Journal of Biophotonics最新文献_第5页

Endothelial c-Myc and Doxorubicin-Induced Metabolic Alterations: A Multi-Organ Optical Imaging Study 内皮c-Myc和阿霉素诱导的代谢改变：一项多器官光学成像研究。

IF 2 3区物理与天体物理

Journal of Biophotonics Pub Date : 2025-04-21 DOI: 10.1002/jbio.70037

Parisa Nategh, Mehrnoosh Neghabi, Busenur Ceyhan, Jacqueline F. Machi, Homan A. Rahbar, Maya S. Rodriguez, Aline G. Santana, Claudia O. Rodrigues, Mahsa Ranji

{"title":"Endothelial c-Myc and Doxorubicin-Induced Metabolic Alterations: A Multi-Organ Optical Imaging Study","authors":"Parisa Nategh, Mehrnoosh Neghabi, Busenur Ceyhan, Jacqueline F. Machi, Homan A. Rahbar, Maya S. Rodriguez, Aline G. Santana, Claudia O. Rodrigues, Mahsa Ranji","doi":"10.1002/jbio.70037","DOIUrl":"10.1002/jbio.70037","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Significance</h3>\u0000 \u0000 <p>Endothelial c-Myc plays a critical role in redox homeostasis, with its deletion potentially exacerbating oxidative stress, particularly, during chemotherapy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To assess the metabolic impact of endothelial c-Myc knockout (KO) and Doxorubicin (DOXO) treatment on kidneys, hearts, and livers using 3D optical cryo-imaging.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Approach</h3>\u0000 \u0000 <p>Redox ratios (NADH/FAD) were analyzed in control (CT) and KO mice treated with DOXO or saline to evaluate mitochondrial function and oxidative states.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>KO tissues showed significant reductions in redox ratios, indicating an oxidized state, with kidneys exhibiting up to a 51.42% decrease. DOXO treatment further exacerbated oxidative stress in KO tissues, while CT groups demonstrated protective effects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Endothelial c-Myc is crucial for redox balance and protection against chemotherapy-induced oxidative damage, offering insights for targeted therapeutic strategies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":184,"journal":{"name":"Journal of Biophotonics","volume":"18 9","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144046077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Combined Transcranial Magnetic Stimulation and Photobiomodulation in Mild Cognitive Impairment: A Randomized Controlled Trial 经颅磁刺激和光生物调节联合治疗轻度认知障碍：一项随机对照试验。

IF 2 3区物理与天体物理

Journal of Biophotonics Pub Date : 2025-04-20 DOI: 10.1002/jbio.70019

Da Han, Zengyong Li, Jingsha Zhang, Ping Xie

{"title":"Effects of Combined Transcranial Magnetic Stimulation and Photobiomodulation in Mild Cognitive Impairment: A Randomized Controlled Trial","authors":"Da Han, Zengyong Li, Jingsha Zhang, Ping Xie","doi":"10.1002/jbio.70019","DOIUrl":"10.1002/jbio.70019","url":null,"abstract":"<div>\u0000 \u0000 <p>This study evaluates the synergistic effects of transcranial magnetic stimulation (TMS) and transcranial photobiomodulation (tPBM) on working memory (WM) in mild cognitive impairment (MCI) patients. In a randomized controlled trial with 88 participants, utilizing a complex WM task (Δ<i>K</i> = 6.41, <i>p</i> = 0.004) alongside functional near-infrared spectroscopy (fNIRS) to assess cognitive performance and neural correlates(neural metrics from fNIRS indicated enhanced functional connectivity [<i>p</i> = 0.015] and increased wavelet amplitude in task-relevant cortical regions [<i>p</i> = 0.001]), our results indicated that the combined intervention significantly outperformed both monostimulation and sham stimulation in improving WM capacity. A notable strength of this study is the simultaneous application of TMS and tPBM, which maximizes potential synergistic effects while addressing the physical constraints associated with traditional noninvasive brain stimulation (NIBS). Findings underscore dual neuromodulation as a promising noninvasive intervention for MCI, offering insights into cognitive enhancement mechanisms.</p>\u0000 </div>","PeriodicalId":184,"journal":{"name":"Journal of Biophotonics","volume":"18 8","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sub-Second Optical Coherence Tomography Angiography Protocol for Intraoral Imaging Using an Efficient Super-Resolution Network 亚秒光学相干层析血管造影方案在口腔内成像使用高效的超分辨率网络。

IF 2 3区物理与天体物理

Journal of Biophotonics Pub Date : 2025-04-20 DOI: 10.1002/jbio.70050

Jinpeng Liao, Tianyu Zhang, Chunhui Li, Zhihong Huang

{"title":"Sub-Second Optical Coherence Tomography Angiography Protocol for Intraoral Imaging Using an Efficient Super-Resolution Network","authors":"Jinpeng Liao, Tianyu Zhang, Chunhui Li, Zhihong Huang","doi":"10.1002/jbio.70050","DOIUrl":"10.1002/jbio.70050","url":null,"abstract":"<div>\u0000 \u0000 <p>This study introduces a 200 kHz swept-source optical coherence tomography system-based fast optical coherence tomography angiography (OCTA) protocol for intraoral imaging by integrating an efficient Intraoral Micro-Angiography Super-Resolution Transformer (IMAST) model. This protocol reduces acquisition time to ~0.3 s by reducing the spatial sampling resolution, thereby minimizing motion artifacts while maintaining a field of view and image quality. The IMAST model utilizes a transformer-based architecture combined with convolutional operations to reconstruct high-resolution intraoral OCTA images from reduced-resolution scans. Experimental results from various intraoral sites and conditions show the model's robustness and high performance in enhancing image quality compared to existing deep-learning methods. Besides, IMAST shows advantages in model complexity, inference time, and computational cost, underscoring its suitability for clinical environments. These findings support the potential of our approach for noninvasive oral disease diagnosis, reducing patient discomfort and facilitating early detection of malignancies, thus serving as a valuable tool for oral assessment.</p>\u0000 </div>","PeriodicalId":184,"journal":{"name":"Journal of Biophotonics","volume":"18 9","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum to: Raman Spectroscopic Analysis of Human Blood Serum of Glaucoma Patients Supplemented With Macular Pigment Carotenoids 补充黄斑色素类胡萝卜素的青光眼患者血清拉曼光谱分析的勘误。

IF 2 3区物理与天体物理

Journal of Biophotonics Pub Date : 2025-04-14 DOI: 10.1002/jbio.70000

Joy Udensi, Ekaterina Loskutova, James Loughman, Hugh J. Byrne

{"title":"Erratum to: Raman Spectroscopic Analysis of Human Blood Serum of Glaucoma Patients Supplemented With Macular Pigment Carotenoids","authors":"Joy Udensi, Ekaterina Loskutova, James Loughman, Hugh J. Byrne","doi":"10.1002/jbio.70000","DOIUrl":"10.1002/jbio.70000","url":null,"abstract":"<p>J. Udensi, E. Loskutova, J. Loughman, and H. J. Byrne, “Raman Spectroscopic Analysis of Human Blood Serum of Glaucoma Patients Supplemented With Macular Pigment Carotenoids,” <i>Journal of Biophotonics</i> 17 (2024): e202400060, https://doi.org/10.1002/jbio.202400060.</p><p>This erratum corrects the second last paragraph in the Discussion section of the above article [<span>1</span>].</p><p>In the light of further evaluation of the clinical data of the ENIGMA study [<span>2, 3</span>], the authors became aware of a necessary adjustment to the final sentence of the second last paragraph of the Discussion section (4). This should read;</p><p>“In this context, the extreme cases noted in the matched patients' analysis reveals a potentially significant trend, indicating that the patients which registered the lowest baseline levels of carotenoids registered the highest impact of the supplementation regimen, whereas the patients which had the highest levels of baseline carotenoids were impacted least by supplementation.”</p><p>This modification does not change the paper's results.</p><p>The authors declare no conflicts of interest.</p>","PeriodicalId":184,"journal":{"name":"Journal of Biophotonics","volume":"18 6","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbio.70000","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surface-Modified Micro-Ring-Resonator Sensors for HMGB1 Detection on a Chip-Scale Platform 芯片级平台上用于HMGB1检测的表面修饰微环谐振器传感器。

IF 2 3区物理与天体物理

Journal of Biophotonics Pub Date : 2025-04-14 DOI: 10.1002/jbio.70038

Xin Kang, Peng Qin, Xiaotong Zhang, Jianguo Wang, Ruiduo Wang, Liang Fang, Sheng Liu, Xuetao Gan

引用次数: 0

Shear Wave Optical Coherence Elastography Imaging by Deep Learning 基于深度学习的剪切波光学相干弹性成像。

IF 2 3区物理与天体物理

Journal of Biophotonics Pub Date : 2025-04-10 DOI: 10.1002/jbio.70027

Xingyu Zhou, Shenju Zhu, Kexin Shen, Qingying Wang, Cheng Lu, Hebei Gao, Dexi Zhu

{"title":"Shear Wave Optical Coherence Elastography Imaging by Deep Learning","authors":"Xingyu Zhou, Shenju Zhu, Kexin Shen, Qingying Wang, Cheng Lu, Hebei Gao, Dexi Zhu","doi":"10.1002/jbio.70027","DOIUrl":"10.1002/jbio.70027","url":null,"abstract":"<div>\u0000 \u0000 <p>Quantifying ocular tissue mechanical properties is pivotal for elucidating eye disease etiology and progression. Optical coherence elastography (OCE), leveraging high-resolution optical coherence tomography, promises tissue stiffness assessment. Traditional OCE relies on data processing of the time-of-flight method and encounters challenges like low repeatability. Our study presents an optimized data processing workflow integrating OCE with deep learning to predict ocular tissue biomechanical properties. The concentration prediction network (CPN), a 3D convolutional neural network, predicts sample's concentrations and calculates the Young's modulus based on the relationship between agar concentration and Young's modulus from mechanical testing. The CPN showed high accuracy, with a mean absolute error of 0.028 ± 0.036 for training and 0.036 ± 0.024 for testing data of agar phantoms. In situ porcine corneas with various intraocular pressures was measured, yielding corneal biomechanical distribution via deep learning method. This approach enhances the efficiency of OCE and underscores potential clinical applications in ophthalmology.</p>\u0000 </div>","PeriodicalId":184,"journal":{"name":"Journal of Biophotonics","volume":"18 9","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144046404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-Invasive Depth Profiling of Base Cosmetic Formulations in the Skin Using Handheld Confocal Raman Spectroscopy 使用手持式共聚焦拉曼光谱对皮肤中基础化妆品配方进行无创深度分析。

IF 2 3区物理与天体物理

Journal of Biophotonics Pub Date : 2025-04-10 DOI: 10.1002/jbio.202400423

Valerie Xinhui Teo, Renzhe Bi, Sze Han Lee, James Chan, Steven Tien Guan Thng, Malini Olivo, U. S. Dinish

{"title":"Non-Invasive Depth Profiling of Base Cosmetic Formulations in the Skin Using Handheld Confocal Raman Spectroscopy","authors":"Valerie Xinhui Teo, Renzhe Bi, Sze Han Lee, James Chan, Steven Tien Guan Thng, Malini Olivo, U. S. Dinish","doi":"10.1002/jbio.202400423","DOIUrl":"10.1002/jbio.202400423","url":null,"abstract":"<div>\u0000 \u0000 <p>Ceramide-based and aqueous-based moisturizers have distinct absorption and retention characteristics in skin. Conventional methods like Transepidermal Water Loss (TEWL) and Corneometry are limited by environmental factors, and no current in vivo method measures ceramide content in skin. This research explores the use of a handheld Confocal Raman Spectroscopy (CRS) system to non-invasively analyze the absorption kinetics of these moisturizers. Measurements were taken on 40 subjects, including healthy individuals (<i>n</i> = 20) and those with atopic dermatitis (<i>n</i> = 20). Results showed that ceramide-based creams retained ceramide in the stratum corneum for longer periods, particularly 24 h post-application, compared to aqueous-based creams. Validation against Liquid Chromatography-Mass Spectrometry (LCMS) for ceramide NP in four healthy subjects showed a strong correlation (<i>r</i> = 0.96). These findings suggest that handheld CRS can improve the evaluation of skincare formulations, advancing the development of personalized skincare solutions.</p>\u0000 </div>","PeriodicalId":184,"journal":{"name":"Journal of Biophotonics","volume":"18 6","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144046394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RGB-Image-Based Real-Time Hemodynamic Monitoring of Intraperitoneal Organs in Rats Using a Standard Laparoscopic Imaging System 使用标准腹腔镜成像系统对大鼠腹腔内器官进行基于 RGB 图像的实时血流动力学监测。

IF 2 3区物理与天体物理

Journal of Biophotonics Pub Date : 2025-04-08 DOI: 10.1002/jbio.70030

Rokeya Khatun, Yurika Suzuki, Koyuki Kashiwagi, Yuki Nagahama, Tetsuo Ikeda, Hajime Nagahara, Izumi Nishidate

{"title":"RGB-Image-Based Real-Time Hemodynamic Monitoring of Intraperitoneal Organs in Rats Using a Standard Laparoscopic Imaging System","authors":"Rokeya Khatun, Yurika Suzuki, Koyuki Kashiwagi, Yuki Nagahama, Tetsuo Ikeda, Hajime Nagahara, Izumi Nishidate","doi":"10.1002/jbio.70030","DOIUrl":"10.1002/jbio.70030","url":null,"abstract":"<div>\u0000 \u0000 <p>The aim of this study is to validate an approach to monitor the spatial and temporal hemodynamics of intraperitoneal organs using a commercially available laparoscopic system. The approach to create a spatial map of tissue oxygen saturation (StO<sub>2</sub>) and total hemoglobin concentration (<i>C</i>\u0000 <sub>HbT</sub>) is based on a multiple regression model using Monte Carlo simulation of light transport in tissues to specify relationships between RGB values, oxygenated hemoglobin concentration, and deoxygenated hemoglobin concentration. Experiments with an optical phantom are performed to confirm the ability of the approach to detect changes in StO<sub>2</sub> and <i>C</i>\u0000 <sub>HbT</sub> under different working distances of the endoscope that may occur during actual surgery. In vivo experiments in rats confirm that the proposed approach can quantitatively monitor changes in StO<sub>2</sub> and <i>C</i>\u0000 <sub>HbT</sub> induced in the small intestine, liver, and cecum. The proposed approach has the potential as a tool for monitoring intraperitoneal organs in real time during laparoscopy.</p>\u0000 </div>","PeriodicalId":184,"journal":{"name":"Journal of Biophotonics","volume":"18 9","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Label-Free Typing of Colorectal Cancer by Optical Time-Stretch Imaging Flow Cytometry With Multi-Instance Learning 基于多实例学习的光学时间拉伸成像流式细胞术在结直肠癌无标记分型中的应用。

IF 2 3区物理与天体物理

Journal of Biophotonics Pub Date : 2025-04-07 DOI: 10.1002/jbio.70026

Sini Pi, Liye Mei, Liang Tao, Sisi Mei, Zhaoyi Ye

{"title":"Label-Free Typing of Colorectal Cancer by Optical Time-Stretch Imaging Flow Cytometry With Multi-Instance Learning","authors":"Sini Pi, Liye Mei, Liang Tao, Sisi Mei, Zhaoyi Ye","doi":"10.1002/jbio.70026","DOIUrl":"10.1002/jbio.70026","url":null,"abstract":"<div>\u0000 \u0000 <p>Colorectal cancer (CRC) is one of the most prevalent gastrointestinal malignancies, necessitating the study of cellular and molecular changes within the tumor microenvironment. While pathological image analysis remains the gold standard, its labor-intensive nature limits its broad application. This study proposes a label-free CRC typing approach using intelligent optical time-stretch (OTS) imaging flow cytometry combined with multi-instance learning. Specifically, we construct a high-throughput cell image acquisition system by integrating OTS imaging with microfluidic cell focusing, capturing 363 931 cell images from 10 clinical samples. To address cell diversity and heterogeneity, we employ a multi-instance learning framework, which incorporates a multi-level attention mechanism to explore feature interactions at both channel and instance levels. Finally, we apply a majority voting mechanism to enable efficient label-free CRC typing. Our method achieves an accuracy of 85.78% in distinguishing normal and cancerous cells, while encouraging CRC typing performance across all 10 clinical samples.</p>\u0000 </div>","PeriodicalId":184,"journal":{"name":"Journal of Biophotonics","volume":"18 8","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143805211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of Near-Infrared Characteristic Bands of Small Intestine Necrosis Based on Least Trimmed Squares With Regularization 基于正则化最小裁剪二乘的小肠坏死近红外特征波段识别。

IF 2 3区物理与天体物理

Journal of Biophotonics Pub Date : 2025-04-06 DOI: 10.1002/jbio.70023

Jingzhi Li, Chenxi Peng, Yuxuan Hou, Guangzao Huang, Lechao Zhang, Xiaojing Chen, Zhonghao Xie, Shujat Ali, Libin Zhu, Xiaoqing Chen

{"title":"Identification of Near-Infrared Characteristic Bands of Small Intestine Necrosis Based on Least Trimmed Squares With Regularization","authors":"Jingzhi Li, Chenxi Peng, Yuxuan Hou, Guangzao Huang, Lechao Zhang, Xiaojing Chen, Zhonghao Xie, Shujat Ali, Libin Zhu, Xiaoqing Chen","doi":"10.1002/jbio.70023","DOIUrl":"10.1002/jbio.70023","url":null,"abstract":"<div>\u0000 \u0000 <p>Hyperspectral imaging is a promising tool for identifying ischemic necrotic small intestine. To analyze the causes of small bowel necrosis, studying characteristic bands is crucial. However, differences in samples and spectral acquisition devices limit the availability of all bands for analysis, posing challenges in selecting bands adapted to individual variations. This study proposed a method based on the least trimmed squares algorithm, enhanced with regularization, to identify characteristic bands. The method successfully differentiated normal and necrotic tissue and analyzed necrosis causes, which originated from the same rabbit, different rabbits, and different necrosis durations. It identified 763 nm as the characteristic band, corresponding to the deoxyhemoglobin absorption peak. This approach offers accurate, automated band identification while addressing sample and device discrepancies, enabling the selection of more suitable characteristic bands.</p>\u0000 </div>","PeriodicalId":184,"journal":{"name":"Journal of Biophotonics","volume":"18 8","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0