Effects of Combined Transcranial Magnetic Stimulation and Photobiomodulation in Mild Cognitive Impairment: A Randomized Controlled Trial

IF 2 3区物理与天体物理 Q3 BIOCHEMICAL RESEARCH METHODS

Journal of Biophotonics Pub Date : 2025-04-20 DOI:10.1002/jbio.70019

Da Han, Zengyong Li, Jingsha Zhang, Ping Xie

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Abstract

This study evaluates the synergistic effects of transcranial magnetic stimulation (TMS) and transcranial photobiomodulation (tPBM) on working memory (WM) in mild cognitive impairment (MCI) patients. In a randomized controlled trial with 88 participants, utilizing a complex WM task (ΔK = 6.41, p = 0.004) alongside functional near-infrared spectroscopy (fNIRS) to assess cognitive performance and neural correlates(neural metrics from fNIRS indicated enhanced functional connectivity [p = 0.015] and increased wavelet amplitude in task-relevant cortical regions [p = 0.001]), our results indicated that the combined intervention significantly outperformed both monostimulation and sham stimulation in improving WM capacity. A notable strength of this study is the simultaneous application of TMS and tPBM, which maximizes potential synergistic effects while addressing the physical constraints associated with traditional noninvasive brain stimulation (NIBS). Findings underscore dual neuromodulation as a promising noninvasive intervention for MCI, offering insights into cognitive enhancement mechanisms.

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经颅磁刺激和光生物调节联合治疗轻度认知障碍：一项随机对照试验。

本研究评价了经颅磁刺激（TMS）和经颅光生物调节（tPBM）对轻度认知障碍（MCI）患者工作记忆（WM）的协同作用。在一项有88名参与者的随机对照试验中，利用复杂的WM任务（ΔK = 6.41, p = 0.004）和功能性近红外光谱（fNIRS）来评估认知表现和神经相关性（fNIRS的神经指标表明功能连通性增强[p = 0.015]，任务相关皮质区域的小波振幅增加[p = 0.001]）。我们的研究结果表明，联合干预在提高WM能力方面明显优于单刺激和假刺激。本研究的一个显著优势是同时应用TMS和tPBM，在解决传统无创脑刺激（NIBS）相关的物理限制的同时，最大限度地发挥潜在的协同效应。研究结果强调了双重神经调节作为MCI的有前途的无创干预，为认知增强机制提供了见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Biophotonics 生物-生化研究方法

CiteScore

5.70

自引率

7.10%

发文量

248

审稿时长

1 months

期刊介绍： The first international journal dedicated to publishing reviews and original articles from this exciting field, the Journal of Biophotonics covers the broad range of research on interactions between light and biological material. The journal offers a platform where the physicist communicates with the biologist and where the clinical practitioner learns about the latest tools for the diagnosis of diseases. As such, the journal is highly interdisciplinary, publishing cutting edge research in the fields of life sciences, medicine, physics, chemistry, and engineering. The coverage extends from fundamental research to specific developments, while also including the latest applications.