rate can be adjusted at different levels by pressing the button so that it can be used by different groups of people for rapid self-aid and recovery from fatigue. The device can be worn in advance if required. In-vitro tests showed that the transdermal delivery rate of the device was between 0.02642 and 0.1059 mg/h cm². As a proof-of-concept application, in-vivo experiments showed that the device could reverse life-threatening shock reactions in a piglet model of hemorrhagic shock through the delivery of epinephrine.","PeriodicalId":18560,"journal":{"name":"Microsystems & Nanoengineering","volume":"11 1","pages":"92"},"PeriodicalIF":7.3,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Direct extraction of respiratory information from pulse waves using a finger-inspired flexible pressure sensor system. 直接提取呼吸信息从脉搏波使用手指启发柔性压力传感器系统。

IF 7.3 1区工程技术

Microsystems & Nanoengineering Pub Date : 2025-05-16 DOI: 10.1038/s41378-025-00924-4

Xikuan Zhang, Jin Chai, Lingxiao Xu, Shixuan Mei, Xin Wang, Yunlong Zhao, Chenyang Xue, Yongjun Wang, Danfeng Cui, Zengxing Zhang, Haiyan Zhang, Libo Gao

{"title":"Direct extraction of respiratory information from pulse waves using a finger-inspired flexible pressure sensor system.","authors":"Xikuan Zhang, Jin Chai, Lingxiao Xu, Shixuan Mei, Xin Wang, Yunlong Zhao, Chenyang Xue, Yongjun Wang, Danfeng Cui, Zengxing Zhang, Haiyan Zhang, Libo Gao","doi":"10.1038/s41378-025-00924-4","DOIUrl":"10.1038/s41378-025-00924-4","url":null,"abstract":"The long-term monitoring of respiratory status is crucial for the prevention and diagnosis of respiratory diseases. However, existing continuous respiratory monitoring devices are typically bulky and require either chest strapping or proximity to the nasal area, which compromises user comfort and may disrupt the monitoring process. To overcome these challenges, we have developed a flexible, attachable, lightweight, and miniaturized system designed for extended wear on the wrist. This system incorporates signal acquisition circuitry, a mobile client, and a deep neural network, facilitating long-term respiratory monitoring. Specifically, we fabricated a highly sensitive (11,847.24 kPa-1) flexible pressure sensor using a screen printing process, which is capable of functioning beyond 70,000 cycles. Additionally, we engineered a bidirectional long short-term memory (BiLSTM) neural network, enhanced with a residual module, to classify various respiratory states including slow, normal, fast, and simulated breathing. The system achieved a dataset classification accuracy exceeding 99.5%. We have successfully demonstrated a stable, cost-effective, and durable respiratory sensor system that can quantitatively collect and store respiratory data for individuals and groups. This system holds potential for everyday monitoring of physiological signals and healthcare applications.","PeriodicalId":18560,"journal":{"name":"Microsystems & Nanoengineering","volume":"11 1","pages":"90"},"PeriodicalIF":7.3,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanojet visualization and dark-field imaging of optically trapped vaterite capsules with endoscopic illumination. 内窥镜照明下光捕获水晶石胶囊的纳米射流可视化和暗场成像。

IF 7.3 1区工程技术

Microsystems & Nanoengineering Pub Date : 2025-05-16 DOI: 10.1038/s41378-025-00951-1

Andrei Ushkov, Andrey Machnev, Denis Kolchanov, Toms Salgals, Janis Alnis, Vjaceslavs Bobrovs, Pavel Ginzburg

{"title":"Nanojet visualization and dark-field imaging of optically trapped vaterite capsules with endoscopic illumination.","authors":"Andrei Ushkov, Andrey Machnev, Denis Kolchanov, Toms Salgals, Janis Alnis, Vjaceslavs Bobrovs, Pavel Ginzburg","doi":"10.1038/s41378-025-00951-1","DOIUrl":"10.1038/s41378-025-00951-1","url":null,"abstract":"Optical responsivity grants biomedical capsules additional capabilities, promoting them towards multifunctional theragnostic nanodevices. In this endeavor, screening candidates under conditions that closely resemble in situ environments is crucial for both the initial optimization and the subsequent inspection stages of development and operation. Optical tweezers equipped with dark-field spectroscopy are among the preferable tools for nanoparticle imaging and refractometry. However, the effectiveness of conventional illumination and light collection arrangements for inspecting anisotropic complex inner composition particles is quite limited due to reduced collection angles, which can result in the omission of features in scattering diagrams. Here we introduce an endoscopic dark-field illumination scheme, where light is launched on an optically trapped particle from a single-mode fiber, immersed into a fluid cell. This arrangement disentangles illumination and collection paths, thus allowing the collection of scattered light with a very high numerical aperture. This methodology is applied to vaterite capsules, which are known to possess strong anisotropic responses. Tweezer configuration allows revealing optical properties for different crystallographic orientations of vaterite, which is complex to do otherwise. Furthermore, endoscopic dark-field images reveal the emergence of polarization-dependent long-range photonic nanojets, which are capable of interacting with nearby particles, demonstrating a new pathway for nanojet image formation.","PeriodicalId":18560,"journal":{"name":"Microsystems & Nanoengineering","volume":"11 1","pages":"91"},"PeriodicalIF":7.3,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combining time domain modulation optofluidics and high dynamic range imaging for multiplexed, high throughput digital droplet assays. 结合时域调制光流体和多路、高通量数字液滴分析的高动态范围成像。

IF 7.3 1区工程技术

Microsystems & Nanoengineering Pub Date : 2025-05-16 DOI: 10.1038/s41378-025-00918-2

Yasemin Atiyas, Michael J Siedlik, Stephanie J Yang, David A Issadore

{"title":"Combining time domain modulation optofluidics and high dynamic range imaging for multiplexed, high throughput digital droplet assays.","authors":"Yasemin Atiyas, Michael J Siedlik, Stephanie J Yang, David A Issadore","doi":"10.1038/s41378-025-00918-2","DOIUrl":"10.1038/s41378-025-00918-2","url":null,"abstract":"Digital enzyme-linked immunoassays (dELISA) have been successfully applied to the ultrasensitive quantification of analytes, including nucleic acids, proteins, cells, and extracellular vesicles, achieving robust detection limits in complex clinical specimens such as blood, and demonstrating utility across a broad range of clinical applications. The ultrasensitivity of dELISA comes from partitioning single analytes, captured onto a microbead, into millions of compartments so that they can be counted individually. There is particular interest in using dELISA for multiplexed measurements, but generating and detecting the billions of compartments necessary to perform multiplexed ultrasensitive dELISA remains a challenge. To address this, we have developed a high-throughput, optofluidic platform that performs quantitative fluorescence measurements on five populations of microbeads, each encoded with distinct ratios of two fluorescent dyes, for digital assays. The key innovation of our work is the parallelization of droplet generation and detection, combined with time-domain encoding of the excitation sources into distinct patterns that barcode the emission signal of both dyes within each bead, achieving high throughput (6 × 106 droplets/min) and accurate readout. Additionally, we modulate the exposure settings of the digital camera, capturing images of multiplexed beads and the droplet fluorescent substrate in consecutive frames, a method inspired by high dynamic range (HDR) photography. Our platform accurately classifies five populations of dual-encoded beads (accuracy > 99%) and detects bead-bound streptavidin-horseradish peroxidase molecules in a third fluorescence channel. This work establishes the technological foundation to combine high multiplexing and high throughput for droplet digital assays.","PeriodicalId":18560,"journal":{"name":"Microsystems & Nanoengineering","volume":"11 1","pages":"93"},"PeriodicalIF":7.3,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An eighteen-organ microphysiological system coupling a vascular network and excretion system for drug discovery. 一个由18个器官组成的微生理系统，连接血管网络和排泄系统，用于药物发现。

IF 7.3 1区工程技术

Microsystems & Nanoengineering Pub Date : 2025-05-14 DOI: 10.1038/s41378-025-00933-3

Jing Wang, Huixue Zhang, Yueyang Qu, Yang Yang, Shuhui Xu, Zhenni Ji, Yuxiu Wang, Xiuli Zhang, Yong Luo

{"title":"An eighteen-organ microphysiological system coupling a vascular network and excretion system for drug discovery.","authors":"Jing Wang, Huixue Zhang, Yueyang Qu, Yang Yang, Shuhui Xu, Zhenni Ji, Yuxiu Wang, Xiuli Zhang, Yong Luo","doi":"10.1038/s41378-025-00933-3","DOIUrl":"https://doi.org/10.1038/s41378-025-00933-3","url":null,"abstract":"Physiological supporting systems, such as the vascular network and excretion system, are crucial for the effective functioning of organs. This study demonstrates that when a body-on-a-chip microdevice is coupled with miniaturized physiological support systems, it can create a multi-organ microphysiological system capable of more accurately mimicking the physiological complexity of a body, thereby offering potential for preclinical drug testing. To exemplify this concept, we have developed a model system comprising 18 types of microtissues interconnected by a vascular network that replicates the in vivo blood distribution among the organs. Furthermore, this system includes an excretory system with a micro-stirrer that ensures elimination efficiency akin to in vivo conditions. Our findings indicate that this system can: (1) survive and function for almost two months; (2) achieve two-compartment pharmacokinetics of a drug; (3) investigate the dynamic relationship between the tissue distribution and toxicity of a drug; (4) establish the multimorbidity model and evaluate the effectiveness of polypharmacy, challenging tasks with traditional animal models; (5) reduce animal usage in drug evaluations. Notably, features from points (2) to (4) are capabilities not achievable by other in vitro models. The strategy proposed in this study can also be applied to the development of multi-organ microphysiological systems that mimic the physiological complexity of human organs or the entire body.","PeriodicalId":18560,"journal":{"name":"Microsystems & Nanoengineering","volume":"11 1","pages":"89"},"PeriodicalIF":7.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12078732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bio-inspired artificial hair flow sensors: a comprehensive review of design, fabrication, enhancements, and applications. 仿生人工发流传感器：设计、制造、增强和应用的全面回顾。

IF 7.3 1区工程技术

Microsystems & Nanoengineering Pub Date : 2025-05-13 DOI: 10.1038/s41378-025-00895-6

Lansheng Zhang, Zheyi Hang, Huan Hu

{"title":"Bio-inspired artificial hair flow sensors: a comprehensive review of design, fabrication, enhancements, and applications.","authors":"Lansheng Zhang, Zheyi Hang, Huan Hu","doi":"10.1038/s41378-025-00895-6","DOIUrl":"10.1038/s41378-025-00895-6","url":null,"abstract":"Flow measurement is critical in various sectors, including industry, agriculture, medicine, and environmental monitoring. There is a growing need for compact, sensitive, scalable, and energy-efficient flow sensors, particularly for applications in unmanned aerial vehicles, unmanned underwater vehicles, biomedicine, and bionic robotics. Inspired by biological mechanosensory structures, artificial hair and hair cell flow sensors have emerged as promising solutions. This study offers a comprehensive review of the progress, underlying principles, performance optimization techniques, and applications of hair flow sensors. We provide an overview of the biological mechanisms of hair as mechanical receptors. Subsequently, we explain the design and fabrication techniques of artificial hair flow sensors, highlighting the challenges associated with replicating and integrating hair structures. The study further explores strategies for sensor enhancement and their diverse applications. Finally, we conclude by outlining the challenges and prospects of hair sensor technology, along with its potential to address specific flow-sensing requirements. While most applications of artificial hair cell flow sensors are still in the research stage, they offer substantial potential for flow measurement. Future progress in materials science, structural design, and sensing mechanisms is anticipated to drive the development of these sensors, opening up new avenues for scientific research and commercial applications.","PeriodicalId":18560,"journal":{"name":"Microsystems & Nanoengineering","volume":"11 1","pages":"88"},"PeriodicalIF":7.3,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-sized microelectrode array coupled with micro-electroporation for effective recording of intracellular action potential. 多尺寸微电极阵列与微电穿孔相结合，有效记录细胞内动作电位。

IF 7.3 1区工程技术

Microsystems & Nanoengineering Pub Date : 2025-05-13 DOI: 10.1038/s41378-025-00887-6

Xingyuan Xu, Zhengjie Liu, Jing Liu, Chuanjie Yao, Xi Chen, Xinshuo Huang, Shuang Huang, Peng Shi, Mingqiang Li, Li Wang, Yu Tao, Hui-Jiuan Chen, Xi Xie

{"title":"Multi-sized microelectrode array coupled with micro-electroporation for effective recording of intracellular action potential.","authors":"Xingyuan Xu, Zhengjie Liu, Jing Liu, Chuanjie Yao, Xi Chen, Xinshuo Huang, Shuang Huang, Peng Shi, Mingqiang Li, Li Wang, Yu Tao, Hui-Jiuan Chen, Xi Xie","doi":"10.1038/s41378-025-00887-6","DOIUrl":"10.1038/s41378-025-00887-6","url":null,"abstract":"Microelectrode arrays (MEAs) are essential tools for studying the extracellular electrophysiology of cardiomyocytes in a multi-channel format. However, they typically lack the capability to record intracellular action potentials (APs). Recent studies have relied on costly fabrication of high-resolution microelectrodes combined with electroporation for intracellular recordings, but the impact of microelectrode size on micro-electroporation and the quality of intracellular signal acquisition has yet to be explored. Understanding these effects could facilitate the design of microelectrodes of various sizes to enable lower-cost manufacturing processes. In this study, we investigated the influence of microelectrode size on intracellular AP parameters and recording metrics post-micro-electroporation through simulations and experiments. We fabricated microelectrodes of different sizes using standard photolithography techniques to record cardiomyocyte APs from various culture environments with coupled micro-electroporation. Our findings indicate that larger microelectrodes generally recorded electrophysiological signals with higher amplitude and better signal-to-noise ratios, while smaller electrodes exhibited higher perforation efficiency, AP duration, and single-cell signal ratios. This work demonstrates that the micro-electroporation technique can be applied to larger microelectrodes for intracellular recordings, rather than being limited to high-resolution designs. This approach may provide new opportunities for fabricating microelectrodes using alternative low-cost manufacturing techniques for high-quality intracellular AP recordings.","PeriodicalId":18560,"journal":{"name":"Microsystems & Nanoengineering","volume":"11 1","pages":"85"},"PeriodicalIF":7.3,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0