Enhancing the Diagnostic Evaluation of Thyroid Functionality Using Diffuse Reflectance Spectroscopy and Regression Models

IF 2 3区 物理与天体物理 Q3 BIOCHEMICAL RESEARCH METHODS
W. Anto Win Shalini, T. Rajalakshmi, S. Vasanthadev Suryakala
{"title":"Enhancing the Diagnostic Evaluation of Thyroid Functionality Using Diffuse Reflectance Spectroscopy and Regression Models","authors":"W. Anto Win Shalini,&nbsp;T. Rajalakshmi,&nbsp;S. Vasanthadev Suryakala","doi":"10.1002/jbio.70010","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>Thyroid dysfunction is a prevalent global health concern that necessitates the development of effective and non-invasive screening methods to enable early detection. The application of Diffuse Reflectance Spectroscopy (DRS) in conjunction with preprocessing and predictive models for thyroid dysfunction diagnosis is investigated. The raw spectral data captured from 31 individuals with thyroid dysfunction are subjected to spectral preprocessing techniques like, Standard Normal Variate (SNV), Multiplicative Scatter Correction (MSC), and Baseline Correction. The preprocessed data subjected to regression models like Partial Least Squares Regression (PLSR), Principal Component Regression (PCR), LASSO, Random Forest, Ridge Regression, Gaussian Process Regression (GPR), and Bayesian Regression were employed to analyse the efficacy of the models. The PLSR model in concurrence with SNV outperforms other regression models by achieving an <i>R</i>\n <sup>2</sup> of 0.93, RMSE of 0.29, and MSE of 0.08, indicating low predictive error. The goodness of fit was also evaluated using Pearson's chi-squared test.</p>\n </div>","PeriodicalId":184,"journal":{"name":"Journal of Biophotonics","volume":"18 8","pages":""},"PeriodicalIF":2.0000,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Biophotonics","FirstCategoryId":"101","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jbio.70010","RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
引用次数: 0

Abstract

Thyroid dysfunction is a prevalent global health concern that necessitates the development of effective and non-invasive screening methods to enable early detection. The application of Diffuse Reflectance Spectroscopy (DRS) in conjunction with preprocessing and predictive models for thyroid dysfunction diagnosis is investigated. The raw spectral data captured from 31 individuals with thyroid dysfunction are subjected to spectral preprocessing techniques like, Standard Normal Variate (SNV), Multiplicative Scatter Correction (MSC), and Baseline Correction. The preprocessed data subjected to regression models like Partial Least Squares Regression (PLSR), Principal Component Regression (PCR), LASSO, Random Forest, Ridge Regression, Gaussian Process Regression (GPR), and Bayesian Regression were employed to analyse the efficacy of the models. The PLSR model in concurrence with SNV outperforms other regression models by achieving an R 2 of 0.93, RMSE of 0.29, and MSE of 0.08, indicating low predictive error. The goodness of fit was also evaluated using Pearson's chi-squared test.

利用漫反射光谱和回归模型增强甲状腺功能的诊断评价。
甲状腺功能障碍是全球普遍关注的健康问题,因此有必要开发有效的非侵入性筛查方法,以实现早期检测。本文研究了结合预处理和预测模型应用漫反射光谱(DRS)诊断甲状腺功能障碍的情况。从 31 名甲状腺功能障碍患者身上采集的原始光谱数据经过了光谱预处理技术,如标准正态变异(SNV)、乘法散射校正(MSC)和基线校正。对预处理后的数据采用部分最小二乘法回归(PLSR)、主成分回归(PCR)、LASSO、随机森林、岭回归、高斯过程回归(GPR)和贝叶斯回归等回归模型来分析模型的有效性。与 SNV 一致的 PLSR 模型优于其他回归模型,其 R2 为 0.93,RMSE 为 0.29,MSE 为 0.08,表明预测误差较低。拟合优度还通过皮尔逊卡方检验进行了评估。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Journal of Biophotonics
Journal of Biophotonics 生物-生化研究方法
CiteScore
5.70
自引率
7.10%
发文量
248
审稿时长
1 months
期刊介绍: The first international journal dedicated to publishing reviews and original articles from this exciting field, the Journal of Biophotonics covers the broad range of research on interactions between light and biological material. The journal offers a platform where the physicist communicates with the biologist and where the clinical practitioner learns about the latest tools for the diagnosis of diseases. As such, the journal is highly interdisciplinary, publishing cutting edge research in the fields of life sciences, medicine, physics, chemistry, and engineering. The coverage extends from fundamental research to specific developments, while also including the latest applications.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信