Journal of Biophotonics最新文献

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Assessing Plantar Skin Epidermal Layer in Response to Various Insole Hardness via Deep Learning Enabled Optical Coherence Tomography Analysis 通过深度学习光学相干断层扫描分析评估足底皮肤表皮层对不同鞋垫硬度的响应。
IF 2 3区 物理与天体物理
Journal of Biophotonics Pub Date : 2026-08-04 DOI: 10.1002/jbio.70330
Ardha Ardea Prisilla, Yih-Kuen Jan, Ben-Yi Liau, Chien-Cheng Tai, Gilang Titah Ramadhan, Sheena Christabel Pravin, Kiruthika Venkataramani, Winson Chiu-Chun Lee, Congo Tak Shing Ching, Chi-Wen Lung
{"title":"Assessing Plantar Skin Epidermal Layer in Response to Various Insole Hardness via Deep Learning Enabled Optical Coherence Tomography Analysis","authors":"Ardha Ardea Prisilla,&nbsp;Yih-Kuen Jan,&nbsp;Ben-Yi Liau,&nbsp;Chien-Cheng Tai,&nbsp;Gilang Titah Ramadhan,&nbsp;Sheena Christabel Pravin,&nbsp;Kiruthika Venkataramani,&nbsp;Winson Chiu-Chun Lee,&nbsp;Congo Tak Shing Ching,&nbsp;Chi-Wen Lung","doi":"10.1002/jbio.70330","DOIUrl":"10.1002/jbio.70330","url":null,"abstract":"<p>We tested walking interventions using adjustable air-insoles with hardness values of 80, 160, and 240 mmHg over walking durations of 10 and 20 min. Optical coherence tomography (OCT) was used to measure the thickness of the stratum corneum (SC) and living epidermis (ED) in three different locations: the big toe (T1), first metatarsal head (M1), and second metatarsal head (M2), and deep learning was used to compare the difference in thickness between SC and ED. The results indicate that SC thickness increases in M1 is statistically significant after 20 min walking interventions using 80 mmHg insole hardness, and SC thickness decreases in T1 and M1 are statistically significant after 20 min walking using 160 mmHg insole hardness. Changes in SC and ED thickness observed in this study highlight their potential relevance in evaluating plantar tissue health in the context of DFU prevention.</p>","PeriodicalId":184,"journal":{"name":"Journal of Biophotonics","volume":"19 8","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13435239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148671783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Can Photoacoustic Imaging Provide a Sensitive Marker for Early Detection of Diabetic Nephropathy 光声成像能作为早期发现糖尿病肾病的敏感标志物吗
IF 2 3区 物理与天体物理
Journal of Biophotonics Pub Date : 2026-07-31 DOI: 10.1002/jbio.70339
Tingting Qiu, Jiazhi Cao, Xijing Yang, Yan Luo, Hong Wang, Wenwu Ling
{"title":"Can Photoacoustic Imaging Provide a Sensitive Marker for Early Detection of Diabetic Nephropathy","authors":"Tingting Qiu,&nbsp;Jiazhi Cao,&nbsp;Xijing Yang,&nbsp;Yan Luo,&nbsp;Hong Wang,&nbsp;Wenwu Ling","doi":"10.1002/jbio.70339","DOIUrl":"https://doi.org/10.1002/jbio.70339","url":null,"abstract":"<div>\u0000 \u0000 <p>Diabetic nephropathy (DN) is the leading cause of chronic kidney disease. Albuminuria or glomerular filtration rate (GFR) test is time-consuming with low sensitivity. Here, we used a photoacoustic imaging (PAI) system to evaluate the pathophysiological change of DN in mice models in vivo. The results showed that compared with the control group, the average blood oxygen saturation (sO<sub>2</sub> Avr) significantly elevated at early-stage group, then gradually decreased at the advanced stage. The average hemoglobin concentration (HbT Avr) and lipid PA signal intensity dramatically drop down at advanced stage of DN. The AUC of sO<sub>2</sub> Avr for diagnosis of early stage DN was 0.847 (95% CI: 0.636–1.0). The AUCs of HbT Avr and lipid PA signal intensity for diagnosis of advanced-stage DN were 0.917 (95% CI: 0.795–1.0), 0.875 (95% CI: 0.734–1.0). In conclusion, PAI was potentially useful for the early evaluation of DN.</p>\u0000 </div>","PeriodicalId":184,"journal":{"name":"Journal of Biophotonics","volume":"19 8","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148617313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hexagonal Hollow-Core Photonic Crystal Fiber for High-Sensitivity Terahertz Glucose Detection 用于高灵敏度太赫兹葡萄糖检测的六方空心光子晶体光纤
IF 2 3区 物理与天体物理
Journal of Biophotonics Pub Date : 2026-07-30 DOI: 10.1002/jbio.70332
Mohammad Abdullah-Al-Shafi, Shuvo Sen, Mashiyat Mubassera, Md. Tanvir Hossain Hawlader
{"title":"Hexagonal Hollow-Core Photonic Crystal Fiber for High-Sensitivity Terahertz Glucose Detection","authors":"Mohammad Abdullah-Al-Shafi,&nbsp;Shuvo Sen,&nbsp;Mashiyat Mubassera,&nbsp;Md. Tanvir Hossain Hawlader","doi":"10.1002/jbio.70332","DOIUrl":"https://doi.org/10.1002/jbio.70332","url":null,"abstract":"<p>Diabetes mellitus is a rapidly escalating global health concern, often leading to severe complications such as neuropathy, vision impairment, vascular dysfunction, and renal failure. In this work, we present a newly designed hexagonal photonic crystal fiber (HPhCF) sensor for the noninvasive detection of urine glucose, offering a compact, fabrication-friendly design. The proposed HPhCF demonstrates strong RS performance across a range of analyte concentrations. Specifically, RS values of 96.90%, 96.86%, 96.40%, 96.35%, 95.88%, and 95.78% are obtained for concentrations of 0–15 mg·dL<sup>−1</sup>, 0.625 g·dL<sup>−1</sup>, 1.25 g·dL<sup>−1</sup>, 2.5 g·dL<sup>−1</sup>, 5 g·dL<sup>−1</sup>, and 10 g·dL<sup>−1</sup>, respectively. These results indicate a gradual decline in sensitivity with increasing analyte concentration, while overall maintaining consistently high performance. Because of its simple structural configuration and compatibility with established photonic fabrication methods, the proposed sensor demonstrates strong potential as a low-cost and highly sensitive diagnostic tool for early-stage diabetes screening and ongoing glucose monitoring in biomedical settings.</p>","PeriodicalId":184,"journal":{"name":"Journal of Biophotonics","volume":"19 8","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbio.70332","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148616837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study of the Spectral-Luminescent Properties of Saliva in Patients With Lung Cancer 肺癌患者唾液光谱发光特性的研究。
IF 2 3区 物理与天体物理
Journal of Biophotonics Pub Date : 2026-07-29 DOI: 10.1002/jbio.70333
K. T. Shakeyev, A. K. Zeinidenov, A. K. Aimukhanov, A. M. Alekseev, G. K. Kelgali, A. G. Zhumina, U. K. Sagyngali, D. V. Shestakov, G. M. Turgambekov, A. Zh. Mendibayeva, A. A. Amangeldina
{"title":"Study of the Spectral-Luminescent Properties of Saliva in Patients With Lung Cancer","authors":"K. T. Shakeyev,&nbsp;A. K. Zeinidenov,&nbsp;A. K. Aimukhanov,&nbsp;A. M. Alekseev,&nbsp;G. K. Kelgali,&nbsp;A. G. Zhumina,&nbsp;U. K. Sagyngali,&nbsp;D. V. Shestakov,&nbsp;G. M. Turgambekov,&nbsp;A. Zh. Mendibayeva,&nbsp;A. A. Amangeldina","doi":"10.1002/jbio.70333","DOIUrl":"10.1002/jbio.70333","url":null,"abstract":"<div>\u0000 \u0000 <p>This study evaluated whether multimodal spectroscopic analysis of saliva can differentiate patients with lung cancer from healthy individuals. Unstimulated saliva samples were collected from 57 patients with lung cancer and 36 healthy controls. TEM and DLS revealed increased heterogeneity of the salivary colloidal fraction and a shift toward larger particle populations in lung cancer. UV–Vis spectroscopy showed a hypsochromic shift of the main absorption peak (279–261 nm), while fluorescence intensity at 510 nm increased 1.9-fold with additional emission bands at 617 and 680 nm. Reflectance decreased across the measured spectral range. ATR-FTIR identified the Amide III/asymmetric PO<sub>2</sub><sup>−</sup> region (1350–1180 cm<sup>−1</sup>) as the most discriminative interval (AUC = 0.854). Fluorescence-based classification achieved an AUC of 0.706, with 73.1% sensitivity and 76.3% specificity. <sup>1</sup>H NMR revealed alterations in metabolites associated with metabolic reprogramming.</p>\u0000 </div>","PeriodicalId":184,"journal":{"name":"Journal of Biophotonics","volume":"19 8","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148611469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Minimally Invasive Raman Spectroscopy for Detection of Lymph Node Metastasis of Oral Squamous Cell Carcinoma 微创拉曼光谱检测口腔鳞状细胞癌淋巴结转移
IF 2 3区 物理与天体物理
Journal of Biophotonics Pub Date : 2026-07-29 DOI: 10.1002/jbio.70334
Panchali Saha, Poonam Joshi, Arti Hole, Pankaj Chaturvedi, C. Murali Krishna
{"title":"Minimally Invasive Raman Spectroscopy for Detection of Lymph Node Metastasis of Oral Squamous Cell Carcinoma","authors":"Panchali Saha,&nbsp;Poonam Joshi,&nbsp;Arti Hole,&nbsp;Pankaj Chaturvedi,&nbsp;C. Murali Krishna","doi":"10.1002/jbio.70334","DOIUrl":"https://doi.org/10.1002/jbio.70334","url":null,"abstract":"<div>\u0000 \u0000 <p>Lymph node metastasis (LNM) is a critical prognostic factor in oral squamous cell carcinoma (OSCC), yet its preoperative assessment remains challenging. This study evaluated serum and salivary Raman spectroscopy (RS) for LNM detection in OSCC. Serum and saliva samples from 36 OSCC patients [16 node-positive (N+) and 20 node-negative (N0)] and 15 healthy controls were analysed using RS. Classification models were developed using RS data of individual biofluids and with fusion strategies. The serum model identified 87.5% of N+ and 85% of N0 cases, while saliva showed comparable performance for N+ but lower accuracy for N0. Low-level fusion improved N+ classification. Mid-level fusion achieved the best overall performance, correctly identifying 100% of N+ and 85% of N0 cases. Spectral analysis revealed alterations associated with proteins, β-carotenoids, deoxyhaemoglobin and lipids across the study groups. These findings demonstrate the potential of biofluid-based RS for minimally invasive LNM assessment in OSCC.</p>\u0000 </div>","PeriodicalId":184,"journal":{"name":"Journal of Biophotonics","volume":"19 8","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148616515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of Sample Preparation Methods for Porcine Tissue: Calibration-Free LIBS for In Vivo Applications 猪组织样品制备方法的影响:体内应用免校准LIBS。
IF 2 3区 物理与天体物理
Journal of Biophotonics Pub Date : 2026-07-29 DOI: 10.1002/jbio.70327
Edith Böhmer, Oana-Maria Thoma, Maximilian J. Waldner, Florian Klämpfl, Michael Schmidt, Martin Hohmann
{"title":"Influence of Sample Preparation Methods for Porcine Tissue: Calibration-Free LIBS for In Vivo Applications","authors":"Edith Böhmer,&nbsp;Oana-Maria Thoma,&nbsp;Maximilian J. Waldner,&nbsp;Florian Klämpfl,&nbsp;Michael Schmidt,&nbsp;Martin Hohmann","doi":"10.1002/jbio.70327","DOIUrl":"10.1002/jbio.70327","url":null,"abstract":"<p>Calibration-free laser-induced breakdown spectroscopy (CF-LIBS) has the advantage of eliminating the need for complex sample preparation. This study investigates the impact of various preparation techniques on porcine tissue. These methods include embedding the tissue in PBS or deionised water, and analysing untreated tissue or tissue that has been cut using liquid nitrogen. The results demonstrate that embedding samples does result in changes to the LIBS spectra. Minor deviations in the magnesium and sodium intensity ratios were observed in the skin. However, it should be noted that embedded samples may exhibit altered elemental signatures due to ionic exchange with the immersion medium, despite facilitating sample handling. It is important to note that the immediate measurement of untreated samples is critical, as post-mortem changes can lead to shifts in elemental concentrations. These findings show that CF-LIBS can be reliably performed on untreated biological samples, thus supporting its use in vivo diagnostics.</p>","PeriodicalId":184,"journal":{"name":"Journal of Biophotonics","volume":"19 7","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbio.70327","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148611456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dual Optical Elastography Techniques Reveal the Regulation of Corneal Stiffness by Collagen XIV 双光学弹性成像技术揭示胶原蛋白对角膜硬度的调节作用。
IF 2 3区 物理与天体物理
Journal of Biophotonics Pub Date : 2026-07-26 DOI: 10.1002/jbio.70329
Sajedeh Saeidi Fard, Amandeep Singh, Manmohan Singh, Alexander W. Schill, Salavat R. Aglyamov, Mei Sun, Giuliano Scarcelli, Edgar M. Espana, Kirill V. Larin
{"title":"Dual Optical Elastography Techniques Reveal the Regulation of Corneal Stiffness by Collagen XIV","authors":"Sajedeh Saeidi Fard,&nbsp;Amandeep Singh,&nbsp;Manmohan Singh,&nbsp;Alexander W. Schill,&nbsp;Salavat R. Aglyamov,&nbsp;Mei Sun,&nbsp;Giuliano Scarcelli,&nbsp;Edgar M. Espana,&nbsp;Kirill V. Larin","doi":"10.1002/jbio.70329","DOIUrl":"10.1002/jbio.70329","url":null,"abstract":"<div>\u0000 \u0000 <p>Collagen XIV is a fibril-associated collagen with interrupted triple helices (FACIT) that helps regulate collagen fibril spacing, alignment, and extracellular matrix organization. Its role in corneal biomechanics remains incompletely understood. Here, we investigated murine wild-type (WT) and collagen XIV-deficient (<i>Col14a1</i><sup>−/−</sup>) corneas using complementary optical elastography modalities: Brillouin microscopy and air-coupled ultrasound optical coherence elastography (ACUS-OCE). Brillouin microscopy generated high-resolution maps of Brillouin frequency shift in WT and <i>Col14a1</i><sup>−/−</sup> corneas (<i>N</i> = 4 per group), while ACUS-OCE measured elastic wave speed in WT (<i>N</i> = 8) and <i>Col14a1</i><sup>−/−</sup> (<i>N</i> = 7) corneas. Both methods showed reduced mechanical metrics in <i>Col14a1</i><sup>−/−</sup> corneas, with lower Brillouin frequency shift and lower OCE-derived wave speed relative to WT controls. These findings support collagen XIV as a regulator of corneal stromal biomechanics and demonstrate the value of combining Brillouin microscopy with ACUS-OCE for detecting biomechanical alterations in murine corneas.</p>\u0000 </div>","PeriodicalId":184,"journal":{"name":"Journal of Biophotonics","volume":"19 7","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148595262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Influence of Formaldehyde Fixation Media on the Raman Spectroscopic Analysis of Oral Squamous Cell Carcinoma 甲醛固定介质对口腔鳞状细胞癌拉曼光谱分析的影响。
IF 2 3区 物理与天体物理
Journal of Biophotonics Pub Date : 2026-07-26 DOI: 10.1002/jbio.70326
Levi Matthies, Jasper F. Tegtmeyer, Caroline Pessler, Medhanie T. Gebrekidan, Katharina H. Besch, Ralf Smeets, Andreas S. Braeuer, Martin Gosau, Christian Knipfer
{"title":"The Influence of Formaldehyde Fixation Media on the Raman Spectroscopic Analysis of Oral Squamous Cell Carcinoma","authors":"Levi Matthies,&nbsp;Jasper F. Tegtmeyer,&nbsp;Caroline Pessler,&nbsp;Medhanie T. Gebrekidan,&nbsp;Katharina H. Besch,&nbsp;Ralf Smeets,&nbsp;Andreas S. Braeuer,&nbsp;Martin Gosau,&nbsp;Christian Knipfer","doi":"10.1002/jbio.70326","DOIUrl":"10.1002/jbio.70326","url":null,"abstract":"<p>Raman Difference spectroscopy (RDS) presents a promising, non-invasive approach for facilitating rapid diagnosis of oral squamous cell carcinoma (OSCC). Many ex vivo studies rely on formalin-embedded tissue specimens. Spectroscopic changes and classification of formalin-fixed OSCC tissues were investigated. In an analysis of 47 specimens (<i>n =</i> 30 OSCC, <i>n</i> = 17 physiological mucosa), RDS was employed at 180 distinct measurement loci after storage in saline, and again at 125 measurement loci after storage in formalin. For classification, Principal Component Analysis (PCA) and Linear Discriminant Analysis (LDA) were utilized. In distinguishing OSCC from physiological mucosa, LDA revealed a higher sensitivity (97.6% for NaCl-stored vs. 90.9% for formalin-fixed tissues), specificity (93.0% vs. 78.6%), and overall classification accuracy (95.2% vs. 85.4%) for specimens stored in saline. While formalin fixation is valuable for tissue preservation in histopathology, Raman spectra of OSCC tissues were substantially altered, with implications for validation of innovative optical techniques such as Raman Spectroscopy.</p>","PeriodicalId":184,"journal":{"name":"Journal of Biophotonics","volume":"19 7","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13401759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148595243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neural Network–Based Depth Retrieval of Fluorescent Targets From Wide-Field Fluorescence Intensity Images in Scattering Tissues 基于神经网络的散射组织宽场荧光强度图像荧光目标深度检索。
IF 2 3区 物理与天体物理
Journal of Biophotonics Pub Date : 2026-07-26 DOI: 10.1002/jbio.70325
Meital Harel, Neelima Chacko, Menachem Motiei, Amos Azaria, Rinat Ankri
{"title":"Neural Network–Based Depth Retrieval of Fluorescent Targets From Wide-Field Fluorescence Intensity Images in Scattering Tissues","authors":"Meital Harel,&nbsp;Neelima Chacko,&nbsp;Menachem Motiei,&nbsp;Amos Azaria,&nbsp;Rinat Ankri","doi":"10.1002/jbio.70325","DOIUrl":"10.1002/jbio.70325","url":null,"abstract":"<p>Fluorescence imaging (FI) is widely used in in vivo and cellular studies. However, accurate depth determination of fluorescent targets in vivo remains challenging due to strong photon scattering and absorption in biological tissues. In this study, we developed and validated a machine learning (ML)-based framework, supported by Monte Carlo (MC) simulations, for accurate depth estimation of near-infrared (NIR) fluorescent targets in turbid media. An optimized MC model was constructed to simulate NIR fluorescence photon propagation, generating datasets of fluorescence images corresponding to target depths between 0.1 and 1 cm. Experimental validation was conducted over a depth range of 0.1–0.7 cm using tissue-mimicking phantoms designed to replicate the optical properties of human skin, as well as on an in vivo model incorporating fluorescent gold nanostructures imaged with computed tomography (CT) and wide-field FI. The results were quantitatively validated using two performance metrics: rounded accuracy and root mean squared error (RMSE).</p>","PeriodicalId":184,"journal":{"name":"Journal of Biophotonics","volume":"19 7","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13401773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148595239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparing the Effects of Chemical Optical Clearing Agents and Mechanical Compression on the Optical Attenuation of Porcine Skin 化学光清除剂与机械压缩剂对猪皮光衰减的影响比较。
IF 2 3区 物理与天体物理
Journal of Biophotonics Pub Date : 2026-07-24 DOI: 10.1002/jbio.70323
Camila Ramos Silva, Tania Mateus Yoshimura, Jailda Nonato dos Santos Oliveira, Marcus Paulo Raele, Marcos Antonio Hortellani, Martha Simões Ribeiro, Denise Maria Zezell, Marcello Magri Amaral
{"title":"Comparing the Effects of Chemical Optical Clearing Agents and Mechanical Compression on the Optical Attenuation of Porcine Skin","authors":"Camila Ramos Silva,&nbsp;Tania Mateus Yoshimura,&nbsp;Jailda Nonato dos Santos Oliveira,&nbsp;Marcus Paulo Raele,&nbsp;Marcos Antonio Hortellani,&nbsp;Martha Simões Ribeiro,&nbsp;Denise Maria Zezell,&nbsp;Marcello Magri Amaral","doi":"10.1002/jbio.70323","DOIUrl":"10.1002/jbio.70323","url":null,"abstract":"<p>Light scattering remains a primary challenge for deep-tissue optical diagnostics and therapies. While Optical Clearing Agents (OCAs) are used to reduce skin attenuation, Mechanical Compression (MC) is also applied in clinical settings despite its inconclusive results. Their relative effectiveness under standardized conditions remains poorly characterized. This study quantitatively compares various OCA formulations, including mineral oil, PEG-400, fructose, and tartrazine, with enhancers such as oleic acid and 1,2-propanediol, under load-dependent MC (1.6–47 kPa). Using spectral-domain OCT at 840 nm on porcine skin, we found that PEG-400/oleic acid (80/20%) achieved the highest efficiency, reducing the optical attenuation coefficient (OAC) by 23.8% ± 1.7% within 15 min. Fructose-based and aqueous tartrazine formulations also showed significant reductions (16.8% and 20.4%). Conversely, our results show that MC does not effectively reduce skin optical attenuation. These findings demonstrate that OCAs provide a more potent, stable reduction in OAC, offering a superior strategy for optimizing light delivery.</p>","PeriodicalId":184,"journal":{"name":"Journal of Biophotonics","volume":"19 7","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13400900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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