Metabolites最新文献_第3页

Cellular Metabolomics Reveals Differences in the Scope of Liver Protection Between Ammonium-Based Glycyrrhizinate and Magnesium Isoglycyrrhizinate. 细胞代谢组学揭示氨基甘草酸盐和异甘草酸镁在肝脏保护范围上的差异。

IF 3.4 3区生物学

Metabolites Pub Date : 2025-04-10 DOI: 10.3390/metabo15040263

Yihua Zhang, Han Hao, Hui Li, Qiong Duan, Xiaoming Zheng, Yan Feng, Kun Yang, Shigang Shen

{"title":"Cellular Metabolomics Reveals Differences in the Scope of Liver Protection Between Ammonium-Based Glycyrrhizinate and Magnesium Isoglycyrrhizinate.","authors":"Yihua Zhang, Han Hao, Hui Li, Qiong Duan, Xiaoming Zheng, Yan Feng, Kun Yang, Shigang Shen","doi":"10.3390/metabo15040263","DOIUrl":"https://doi.org/10.3390/metabo15040263","url":null,"abstract":"Background: Despite the well-established liver-protective efficacy of monoammonium glycyrrhizinate (MONO), diammonium glycyrrhizinate (DIAM), and magnesium isoglycyrrhizinate (MAGN), which has been translated into clinical practice, their clinical differentiation remains elusive owing to their structural similarities and overlapping therapeutic effects. Methods: The present study delves into the pharmacokinetics, cellular-level liver-protective potencies, and underlying mechanisms of action of these three compounds through a comprehensive analysis. Results: The findings reveal that both DIAM and MAGN exhibit superior bioavailability and hepatoprotective profiles compared to MONO. Notably, an investigation of the metabolic pathways mediating liver protection in normal human liver cells (LO2), utilizing an ultra-performance liquid chromatography-time of flight tandem mass spectrometry (UPLC-TOF-MS/MSe) platform, demonstrated that MAGN augments antioxidant components, thereby favoring its application in drug-induced liver injury (DILI). Conversely, DIAM appears to be a more suitable candidate for addressing non-alcoholic fatty liver disease (NAFLD) and viral hepatitis. Conclusion: This study contributes novel perspectives on the mechanisms of action and potential clinical utilities of DIAM and MAGN in liver disease prevention and management.","PeriodicalId":18496,"journal":{"name":"Metabolites","volume":"15 4","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12029898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact on Metabolism Generated by Surgical and Pharmacological Interventions for Weight Loss in Women with Infertility. 不孕妇女减肥手术和药物干预对代谢的影响。

IF 3.4 3区生物学

Metabolites Pub Date : 2025-04-10 DOI: 10.3390/metabo15040260

Paulo César Gete Palacios, Alberto Moscona-Nissan, Renata Saucedo, Aldo Ferreira-Hermosillo

{"title":"Impact on Metabolism Generated by Surgical and Pharmacological Interventions for Weight Loss in Women with Infertility.","authors":"Paulo César Gete Palacios, Alberto Moscona-Nissan, Renata Saucedo, Aldo Ferreira-Hermosillo","doi":"10.3390/metabo15040260","DOIUrl":"https://doi.org/10.3390/metabo15040260","url":null,"abstract":"Obesity increases the risk of anovulation, insulin resistance, hyperandrogenism, and endometrial dysfunction, resulting in women with infertility and increasing preconceptional and pregnancy complications. Bariatric surgery has been described as the most effective intervention for obesity, with improved fertility outcomes. However, its invasive nature increases the potential of nutritional deficiencies and the need for a delayed conception post-surgery. On the other hand, pharmacological treatments such as glucagon-like-peptide 1 receptor agonists offer non-invasive alternatives with promising results in body weight, improving insulin sensitivity and restoring ovarian function. However, their use must be discontinued before conception due to potential fetal risks. Other available pharmacological treatment options encompass topiramate, phentermine, and Orlistat. The choice of treatment must be individualized considering cost-effectiveness, accessibility, obesity severity, reproductive goals, and associated risks within each patient. A multidisciplinary approach is essential to optimize metabolic and reproductive health in obesity and infertility. This review will examine the impact on metabolism when comparing surgical and pharmacological interventions for weight loss in women with infertility.","PeriodicalId":18496,"journal":{"name":"Metabolites","volume":"15 4","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12029110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combined Effects of Rhodiola Rosea and Caffeine Supplementation on Straight Punch Explosive Power in Untrained and Trained Boxing Volunteers: A Synergistic Approach. 补充红景天和咖啡因对未训练和训练拳击志愿者直拳爆发力的联合影响：一种协同方法。

IF 3.4 3区生物学

Metabolites Pub Date : 2025-04-10 DOI: 10.3390/metabo15040262

Biaoxu Tao, Hao Sun, Huixin Li, Zhiqin Xu, Yuan Xu, Liqi Chen, Chengzhe Ma, Xiaoyu Zhang, Longqi Yu, Shanjun Bao, Chang Liu

{"title":"Combined Effects of Rhodiola Rosea and Caffeine Supplementation on Straight Punch Explosive Power in Untrained and Trained Boxing Volunteers: A Synergistic Approach.","authors":"Biaoxu Tao, Hao Sun, Huixin Li, Zhiqin Xu, Yuan Xu, Liqi Chen, Chengzhe Ma, Xiaoyu Zhang, Longqi Yu, Shanjun Bao, Chang Liu","doi":"10.3390/metabo15040262","DOIUrl":"https://doi.org/10.3390/metabo15040262","url":null,"abstract":"Objectives: This study aimed to investigate the effects of combined supplementation with Rhodiola rosea (RHO) and caffeine (CAF) on the explosive power and sustained output capacity of lead and rear straight punches in both untrained and trained volunteers, with a focus on potential synergistic effects.Methods: randomized, double-blind, placebo-controlled design was employed, enrolling 96 participants (48 untrained, 48 trained). Participants were stratified and randomly assigned to the control (CTR), CAF, RHO, or CAF+RHO group. All subjects completed an 8-week standardized boxing training program (twice per week). Punch performance was assessed using professional boxing equipment and a biomechanical testing system, evaluating lead and rear straight punches, ground reaction force (GRF), and a 30 s continuous punching test.Results: the CAF+RHO group showed significant improvements in both untrained and trained volunteers. Com-pared to the RHO group, this group demonstrated higher lead punch velocity, shorter bi-lateral peak force time during rear punches, and more punches in the 30 s test (p < 0.05). Compared to the CAF group, the CAF+RHO group exhibited greater rear punch force, higher bilateral peak force during lead punches, increased forefoot peak force in rear punches, and improved 30 s power output (p < 0.05). The CAF+RHO group also outperformed the CTR group across all parameters (p < 0.05).Conclusions: Combined supple mentation with CAF and RHO significantly enhances both explosive power and sustained output in boxing performance. This may result from improved energy metabolism efficiency and neuromuscular coordination, providing a promising nutritional strategy for high-intensity intermittent exercise.","PeriodicalId":18496,"journal":{"name":"Metabolites","volume":"15 4","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12029514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Optimal Protective 25-Hydroxyvitamin D Level for Different Health Outcomes in Adults: A Brief Summary of Dose-Response Meta-Analyses. 成人不同健康结果的最佳保护性25-羟基维生素D水平：剂量-反应荟萃分析的简要总结

IF 3.4 3区生物学

Metabolites Pub Date : 2025-04-10 DOI: 10.3390/metabo15040264

Cem Ekmekcioglu, Michael Poteser

引用次数: 0

Vitamin D and Its Role in Rheumatic Diseases. 维生素D及其在风湿病中的作用。

IF 3.4 3区生物学

Metabolites Pub Date : 2025-04-09 DOI: 10.3390/metabo15040259

Maritza Vidal, Nancy E Lane

引用次数: 0

Assessment of Biochemical Composition of Fruits of Hippophae rhamnoides (Elaeagnaceae juss.), Viburnum opulus (Viburnaceae raf.) and Lonicera caerulea subsp. altaica (Caprifoliaceae juss.). 沙棘（Elaeagnaceae, juss.）、桃荚蒾（Viburnum opulus, Viburnaceae, raf.）和金银花（Lonicera caerulea亚种）果实生化成分的评价。菖蒲属（菖蒲科）。

IF 3.4 3区生物学

Metabolites Pub Date : 2025-04-09 DOI: 10.3390/metabo15040256

Tatiana Vdovina, Olga Lagus, Andrei Vinokurov, Zhanar Aimenova, Aidar Sumbembayev

{"title":"Assessment of Biochemical Composition of Fruits of Hippophae rhamnoides (Elaeagnaceae juss.), Viburnum opulus (Viburnaceae raf.) and Lonicera caerulea subsp. altaica (Caprifoliaceae juss.).","authors":"Tatiana Vdovina, Olga Lagus, Andrei Vinokurov, Zhanar Aimenova, Aidar Sumbembayev","doi":"10.3390/metabo15040256","DOIUrl":"https://doi.org/10.3390/metabo15040256","url":null,"abstract":"Background/Objectives: This study explores the biochemical diversity of Hippophae rhamnoides, Viburnum opulus, and Lonicera caerulea subsp. altaica to identify genotypes rich in bioactive compounds for breeding nutritionally valuable cultivars. Methods: Selected forms and cultivars of each species were evaluated for key biochemical traits. Analyses included quantification of vitamins (C, B9, B12), sugars, organic acids, carotenoids, and flavonoids using HPLC and TLC. Results: In H. rhamnoides, vitamin C content ranged widely, with 'Pamyati Baytulina Sh-9-81' reaching 156.0 mg/%, while 'Shetlastinka No. 7' showed the most favorable sugar-to-vitamin C ratio. 'Krasnoplodnaya K-14-81' had the highest carotenoids (55.3 mg/100 g), and 'Dolgozhdannaya No. 5' was notable for flavonoid richness. In V. opulus, considerable variation was observed in vitamin content, sugars, and dry matter; 'Zhemchuzhnoe Ozhele' and 'Shtambovaya' were rich in rutin and robinin. In L. caerulea subsp. altaica, forms No. 5, 7, and 9 stood out for vitamin C, sugar, and flavonoid content. Hyperoside, isorhamnetin, and myricetin were common, while kaempferol and hypolaetin were form-specific. Conclusions:H. rhamnoides demonstrated the highest variability in biochemical composition, while L. caerulea subsp. altaica showed a particularly rich flavonoid profile. These species offer valuable genetic resources for developing biofortified cultivars suited to both nutritional and adaptive breeding goals.","PeriodicalId":18496,"journal":{"name":"Metabolites","volume":"15 4","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12029084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aromatic Volatile Substances in Different Types of Guangnan Dixu Tea Based on HS-SPME-GC-MS Odor Activity Value. 基于HS-SPME-GC-MS的不同类型广南地茶香气挥发性物质气味活性值研究

IF 3.4 3区生物学

Metabolites Pub Date : 2025-04-09 DOI: 10.3390/metabo15040257

Ying Feng, Di Tian, Chaoliang Wang, Yong Huang, Yang Luo, Xiuqiong Zhang, Lei Li

{"title":"Aromatic Volatile Substances in Different Types of Guangnan Dixu Tea Based on HS-SPME-GC-MS Odor Activity Value.","authors":"Ying Feng, Di Tian, Chaoliang Wang, Yong Huang, Yang Luo, Xiuqiong Zhang, Lei Li","doi":"10.3390/metabo15040257","DOIUrl":"https://doi.org/10.3390/metabo15040257","url":null,"abstract":"Dixu tea is one of the characteristic tea germplasm resources of southeastern Yunnan, and is also a precious wild tea germplasm resource. Background: In order to further develop Dixu tea products and improve their flavor, this article studies the effects of different processing methods on the aroma quality of Dixu tea. Methods: A comprehensive analysis of the aroma quality of Diwei tea was conducted using HS-SPME combined with GC-MS and multivariate statistical analysis. A principal component analysis (PCA) was applied to process the detected volatile substances and an orthogonal partial least squares-discriminant analysis (OPLS-DA) model was established. We evaluated the contribution of major compounds in the tea aroma by calculating the odor activity value (OAV). Results: The results showed that a total of 67 compounds were identified. A total of 27 major aromatic volatile compounds (OAV > 1) were screened, and 17 key differential volatile compounds were identified in different tea samples, including octanoic acid, d-citrol, laurene, hexanal, citral, β-cyclic citral, trans-2-hexenal, γ-nonanolide, β-ionone, geranylacetone, 1,1,6-trimethyl-1,2-dihydronaphthalene, geraniol, methyl salicylate, linalool, nerolidol, and 7,11-dimethyl-3-methylene-1,6,10-dodecatriene. Combined with the OAV analysis, it is shown that a floral fragrance is a common feature of Guangnan Dixu tea varieties. In addition, white tea also has a fragrant aroma, while black tea, green tea, and bamboo tube tea are all accompanied by a fruity aroma. Conclusions: In summary, processing techniques regulate the aroma characteristics of various types of tea by changing the types and contents of volatile aroma compounds. This provides a theoretical basis for exploring and utilizing tea production resources in the future.","PeriodicalId":18496,"journal":{"name":"Metabolites","volume":"15 4","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12029467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug Repurposing for Non-Alcoholic Fatty Liver Disease by Analyzing Networks Among Drugs, Diseases, and Genes. 通过分析药物、疾病和基因之间的网络，对非酒精性脂肪性肝病的药物再利用。

IF 3.4 3区生物学

Metabolites Pub Date : 2025-04-09 DOI: 10.3390/metabo15040255

Md Altaf-Ul-Amin, Ahmad Kamal Nasution, Rumman Mahfujul Islam, Pei Gao, Naoaki Ono, Shigehiko Kanaya

{"title":"Drug Repurposing for Non-Alcoholic Fatty Liver Disease by Analyzing Networks Among Drugs, Diseases, and Genes.","authors":"Md Altaf-Ul-Amin, Ahmad Kamal Nasution, Rumman Mahfujul Islam, Pei Gao, Naoaki Ono, Shigehiko Kanaya","doi":"10.3390/metabo15040255","DOIUrl":"https://doi.org/10.3390/metabo15040255","url":null,"abstract":"Background/objectives: Drug development for complex diseases such as NAFLD is often lengthy and expensive. Drug repurposing, the process of finding new therapeutic uses for existing drugs, presents a promising alternative to traditional approaches. This study aims to identify potential repurposed drugs for NAFLD by leveraging disease-disease relationships and drug-target data from the BioSNAP database.Methods: A bipartite network was constructed between drugs and their target genes, followed by the application of the BiClusO bi-clustering algorithm to identify high-density clusters. Clusters with significant associations with NAFLD risk genes were considered to predict potential drug candidates. Another set of candidates was determined based on disease similarity.Results: A novel ranking methodology was developed to evaluate and prioritize these candidates, supported by a comprehensive literature review of their effectiveness in NAFLD treatment.Conclusions: This research demonstrates the potential of drug repurposing to accelerate the development of therapies for NAFLD, offering valuable insights into novel treatment strategies for complex diseases.","PeriodicalId":18496,"journal":{"name":"Metabolites","volume":"15 4","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12029302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum Amino Acid Profiles in Dogs with a Congenital Portosystemic Shunt. 先天性门系统分流犬的血清氨基酸谱。

IF 3.4 3区生物学

Metabolites Pub Date : 2025-04-09 DOI: 10.3390/metabo15040258

Robert Kyle Phillips, Amanda B Blake, Michael S Tivers, Alex Chan, Patricia E Ishii, Jan S Suchodolski, Jörg M Steiner, Jonathan A Lidbury

{"title":"Serum Amino Acid Profiles in Dogs with a Congenital Portosystemic Shunt.","authors":"Robert Kyle Phillips, Amanda B Blake, Michael S Tivers, Alex Chan, Patricia E Ishii, Jan S Suchodolski, Jörg M Steiner, Jonathan A Lidbury","doi":"10.3390/metabo15040258","DOIUrl":"https://doi.org/10.3390/metabo15040258","url":null,"abstract":"Background/Objectives: A functional liver is vital for normal protein metabolism. Alterations of circulating amino acid (AA) concentrations have previously been reported in dogs with hepatocellular carcinoma, chronic hepatitis, and hepatocutaneous syndrome. The purpose of this study was to compare serum AA profiles between dogs with a congenital portosystemic shunt (CPSS) and healthy control dogs. Methods: Serum samples were collected from 50 dogs with an extrahepatic congenital portosystemic shunt (eCPSS) and 10 dogs with an intrahepatic congenital portosystemic shunt (iCPSS) at time of surgical intervention and from 21 healthy control dogs. Serum AA and other nitrogenous compounds were measured with a dedicated amino acid analyzer. The concentration of each AA was compared between groups using a Kruskal-Wallis test followed by Dunn's multiple comparisons tests, as appropriate. The Benjamini-Hochberg procedure was used to control for false discovery. Significance was set at q < 0.05. Results: Compared to healthy controls, dogs with a CPSS had significantly increased serum concentrations of ammonia, asparagine, glutamic acid, histidine, phenylalanine, serine, and tyrosine and had significantly decreased concentrations of isoleucine, leucine, threonine, urea, and valine. There were no significant differences in serum AA concentrations between dogs with an eCPSS and dogs with an iCPSS. Conclusions: Dogs with a CPSS had altered serum AA concentrations compared to healthy control dogs, including decreased branched-chain amino acids (BCAAs) and increased aromatic amino acids (AAAs). In summary, serum AA profiles can differentiate dogs with a CPSS from healthy dogs but not dogs with an eCPSS from dogs with an iCPSS.","PeriodicalId":18496,"journal":{"name":"Metabolites","volume":"15 4","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12029160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kinetics of Manganese Peroxidase Using Simple Phenolic Compounds as Substrates. 以简单酚类化合物为底物的锰过氧化物酶动力学。

IF 3.4 3区生物学

Metabolites Pub Date : 2025-04-09 DOI: 10.3390/metabo15040254

Madeline G Gruenberg, Jonathan J Halvorson, Michael A Schmidt

引用次数: 0