Ni He, Chenrui Li, Jiali Liu, Xiaolong Zhang, Liming Li, Cuixia Dai
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引用次数: 0
Abstract
Aging is a process of progressive functional decline associated with increasing age. The process and mechanism of aging have long been widely concerned, but long-term in vivo evaluations of the visual nervous system have not been previously reported. In this study, naturally aging mouse models were used for long-term serial evaluation, and the changes in structure and blood flow of the retina and cerebral cortex were systematically analyzed. Optical Coherence Tomography (OCT) and Optical Coherence Tomography Angiography (OCTA) were performed on mice at 3, 6, 9, and 12 months of age, respectively. Structural and vascular changes with age were quantitatively evaluated. Results show that the reduction of structural thickness and vascular density of the retinal and cerebral cortex is observed. A significant correlation is also found between structural and vascular changes in the retina and cerebral cortex, indicating a consistent impact of aging on the visual nervous system.
期刊介绍:
The first international journal dedicated to publishing reviews and original articles from this exciting field, the Journal of Biophotonics covers the broad range of research on interactions between light and biological material. The journal offers a platform where the physicist communicates with the biologist and where the clinical practitioner learns about the latest tools for the diagnosis of diseases. As such, the journal is highly interdisciplinary, publishing cutting edge research in the fields of life sciences, medicine, physics, chemistry, and engineering. The coverage extends from fundamental research to specific developments, while also including the latest applications.