Journal of Biophotonics最新文献_第7页

A Compact Prism-Based Microscope for Highly Sensitive Measurements in Fluid Biopsy 一种紧凑的棱镜显微镜，用于液体活检的高灵敏度测量。

IF 2 3区物理与天体物理

Journal of Biophotonics Pub Date : 2025-02-05 DOI: 10.1002/jbio.202400519

Laura Perego, Caterina Dallari, Chiara Falciani, Alessandro Pini, Lucia Gardini, Caterina Credi, Francesco Saverio Pavone

{"title":"A Compact Prism-Based Microscope for Highly Sensitive Measurements in Fluid Biopsy","authors":"Laura Perego, Caterina Dallari, Chiara Falciani, Alessandro Pini, Lucia Gardini, Caterina Credi, Francesco Saverio Pavone","doi":"10.1002/jbio.202400519","DOIUrl":"10.1002/jbio.202400519","url":null,"abstract":"<p>The increasing demand for sensitive, portable, and affordable disease detection methods has spurred the development of advanced biosensors for rapid early-stage diagnosis, population mass screening, and bed-monitoring. Current high-sensitivity devices face hurdles such as high production costs and challenges in multiplexed signal detection. To address these, we developed a prism-based total internal reflection system which, in combination with surface functionalization techniques of gold nanoparticles, enables evanescent wave scattering for highly sensitive and rapid detection of specific analytes in both synthetic and human liquid samples. To validate its efficacy, we conducted scattering experiments in synthetic and human serum samples, exploiting functionalized AuNPs to recognize bacterial lipopolysaccharides as biomarkers for sepsis disease. We demonstrate a remarkable sensitivity in the femtogram per mL concentration range for this specific pathological biomarker. Based on this result we envisage the potential adoption of our technique for liquid biopsy in the clinical scenario.</p>","PeriodicalId":184,"journal":{"name":"Journal of Biophotonics","volume":"18 4","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbio.202400519","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction of Non-Uniform Rotational Distortion in the Proximally Controlled Endoscopic OCTA 近端控制内镜OCTA非均匀旋转畸变的校正。

IF 2 3区物理与天体物理

Journal of Biophotonics Pub Date : 2025-02-04 DOI: 10.1002/jbio.202400467

Zehua Guan, Qiang Li, Chen Niu, Shuhao Fan, Huanhuan Yu, Wenjuan Wu, Xiangfei Feng, Cuixia Dai

{"title":"Correction of Non-Uniform Rotational Distortion in the Proximally Controlled Endoscopic OCTA","authors":"Zehua Guan, Qiang Li, Chen Niu, Shuhao Fan, Huanhuan Yu, Wenjuan Wu, Xiangfei Feng, Cuixia Dai","doi":"10.1002/jbio.202400467","DOIUrl":"10.1002/jbio.202400467","url":null,"abstract":"<div>\u0000 \u0000 <p>Endoscopic Optical Coherence Tomography (OCT) can provide high-resolution cross-sectional images for internal organ tissues. Combining the endoscopic imaging with Optical Coherence Tomography Angiography (OCTA), information of blood vessels in superficial lumen tissues is expected to be acquired. However, in endoscopic OCT systems using proximal scanning probes, performance of OCTA encounters significant challenges due to non-uniform rotational distortion (NURD) caused by the non-constant rotation of the distal imaging unit. In this study, we proposed a registration method for endoscopic OCTA imaging in a proximally controlled OCT System. Global registration and A-line registration were employed to correct the distortion caused by mechanical friction between the catheter sheath and torque coil. Experimental performances in both microfluidic channel and rat rectum show significant correction of NURD. Our study achieved the first implementation of endoscopic OCTA under a spiral B-scan rotation scheme in a proximally controlled OCT system, facilitating clear visualization of blood flow.</p>\u0000 </div>","PeriodicalId":184,"journal":{"name":"Journal of Biophotonics","volume":"18 4","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experimental Research on the Process and Performance of Composite Dressing-Assisted Laser Joining of Ruptured Tendons 复合敷料辅助激光连接断裂肌腱的工艺与性能试验研究。

IF 2 3区物理与天体物理

Journal of Biophotonics Pub Date : 2025-02-03 DOI: 10.1002/jbio.202400528

Jun Huang, Yanyu Li, Mintao Yan, Jinjin Wu, Kehong Wang

引用次数: 0

Portable Nd:YAG Laser-Enhanced Photoacoustic Spectral Sensing for Breast Tissues: Toward Oncological Theranostics 便携式Nd:YAG激光增强光声光谱传感乳腺组织：肿瘤治疗。

IF 2 3区物理与天体物理

Journal of Biophotonics Pub Date : 2025-02-01 DOI: 10.1002/jbio.202400430

Suhel Khan, Sramana Mukhopadhyay, M. S. Ansari, R. K. Patidar, Saikat Das, Srivathsan Vasudevan

{"title":"Portable Nd:YAG Laser-Enhanced Photoacoustic Spectral Sensing for Breast Tissues: Toward Oncological Theranostics","authors":"Suhel Khan, Sramana Mukhopadhyay, M. S. Ansari, R. K. Patidar, Saikat Das, Srivathsan Vasudevan","doi":"10.1002/jbio.202400430","DOIUrl":"10.1002/jbio.202400430","url":null,"abstract":"<div>\u0000 \u0000 <p>A solid-state laser is preferred for generating light in a photoacoustic (PA) system because of its high energy and coherence. However, conventional Nd:YAG lasers are bulky, complex, and expensive. This article introduces a portable alternative: a custom-built Nd:YAG laser with an in-house power supply that delivers 0–30 A current pulses with a 1500 μs pulse width, providing efficient thermal management. A pockels cell driver generates 10 ns pulses with 3.84 mJ/c<i>m</i>\u0000 <sup>2</sup> laser energy density. Implemented for noninvasive breast cancer diagnosis, The peak frequency obtained from three different samples was 0.23 ± 0.1, 0.26 ± 0.13, and 1.80 ± 0.14 MHz, respectively, for Normal, Fibrotic, and Tumor tissues. In addition to the dominant frequency peaks the spectral energy of the PASR spectra has also been investigated to characterize the breast tissue samples. The developed laser successfully differentiates between carcinoma, fibrocystic disease, and normal breast tissue based on quantitative PA spectral parameters.</p>\u0000 </div>","PeriodicalId":184,"journal":{"name":"Journal of Biophotonics","volume":"18 4","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Relationship Between the Optical Properties of Articular Cartilage and the Biomechanical Parameters of the Tissue 关节软骨光学特性与组织生物力学参数的关系。

IF 2 3区物理与天体物理

Journal of Biophotonics Pub Date : 2025-01-31 DOI: 10.1002/jbio.202400460

Iman Kafian-Attari, Mohammad Ebrahimi, Ervin Nippolainen, Arash Mirhashemi, Petri Paakkari, Florian Bergmann, Florian Foschum, Alwin Kienle, Juha Töyräs, Isaac Afara

{"title":"The Relationship Between the Optical Properties of Articular Cartilage and the Biomechanical Parameters of the Tissue","authors":"Iman Kafian-Attari, Mohammad Ebrahimi, Ervin Nippolainen, Arash Mirhashemi, Petri Paakkari, Florian Bergmann, Florian Foschum, Alwin Kienle, Juha Töyräs, Isaac Afara","doi":"10.1002/jbio.202400460","DOIUrl":"10.1002/jbio.202400460","url":null,"abstract":"<p>This study investigates the relationship between the optical properties of articular cartilage with its biomechanical parameters. The absorption and reduced scattering coefficients of articular cartilage, and average maximum penetration depth, average maximum lateral spread, and average path length of photons were estimated by optical measurements and Monte Carlo simulation. The equilibrium and instantaneous moduli, and initial fibrillar network, strain-dependent fibrillar network, and nonfibrillar network moduli, and initial and deformation-dependent permeability of the tissue were estimated by multistep stress-relaxation measurement and fibril-reinforced poroelastic modeling. The relationship between the optical properties and biomechanical parameters was assessed using predictive regression modeling. A strong relationship was found between reduced scattering coefficients, averaged maximum penetration depth, averaged maximum lateral spread, and average path length of photons with equilibrium, instantaneous, and initial fibrillar network moduli. We attribute this relationship to the collagen fibers as the main contributor to the scattering and biomechanical properties of the tissue.</p>","PeriodicalId":184,"journal":{"name":"Journal of Biophotonics","volume":"18 4","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbio.202400460","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Non-invasive Lung Disease Study of Exhaled Breath Nitric Oxide Based on Ultraviolet Differential Absorption Spectroscopy Techniques 基于紫外差分吸收光谱技术的呼气一氧化氮无创肺部疾病研究。

IF 2 3区物理与天体物理

Journal of Biophotonics Pub Date : 2025-01-28 DOI: 10.1002/jbio.202400481

Chaoyang Li, Xiaoning Chen, Wei Li, Xuan Zhou, Huiyuan Gong

{"title":"A Non-invasive Lung Disease Study of Exhaled Breath Nitric Oxide Based on Ultraviolet Differential Absorption Spectroscopy Techniques","authors":"Chaoyang Li, Xiaoning Chen, Wei Li, Xuan Zhou, Huiyuan Gong","doi":"10.1002/jbio.202400481","DOIUrl":"10.1002/jbio.202400481","url":null,"abstract":"<div>\u0000 \u0000 <p>In this study, a non-invasive device based on ultraviolet differential absorption spectroscopy (UV-DOAS) technology for detecting fractional exhaled nitric oxide (FeNO)was developed and clinically validated in patients with various lung diseases. The diagnostic potential of FeNO was explored by analysing subgroups of patients with lung cancer, nodules, and other disease. The results showed that FeNO concentrations were significantly higher in patients with malignant tumours than in healthy controls (<i>p</i> < 0.01). The diagnostic efficacy of FeNO in different lung diseases was confirmed by ROC analysis: the AUC values were 0.925 for malignant tumours, 0.925 for suspected malignant/benign tumours, 0.792 for benign lesions, and 0.938 for infectious/inflammatory diseases. The significant postoperative FeNO level decrease supports the diagnostic use of FeNO in different stages of the disease. Compared with conventional electrochemical, chemiluminescent and fluorescent probe methods, the UV-DOAS technique has significant advantages regarding sensitivity and portability, suggesting its potential for clinical application.</p>\u0000 </div>","PeriodicalId":184,"journal":{"name":"Journal of Biophotonics","volume":"18 4","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep Learning and Hyperspectral Imaging for Liver Cancer Staging and Cirrhosis Differentiation 深度学习和高光谱成像在肝癌分期和肝硬化鉴别中的应用。

IF 2 3区物理与天体物理

Journal of Biophotonics Pub Date : 2025-01-28 DOI: 10.1002/jbio.202400557

Tianyi Hang, Danfeng Fan, Tiefeng Sun, Zhengyuan Chen, Xiaoqing Yang, Xiaoqing Yue

{"title":"Deep Learning and Hyperspectral Imaging for Liver Cancer Staging and Cirrhosis Differentiation","authors":"Tianyi Hang, Danfeng Fan, Tiefeng Sun, Zhengyuan Chen, Xiaoqing Yang, Xiaoqing Yue","doi":"10.1002/jbio.202400557","DOIUrl":"10.1002/jbio.202400557","url":null,"abstract":"<div>\u0000 \u0000 <p>Liver malignancies, particularly hepatocellular carcinoma (HCC), pose a formidable global health challenge. Conventional diagnostic techniques frequently fall short in precision, especially at advanced HCC stages. In response, we have developed a novel diagnostic strategy that integrates hyperspectral imaging with deep learning. This innovative approach captures detailed spectral data from tissue samples, pinpointing subtle cellular differences that elude traditional methods. A sophisticated deep convolutional neural network processes this data, effectively distinguishing high-grade liver cancer from cirrhosis with an accuracy of 89.45%, a sensitivity of 90.29%, and a specificity of 88.64%. For HCC differentiation specifically, it achieves an impressive accuracy of 93.73%, sensitivity of 92.53%, and specificity of 90.07%. Our results underscore the potential of this technique as a precise, rapid, and non-invasive diagnostic tool that surpasses existing clinical methods in staging liver cancer and differentiating cirrhosis.</p>\u0000 </div>","PeriodicalId":184,"journal":{"name":"Journal of Biophotonics","volume":"18 4","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wearable Multimodal Optical Analyzers: Physiological Variability and Reproducibility of Measurements 可穿戴式多模态光学分析仪：测量的生理变异性和可重复性。

IF 2 3区物理与天体物理

Journal of Biophotonics Pub Date : 2025-01-28 DOI: 10.1002/jbio.202400527

Yu. I. Loktionova, E. V. Zharkikh, V. E. Parshakova, V. V. Sidorov, A. V. Dunaev

引用次数: 0

Enhancing Functional Breast Imaging: A sCMOS Camera-Based Lock-in Implementation for Dynamic Tomography 增强功能性乳房成像：基于sCMOS相机的动态断层扫描锁定实现。

IF 2 3区物理与天体物理

Journal of Biophotonics Pub Date : 2025-01-23 DOI: 10.1002/jbio.202400473

Yujie Zheng, Limin Zhang, Weijie Song, Feng Gao, Dongyuan Liu

引用次数: 0

Photobiomodulation Combined With Human Umbilical Cord Mesenchymal Stem Cells Modulates the Polarization of Microglia 光生物调节联合人脐带间充质干细胞对小胶质细胞极化的调节。